{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T02:08:04Z","timestamp":1760234884013,"version":"build-2065373602"},"reference-count":28,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2021,6,24]],"date-time":"2021-06-24T00:00:00Z","timestamp":1624492800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Audiology Research"],"abstract":"<jats:p>Background\/Aim: the aim of this study was to assess the skull vibration-induced nystagmus test (SVINT) results and vestibular residual function after horizontal semicircular canal (HSCC) plugging. Methods: In this retrospective chart review performed in a tertiary referral center, 11 patients who underwent unilateral horizontal semicircular canal plugging (uHSCCP) for disabling Meni\u00e8re\u2019s disease (MD) were included. The skull vibration-induced nystagmus (SVIN) slow-phase velocity (SPV) was compared with the results of the caloric test (CaT), video head impulse test (VHIT), and cervical vestibular-evoked myogenic potentials (cVEMP) performed on the same day. Results: Overall, 10 patients had a strong SVIN beating toward the intact side (Horizontal SVIN-SPV: 8.8\u00b0\/s \u00b1 5.6\u00b0\/s), 10 had a significant or severe ipsilateral CaT hypofunction, 10 had an ipsilateral horizontal VHIT gain impairment, and 3 had altered cVEMP on the operated side. Five had sensorineural hearing worsening. SVIN-positive results were correlated with CaT and horizontal VHIT (HVHIT) results (p &lt; 0.05) but not with cVEMP. SVIN-SPV was correlated with CaT hypofunction in % (p &lt; 0.05). Comparison of pre- and postoperative CaT % hypofunction showed a significant worsening (p = 0.028). Conclusion: SVINT results in a human model of horizontal canal plugging are well correlated with vestibular tests exploring horizontal canal function, but not with cVEMP. SVINT always showed a strong lesional nystagmus beating away from the lesion side. SVIN acts as a good marker of HSCC function. This surgical technique showed invasiveness regarding horizontal canal vestibular function.<\/jats:p>","DOI":"10.3390\/audiolres11030028","type":"journal-article","created":{"date-parts":[[2021,6,24]],"date-time":"2021-06-24T11:01:38Z","timestamp":1624532498000},"page":"301-312","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Skull Vibration-Induced Nystagmus Test in a Human Model of Horizontal Canal Plugging"],"prefix":"10.3390","volume":"11","author":[{"given":"Georges","family":"Dumas","sequence":"first","affiliation":[{"name":"Department of Oto-Rhino-Laryngology, Head and Neck Surgery, University Hospital, 38043 Grenoble, France"},{"name":"EA 3450 DevAH, Development, Adaptation and Handicap, Faculty of Medicine, University of Lorraine, 54500 Vandoeuvre-l\u00e8s-Nancy, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5269-1403","authenticated-orcid":false,"given":"Christol","family":"Fabre","sequence":"additional","affiliation":[{"name":"Department of Oto-Rhino-Laryngology, Head and Neck Surgery, University Hospital, 38043 Grenoble, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Charpiot","sequence":"additional","affiliation":[{"name":"Service d\u2019ORL et CCF, Aveue Moli\u00e8re, H\u00f4pital de Hautepierre, H\u00f4pitaux Universitaires de Strasbourg, CEDEX, 67098 Strasbourg, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lea","family":"Fath","sequence":"additional","affiliation":[{"name":"Service d\u2019ORL et CCF, Aveue Moli\u00e8re, H\u00f4pital de Hautepierre, H\u00f4pitaux Universitaires de Strasbourg, CEDEX, 67098 Strasbourg, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hella","family":"Chaney-Vuong","sequence":"additional","affiliation":[{"name":"Service d\u2019ORL et CCF, Aveue Moli\u00e8re, H\u00f4pital de Hautepierre, H\u00f4pitaux Universitaires de Strasbourg, CEDEX, 67098 Strasbourg, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Perrin","sequence":"additional","affiliation":[{"name":"EA 3450 DevAH, Development, Adaptation and Handicap, Faculty of Medicine, University of Lorraine, 54500 Vandoeuvre-l\u00e8s-Nancy, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00e9bastien","family":"Schmerber","sequence":"additional","affiliation":[{"name":"Department of Oto-Rhino-Laryngology, Head and Neck Surgery, University Hospital, 38043 Grenoble, France"},{"name":"BrainTech Lab INSERM UMR 2015, 38043 