{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T04:40:36Z","timestamp":1759207236467,"version":"3.44.0"},"reference-count":37,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T00:00:00Z","timestamp":1759017600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"ISCIII","doi-asserted-by":"crossref","award":["19\/00414"],"award-info":[{"award-number":["19\/00414"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100008530","name":"ERDF","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"crossref"}]},{"name":"\u201cA way to make Europe\u201d Instituto de Salud Carlos III. Ministerio de Ciencia, Innovaci\u00f3n y Universidades, Government of Spain"}],"content-domain":{"domain":["www.mdpi.com"],"crossmark-restriction":true},"short-container-title":["Audiology Research"],"abstract":"<jats:p>Background\/Objectives: Skull vibration-induced nystagmus (SVIN) is a rapid bedside test that reveals vestibular asymmetry. Its clinical utility in M\u00e9ni\u00e8re\u2019s disease (MD) remains controversial, particularly regarding its association with radiological endolymphatic hydrops (EH). This study aimed to evaluate the relationship between SVIN, audiovestibular parameters, and EH severity in patients with unilateral definite MD. Methods: This prospective observational study was conducted at a tertiary academic referral center and included patients with unilateral MD who underwent SVIN testing (SVT), audiovestibular evaluation (PTA, cVEMP, oVEMP, vHIT, and caloric testing), and 3T MRI with gadolinium-enhanced 3D-FLAIR sequences to quantify EH. Results: In total, 84 patients were included in the study. SVIN was present in 57.14% of patients (n = 48), with ipsilesional nystagmus being the most frequent subtype (64.58%). Patients with SVIN had significantly higher vestibular EH (p = 0.017) and vestibular endolymphatic ratio (REL) in the affected ear (p = 0.019). Disease duration (p = 0.026) and shorter time since last vertigo spell (p = 0.018) were also associated with SVIN presence. REL correlated moderately with disease duration (r = 0.390, p &lt; 0.001), PTA (r = 0.576, p &lt; 0.001), and number of vertigo spells (r = 0.236, p = 0.031), but not with time since last crisis (r = \u22120.127, p = 0.252). ROC analysis yielded an AUC of 0.735 for REL in predicting SVIN. Conclusions: SVIN correlates with the severity of vestibular EH. This finding indicates a stimulus-locked response of a vestibular asymmetry rather than a purely structural alteration.<\/jats:p>","DOI":"10.3390\/audiolres15050125","type":"journal-article","created":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T08:00:32Z","timestamp":1759132832000},"page":"125","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Vibration-Induced Nystagmus in Patients with M\u00e9ni\u00e8re\u2019s Disease: Is There a Correlation to Endolymphatic Hydrops?"],"prefix":"10.3390","volume":"15","author":[{"given":"Joan","family":"Lorente-Piera","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Cl\u00ednica Universidad de Navarra, 31008 Pamplona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9982-7951","authenticated-orcid":false,"given":"Melissa","family":"Blanco","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Cl\u00ednica Universidad de Navarra, 28027 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0781-9679","authenticated-orcid":false,"given":"Raquel","family":"Manrique-Huarte","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Cl\u00ednica Universidad de Navarra, 31008 Pamplona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana","family":"David","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Hospital Universitario General de Villalba, 28400 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7313-4590","authenticated-orcid":false,"given":"Victor","family":"Suarez-Vega","sequence":"additional","affiliation":[{"name":"Department of Radiology, Cl\u00ednica Universidad de Navarra, 28027 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angel","family":"Batuecas-Caletr\u00edo","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Complejo Asistencial Universitario de Salamanca, University of Salamanca, 37008 Salamanca, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0179-7018","authenticated-orcid":false,"given":"Gloria Lia\u00f1o","family":"Esteve","sequence":"additional","affiliation":[{"name":"Department of Radiology, Cl\u00ednica Universidad de Navarra, 28027 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9692-3808","authenticated-orcid":false,"given":"Pablo","family":"Dominguez","sequence":"additional","affiliation":[{"name":"Department of Radiology, Cl\u00ednica Universidad de Navarra, 28027 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1192-5901","authenticated-orcid":false,"given":"Nicol\u00e1s","family":"P\u00e9rez-Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Cl\u00ednica Universidad de Navarra, 28027 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Dumas, G., Curthoys, I.S., Lion, A., Perrin, P., and Schmerber, S. (2017). The Skull Vibration-Induced Nystagmus Test of Vestibular Function\u2014A Review. Front. Neurol., 8.","DOI":"10.3389\/fneur.2017.00041"},{"key":"ref_2","first-page":"85","article-title":"Vibration induced nystagmus in normal subjects and in patients with dizziness. A videonystagmography study","volume":"124","author":"Perez","year":"2003","journal-title":"Rev. Laryngol. Otol. Rhinol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1097\/WCO.0000000000000770","article-title":"Physiology, clinical