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Although estimating subglottal pressure during phonation is an important component of a standard voice assessment, current methods for estimating subglottal pressure rely on non-natural speech tasks in a clinical or laboratory setting. This study reports on the validation of a method for subglottal pressure estimation in individuals with and without voice disorders that can be translated to connected speech to enable the monitoring of vocal function and behavior in real-world settings. During a laboratory calibration session, a participant-specific multiple regression model was derived to estimate subglottal pressure from a neck-surface vibration signal that can be recorded during natural speech production. The model was derived for vocally typical individuals and patients diagnosed with phonotraumatic vocal fold lesions, primary muscle tension dysphonia, and unilateral vocal fold paralysis. Estimates of subglottal pressure using the developed method exhibited significantly lower error than alternative methods in the literature, with average errors ranging from 1.13 to 2.08 cm H2O for the participant groups. The model was then applied during activities of daily living, thus yielding ambulatory estimates of subglottal pressure for the first time in these populations. Results point to the feasibility and potential of real-time monitoring of subglottal pressure during an individual\u2019s daily life for the prevention, assessment, and treatment of voice disorders.<\/jats:p>","DOI":"10.3390\/app122110692","type":"journal-article","created":{"date-parts":[[2022,10,23]],"date-time":"2022-10-23T20:43:50Z","timestamp":1666557830000},"page":"10692","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Ambulatory Monitoring of Subglottal Pressure Estimated from Neck-Surface Vibration in Individuals with and without Voice Disorders"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4346-2489","authenticated-orcid":false,"given":"Juan P.","family":"Cort\u00e9s","sequence":"first","affiliation":[{"name":"Center for Laryngeal Surgery and Voice Rehabilitation, Massachusetts General Hospital, Boston, MA 02114, USA"},{"name":"Department of Electronic Engineering, Universidad T\u00e9cnica Federico Santa Mar\u00eda, Valpara\u00edso 2390123, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon Z.","family":"Lin","sequence":"additional","affiliation":[{"name":"Center for Laryngeal Surgery and Voice Rehabilitation, Massachusetts General Hospital, Boston, MA 02114, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine L.","family":"Marks","sequence":"additional","affiliation":[{"name":"Center for Laryngeal Surgery and Voice Rehabilitation, Massachusetts General Hospital, Boston, MA 02114, USA"},{"name":"Communication Sciences and Disorders, MGH Institute of Health Professions, Boston, MA 02129, USA"},{"name":"Speech, Language & Hearing Sciences Department, College of Health & Rehabilitation: Sargent College, Boston University, Boston, MA 02215, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9013-6830","authenticated-orcid":false,"given":"V\u00edctor M.","family":"Espinoza","sequence":"additional","affiliation":[{"name":"Department of Sound, Universidad de Chile, Santiago 8380453, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6975-4247","authenticated-orcid":false,"given":"Emiro J.","family":"Ibarra","sequence":"additional","affiliation":[{"name":"Department of Electronic Engineering, Universidad T\u00e9cnica Federico Santa Mar\u00eda, Valpara\u00edso 2390123, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5581-4392","authenticated-orcid":false,"given":"Mat\u00edas","family":"Za\u00f1artu","sequence":"additional","affiliation":[{"name":"Department of Electronic Engineering, Universidad T\u00e9cnica Federico Santa Mar\u00eda, Valpara\u00edso 2390123, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert E.","family":"Hillman","sequence":"additional","affiliation":[{"name":"Center for Laryngeal Surgery and Voice Rehabilitation, Massachusetts General Hospital, Boston, MA 02114, USA"},{"name":"Communication Sciences and Disorders, MGH Institute of Health Professions, Boston, MA 02129, USA"},{"name":"Department of Surgery, Massachusetts General Hospital\u2013Harvard Medical School, Boston, MA 02114, USA"},{"name":"Speech and Hearing Bioscience and Technology, Division of Medical Sciences, Harvard Medical School, Boston, MA 02115, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daryush D.","family":"Mehta","sequence":"additional","affiliation":[{"name":"Center for Laryngeal Surgery and Voice Rehabilitation, Massachusetts General Hospital, Boston, MA 02114, USA"},{"name":"Communication Sciences and Disorders, MGH Institute of Health Professions, Boston, MA 02129, USA"},{"name":"Department of 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