Grenoble, France"},{"name":"Otologie, Neuro-Otologie, Implants Auditifs, Centre d\u2019Implantation Cochl\u00e9aire des Alpes, Clinique Universitaire Oto-Rhino-Laryngologie, Universit\u00e9 Grenoble Alpes, INSERM UMR 1205, CHU A. Michallon BP 217, CEDEX 09, 38043 Grenoble, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,6,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1097\/MAO.0b013e3181ca85a2","article-title":"Lateral semicircular canal plugging in severe M\u00e9ni\u00e8re\u2019s disease: A clinical prospective study about 28 patients","volume":"31","author":"Charpiot","year":"2010","journal-title":"Otol. Neurotol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1080\/00016480701477677","article-title":"Nystagmus induced by high frequency vibrations of the skull in total unilateral peripheral vestibular lesions","volume":"128","author":"Dumas","year":"2008","journal-title":"Acta Otolaryngol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.anorl.2016.04.002","article-title":"How to perform the skull vibration-induced nystagmus test (SVINT)","volume":"133","author":"Dumas","year":"2016","journal-title":"Eur. Ann. Otorhinolaryngol. Head Neck Dis."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Dumas, G., Curthoys, I.S., Lion, A., Perrin, P., and Schmerber, S. (2017). The Skull Vibration-Induced Nystagmus Test of Vestibular Function-A Review. Front. Neurol., 8.","DOI":"10.3389\/fneur.2017.00041"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1007\/s00221-017-4874-y","article-title":"The new vestibular stimuli: Sound and vibration-anatomical, physiological and clinical evidence","volume":"235","author":"Curthoys","year":"2017","journal-title":"Exp. Brain Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1111\/1440-1681.12222","article-title":"Neural basis of new clinical vestibular tests: Otolithic neural responses to sound and vibration","volume":"41","author":"Curthoys","year":"2014","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1007\/s00221-014-4192-6","article-title":"How does high-frequency sound or vibration activate vestibular receptors?","volume":"233","author":"Curthoys","year":"2015","journal-title":"Exp. Brain Res."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/BF00584116","article-title":"Discharge properties of afferent fibres of the goldfish semicircular canal with high frequency stimulation","volume":"388","author":"Hartmann","year":"1980","journal-title":"Pfl\u00fcgers Arch."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1097\/WNR.0000000000000539","article-title":"Topographic analysis of the skull vibration-induced nystagmus test with piezoelectric accelerometers and force sensors","volume":"27","author":"Dumas","year":"2016","journal-title":"Neuroreport"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S0003-438X(05)82366-7","article-title":"Comment faire un examen calorique","volume":"122","author":"Dumas","year":"2005","journal-title":"Ann. Otolaryngol. Chir. Cervico-Faciale"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1212\/01.wnl.0000261902.31303.cf","article-title":"Head-shaking nystagmus and new technology","volume":"68","author":"Hain","year":"2007","journal-title":"Neurology"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"McGarvie, L.A., MacDougall, H.G., Halmagyi, G.M., Burgess, A.M., Weber, K.P., and Curthoys, I.S. (2015). The Video Head Impulse Test (vHIT) of Semicircular Canal Function-Age-Dependent Normative Values of VOR Gain in Healthy Subjects. Front. Neurol., 6.","DOI":"10.3389\/fneur.2015.00154"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.anorl.2017.08.008","article-title":"Comparison of Video Head Impulse Test and Caloric Reflex Test in advanced unilateral definite Meni\u00e8re\u2019s disease","volume":"135","author":"Rubin","year":"2018","journal-title":"Eur. Ann. Otorhinolaryngol. Head Neck Dis."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.3109\/00016489.2014.939300","article-title":"Caloric stimulation and video-head impulse testing in M\u00e9ni\u00e8re\u2019s disease and vestibular migraine","volume":"134","author":"Heinze","year":"2014","journal-title":"Acta Otolaryngol."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Nakashima, T., Pyykk\u00f6, I., Arroll, M.A., Casselbrant, M.L., Foster, C.A., Manzoor, N.F., Megerian, C.A., Naganawa, S., and Young, Y.