{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T02:36:13Z","timestamp":1788834973278,"version":"build-2803163510"},"reference-count":25,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T00:00:00Z","timestamp":1697587200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Audiology Research"],"abstract":"<jats:p>Ototoxic drugs can result in hearing loss and tinnitus. Early detection of the ototoxic process can help minimize or prevent these consequences. The American Speech\u2013Language\u2013Hearing Association has provided guidelines for monitoring ototoxicity, whereas Italy has not yet implemented a national monitoring protocol. This study aims to assess the current state of ototoxicity monitoring in patients receiving cisplatin therapy. A self-administered survey has been used to gather information from oncologists, audiologists, and ENT specialists. The research was conducted at Santa Maria della Misericordia hospital in Perugia. Two questionnaires were administered, one to ENT\/audiology specialists and another to oncology specialists. Both questionnaires were used to collect information on awareness of chemotherapy-induced ototoxicity. A comprehensive understanding of cisplatin-induced ototoxicity has been widely established (100%). The most commonly reported audiological symptoms by patients were hearing loss (100%) and tinnitus (87.5%). The majority of ENT and audiologists (93.8%) and oncologists (92.9%) expressed the need for a specific ototoxic monitoring program. However, they noted the absence of a well-defined ototoxicity monitoring protocol. A well-established and efficient ototoxic monitoring system facilitates early detection of ototoxic hearing loss and subsequent rehabilitation of inevitable hearing impairment.<\/jats:p>","DOI":"10.3390\/audiolres13050069","type":"journal-article","created":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T07:15:36Z","timestamp":1697699736000},"page":"779-790","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Practice of Monitoring Cisplatin-Induced Ototoxicity by Audiology, ENT, and Oncology Specialists: A Survey-Based Study in a Single Italian Medical Center"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4875-1201","authenticated-orcid":false,"given":"Valeria","family":"Gambacorta","sequence":"first","affiliation":[{"name":"Department of Medicine & Surgery, Section of Otorhinolaryngology, University of Perugia, 06126 Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Orzan","sequence":"additional","affiliation":[{"name":"Audiology and Otorhinolaryngology Unit, Institute for Maternal and Child Health IRCCS \u201cBurlo Garofolo\u201d, 34137 Trieste, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Faralli","sequence":"additional","affiliation":[{"name":"Department of Medicine & Surgery, Section of Otorhinolaryngology, University of Perugia, 06126 Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Gull\u00e0","sequence":"additional","affiliation":[{"name":"Department of Medicine & Surgery, Section of Otorhinolaryngology, University of Perugia, 06126 Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6551-8893","authenticated-orcid":false,"given":"Ruggero","family":"Lapenna","sequence":"additional","affiliation":[{"name":"Department of Medicine & Surgery, Section of Otorhinolaryngology, University of Perugia, 06126 Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Baietta","sequence":"additional","affiliation":[{"name":"Department of Medicine & Surgery, Section of Otorhinolaryngology, University of Perugia, 06126 Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Verena","family":"De Angelis","sequence":"additional","affiliation":[{"name":"Clinical Oncology, Santa Maria della Misericordia Hospital, University of Perugia, 06126 Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giampietro","family":"Ricci","sequence":"additional","affiliation":[{"name":"Department of Medicine & Surgery, Section of Otorhinolaryngology, University of Perugia, 06126 Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1055\/s-0039-1684046","article-title":"Ototoxicity: Visualized in concept maps","volume":"40","author":"Watts","year":"2019","journal-title":"Semin. Hear."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1055\/s-0039-1684041","article-title":"A review of cisplatin-associated ototoxicity","volume":"40","author":"Paken","year":"2019","journal-title":"Semin. Hear."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.ncl.2005.03.001","article-title":"Bedside assessment of the dizzy patient","volume":"23","author":"Tusa","year":"2005","journal-title":"Neurol. Clin."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"S29","DOI":"10.1080\/14992027.2018.1460495","article-title":"Current practice of ototoxicity management across the United Kingdom (UK)","volume":"57","author":"Maru","year":"2018","journal-title":"Int. J. Audiol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"59","DOI":"10.7874\/jao.2017.00360","article-title":"Ototoxicity: A challenge in diagnosis and treatment","volume":"22","author":"Ganesan","year":"2018","journal-title":"J. Audiol. Otol."},{"key":"ref_6","unstructured":"Swanepoel, D.W., and Louw, B. (2010). HIV\/AIDS Related Communication, Hearing and Swallowing Disorders, Plural Publishing."