{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T02:35:08Z","timestamp":1778726108797,"version":"3.51.4"},"reference-count":55,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2022,7,5]],"date-time":"2022-07-05T00:00:00Z","timestamp":1656979200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University of Basel","award":["3MS1052"],"award-info":[{"award-number":["3MS1052"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Audiology Research"],"abstract":"<jats:p>This systematic review investigates ear cooling and cryotherapy in the prevention and treatment of inner ear damage and disease, within the context of animal models and clinical studies. A literature search was carried out in the databases Pubmed and Cochrane Library. Ten studies were identified concerning the otoprotective properties of cryotherapy. Nine of these were rodent in vivo studies (mice, rats, gerbils, guinea pigs). One study involved human subjects and investigated cryotherapy in idiopathic sensorineural hearing loss. The studies were heterogeneous in their goals, methods, and the models used. Disorder models included ischemia and noise damage, ototoxicity (cisplatin and aminoglycoside), and CI-electrode insertion. All ten studies demonstrated significant cryotherapeutic otoprotection for their respective endpoints. No study revealed or expressly investigated otodestructive effects. While limited in number, all of the studies within the scope of the review demonstrated some degree of cryotherapeutic, otoprotective effect. These promising results support the conducting of further work to explore and refine the clinical applicability and impact of cryotherpeutics in otolaryngology.<\/jats:p>","DOI":"10.3390\/audiolres12040038","type":"journal-article","created":{"date-parts":[[2022,7,5]],"date-time":"2022-07-05T10:21:33Z","timestamp":1657016493000},"page":"377-387","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The Otoprotective Effect of Ear Cryotherapy: Systematic Review and Future Perspectives"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8204-5285","authenticated-orcid":false,"given":"Dominik","family":"P\u00e9us","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, University of Oldenburg, 26122 Oldenburg, Germany"},{"name":"Department of Otorhinolaryngology, Cantonal Hospital Baselland, 4410 Liestal, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaumiya","family":"Sellathurai","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Cantonal Hospital Baselland, 4410 Liestal, Switzerland"},{"name":"Department of Biomedicine, University of Basel, 4001 Basel, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"Newcomb","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, University of Oldenburg, 26122 Oldenburg, Germany"},{"name":"The Software Revolution, Inc., Kirkland, WA 98034, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kurt","family":"Tschopp","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Cantonal Hospital Baselland, 4410 Liestal, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Radeloff","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, University of Oldenburg, 26122 Oldenburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1001\/jamaoto.2020.0674","article-title":"Health-Related Quality of Life Changes Associated With Hearing Loss","volume":"146","author":"Dixon","year":"2020","journal-title":"JAMA Otolaryngol. 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