-H. (2016). Meniere\u2019s disease. Nat. Rev. Dis. Primers, 2.","DOI":"10.1038\/nrdp.2016.28"},{"key":"ref_16","first-page":"704","article-title":"[Evaluation of vestibular evoked myogenic potential, caloric test and cochlear electrogram in the diagnosis of Meniere\u2019s disease]","volume":"33","author":"Xu","year":"2019","journal-title":"J. Clin. Otorhinolaryngol. Head Neck Surg."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1007\/s00405-019-05735-8","article-title":"Video head impulse test and caloric test in definite M\u00e9ni\u00e8re\u2019s disease","volume":"277","author":"Limviriyakul","year":"2020","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"859","DOI":"10.3109\/00016489.2015.1015606","article-title":"What does the dissociation between the results of video head impulse versus caloric testing reveal about the vestibular dysfunction in M\u00e9ni\u00e8re\u2019s disease?","volume":"135","author":"McGarvie","year":"2015","journal-title":"Acta Otolaryngol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"321","DOI":"10.3109\/00016488509126555","article-title":"Caloric responses after horizontal canal inactivation","volume":"100","author":"Paige","year":"1985","journal-title":"Acta Otolaryngol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1097\/MAO.0b013e31822f0b6b","article-title":"High-frequency skull vibration-induced nystagmus test in partial vestibular lesions","volume":"32","author":"Dumas","year":"2011","journal-title":"Otol. Neurotol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1111\/j.1749-6632.2001.tb03752.x","article-title":"Physiology of the semicircular canals after surgical plugging","volume":"942","author":"Rabbitt","year":"2001","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1080\/00016489.2020.1809706","article-title":"Skull vibration-induced nystagmus in vestibular neuritis","volume":"140","year":"2020","journal-title":"Acta Otolaryngol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1097\/MAO.0000000000000743","article-title":"Head-shaking and Vibration-induced Nystagmus During and Between the Attacks of Unilateral M\u00e9ni\u00e8re\u2019s Disease","volume":"36","author":"Lee","year":"2015","journal-title":"Otol. Neurotol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"444","DOI":"10.14639\/0392-100X-N0776","article-title":"Evaluation of a large cohort of adult patients with M\u00e9ni\u00e8re\u2019s disease: Bedside and clinical history","volume":"40","author":"Teggi","year":"2020","journal-title":"Acta Otorhinolaryngol. Ital."},{"key":"ref_25","first-page":"121","article-title":"Skull vibration induced nystagmus test in M\u00e9ni\u00e8re\u2019s disease","volume":"70","author":"Dumas","year":"2020","journal-title":"Otorinolaryngologia"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Chen, L., Xu, H., Wang, W.-Q., Zhang, Q.-Q., Lv, Q.-Y., and Song, X.-C. (2016). Evaluation of the otolith function using c\/oVEMPs in patients with M\u00e9ni\u00e8re\u2019s disease. J. Otolaryngol. Head Neck Surg., 45.","DOI":"10.1186\/s40463-016-0152-4"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"e961","DOI":"10.1097\/MAO.0000000000002791","article-title":"Activation of Guinea Pig Irregular Semicircular Canal Afferents by 100 Hz Vibration: Clinical Implications for Vibration-induced Nystagmus and Vestibular-evoked Myogenic Potentials","volume":"41","author":"Dlugaiczyk","year":"2020","journal-title":"Otol. Neurotol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.anorl.2019.04.008","article-title":"Skull vibration induced nystagmus in patients with superior semicircular canal dehiscence","volume":"136","author":"Dumas","year":"2019","journal-title":"Eur. Ann. Otorhinolaryngol. Head Neck Dis."}],"container-title":["Audiology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2039-4349\/11\/3\/28\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:22:53Z","timestamp":1760163773000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2039-4349\/11\/3\/28"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,24]]},"references-count":28,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2021,9]]}},"alternative-id":["audiolres11030028"],"URL":"https:\/\/doi.org\/10.3390\/audiolres11030028","relation":{},"ISSN":["2039-4349"],"issn-type":[{"type":"electronic","value":"2039-4349"}],"subject":[],"published":{"date-parts":[[2021,6,24]]}}}