{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T13:46:59Z","timestamp":1765547219687,"version":"build-2065373602"},"reference-count":55,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2024,2,17]],"date-time":"2024-02-17T00:00:00Z","timestamp":1708128000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Audiology Research"],"abstract":"<jats:p>The aim of the present study was to investigate adverse effects of head injury, neck trauma, and chronic noise exposure on the complaint profile in people with M\u00e9ni\u00e8re\u2019s disease (MD). The study used a retrospective design. Register data of 912 patients with MD from the Finnish M\u00e9ni\u00e8re Federation database were studied. The data comprised case histories of traumatic brain injury (TBI), neck trauma and occupational noise exposure, MD specific complaints, impact related questions, and the E-Qol health-related quality of life instrument. TBI was classified based on mild, moderate, and severe categories of transient loss of consciousness (TLoC). The mean age of the participants was 60.2 years, the mean duration of the disease was 12.6 years, and 78.7% were females. Logistic regression analysis, linear correlation, and pairwise comparisons were used in evaluating the associations. 19.2% of the participants with MD had a history of TBI. The phenotype of participants with TBI was associated with frequent vestibular drop attacks (VDA), presyncope, headache-associated vertigo, and a reduction in the E-QoL. Logistic regression analysis explained the variability of mild TBI in 6.8%. A history of neck trauma was present in 10.8% of the participants. Neck trauma associated with vertigo (NTwV) was seen in 47 and not associated with vertigo in 52 participants. The phenotype of NTwV was associated with balance problems, VDA, physical strain-induced vertigo, and hyperacusia. Logistic regression analysis explained 8.7% of the variability of the complaint profile. Occupational noise exposure was recorded in 25.4% of the participants and correlated with the greater impact of tinnitus, hyperacusis, and hearing loss. Neither the frequency, duration, or severity of vertigo or nausea were significantly different between the baseline group and the TBI, NTwV, or noise-exposure groups. The results indicate that TBI and NTwV are common among MD patients and may cause a confounder effect.<\/jats:p>","DOI":"10.3390\/audiolres14010019","type":"journal-article","created":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T08:43:48Z","timestamp":1708505028000},"page":"204-216","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Association of Head Injury, Neck Injury or Acoustic Trauma on Phenotype of M\u00e9ni\u00e8re\u2019s Disease"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7172-7408","authenticated-orcid":false,"given":"Ilmari","family":"Pyykk\u00f6","sequence":"first","affiliation":[{"name":"Hearing and Balance Research Unit, Field of Otolaryngology, Tampere University, 33100 Tampere, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2058-5574","authenticated-orcid":false,"given":"Vinay","family":"Vinay","sequence":"additional","affiliation":[{"name":"Department of Neuromedicine and Movement Sciences, Norwegian University of Science and Technology, 7491 Trondheim, Norway"},{"name":"Department of Otolaryngology-Head and Neck Surgery, University of Colorado School of Medicine, Aurora, CO 80045, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4487-432X","authenticated-orcid":false,"given":"Artur","family":"Vetkas","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Tartu, 50090 Tartu, Estonia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0315-7092","authenticated-orcid":false,"given":"Jing","family":"Zou","sequence":"additional","affiliation":[{"name":"Hearing and Balance Research Unit, Field of Otolaryngology, Tampere University, 33100 Tampere, Finland"},{"name":"Department of Otolaryngology-Head and Neck Surgery, Center for Otolaryngology-Head & Neck Surgery of the Chinese PLA, Changhai Hospital, Second Military Medical University, Shanghai 201823, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1254-8407","authenticated-orcid":false,"given":"Vinaya","family":"Manchaiah","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, University of Colorado School of Medicine, Aurora, CO 80045, USA"},{"name":"UCHealth Hearing and Balance, University of Colorado Hospital, Aurora, CO 80045, USA"},{"name":"Virtual Hearing Lab., Collaborative Initiative between University of Colorado School of Medicine and University of Pretoria, Aurora, CO 80045, USA"},{"name":"Department of Speech-Language Pathology and Audiology, University of Pretoria, Pretoria 0001, South Africa"},{"name":"Department of Speech and Hearing, School of Allied Health Sciences, Manipal University, Manipal 576104, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.pmedr.2018.10.008","article-title":"The global burden of multiple chronic conditions: A narrative review","volume":"12","author":"Hajat","year":"2018","journal-title":"Prev. 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