{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:27:42Z","timestamp":1788827262836,"version":"build-2803163510"},"reference-count":28,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T00:00:00Z","timestamp":1775433600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["52473137"],"award-info":[{"award-number":["52473137"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"award":["52473137"],"award-info":[{"award-number":["52473137"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ARM"],"abstract":"<jats:p>Background: Stroke-associated pneumonia (SAP) is a common complication after acute ischemic stroke and contributes to worse recovery and greater resource use. Nutritional and inflammatory dysregulation have been implicated in both SAP susceptibility and adverse prognosis. Objective: To examine whether admission inflammatory and nutritional markers are associated with the development of SAP and with short-term functional prognosis. Methods: We performed a retrospective single-centre cohort study of consecutive patients with acute ischemic stroke admitted between 1 January 2015 and 31 December 2024 (N=303;SAPn=108,non\u2212SAPn=195). Admission laboratory indices (albumin, CRP, fibrinogen, WBC, PCT, and prealbumin) in the first 24 h and clinical variables were analysed. Multivariable logistic regression identified factors independently associated with SAP; the relationship between SAP and early functional recovery was assessed in adjusted outcome models. A nomogram integrating key predictors was developed and its apparent discrimination is reported. Results: SAP occurred in 35.6% of patients. Factors independently associated with SAP included nasogastric tube placement (OR: 7.02, 95% CI: 3.50\u201314.62), venous thromboembolism (OR: 3.20, 95% CI: 1.62\u20136.31), cognitive impairment (OR: 2.90, 95% CI: 1.32\u20136.36), and elevated inflammatory markers (WBC OR: 1.52, 95% CI: 1.28\u20131.80; fibrinogen OR: 1.37, 95% CI: 1.02\u20131.84; CRP OR: 1.01, 95% CI: 1.00\u20131.03). Higher admission serum albumin was associated with lower odds of SAP (OR: 0.92, 95% CI: 0.86\u20130.98). The nomogram showed strong apparent discrimination (AUC: 0.90, 95% CI: 0.86\u20130.94). After multivariable adjustment, SAP remained associated with poorer short-term functional improvement (adjusted OR: 6.99, 95% CI: 3.05\u201317.54) and greater healthcare utilization (median length of stay: 39.6 vs. 30.6 days; median cost: USD 12,836 vs. 6585). Conclusion: In this retrospective cohort, admission markers of nutritional depletion and inflammatory activation were associated not only with increased likelihood of SAP, but also with adverse early functional outcomes. These association-based findings support early risk stratification using routine admission markers; prospective studies and external validation are required before clinical implementation.<\/jats:p>","DOI":"10.3390\/arm94020023","type":"journal-article","created":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T08:09:00Z","timestamp":1775549340000},"page":"23","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Stroke-Associated Pneumonia and Impaired Functional Recovery After Stroke: The Role of Nutritional-Inflammatory Factors"],"prefix":"10.3390","volume":"94","author":[{"given":"Rongjian","family":"Feng","sequence":"first","affiliation":[{"name":"Rehabilitation Medicine Center and Institute of Rehabilitation Medicine, Center for Preclinical Safety Evaluation of Drugs, West China Hospital, Sichuan University, Chengdu 610041, China"},{"name":"Key Laboratory of Rehabilitation Medicine in Sichuan Province, West China Hospital, Sichuan University, Chengdu 610041, China"},{"name":"Department of Rehabilitation Medicine, Sichuan Academy of Medical Sciences & Sichuan Provincial People\u2019s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chonggui","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Sichuan Academy of Medical Sciences & Sichuan Provincial People\u2019s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, Sichuan Academy of Medical Sciences & Sichuan Provincial People\u2019s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mao","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, Sichuan Academy of Medical Sciences & Sichuan Provincial People\u2019s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5448-2477","authenticated-orcid":false,"given":"Meng","family":"Qin","sequence":"additional","affiliation":[{"name":"Rehabilitation Medicine Center and Institute of Rehabilitation Medicine, Center for Preclinical Safety Evaluation of Drugs, West China Hospital, Sichuan University, Chengdu 610041, China"},{"name":"Key Laboratory of Rehabilitation Medicine in Sichuan Province, West China Hospital, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quan","family":"Wei","sequence":"additional","affiliation":[{"name":"Rehabilitation Medicine Center and Institute of Rehabilitation Medicine, Center for Preclinical Safety Evaluation of Drugs, West China Hospital, Sichuan University, Chengdu 610041, China"},{"name":"Key Laboratory of Rehabilitation Medicine in Sichuan Province, West China Hospital, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"16777","DOI":"10.2147\/JIR.S541879","article-title":"Association of the Cumulative Inflammatory Index and Long-Term Mortality in Stroke-Associated Pneumonia","volume":"18","author":"Gao","year":"2025","journal-title":"J. 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