{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T20:16:45Z","timestamp":1775333805305,"version":"3.50.1"},"reference-count":38,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T00:00:00Z","timestamp":1712707200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"MEDIWEB-AUDISTIMPHARMA"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Audiology Research"],"abstract":"<jats:p>The aim of this study is to evaluate the efficacy of taking a daily supplement based on active compounds (AUDISTIM\u00ae Day Night: A D\/N) in alleviating tinnitus-related disability, as suggested by previous real-life studies. This double-blind randomized placebo-controlled study was conducted in adults with mild to severe tinnitus receiving a 3-month supplementation with A D\/N (magnesium, vitamins, phytochemicals) or placebo (excipients without active ingredients). Tinnitus-related handicap (THI), psychological stress (MSP-9), and sleep quality (PSQI) were assessed at baseline and during intervention, perceived impression of tinnitus improvement at the end of the follow-up. The full set analysis included 114 patients (59 A D\/N, 55 placebo) aged 53.8 \u00b1 11.4 years, 58% women, with fluctuating (45%) or permanent (55%) tinnitus from 9.3 \u00b1 9.4 years. A D\/N supplementation led to greater changes in THI (\u221213.2 \u00b1 16.0 vs. \u22126.2 \u00b1 14.4, p = 0.0158, Cohen\u2019s d = 0.44) at 3 months (primary outcome), especially with continuous tinnitus (\u221215.0 \u00b1 16.3 vs. \u22124.6 \u00b1 12.8, p = 0.0065), and, to a lesser extent, at 1 month (\u22129.8 \u00b1 13.1 for A vs. \u22124.3 \u00b1 12.1, p = 0.0213). PSQI significantly improved over time in both groups, but MSP-9 only with A D\/N. In lines with previous observational studies, both clinical (THI score &gt; 7 pts) and statistical (vs. placebo) improvement, more pronounced in permanent tinnitus, demonstrate the effectiveness of the combination of active compounds and support its use in the management of mild to severe tinnitus.<\/jats:p>","DOI":"10.3390\/audiolres14020031","type":"journal-article","created":{"date-parts":[[2024,4,11]],"date-time":"2024-04-11T09:37:31Z","timestamp":1712828251000},"page":"359-371","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["AUDISTIM\u00ae Day\/Night Alleviates Tinnitus-Related Handicap in Patients with Chronic Tinnitus: A Double-Blind Randomized Placebo-Controlled Trial"],"prefix":"10.3390","volume":"14","author":[{"given":"Didier","family":"Portmann","sequence":"first","affiliation":[{"name":"Institut G PORTMANN, 114, avenue d\u2019Ar\u00e8s, 33000 Bordeaux, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie Jos\u00e9","family":"Esteve-Fraysse","sequence":"additional","affiliation":[{"name":"Centre d\u2019Exploration Fonctionnelle d\u2019Otoneurologie, 10, rue Falgui\u00e8re, 75015 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Frachet","sequence":"additional","affiliation":[{"name":"Hospital Rothschild-AP-HP, 5, rue Santerre, 75012 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florent","family":"Herpin","sequence":"additional","affiliation":[{"name":"CEN, 18, rue P. Kergomard, 21000 Dijon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florian","family":"Rigaudier","sequence":"additional","affiliation":[{"name":"CEN, 18, rue P. Kergomard, 21000 Dijon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3669-0176","authenticated-orcid":false,"given":"Christine","family":"Juhel","sequence":"additional","affiliation":[{"name":"CEN, 18, rue P. Kergomard, 21000 Dijon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,10]]},"reference":[{"key":"ref_1","unstructured":"(2024, February 28). ICD11, Tinnitus. Available online: https:\/\/icd.who.int\/browse\/2024-01\/mms\/en#1089305710."},{"key":"ref_2","unstructured":"McFadden, D. (1982). 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