{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:41:25Z","timestamp":1760146885234,"version":"build-2065373602"},"reference-count":30,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T00:00:00Z","timestamp":1734652800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Audiology Research"],"abstract":"<jats:p>Objectives: to retrospectively evaluate the clinical relevance of the 1000\/500 Hz inter-frequency amplitude ratio (IFAR) in cervical and ocular vestibular evoked myogenic potentials (cVEMPs and oVEMPs) in patients with unilateral definite M\u00e9ni\u00e8re\u2019s disease (MD) to identify the pathological ear. Method: cVEMPs and oVEMPs results obtained at 500 Hz and 1000 Hz were retrospectively analyzed in 28 patients with unilateral definite MD. 1000\/500 Hz IFAR were calculated and compared for each ear. Spearman correlation tests between patient age and 1000\/500 Hz IFAR were also performed. Results: No significant difference was observed between the 1000\/500 Hz IFAR calculated in both pathological and healthy ears when the cVEMPs were performed (p = 0.74; Wilcoxon signed-rank test). 1000\/500 Hz IFAR results obtained in healthy and pathological ears were also not different for oVEMPs (p = 0.73; Wilcoxon signed-rank test). Analysis of modified 1000\/500 Hz IFARs for healthy and pathological ears showed no difference in both cVEMPs and oVEMPs (p = 0.44; p = 0.95, respectively; Wilcoxon signed-rank test). There was a significant positive correlation between IFARs, modified IFARs, and patient age for cVEMPs (p = 0.017; p = 0.012, respectively, Spearman\u2019s correlation test). A significant positive correlation was also found between modified IFARs and the subject age in oVEMPs (p = 0.019, Spearman\u2019s correlation test). Conclusions: We did not observe any significant increase of 1000\/500 Hz IFARs and 1000\/500 Hz modified IFARs in ears affected by definite MD compared to healthy ears. Moreover, our research suggests that the age of the participants may influence IFAR results, which may lead to misdiagnosis in the elderly. It is, therefore, essential to conduct further prospective studies in larger cohorts, stratifying results by participant age, to better understand the role of 1000\/500 Hz IFAR values in the diagnosis of MD.<\/jats:p>","DOI":"10.3390\/audiolres14060093","type":"journal-article","created":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T07:42:18Z","timestamp":1734680538000},"page":"1126-1135","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Assessment of the Inter-Frequency Amplitude Ratio (1000\/500 Hz) in cVEMP and oVEMP for the Diagnosis of M\u00e9ni\u00e8re\u2019s Disease"],"prefix":"10.3390","volume":"14","author":[{"given":"Sacha","family":"Drabkin","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Centre Hospitalier Universitaire de Charleroi, Chauss\u00e9e de Bruxelles 140, 6042 Charleroi, Belgium"},{"name":"Otology Study Group, Young Otolaryngologists-International Federation of Otorhinolaryngological Societies, 13005 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1251-0185","authenticated-orcid":false,"given":"Antonino","family":"Maniaci","sequence":"additional","affiliation":[{"name":"Otology Study Group, Young Otolaryngologists-International Federation of Otorhinolaryngological Societies, 13005 Paris, France"},{"name":"Department of Medicine and Surgery, University of Enna Kore, 94100 Enna, Italy"},{"name":"Department of Surgery, Asp 7 Ragusa, Modica Hospital, 97100 Ragusa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8127-5045","authenticated-orcid":false,"given":"Mario","family":"Lentini","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, University of Enna Kore, 94100 Enna, Italy"},{"name":"Department of Surgery, Asp 7 Ragusa, Modica Hospital, 97100 Ragusa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1781-2809","authenticated-orcid":false,"given":"Giannicola","family":"Iannella","sequence":"additional","affiliation":[{"name":"Otology Study Group, Young Otolaryngologists-International Federation of Otorhinolaryngological Societies, 13005 Paris, France"},{"name":"Department of \u2018Organi di Senso\u2019, University \u201cSapienza\u201d, 00185 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Tainmont","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Centre Hospitalier Universitaire de Charleroi, Chauss\u00e9e de Bruxelles 140, 6042 Charleroi, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7319-661X","authenticated-orcid":false,"given":"Christophe","family":"Lelubre","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Centre Hospitalier Universitaire de Charleroi, Charleroi, Chauss\u00e9e de Bruxelles 140, 6042 Charleroi, Belgium"},{"name":"Faculty of Medicine and Pharmacy, University of Mons (UMons), 7000 Mons, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5545-6927","authenticated-orcid":false,"given":"Quentin","family":"Mat","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Centre Hospitalier Universitaire de Charleroi, Chauss\u00e9e de Bruxelles 140, 6042 Charleroi, Belgium"},{"name":"Otology Study Group, Young Otolaryngologists-International Federation of Otorhinolaryngological Societies, 13005 Paris, France"},{"name":"Faculty of Medicine and Pharmacy, University of Mons (UMons), 7000 Mons, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"5173","DOI":"10.1007\/s00405-022-07366-y","article-title":"Depression scores and quality of life of vertiginous patients, suffering from different vestibular disorders","volume":"279","author":"Maihoub","year":"2022","journal-title":"Eur. 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