{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:32:56Z","timestamp":1787027576372,"version":"build-2736575974"},"reference-count":29,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T00:00:00Z","timestamp":1750204800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Audiology Research"],"abstract":"<jats:p>Objectives: This study aimed to analyse the haematological parameters in relation to subjective tinnitus. We hypothesise that abnormal haematological findings may correlate with increased severity and chronicity of tinnitus. This research could lead to improved diagnostic methods and more targeted treatments. Material and Methods: A total of 439 patients with primary subjective tinnitus and 274 individuals without tinnitus were enrolled. These participants underwent comprehensive laboratory testing, which included haematological parameters. Results: When comparing the white blood cell levels between the tinnitus group and the control group, no statistically significant differences were found (p = 0.743). Similarly, comparisons of red blood cell levels (p = 0.250), haemoglobin levels (p = 0.087), and haematocrit levels (p = 0.066) also revealed no significant differences. The platelet levels showed no significant difference between the two groups (p = 0.782). According to a logistic regression model, lower levels of haemoglobin (p = 0.000) and platelets (p = 0.000) significantly predicted higher scores on the Tinnitus Handicap Inventory, indicating self-reported tinnitus severity. Furthermore, lower haemoglobin levels were significant predictors (p = 0.04) of developing bilateral tinnitus. Using Spearman\u2019s correlation test, a statistically significant negative correlation (p = 0.029) was observed between red blood cell levels and the onset of tinnitus. The frequency of tinnitus demonstrated a significant positive correlation with haemoglobin levels (p = 0.04) and haematocrit levels (p = 0.043). Conversely, platelet levels showed a significant negative correlation with both tinnitus intensity (p = 0.002) and the onset of tinnitus (p = 0.033). Conclusions: While the haematological parameters showed no significant differences between the tinnitus and control groups, further analyses indicated that certain parameters, such as haemoglobin and haematocrit levels, could potentially influence tinnitus, necessitating further investigation.<\/jats:p>","DOI":"10.3390\/audiolres15030072","type":"journal-article","created":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T05:30:42Z","timestamp":1750224642000},"page":"72","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Exploring How Blood Cell Levels Influence Subjective Tinnitus: A Cross-Sectional Case-Control Study"],"prefix":"10.3390","volume":"15","author":[{"given":"Stefani","family":"Maihoub","sequence":"first","affiliation":[{"name":"Maihoub ENT Clinic, Aliakmona Street 16, Limassol 3117, Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panayiota","family":"Mavrogeni","sequence":"additional","affiliation":[{"name":"T\u00f3th Ilona Health Service, Clinical Medical Institute, G\u00f6rgey Art\u00far T\u00e9r 8, 1212 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9848-1353","authenticated-orcid":false,"given":"G\u00e1bor D\u00e9nes","family":"R\u00e9p\u00e1ssy","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery, Semmelweis University, Szigony u. 36, 1083 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4417-5166","authenticated-orcid":false,"given":"Andr\u00e1s","family":"Moln\u00e1r","sequence":"additional","affiliation":[{"name":"Opera Clinic, Protone Audio Kft., L\u00e1z\u00e1r u. 4, 1065 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1001\/jamaneurol.2022.2189","article-title":"Global Prevalence and Incidence of Tinnitus: A Systematic Review and Meta-analysis","volume":"79","author":"Jarach","year":"2022","journal-title":"JAMA Neurol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"S50","DOI":"10.1055\/a-1950-6149","article-title":"Tinnitus and Influencing Comorbidities. Tinnitus und beeinflussende Komorbidit\u00e4ten","volume":"102","author":"Mazurek","year":"2023","journal-title":"Laryngorhinootologie"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/s10162-013-0371-6","article-title":"Tinnitus and patterns of hearing loss","volume":"14","author":"Tan","year":"2013","journal-title":"J. Assoc. Res. Otolaryngol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3988\/jcn.2021.17.1.1","article-title":"Tinnitus Update","volume":"17","author":"Han","year":"2021","journal-title":"J. Clin. Neurol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.ctim.2019.07.018","article-title":"Changes in tinnitus and physiological biomarkers of stress in response to short-term broadband noise and sounds of nature","volume":"46","author":"Aydin","year":"2019","journal-title":"Complement. Ther. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1002\/lary.26107","article-title":"Relationships between tinnitus and the prevalence of anxiety and depression","volume":"127","author":"Bhatt","year":"2017","journal-title":"Laryngoscope"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1097\/MAO.0000000000003579","article-title":"Association Between Tinnitus and Hypertension: A Cross-Sectional Analysis of the National Health and Nutrition Examination Survey","volume":"43","author":"Patel","year":"2022","journal-title":"Otol. Neurotol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"e198","DOI":"10.1055\/s-0039-1698775","article-title":"An Investigation of Hearing (250\u201320,000\u2009Hz) in Children with Endocrine Diseases and Evaluation of Tinnitus and Vertigo Symptoms","volume":"24","author":"Kocyigit","year":"2020","journal-title":"Int. Arch. Otorhinolaryngol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1590\/S0104-56872009000400005","article-title":"Tinnitus sensation pre and post nutritional intervention in metabolic disorders","volume":"1","author":"Almeida","year":"2009","journal-title":"Pro. Fono."