{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T10:19:55Z","timestamp":1763720395061,"version":"3.45.0"},"reference-count":24,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T00:00:00Z","timestamp":1763683200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"MEDEL"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Audiology Research"],"abstract":"<jats:p>Introduction: Cochlear implantation is the treatment of choice for severe hearing loss and deafness. Cholesteatomas can cause this deafness. A frequently used procedure in the course of surgical rehabilitation is a subtotal petrosectomy combined with a cochlear implant. The clinical follow-up of residual cholesteatomas is related to the blind sac closure difficult. Cholesteatoma MRI sequence-related CI magnet artefacts make follow-up challenging. Recent developments in combining cochlear implants and necessary MRI examinations enable the assessment of the internal auditory canal and cochlea. The study aimed to develop a procedure for detecting cholesteatomas in patients with cochlear implants using magnetic resonance imaging (MRI). Methods: Ex vivo MRI examinations were performed on five volunteers with fixed cochlear implants (Medel Synchrony) and swim caps. MRI examinations were performed at 1.5 T and 3 T using EPI, HASTE, and RESOLVE sequences (Siemens). The position of the implant was 12 cm distal to the external auditory canal, with anteversional head position of the volunteers in the MRI. Results: Due to artefact effects, assessment of the ipsilateral and contralateral mastoid is not possible with EPI sequences and a cochlear implant. The combination of cholesteatoma-detecting MARS sequences (HASTE, RESOLVE), a distal implant position, and a specific head position allows the assessment of the ipsilateral mastoid. Conclusions: Postoperative cholesteatoma assessment after CI implantation and subtotal petrosectomy appears to be possible under 1.5 T and 3 T, considering the MRI sequence, implant position, and head position.<\/jats:p>","DOI":"10.3390\/audiolres15060162","type":"journal-article","created":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T09:50:26Z","timestamp":1763718626000},"page":"162","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Concept for MRI-Based Cholesteatoma Detection in Cochlear Implant Recipients"],"prefix":"10.3390","volume":"15","author":[{"given":"Lukas","family":"Woltersdorf","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, Medical School OWL, Bielefeld University, Campus Mitte, Klinikum, 33604 Bielefeld, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rayoung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, Medical School OWL, Bielefeld University, Campus Mitte, Klinikum, 33604 Bielefeld, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Rempen","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, Medical School OWL, Bielefeld University, Campus Mitte, Klinikum, 33604 Bielefeld, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Pfeiffer","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, Medical School OWL, Bielefeld University, Campus Mitte, Klinikum, 33604 Bielefeld, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars-Uwe","family":"Scholtz","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, Medical School OWL, Bielefeld University, Campus Mitte, Klinikum, 33604 Bielefeld, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christiane","family":"Schimmack","sequence":"additional","affiliation":[{"name":"Diranuk, Radiology Center, 33602 Bielefeld, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Eickenj\u00e4ger","sequence":"additional","affiliation":[{"name":"Diranuk, Radiology Center, 33602 Bielefeld, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R\u00fcdiger","family":"Steinbach","sequence":"additional","affiliation":[{"name":"Diranuk, Radiology Center, 33602 Bielefeld, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4161-8304","authenticated-orcid":false,"given":"Ingo","family":"Todt","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, Medical School OWL, Bielefeld University, Campus Mitte, Klinikum, 33604 Bielefeld, Germany"},{"name":"Alexianer St. Gertrauden-Krankenhaus, Paretzerstr. 12, 10713 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"4225","DOI":"10.1007\/s00405-020-06525-3","article-title":"Two-phase survey on the frequency of use and safety of MRI for hearing implant recipients","volume":"278","author":"Mertens","year":"2021","journal-title":"Eur. Arch. Oto-Rhino-Laryngol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1097\/MAO.0000000000000720","article-title":"MRI Artifacts and Cochlear Implant Positioning at 3 T In Vivo","volume":"36","author":"Todt","year":"2015","journal-title":"Otol. Neurotol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"e401","DOI":"10.1097\/MAO.0000000000001569","article-title":"Pain Free 3 T MRI Scans in Cochlear Implantees","volume":"38","author":"Todt","year":"2017","journal-title":"Otol. Neurotol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2763","DOI":"10.1007\/s00405-020-06349-1","article-title":"Effect of head position on cochlear implant MRI artifact","volume":"278","author":"Ay","year":"2021","journal-title":"Eur. Arch. Oto-Rhino-Laryngol."