},{"key":"ref_7","first-page":"9","article-title":"Ototoxicity as a side-effect of drugs: Literature review","volume":"10","author":"Skarzynska","year":"2020","journal-title":"J. Hear. Sci."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1002\/phar.2478","article-title":"Drug-Induced Ototoxicity: A Comprehensive Review and Reference Guide","volume":"40","author":"Rizk","year":"2020","journal-title":"Pharmacotherapy"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s00280-019-04012-z","article-title":"Looking beyond the audiogram in ototoxicity associated with platinum-based chemotherapy","volume":"85","author":"Baguley","year":"2020","journal-title":"Cancer Chemother. Pharmacol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1001\/archotol.1993.01880180081015","article-title":"High-frequency monitoring for early detection of cisplatin ototoxicity","volume":"119","author":"Fausti","year":"1993","journal-title":"Arch. Otolaryngol. Neck Surg."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s40463-021-00506-0","article-title":"Insight into the current practice of ototoxicity monitoring during cisplatin therapy","volume":"50","author":"Santucci","year":"2021","journal-title":"J. Otolaryngol. Head Neck Surg."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1177\/0194599812451438a187","article-title":"Video Head Impulse Test Diagnoses Vestibulotoxicity","volume":"147","author":"Halmagyi","year":"2012","journal-title":"Otolaryngol.-Head Neck Surg."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/s12070-015-0949-x","article-title":"Clinical Predictors of Streptomycin- Vestibulotoxicity","volume":"68","author":"Ahmed","year":"2016","journal-title":"Indian J. Otolaryngol. Head Neck Surg."},{"key":"ref_14","unstructured":"American Speech-Language-Hearing Association (2019, January 02). Audiologic Management of Individuals Receiving Cochleotoxic Drug Therapy [Guidelines]. 1994; ASHA 36 (Suppl. 12), pp. 11\u201319. Available online: www.asha.org\/policy."},{"key":"ref_15","unstructured":"American Academy of Audiology (2009). American Academy of Audiology Position Statement and Guidelines: Ototoxicity Monitoring, American Academy of Audiology."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Paken, J., Govender, C.D., Pilla, M., and Sewram, V. (2022). Cisplatin-associated ototoxicity: Perspectives from a single institution cervical cancer cohort and implications for developing a locally responsive monitoring programme in a public healthcare setting. BMC Health Serv. Res., 22.","DOI":"10.1186\/s12913-022-08099-8"},{"key":"ref_17","first-page":"5","article-title":"Audiological monitoring in ototoxicity\u2014Are we doing enough?","volume":"25","year":"2016","journal-title":"ENT Audiol. News"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1080\/14992027.2017.1398421","article-title":"Applying U.S. national guidelines for ototoxicity monitoring in adult patients: Perspectives on patient populations, service gaps, barriers and solutions","volume":"57","author":"Poling","year":"2018","journal-title":"Int. J. Audiol."},{"key":"ref_19","first-page":"a685","article-title":"Perspectives and practices of ototoxicity monitoring","volume":"67","author":"Paken","year":"2020","journal-title":"S. Afr. J. Commun. Disord."},{"key":"ref_20","first-page":"307","article-title":"Perceptions of oncologists at two state hospitals in Gauteng regarding the ototoxic effects of cancer chemotherapy: A pilot study","volume":"3","author":"Hajat","year":"2009","journal-title":"Afr. J. Pharm. Pharmacol."},{"key":"ref_21","first-page":"375","article-title":"Hearing loss-risk factor for cisplatin ototoxicity? Observations","volume":"11","author":"Durrant","year":"1990","journal-title":"Am. J. Otol."},{"key":"ref_22","first-page":"123","article-title":"Changes in transitory evoked otoacoustic emissions in chemotherapy with cisplatin and 5FU","volume":"40","author":"Beck","year":"1992","journal-title":"HNO"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1200\/JCO.2006.07.9723","article-title":"Early changes in auditory function as a result of platinum chemo-therapy: Use of extended high-frequency audiometry and evoked distortion product otoacoustic emissions","volume":"25","author":"Knight","year":"2007","journal-title":"J. Clin. Oncol."},{"key":"ref_24","first-page":"397","article-title":"Early detection of ototoxicity using high frequency tone-burst-evoked auditory brainstem responses","volume":"3","author":"Fausti","year":"1992","journal-title":"J. Am. Acad. Audiol."},{"key":"ref_25","first-page":"253","article-title":"Balance function test correlates of the Dizziness Handicap Inventory","volume":"2","author":"Jacobson","year":"1991","journal-title":"J. Am. Acad. Audiol."}],"container-title":["Audiology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2039-4349\/13\/5\/69\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:08:55Z","timestamp":1760130535000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2039-4349\/13\/5\/69"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,18]]},"references-count":25,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2023,10]]}},"alternative-id":["audiolres13050069"],"URL":"https:\/\/doi.org\/10.3390\/audiolres13050069","relation":{},"ISSN":["2039-4349"],"issn-type":[{"value":"2039-4349","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,18]]}}}