{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T01:46:17Z","timestamp":1790819177918,"version":"4.1.0"},"reference-count":64,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2021,8,6]],"date-time":"2021-08-06T00:00:00Z","timestamp":1628208000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","award":["P50 DC015446"],"award-info":[{"award-number":["P50 DC015446"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Chilean National Commission for Scientific and Technological Research","award":["CONICYT BASAL Grant FB0008"],"award-info":[{"award-number":["CONICYT BASAL Grant FB0008"]}]},{"name":"Chilean National Agency for Research and Development","award":["Beca Doctorado Nacional 21190074"],"award-info":[{"award-number":["Beca Doctorado Nacional 21190074"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Applied Sciences"],"abstract":"<jats:p>The purpose of this paper is to report on the first in vivo application of a recently developed transoral, dual-sensor pressure probe that directly measures intraglottal, subglottal, and vocal fold collision pressures during phonation. Synchronous measurement of intraglottal and subglottal pressures was accomplished using two miniature pressure sensors mounted on the end of the probe and inserted transorally in a 78-year-old male who had previously undergone surgical removal of his right vocal fold for treatment of laryngeal cancer. The endoscopist used one hand to position the custom probe against the surgically medialized scar band that replaced the right vocal fold and used the other hand to position a transoral endoscope to record laryngeal high-speed videoendoscopy of the vibrating left vocal fold contacting the pressure probe. Visualization of the larynx during sustained phonation allowed the endoscopist to place the dual-sensor pressure probe such that the proximal sensor was positioned intraglottally and the distal sensor subglottally. The proximal pressure sensor was verified to be in the strike zone of vocal fold collision during phonation when the intraglottal pressure signal exhibited three characteristics: an impulsive peak at the start of the closed phase, a rounded peak during the open phase, and a minimum value around zero immediately preceding the impulsive peak of the subsequent phonatory cycle. Numerical voice production modeling was applied to validate model-based predictions of vocal fold collision pressure using kinematic vocal fold measures. The results successfully demonstrated feasibility of in vivo measurement of vocal fold collision pressure in an individual with a hemilaryngectomy, motivating ongoing data collection that is designed to aid in the development of vocal dose measures that incorporate vocal fold impact collision and stresses.<\/jats:p>","DOI":"10.3390\/app11167256","type":"journal-article","created":{"date-parts":[[2021,8,6]],"date-time":"2021-08-06T08:01:42Z","timestamp":1628236902000},"page":"7256","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Direct Measurement and Modeling of Intraglottal, Subglottal, and Vocal Fold Collision Pressures during Phonation in an Individual with a Hemilaryngectomy"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6535-573X","authenticated-orcid":false,"given":"Daryush D.","family":"Mehta","sequence":"first","affiliation":[{"name":"Center for Laryngeal Surgery and Voice Rehabilitation, Massachusetts General Hospital, Boston, MA 02114, USA"},{"name":"Department of Surgery, Massachusetts General Hospital\u2013Harvard Medical School, Boston, MA 02114, USA"},{"name":"Speech and Hearing Bioscience and Technology, Division of Medical Sciences, Harvard Medical School, Boston, MA 02115, USA"},{"name":"MGH Institute of Health Professions, Boston, MA 02129, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James B.","family":"Kobler","sequence":"additional","affiliation":[{"name":"Center for Laryngeal Surgery and Voice Rehabilitation, Massachusetts General Hospital, Boston, MA 02114, USA"},{"name":"Department of Surgery, Massachusetts General Hospital\u2013Harvard Medical School, Boston, MA 02114, USA"},{"name":"Speech and Hearing Bioscience and Technology, Division of Medical Sciences, Harvard Medical School, Boston, MA 02115, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven M.","family":"Zeitels","sequence":"additional","affiliation":[{"name":"Center for Laryngeal Surgery and Voice Rehabilitation, Massachusetts General Hospital, Boston, MA 02114, USA"},{"name":"Department of Surgery, Massachusetts General Hospital\u2013Harvard Medical School, Boston, MA 02114, USA"},{"name":"Speech and Hearing Bioscience and Technology, Division of Medical Sciences, Harvard Medical School, Boston, MA 02115, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5581-4392","authenticated-orcid":false,"given":"Mat\u00edas","family":"Za\u00f1artu","sequence":"additional","affiliation":[{"name":"Department of Electronic Engineering, Universidad T\u00e9cnica Federico Santa Mar\u00eda, Valpara\u00edso, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6975-4247","authenticated-orcid":false,"given":"Emiro J.","family":"Ibarra","sequence":"additional","affiliation":[{"name":"Department of Electronic Engineering, Universidad T\u00e9cnica Federico Santa Mar\u00eda, Valpara\u00edso, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel A.","family":"Alzamendi","sequence":"additional","affiliation":[{"name":"Institute for Research and Development on Bioengineering and Bioinformatics, National University of Entre Rios\u2013CONICET, Entre R\u00edos 3100, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"Manriquez","sequence":"additional","affiliation":[{"name":"Department of Electronic Engineering, Universidad T\u00e9cnica Federico Santa Mar\u00eda, Valpara\u00edso, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0057-6731","authenticated-orcid":false,"given":"Byron D.","family":"Erath","sequence":"additional","affiliation":[{"name":"Department of Mechanical & Aeronautical Engineering, Clarkson University, Potsdam, NY 13699, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8746-2491","authenticated-orcid":false,"given":"Sean D.","family":"Peterson","sequence":"additional","affiliation":[{"name":"Department of Mechanical and Mechatronics Engineering, University of Waterloo, Waterloo, ON N2L 3G1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert H.","family":"Petrillo","sequence":"additional","affiliation":[{"name":"Center for Laryngeal Surgery and Voice Rehabilitation, Massachusetts General Hospital, Boston, MA 02114, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert E.","family":"Hillman","sequence":"additional","affiliation":[{"name":"Center for Laryngeal Surgery and Voice Rehabilitation, Massachusetts General Hospital, Boston, MA 02114, USA"},{"name":"Department of Surgery, Massachusetts General Hospital\u2013Harvard Medical School, Boston, MA 02114, USA"},{"name":"Speech and Hearing Bioscience and Technology, Division of Medical Sciences, Harvard Medical School, Boston, MA 02115, USA"},{"name":"MGH Institute of Health Professions, Boston, MA 02129, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,8,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1097\/01.mlg.0000179174.32345.41","article-title":"Voice disorders in the general population: Prevalence, risk factors, and occupational impact","volume":"115","author":"Roy","year":"2005","journal-title":"Laryngoscope"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2359","DOI":"10.1002\/lary.24740","article-title":"The prevalence of voice problems among adults in the United 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