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Sudhoff, H., Gehl, H.B., Scholtz, L.U., and Todt, I. (2020). MRI observation after intralabyrinthine and vestibular schwannoma resection and cochlear implantation. Front. Neurol., 11.","DOI":"10.3389\/fneur.2020.00759"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Sudhoff, H., Scholtz, L.U., Gehl, H.B., and Todt, I. (2021). Quality Control after Intracochlear Intralabyrinthine Schwannoma Resection and Cochlear Implantation. Brain Sci., 11.","DOI":"10.3389\/fneur.2020.00759"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1148\/rg.2018170135","article-title":"MR imaging and cochlear implants with retained internal magnets: Reducing artifacts near highly inhomogeneous magnetic fields","volume":"38","author":"Edmonson","year":"2018","journal-title":"RadioGraphics"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"273","DOI":"10.14639\/0392-100X-N2434","article-title":"The usefulness of the O-MAR algorithm in MRI skull base assessment to manage cochlear implant-related artifacts","volume":"43","author":"Canzi","year":"2023","journal-title":"Acta Otorhinolaryngol. Ital."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1097\/MAO.0000000000004517","article-title":"Image Quality Improvement in MRI of Cochlear Implants and Auditory Brainstem Implants After Metal Artifact Reduction Techniques","volume":"46","author":"Winchester","year":"2025","journal-title":"Otol. Neurotol."},{"key":"ref_10","first-page":"363","article-title":"Cinq cas de kyste \u00e9pidermo\u00efde (ou cholest\u00e9atome primitif) de la pyramide p\u00e9treuse.Aspects clinique, radiologique, pathog\u00e9nique et th\u00e9rapeutique. Int\u00e9r\u00eat de la RMN dans la diagnostic et la surveillance post-operatoire [5 cases of epidermoid cyst (or primary cholesteatoma) of the petrous pyramid. Clinical, radiologic, pathogenic and therapeutic aspects. Value of nuclear magnetic resonance in the diagnosis and postoperative monitoring]","volume":"103","author":"Bensimon","year":"1986","journal-title":"Ann. Otolaryngol. Chir. Cervicofac."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1002\/jmri.10118","article-title":"Diffusion\u2013weighted MRI of cholesteatomas of the petrous bone","volume":"15","author":"Fitzek","year":"2002","journal-title":"J. Magn. Reson. Imaging"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1097\/MAO.0b013e31822e938d","article-title":"A systematic review of diffusion-weighted magnetic resonance imaging in the assessment of postoperative cholesteatoma","volume":"32","author":"Jindal","year":"2011","journal-title":"Otol. Neurotol."},{"key":"ref_13","first-page":"1480","article-title":"Single-shot, turbo spin-echo, diffusion-weighted imaging versus spin-echo-planar, diffusion-weighted imaging in the detection of acquired middle ear cholesteatoma","volume":"27","author":"Vercruysse","year":"2006","journal-title":"Am. J. Neuroradiol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/ohn.474","article-title":"Magnetic Resonance Imaging Artifact Associated with Transcutaneous Bone Conduction Implants: Cholesteatoma and Vestibular Schwannoma Surveillance","volume":"170","author":"Nassiri","year":"2024","journal-title":"Otolaryngol, Head Neck Surg."},{"key":"ref_15","first-page":"370","article-title":"Diagnostic performance of multishot echo-planar imaging (RESOLVE) and non-echo-planar imaging (HASTE) diffusion-weighted imaging in cholesteatoma with an emphasis on signal intensity ratio measurement","volume":"30","author":"Bozer","year":"2024","journal-title":"Diagn. Interv. Radiol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1002\/lary.5540680707","article-title":"Primary closure of the radical mastoidectomy wound; a technique to eliminate postoperative care","volume":"68","author":"Rambo","year":"1958","journal-title":"Laryngoscope"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s004050050037","article-title":"Cochlear implantation after subtotal petrosectomies","volume":"255","author":"Bendet","year":"1998","journal-title":"Eur. Arch. Oto-Rhino-Laryngol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"S67","DOI":"10.14639\/0392-100X-suppl.1-43-2023-09","article-title":"Current trends on subtotal petrosectomy with cochlear implantation in recalcitrant chronic middle ear disorders","volume":"43","author":"Canzi","year":"2023","journal-title":"Acta Otorhinolaryngol. Ital."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"5091","DOI":"10.1007\/s00405-025-09431-8","article-title":"Subtotal petrosectomy in cochlear implantation: Gruppo Otologico experience after 348 cases","volume":"282","author":"Morelli","year":"2025","journal-title":"Eur. Arch. Oto-Rhino-Laryngol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"113","DOI":"10.3390\/audiolres12020014","article-title":"Subtotal Petrosectomy (SP) in Cochlear Implantation (CI): A Report of 92 Cases","volume":"12","author":"Aranguez","year":"2022","journal-title":"Audiol. Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1017\/S0022215100145499","article-title":"Further experience with fat graft obliteration of mastoid cavities for cochlear","volume":"113","author":"Gray","year":"1999","journal-title":"J. Laryngol. Otol."},{"key":"ref_22","first-page":"1","article-title":"Subtotal Petrosectomy and Cochlear Implantation: A Systematic Review and Meta-analysis","volume":"147","author":"Yan","year":"2020","journal-title":"Arch. Otolaryngol. Neck Surg."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"103743","DOI":"10.1016\/j.amjoto.2022.103743","article-title":"Disease recidivism after subtotal petrosectomy and ear canal closure","volume":"44","author":"Macielak","year":"2023","journal-title":"Am. J. Otolaryngol."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Eichler, T., Ibrahim, A., Riemann, C., Scholtz, L.U., Gehl, H.B., Goon, P., Sudhoff, H., and Todt, I. (2022). Prospective Evaluation of 3 T MRI Effect on Residual Hearing Function of Cochlea Implantees. 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