{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T21:26:08Z","timestamp":1768080368492,"version":"3.49.0"},"reference-count":22,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T00:00:00Z","timestamp":1712880000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Audiology Research"],"abstract":"<jats:p>Introduction: We present a series of six cases whose clinical presentations exhibited audiovestibular manifestations of a third mobile window mechanism, bearing a reasonable resemblance to M\u00e9ni\u00e8re\u2019s disease and otosclerosis. The occurrence of these cases in such a short period has prompted a review of the underlying causes of its development. Understanding the pathophysiology of third mobile window syndrome and considering these entities in the differential diagnosis of conditions presenting with vertigo and hearing loss with slight air-bone gaps is essential for comprehending this group of pathologies. Materials and Methods: A descriptive retrospective cohort study of six cases diagnosed at a tertiary center. All of them went through auditive and vestibular examinations before and after a therapeutic strategy was performed. Results: Out of 84 cases of dehiscences described in our center during the period from 2014 to 2024, 78 belonged to superior semicircular canal dehiscence, while 6 were other otic capsule dehiscences. Among these six patients with a mean age of 47.17 years (range: 18\u201373), all had some form of otic capsule dehiscence with auditory and\/or vestibular repercussions, measured through hearing and vestibular tests, with abnormalities in the results in five out of six patients. Two of them were diagnosed with M\u00e9ni\u00e8re\u2019s disease (MD). Another two had cochleo-vestibular hydrops without meeting the diagnostic criteria for MD. In two cases, the otic capsule dehiscence diagnosis resulted from an intraoperative complication due to a gusher phenomenon, while in one case, it was an accidental radiological finding. All responded well to the proposed treatment, whether medical or surgical, if needed. Conclusions: Otic capsule dehiscences are relatively new and unfamiliar entities that should be considered when faced with cases clinically suggestive of M\u00e9ni\u00e8re\u2019s disease, with discrepancies in complementary tests or a poor response to treatment. While high-sensitivity and specificity audiovestibular tests exist, completing the study with imaging, especially petrous bone CT scans, is necessary to locate and characterize the otic capsule defect responsible for the clinical presentation.<\/jats:p>","DOI":"10.3390\/audiolres14020032","type":"journal-article","created":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T04:44:26Z","timestamp":1712897066000},"page":"372-385","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Otic Capsule Dehiscences Simulating Other Inner Ear Diseases: Characterization, Clinical Profile, and Follow-Up\u2014Is M\u00e9ni\u00e8re\u2019s Disease the Sole Cause of Vertigo and Fluctuating Hearing Loss?"],"prefix":"10.3390","volume":"14","author":[{"given":"Joan","family":"Lorente-Piera","sequence":"first","affiliation":[{"name":"Otorhinolaryngology Department, University of Navarra Clinic, 31008 Pamplona, Navarra, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Prieto-Matos","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Department, University of Navarra Clinic, 31008 Pamplona, Navarra, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0781-9679","authenticated-orcid":false,"given":"Raquel","family":"Manrique-Huarte","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Department, University of Navarra Clinic, 31008 Pamplona, Navarra, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Octavio","family":"Garaycochea","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Department, University of Navarra Clinic, 31008 Pamplona, Navarra, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo","family":"Dom\u00ednguez","sequence":"additional","affiliation":[{"name":"Radiology Department, University of Navarra Clinic, 31008 Pamplona, Navarra, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Manrique","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Department, University of Navarra Clinic, 31008 Pamplona, Navarra, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,12]]},"reference":[{"key":"ref_1","first-page":"12","article-title":"Editorial: Third Window Syndrome","volume":"18","author":"Wackym","year":"2021","journal-title":"Front. 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