{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T23:26:34Z","timestamp":1791501994935,"version":"4.3.4"},"reference-count":51,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2022,8,22]],"date-time":"2022-08-22T00:00:00Z","timestamp":1661126400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Audiology Research"],"abstract":"<jats:p>Benign paroxysmal positional vertigo (BPPV) usually has a favorable course, although it is possible to observe BPPV with a high recurrence rate. Previous studies suggested that vitamin D deficiency might affect BPPV recurrences, and oxidative stress might play a complementary role in BPPV pathogenesis. This multicentric trial aimed to evaluate the effectiveness of oral nutritional supplementation with a compound of alpha-lipoic acid, Carnosine, and Zinc (LICA\u00ae (Difass International, Coriano (RN), Italy)), vitamins of group B and vitamin D in preventing BPPV recurrences. A total of 128 patients with high recurrence-BPPV were randomized in three arms: Arm 1 consisted of subjects with \u201cinsufficient\u201d or \u201cdeficient\u201d vitamin D blood levels, treated with daily oral supplementation of LICA\u00ae, vitamins of group B and vitamin D3 (800 UI), Arm 2 included BPPV subjects with \u201csufficient\u201d vitamin D who did not receive any nutritional support, and Arm 3 included subjects with a \u201csufficient\u201d serum concentration of vitamin D who received supplementation with a compound of LICA\u00ae and Curcumin. After six months of follow-up, a significant reduction of BPPV relapses compared to the baseline was found only in Arm 1 (\u22122.32, 95% CI: 3.41\u20131.62, p-value &lt; 0.0001). Study results suggested that oral nutritional supplementation with vitamin D3 plus antioxidants can prevent relapses in patients suffering from high recurrence-BPPV.<\/jats:p>","DOI":"10.3390\/audiolres12040045","type":"journal-article","created":{"date-parts":[[2022,8,22]],"date-time":"2022-08-22T05:18:17Z","timestamp":1661145497000},"page":"445-456","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Prevention of Recurrent Benign Paroxysmal Positional Vertigo: The Role of Combined Supplementation with Vitamin D and Antioxidants"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1890-0384","authenticated-orcid":false,"given":"Giacinto Asprella","family":"Libonati","sequence":"first","affiliation":[{"name":"Vestibology & ENT Unit, Giovanni Paolo II Hospital, 07026 Policoro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonello","family":"Leone","sequence":"additional","affiliation":[{"name":"Vestibology & ENT Unit, Giovanni Paolo II Hospital, 07026 Policoro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5233-2478","authenticated-orcid":false,"given":"Salvatore","family":"Martellucci","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Unit, Santa Maria Goretti Hospital, AUSL, 04100 Latina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Gallo","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Unit, Santa Maria Goretti Hospital, AUSL, 04100 Latina, Italy"},{"name":"Department of Sense Organs, Sapienza University of Rome, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Albera","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, University of Turin, 10124 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Lucisano","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, University of Turin, 10124 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Bavazzano","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, Clinical and Instrumental Vestibology, San Martino Polyclinic of Genova, 16132 Genoa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9829-2229","authenticated-orcid":false,"given":"Giuseppe","family":"Chiarella","sequence":"additional","affiliation":[{"name":"Audiology Unit, Regional Centre of Cochlear Implants and ENT Diseases, Department of Experimental and Clinical Medicine, Magna Graecia University, 88100 Catanzaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2352-1146","authenticated-orcid":false,"given":"Pasquale","family":"Viola","sequence":"additional","affiliation":[{"name":"Audiology Unit, Regional Centre of Cochlear Implants and ENT Diseases, Department of Experimental and Clinical Medicine, Magna Graecia University, 88100 Catanzaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Galletti","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Unit, Department of Adult and Development Age Human Pathology \u201cGaetano Barresi\u201d, Policlinico G. 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