{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T07:28:39Z","timestamp":1768289319026,"version":"3.49.0"},"reference-count":31,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2021,2,23]],"date-time":"2021-02-23T00:00:00Z","timestamp":1614038400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Audiology Research"],"abstract":"<jats:p>The aim of this paper was to investigate the role of the psychological variable of alexithymia both as a risk factor for the development of M\u00e9ni\u00e8re\u2019s disease (MD) and as a component that influences the personal experience of MD and the individual quality of life. We collected data from 179 Italian patients who fulfilled criteria for definite MD. Patients filled out validated self-rating questionnaires to assess alexithymia (TAS-20), quality of life (WHOQOL-BREF), anxiety and depression (HADS), perception of stress (PSS) and coping strategies (COPE). Socio-demographic data and MD clinical features were collected using a specific rating form. Subjects affected by MD showed higher levels of alexithymia compared to general population. Among MD patients, those characterized by high levels of alexithymia revealed a significant increase in anxiety and depression, greater perceived stress, a lower quality of life in psychological health and social relationships domains and the use of less mature coping strategies in comparison with MD patients with low or absent alexithymia. Our preliminary data could help in hypothesizing a role of psychological functioning in MD development and in the adaptation to the disease. The presence of alexithymia in patients suffering from MD may constitute a risk factor for the development of anxiety and depression symptoms; greater perceived stress and for poorer psychological and relational quality of life. Therefore, our study design did not allow causal inferences and further studies are needed.<\/jats:p>","DOI":"10.3390\/audiolres11010008","type":"journal-article","created":{"date-parts":[[2021,2,23]],"date-time":"2021-02-23T12:40:16Z","timestamp":1614084016000},"page":"63-72","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Alexithymia in Patients with M\u00e9ni\u00e8re Disease: A Possible Role on Anxiety and Depression"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2948-4638","authenticated-orcid":false,"given":"Roberto","family":"Teggi","sequence":"first","affiliation":[{"name":"ENT Division, Department of ENT, IRCCS San Raffaele Hospital, 20132 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia Yvonne","family":"Finocchiaro","sequence":"additional","affiliation":[{"name":"Clinical Healt Psychology Unit, IRCCS San Raffaele Hospital, 20132 Milan, Italy"},{"name":"Faculty of Psychology, Vita-Salute San Raffaele University, 20132 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio","family":"Ruggieri","sequence":"additional","affiliation":[{"name":"Clinical Healt Psychology Unit, IRCCS San Raffaele Hospital, 20132 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omar","family":"Gatti","sequence":"additional","affiliation":[{"name":"ENT Division, Department of ENT, IRCCS San Raffaele Hospital, 20132 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federica","family":"Rosolen","sequence":"additional","affiliation":[{"name":"Clinical Healt Psychology Unit, IRCCS San Raffaele Hospital, 20132 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Bussi","sequence":"additional","affiliation":[{"name":"ENT Division, Department of ENT, IRCCS San Raffaele Hospital, 20132 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucio","family":"Sarno","sequence":"additional","affiliation":[{"name":"Clinical Healt Psychology Unit, IRCCS San Raffaele Hospital, 20132 Milan, Italy"},{"name":"Faculty of Psychology, Vita-Salute San Raffaele University, 20132 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,2,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Kutlubaev, M.A., Pyykko, I., Hardy, T.A., and G\u00fcrkov, R. (2020). Meni\u00e8re\u2019s disease. Pract Neurol.","DOI":"10.1136\/practneurol-2020-002734"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/s00251-013-0683-z","article-title":"Allelic variants in TLR10 gene may influence bilateral affectation and clinical course of Meniere\u2019s disease","volume":"65","author":"Requena","year":"2013","journal-title":"Immunogenetics"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"S45","DOI":"10.1007\/s00415-015-7988-9","article-title":"Genetics of vestibular disorders: Pathophysiological insights","volume":"263","author":"Frejo","year":"2016","journal-title":"J. Neurol."},{"key":"ref_4","first-page":"217","article-title":"Case reports on two patients with episodic vertigo, fluctuating hearing loss and migraine responding to prophylactic drugs for migraine. Meni\u00e8re\u2019s disease or migraine-associated vertigo?","volume":"30","author":"Teggi","year":"2010","journal-title":"Acta Otorhinolaryngol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3233\/VES-150549","article-title":"Diagnostic criteria for Meni\u00e8re\u2019s disease","volume":"25","author":"Carey","year":"2015","journal-title":"J. Vestib. Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/S0031-9384(02)00935-6","article-title":"Neural substrates linking balance control and anxiety","volume":"77","author":"Balaban","year":"2002","journal-title":"Physiol. Behav."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1007\/s00415-009-0038-8","article-title":"Psychiatric morbidity and comorbidity in different vestibular vertigo syndromes. Results of a prospective longitudinal study over one year","volume":"256","author":"Best","year":"2009","journal-title":"J. Neurol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.jpsychores.2008.05.027","article-title":"Cognitions associated with anxiety in M\u00e9ni\u00e8re\u2019s disease","volume":"66","author":"Kirby","year":"2009","journal-title":"J. Psychosom. Res."