{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T18:02:47Z","timestamp":1774548167348,"version":"3.50.1"},"reference-count":16,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2025,1,26]],"date-time":"2025-01-26T00:00:00Z","timestamp":1737849600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ARM"],"abstract":"<jats:p>Procalcitonin (PCT) is commonly used to evaluate the etiology and severity of pneumonia. PCT has been shown to be elevated at baseline in patients with obesity. The aim of this study is to determine if body mass index (BMI) has an influence on admission PCT level in patients admitted to the hospital with a diagnosis of pneumonia. We conducted a retrospective cohort study that encompassed patient visits to a tertiary care center from 2014 until September 2023. A total of 18,652 patients presented to the emergency department with a diagnosis of pneumonia. A total of 3659 were admitted to the floor, and 2246 were admitted to the MICU. Patients were grouped based on admission BMI into five categories. The Kruskal\u2013Wallis test performed on patients admitted to the floor revealed a statistically significant difference in PCT levels among groups of different BMIs (H = 34.97, df = 4, p &lt; 0.001). In patients admitted to the MICU, the Kruskal\u2013Wallis test revealed a significant difference in PCT levels among groups of different BMIs (H = 32.92, df = 4, p &lt; 0.001). BMI has a statistically significant effect on PCT in patients admitted to the hospital with pneumonia. Patients with higher BMI may exhibit less robust PCT levels, which may impact management decisions.<\/jats:p>","DOI":"10.3390\/arm93010001","type":"journal-article","created":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T03:54:27Z","timestamp":1737950067000},"page":"1","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Evaluating the Effect of Body Mass Index on Procalcitonin Level in Patients with Pneumonia: A Retrospective Cross-Sectional Study"],"prefix":"10.3390","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-5392-9779","authenticated-orcid":false,"given":"Mohammad Z.","family":"Khrais","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Curran","family":"Henson","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7045-7151","authenticated-orcid":false,"given":"Jake","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikhil","family":"Meena","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA"},{"name":"Division of Pulmonary Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1006\/cyto.1999.0607","article-title":"Procalcitonin and calcitonin gene-related peptide decrease LPS-induced tnf production by human circulating blood cells","volume":"12","author":"Monneret","year":"2000","journal-title":"Cytokine"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1530\/eje.1.02046","article-title":"Plasma calcitonin gene-related peptide is increased prior to obesity, and sensory nerve desensitization by capsaicin improves oral glucose tolerance in obese Zucker rats","volume":"153","author":"Gram","year":"2005","journal-title":"Eur. 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Dis."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Mazaheri, T., Ranasinghe, R., Al-Hasani, W., Luxton, J., Kearney, J., Manning, A., Dimitriadis, G.K., Mare, T., and Vincent, R.P. (2022). A cytokine panel and procalcitonin in COVID-19, a comparison between intensive care and non-intensive care patients. PLoS ONE, 17.","DOI":"10.1371\/journal.pone.0266652"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/j.idc.2022.07.004","article-title":"Uses of Procalcitonin as a Biomarker in Critical Care Medicine","volume":"36","author":"Maves","year":"2022","journal-title":"Infect. Dis. Clin. N. Am."},{"key":"ref_8","unstructured":"Centers for Disease Control and Prevention (2024, December 12). 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Biochem."}],"container-title":["Advances in Respiratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2543-6031\/93\/1\/1\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T10:36:42Z","timestamp":1759919802000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2543-6031\/93\/1\/1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,26]]},"references-count":16,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,2]]}},"alternative-id":["arm93010001"],"URL":"https:\/\/doi.org\/10.3390\/arm93010001","relation":{},"ISSN":["2543-6031"],"issn-type":[{"value":"2543-6031","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,26]]}}}