{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T04:47:57Z","timestamp":1760244477678,"version":"build-2065373602"},"reference-count":22,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2022,12,12]],"date-time":"2022-12-12T00:00:00Z","timestamp":1670803200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ARM"],"abstract":"<jats:p>The COVID-19 crisis has highlighted the difficulties that might occur when attempting to oxygenate patients who have suffered a severe pulmonary insult, including in the development of acute respiratory distress syndrome (ARDS). Traditional mechanical ventilation (MV) is effective; however, in severe cases of hypoxia, the use of rescue therapy, such as extracorporeal membrane oxygenation (ECMO), may be required but is also associated with significant complexity and complications. In this review, we describe peritoneal oxygenation; a method of oxygenation that exploits the peritoneum\u2019s gas exchange properties in a fashion that is similar to peritoneal dialysis and has shown considerable promise in animal models. We have conducted a review of the available literature and techniques, including intraperitoneal perfluorocarbons, intraperitoneal jet ventilation, a continuous low-pressure oxygen system (PEROX) and the use of phospholipid-coated oxygen microbubbles (OMBs) through peritoneal microbubble oxygenation (PMO). We conclude that peritoneal oxygenation is a promising technique that warrants further investigation and might be used in clinical settings in the future.<\/jats:p>","DOI":"10.3390\/arm90060057","type":"journal-article","created":{"date-parts":[[2022,12,13]],"date-time":"2022-12-13T04:00:11Z","timestamp":1670904011000},"page":"511-517","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Peritoneal Oxygenation as a Novel Technique for Extrapulmonary Ventilation; A Review and Discussion of the Literature"],"prefix":"10.3390","volume":"90","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0980-7663","authenticated-orcid":false,"given":"James R. M.","family":"Colbourne","sequence":"first","affiliation":[{"name":"Department of Surgery, St. George Hospital, Sydney 2217, Australia"},{"name":"Westmead Hospital, University of Sydney, Sydney 2145, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khaled H.","family":"Altoukhi","sequence":"additional","affiliation":[{"name":"Department of Surgery, St. George Hospital, Sydney 2217, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David L.","family":"Morris","sequence":"additional","affiliation":[{"name":"Department of Surgery, St. George Hospital, Sydney 2217, Australia"},{"name":"St. George and Sutherland Clinical School, University of New South Wales, Sydney 2217, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1515\/jtim-2016-0012","article-title":"Acute Respiratory Distress Syndrome: An Update and Review","volume":"6","author":"Rawal","year":"2018","journal-title":"J. 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