{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T15:19:58Z","timestamp":1773760798142,"version":"3.50.1"},"reference-count":70,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2024,3,24]],"date-time":"2024-03-24T00:00:00Z","timestamp":1711238400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Audiology Research"],"abstract":"<jats:p>Posterior semicircular canal dehiscence (PSCD) has been demonstrated to result in a third mobile window mechanism (TMWM) in the inner ear similar to superior semicircular canal dehiscence (SSCD). Typical clinical and instrumental features of TMWM, including low-frequency conductive hearing loss (CHL), autophony, pulsatile tinnitus, sound\/pressure-induced vertigo and enhanced vestibular-evoked myogenic potentials, have been widely described in cases with PSCD. Nevertheless, video-head impulse test (vHIT) results have been poorly investigated. Here, we present six patients with PSCD presenting with a clinical scenario consistent with a TMWM and an impaired vestibulo-ocular reflex (VOR) for the affected canal on vHIT. In two cases, an additional dehiscence between the facial nerve and the horizontal semicircular canal (HSC) was detected, leading to a concurrent VOR impairment for the HSC. While in SSCD, a VOR gain reduction could be ascribed to a spontaneous \u201cauto-plugging\u201d process due to a dural prolapse into the canal, the same pathomechanism is difficult to conceive in PSCD due to a different anatomical position, making a dural herniation less likely. Alternative putative pathomechanisms are discussed, including an endolymphatic flow dissipation during head impulses as already hypothesized in SSCD. The association of symptoms\/signs consistent with TMWM and a reduced VOR gain for the posterior canal might address the diagnosis toward PSCD.<\/jats:p>","DOI":"10.3390\/audiolres14020028","type":"journal-article","created":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T14:14:12Z","timestamp":1711376052000},"page":"317-333","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Posterior Semicircular Canal Dehiscence with Vestibulo-Ocular Reflex Reduction for the Affected Canal at the Video-Head Impulse Test: Considerations to Pathomechanisms"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2874-5672","authenticated-orcid":false,"given":"Andrea","family":"Castellucci","sequence":"first","affiliation":[{"name":"ENT Unit, Department of Surgery, Azienda USL\u2014IRCCS di Reggio Emilia, 42123 Reggio Emilia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8311-0322","authenticated-orcid":false,"given":"Georges","family":"Dumas","sequence":"additional","affiliation":[{"name":"EA 3450 DevAH\u2013Development, Adaptation and Handicap, Faculty of Medicine, University of Lorraine, 54500 Nancy, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sawsan M.","family":"Abuzaid","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Department, Royal Medical Services, Amman 11855, Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8230-3122","authenticated-orcid":false,"given":"Enrico","family":"Armato","sequence":"additional","affiliation":[{"name":"Ph.D. Program in Development, Adaptation and Handicap, Faculty of Medicine, University of Lorraine, 54500 Vandoeuvre-l\u00e8s-Nancy, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5233-2478","authenticated-orcid":false,"given":"Salvatore","family":"Martellucci","sequence":"additional","affiliation":[{"name":"ENT Unit, Santa Maria Goretti Hospital, Azienda USL di Latina, 04100 Latina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pasquale","family":"Malara","sequence":"additional","affiliation":[{"name":"Audiology & Vestibology Service, Centromedico, 6500 Bellinzona, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamad","family":"Alfarghal","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology\u2014Head and Neck Section, Surgery Department, King Abdulaziz Medical City, Jeddah 21556, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosanna Rita","family":"Ruberto","sequence":"additional","affiliation":[{"name":"Audiology and Ear Surgery Unit, Azienda USL\u2014IRCCS di Reggio Emilia, 42123 Reggio Emilia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pasquale","family":"Brizzi","sequence":"additional","affiliation":[{"name":"Audiology and Ear Surgery Unit, Azienda USL\u2014IRCCS di Reggio Emilia, 42123 Reggio Emilia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelo","family":"Ghidini","sequence":"additional","affiliation":[{"name":"ENT Unit, Department of Surgery, Azienda USL\u2014IRCCS di Reggio Emilia, 42123 Reggio Emilia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5913-1484","authenticated-orcid":false,"given":"Francesco","family":"Comacchio","sequence":"additional","affiliation":[{"name":"ENT Unit, Regional Vertigo Specialized Center, University Hospital of Padova, Sant\u2019Antonio Hospital, 35039 Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00e9bastien","family":"Schmerber","sequence":"additional","affiliation":[{"name":"Department of Oto-Rhino-Laryngology, Head and Neck Surgery, University Hospital, 38043 Grenoble, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,3,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1001\/archotol.124.3.249","article-title":"Sound- and\/or pressure-induced vertigo due to bone dehiscence of the superior semicircular canal","volume":"124","author":"Minor","year":"1998","journal-title":"Arch. 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