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Fuentes-Santamar\u00eda, V., Alvarado, J.C., Melgar-Rojas, P., Gabald\u00f3n-Ull, M.C., Miller, J.M., and Juiz, J.M. (2017). The Role of Glia in the Peripheral and Central Auditory System Following Noise Overexposure: Contribution of TNF-\u03b1 and IL-1\u03b2 to the Pathogenesis of Hearing Loss. Front. Neuroanat., 11.","DOI":"10.3389\/fnana.2017.00009"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Mennink, L.M., Aalbers, M.W., van Dijk, P., and van Dijk, J.M.C. (2022). The Role of Inflammation in Tinnitus: A Systematic Review and Meta-Analysis. J. Clin. Med., 11.","DOI":"10.3390\/jcm11041000"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1007\/s00405-014-3138-8","article-title":"Hungarian adaptation of the Tinnitus Handicap Inventory: Reliability and validity","volume":"272","author":"Bencsik","year":"2015","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Becker, L., Keck, A., Rohleder, N., and M\u00fcller-Voggel, N. (2022). Higher Peripheral Inflammation Is Associated With Lower Orbitofrontal Gamma Power in Chronic Tinnitus. Front. Behav. Neurosci., 6.","DOI":"10.3389\/fnbeh.2022.883926"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/7854_2021_238","article-title":"Neuroinflammation and Tinnitus","volume":"51","author":"Shulman","year":"2021","journal-title":"Curr. Top. Behav. Neurosci."},{"key":"ref_15","first-page":"157","article-title":"Can Mean Platelet Volume be Used as a Thrombosis Marker in Subjective Tinnitus?","volume":"42","year":"2020","journal-title":"J. Clin. Pract. Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1017\/S0022215115000845","article-title":"Neutrophil-to-lymphocyte ratio in patients with severe tinnitus: Prospective, controlled clinical study","volume":"129","author":"Ozbay","year":"2015","journal-title":"J. Laryngol. Otol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"103","DOI":"10.2399\/jmu.2015003005","article-title":"Assessment of Neutrophil-to-Lymphocyte Ratio, Platelet-to-Lymphocyte Ratio and Mean Platelet Volume in Patients with Tinnitus","volume":"5","author":"Bayram","year":"2015","journal-title":"ENT Updates"},{"key":"ref_18","first-page":"102","article-title":"Increased Platelet Activity in Tinnitus Patients","volume":"41","author":"Chrbolka","year":"2020","journal-title":"Neuroendocrinol. Lett."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1177\/000348940611500314","article-title":"Western Blot Immunoassay for HSP-70 Antibodies in Idiopathic Tinnitus: A Preliminary Report","volume":"115","author":"Savastano","year":"2006","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0022-3999(01)00281-1","article-title":"Impact of a Relaxation Training on Psychometric and Immunologic Parameters in Tinnitus Sufferers","volume":"52","author":"Weber","year":"2002","journal-title":"J. Psychosom. Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1080\/14992027.2019.1698775","article-title":"Tinnitus, Hearing Loss and Inflammatory Processes in an Older Portuguese Population","volume":"59","author":"Haider","year":"2020","journal-title":"Int. J. Audiol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"11521158","DOI":"10.1016\/j.anl.2018.04.001","article-title":"Characteristics of tinnitus found in anemia patients and analysis of population-based survey","volume":"45","author":"Sunwoo","year":"2018","journal-title":"Auris Nasus Larynx"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1007\/s00405-008-0663-3","article-title":"Complex level alterations of the 2f (1)-f (2) distortion product due to hypoxia in the guinea pig","volume":"265","author":"Olzowy","year":"2008","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1016\/j.mehy.2006.03.040","article-title":"A model of peripherally developing hearing loss and tinnitus based on the role of hypoxia and ischemia","volume":"67","author":"Mazurek","year":"2006","journal-title":"Med. Hypotheses"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1177\/000348947908800226","article-title":"Tinnitus as a presenting symptom in pernicious anemia","volume":"88","author":"Cochran","year":"1979","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.heares.2016.01.010","article-title":"Pathophysiology of the cochlear intrastrial fluid-blood barrier (review)","volume":"338","author":"Shi","year":"2016","journal-title":"Hear. Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0378-5955(00)00093-9","article-title":"A review of evidence in support of a role for 5-HT in the perception of tinnitus","volume":"145","author":"Simpson","year":"2000","journal-title":"Hear. Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"e420","DOI":"10.1097\/SCS.0000000000002693","article-title":"Can Platelet Indices Be New Biomarkers for Subjective Tinnitus?","volume":"27","year":"2016","journal-title":"J. Craniofac. Surg."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"5798103","DOI":"10.1155\/2018\/5798103","article-title":"Audiovestibular Symptoms in Systemic Autoimmune Diseases","volume":"2018","author":"Ralli","year":"2018","journal-title":"J. Immunol. Res."}],"container-title":["Audiology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2039-4349\/15\/3\/72\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:53:58Z","timestamp":1760032438000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2039-4349\/15\/3\/72"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,18]]},"references-count":29,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,6]]}},"alternative-id":["audiolres15030072"],"URL":"https:\/\/doi.org\/10.3390\/audiolres15030072","relation":{},"ISSN":["2039-4349"],"issn-type":[{"value":"2039-4349","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,18]]}}}