evidence and diagnostic relevance of sound-induced and vibration-induced vestibular stimulation","volume":"33","author":"Curthoys","year":"2020","journal-title":"Curr. Opin. Neurol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1080\/00016489.2020.1809706","article-title":"Skull vibration-induced nystagmus in vestibular neuritis","volume":"140","author":"Nava","year":"2020","journal-title":"Acta Otolaryngol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"3011","DOI":"10.1007\/s00405-015-3889-x","article-title":"Vestibular results after intratympanic gentamicin therapy in disabling M\u00e9ni\u00e8re\u2019s disease","volume":"273","author":"Junet","year":"2016","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1080\/00016489.2021.1872797","article-title":"Vibration-induced nystagmus and head impulse testscreening for vestibular schwannoma","volume":"141","author":"Cuesta","year":"2021","journal-title":"Acta Otolaryngol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"588","DOI":"10.3109\/00016489.2014.888591","article-title":"Skull vibration-induced nystagmus test in unilateral superior canal dehiscence and otosclerosis: A vestibular Weber test","volume":"134","author":"Dumas","year":"2014","journal-title":"Acta Otolaryngol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1159\/000113508","article-title":"Clinical significance of vibration-induced nystagmus","volume":"13","author":"Park","year":"2008","journal-title":"Audiol. Neurotol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1080\/03655230701625019","article-title":"Implication of vibration induced nystagmus in M\u00e9ni\u00e8re\u2019s disease","volume":"127","author":"Hong","year":"2007","journal-title":"Acta Otolaryngol. Suppl."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1097\/MAO.0b013e31822f0b6b","article-title":"High-frequency skull vibration-induced nystagmus test in partial vestibular lesions","volume":"32","author":"Dumas","year":"2011","journal-title":"Otol. Neurotol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1097\/MAO.0000000000000743","article-title":"Head-shaking and vibration-induced nystagmus duringan between the attacks of unilateral M\u00e9ni\u00e8re\u2019s disease","volume":"36","author":"Lee","year":"2015","journal-title":"Otol. Neurotol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"557","DOI":"10.3390\/audiolres11040050","article-title":"The Neural Basis of Skull Vibration Induced Nystagmus (SVIN)","volume":"11","author":"Curthoys","year":"2021","journal-title":"Audiol. Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"498","DOI":"10.3109\/00016489.2011.646357","article-title":"Bedside vestibular examination in patients with unilateral definite M\u00e9ni\u00e8re\u2019s disease","volume":"132","author":"Marques","year":"2012","journal-title":"Acta Otolaryngol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1007\/s00405-010-1442-5","article-title":"Rapid fluctuations in dynamic semicircular canal function in early Meniere\u2019s disease","volume":"268","author":"Manzari","year":"2011","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e168","DOI":"10.1097\/MAO.0000000000001435","article-title":"Ipsilesional Nystagmus Induced by Vibration in Subjects with M\u00e9ni\u00e8re\u2019s Disease or Vestibular Schwannoma","volume":"38","author":"Gamarra","year":"2017","journal-title":"Otol. Neurotol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1288\/00005537-198110000-00019","article-title":"Recovery nystagmus in Menieres-disease","volume":"91","author":"McClure","year":"1981","journal-title":"Laryngoscope"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1097\/MLG.0b013e31802c300c","article-title":"Visualization of endolymphatic hydrops in patients with Meniere\u2019s disease","volume":"117","author":"Nakashima","year":"2007","journal-title":"Laryngoscope"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"43","DOI":"10.2463\/mrms.11.43","article-title":"Visualization of endolymphatic hydrops in M\u00e9ni\u00e8re\u2019s disease after single-dose intravenous gadolinium-based contrast medium: Timing of optimal enhancement","volume":"11","author":"Naganawa","year":"2012","journal-title":"Magn. Reson. Med. Sci."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1097\/AUD.0000000000000584","article-title":"Relationship between audio-vestibular functional tests and inner ear MRI in Meniere\u2019s disease","volume":"40","author":"Quatre","year":"2019","journal-title":"Ear Hear."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.anl.2020.10.009","article-title":"Diagnostic and therapeutic strategies for Meniere\u2019s disease of the Japan Society for Equilibrium Research","volume":"48","author":"Iwasaki","year":"2021","journal-title":"Auris Nasus Larynx."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1080\/21695717.2019.1591009","article-title":"Air and bone stimulation in vestibular evoked myogenic potentials in patients with unilateral M\u00e9ni\u00e8re\u2019s disease and in controls","volume":"17","year":"2019","journal-title":"Hear. Balanc. Commun."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.ncl.2015.04.012","article-title":"Acute unilateral vestibulopathy","volume":"33","author":"Strupp","year":"2015","journal-title":"Neurol. Clin."