},{"key":"ref_9","first-page":"26","article-title":"Alexithymia: A view of the psychosomatic process","volume":"Volume 2","author":"Hill","year":"1976","journal-title":"Modern Trends in Psychosoma Medicine"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1016\/j.neuroimage.2006.04.186","article-title":"Impaired self-awareness and theory of mind: An fMRI study of mentalizing in alexithymia","volume":"32","author":"Moriguchi","year":"2006","journal-title":"NeuroImage"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1111\/j.1365-4632.2008.03726.x","article-title":"Alexithymia and dermatology: The state of the art","volume":"47","author":"Willemsen","year":"2008","journal-title":"Int. J. Dermatol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1159\/000075537","article-title":"New Trends in Alexithymia Research","volume":"73","author":"Taylor","year":"2004","journal-title":"Psychother. Psychosom."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/0022-3999(94)90005-1","article-title":"The twenty-item Toronto Alexithymia scale\u2014I. Item selection and cross-validation of the factor structure","volume":"38","author":"Bagby","year":"1994","journal-title":"J. Psychosom. Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/S0022-3999(96)00228-0","article-title":"Cross validation of the factor structure of the 20-item Toronto Alexithymia Scale: An Italian multicenter study","volume":"41","author":"Bressi","year":"1996","journal-title":"J. Psychosom. Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1023\/B:QURE.0000018486.91360.00","article-title":"The World Health Organization\u2019s WHOQOL-BREF quality of life assessment: Psychometric properties and results of the international field trial. A Report from the WHOQOL Group","volume":"13","author":"Skevington","year":"2004","journal-title":"Qual. Life Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1111\/j.1600-0447.1983.tb09716.x","article-title":"The Hospital Anxiety and Depression Scale","volume":"67","author":"Zigmond","year":"1983","journal-title":"Acta Psychiatr. Scand."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s005200050241","article-title":"Detecting psychological distress in cancer patients: Validity of the Italian version of the Hospital Anxiety and Depression Scale","volume":"7","author":"Costantini","year":"1999","journal-title":"Supportive Care Cancer"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"386","DOI":"10.2307\/2136404","article-title":"A global measure of perceived stress","volume":"24","author":"Cohen","year":"1983","journal-title":"J. Health Soc. Behav."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1097\/00006842-200101000-00002","article-title":"Psychological Stress and Antibody Response to Immunization: A Critical Review of the Human Literature","volume":"63","author":"Cohen","year":"2001","journal-title":"Psychosom. Med."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/0306-4530(94)00077-N","article-title":"Influence of academic stress and season on 24-hour mean concentrations of ACTH, cortisol, and \u03b2-endorphin","volume":"20","author":"Malarkey","year":"1995","journal-title":"Psychoneuroendocrinology"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1093\/abm\/16.3.221","article-title":"Perceived stress and salivary cortisol in daily life","volume":"16","author":"Nicolson","year":"1994","journal-title":"Ann. Behav. Med."},{"key":"ref_22","unstructured":"Fossati, A. Scala per lo Stress Percepito, Traduzione Italiana a cura di Andrea Fossati, Universit\u00e0 Vita-Salute San Raffaele, Milano. 2010. Unpublished."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1037\/0022-3514.56.2.267","article-title":"Assessing coping strategies: A theoretically based approach","volume":"56","author":"Carver","year":"1989","journal-title":"J. Personal. Soc. Psychol."},{"key":"ref_24","first-page":"25","article-title":"Coping Orientations to Problems Experienced: Traduzione e adattamento italiano","volume":"223","author":"Sica","year":"1997","journal-title":"Boll. Psicol. Appl."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1159\/000289147","article-title":"Alexithymia, Neurovegetative Arousal and Neuroticism. An experimental study","volume":"66","author":"Infrasca","year":"1997","journal-title":"Psychother. Psychosom."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/S0022-3999(98)00083-X","article-title":"Sympathetic activity in alexithymics with mother\u2019s low care","volume":"46","author":"Fukunishi","year":"1999","journal-title":"J. Psychosom. Res."},{"key":"ref_27","first-page":"461","article-title":"Increased level of tonic sympathetic arousal in high versus low alexithymic cervical dystonia patients","volume":"52","author":"Greiner","year":"2002","journal-title":"Psychother. Psychosom. Med. Psychol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/S0753-3322(03)00085-4","article-title":"Is there a psychoneuroimmunological pathway between alexithymia and immunity? Immune and physiological correlates of alexithymia","volume":"57","author":"Guilbaud","year":"2003","journal-title":"Biomed. Pharmacother."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/S0022-3999(02)00466-X","article-title":"Cognitive and emotional characteristics of alexithymia: A review of neurobiological studies","volume":"54","author":"Larsen","year":"2003","journal-title":"J. Psychosom. Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1176\/appi.psy.45.3.197","article-title":"Relationships Among Alexithymia, Adverse Childhood Experiences, Sociodemographic Variables, and Actual Mood Disorder: A 2-Year Clinical Follow-Up Study of Patients with Major Depressive Disorder","volume":"45","author":"Honkalampi","year":"2004","journal-title":"J. Psychosom. Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1080\/00223890701629698","article-title":"The Assessment of Alexithymia in Medical Settings: Implications for Understanding and Treating Health Problems","volume":"89","author":"Lumley","year":"2007","journal-title":"J. Personal. Assess."}],"container-title":["Audiology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2039-4349\/11\/1\/8\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T05:27:17Z","timestamp":1760160437000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2039-4349\/11\/1\/8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,23]]},"references-count":31,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,3]]}},"alternative-id":["audiolres11010008"],"URL":"https:\/\/doi.org\/10.3390\/audiolres11010008","relation":{},"ISSN":["2039-4349"],"issn-type":[{"value":"2039-4349","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,23]]}}}