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Su\u00e1rez-Vega, V., Manrique-Huarte, R., Dominguez, P., Blanco, M., Alonso-Burgos, A., and P\u00e9rez-Fern\u00e1ndez, N. (2023). Magnetic Resonance Volumetric Quantification of Vestibular Endolymphatic Hydrops in Patients with Unilateral Definite Meniere\u2019s Disease Using 3D Inversion Recovery with Real Reconstruction (3D-REAL-IR) Sequence. J. Clin. Med., 12.","DOI":"10.3390\/jcm12185965"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"562","DOI":"10.3390\/audiolres14040047","article-title":"Visual Fixation of Skull-Vibration-Induced Nystagmus in Patients with Peripheral Vestibulopathy","volume":"24","author":"Blanco","year":"2024","journal-title":"Audiol. Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"202","DOI":"10.3390\/audiolres12020023","article-title":"Skull Vibration-Induced Nystagmus and High Frequency Ocular Vestibular-Evoked Myogenic Potentials in Superior Canal Dehiscence","volume":"12","author":"Jara","year":"2022","journal-title":"Audiol. Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"126","DOI":"10.3390\/audiolres12020015","article-title":"Is Skull Vibration-Induced Nystagmus Useful in Vestibular Neuritis Follow Up?","volume":"12","author":"Zamora","year":"2022","journal-title":"Audiol. Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1097\/MAO.0b013e3181b0ff1b","article-title":"Lessons from follow-up examinations in patients with vestibular neuritis: How to interpret findings from vestibular function tests at a compensated stage","volume":"30","author":"Park","year":"2009","journal-title":"Otol. Neurotol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1097\/MAO.0b013e318169281f","article-title":"Clinical significance of vibration-induced nystagmus and head-shaking nystagmus through follow-up examinations in patients with vestibular neuritis","volume":"29","author":"Park","year":"2008","journal-title":"Otol. Neurotol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"140","DOI":"10.14639\/0392-100X-N2152","article-title":"Skull vibration-induced nystagmus test in patients candidates for intratympanic gentamicin injection","volume":"43","author":"Ciacca","year":"2023","journal-title":"Acta Otorhinolaryngol. Ital."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/s00234-019-02155-7","article-title":"The value of four stage vestibular hydrops grading and asymmetric perilymphatic enhancement in the diagnosis of M\u00e9ni\u00e8re\u2019s disease on MRI","volume":"61","author":"Bernaerts","year":"2019","journal-title":"Neuroradiology."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1097\/MAO.0b013e31825d9a95","article-title":"In vivo visualized endolymphatic hydrops and inner ear functions in patients with electrocochleographically confirmed M\u00e9ni\u00e8re\u2019s disease","volume":"33","author":"Flatz","year":"2012","journal-title":"Otol. Neurotol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"101314","DOI":"10.1016\/j.bjorl.2023.101314","article-title":"Evaluation of the relationship between endolymphatic hydrops and hearing loss in Meniere\u2019s disease based on three-dimensional real inversion recovery sequence","volume":"89","author":"Huang","year":"2023","journal-title":"Braz. J. Otorhinolaryngol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.anl.2012.07.009","article-title":"Visualization of endolymphatic hydrops and correlation with audio-vestibular functional testing in patients with definite Meniere\u2019s disease","volume":"40","author":"Seo","year":"2013","journal-title":"Auris Nasus Larynx."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Lorente-Piera, J., Su\u00e1rez-Vega, V., Blanco-Pareja, M., Lia\u00f1o, G., Garaycochea, O., Dominguez, P., Manrique-Huarte, R., and P\u00e9rez-Fern\u00e1ndez, N. (2025). Early and certain M\u00e9ni\u00e8re\u2019s disease characterization of predictors of endolymphatic hydrops. Front. Neurology., 28.","DOI":"10.3389\/fneur.2025.1566438"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Li, H., Rajan, G.P., Shaw, J., Rohani, S.A., Ladak, H.M., Agrawal, S., and Rask-Andersen, H. (2021). A synchrotron and Micro-CT study of the human endolymphatic duct system: Is Meniere\u2019s disease caused by an acute endolymph backflow?. Front. Surg., 8.","DOI":"10.3389\/fsurg.2021.662530"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"277","DOI":"10.3233\/VES-200719","article-title":"Auditory biophysics of endolymphatic hydrops","volume":"31","author":"Avan","year":"2021","journal-title":"J. Vestib. Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"6036","DOI":"10.1007\/s00330-024-10620-y","article-title":"Correlation of endolymphatic hydrops and perilymphatic enhancement with the clinical features of M\u00e9ni\u00e8re\u2019s disease","volume":"34","author":"Li","year":"2024","journal-title":"Eur. Radiol."}],"container-title":["Audiology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2039-4349\/15\/5\/125\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T04:13:13Z","timestamp":1759205593000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2039-4349\/15\/5\/125"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,28]]},"references-count":37,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2025,10]]}},"alternative-id":["audiolres15050125"],"URL":"https:\/\/doi.org\/10.3390\/audiolres15050125","relation":{},"ISSN":["2039-4349"],"issn-type":[{"type":"electronic","value":"2039-4349"}],"subject":[],"published":{"date-parts":[[2025,9,28]]}}}