{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T04:51:59Z","timestamp":1781844719298,"version":"3.54.5"},"reference-count":102,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T00:00:00Z","timestamp":1781395200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Audiology Research"],"abstract":"<jats:p>Background\/Objectives: Sensorineural hearing loss (SNHL) is a chronic condition with no established pharmacological treatment. Recent advances in drug-based therapies offer promising opportunities to prevent or treat SNHL. This scoping review summarizes the current landscape of pharmacotherapeutics for SNHL. Methods: This scoping review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR). A literature search of PubMed, Google Scholar, Embase, Scopus, and Web of Science was conducted in 2024 using keywords related to SNHL and pharmacotherapeutics. A review protocol was preregistered on the Open Science Framework. A systematic search of five electronic databases identified published studies from 2004 to 2024 on pharmacological treatments for SNHL in human participants, as well as ongoing clinical trials. Interventions were categorized by mechanism of action: antioxidant therapy, steroid-based combination therapy, hematologic-based therapy, pathway modulator therapy, regenerative therapy, and gene therapy. A narrative synthesis approach was used to map key trends across treatment types, study designs, and outcomes. Results: Sixty-six records met the inclusion criteria, including 48 published studies and 18 ongoing or recently completed clinical trial records. Antioxidants, corticosteroids, hematologic agents, and pathway modulators have demonstrated potential in preventing or treating SNHL caused by cisplatin, aminoglycosides, noise-induced ototoxicity, and intraoperative cochlear implantation trauma. Emerging regenerative and gene therapies show promise as future pharmacologic treatment options. Conclusions: Pharmacologic therapies for SNHL are promising but remain constrained by small sample sizes, heterogeneous study designs, and drug delivery challenges across the blood\u2013labyrinth barrier. Future research should prioritize multicenter randomized trials, optimized delivery strategies, and integration of precision medicine approaches.<\/jats:p>","DOI":"10.3390\/audiolres16030091","type":"journal-article","created":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:49:42Z","timestamp":1781743782000},"page":"91","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pharmacotherapeutic Interventions for Sensorineural Hearing Loss: A Scoping Review"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-3713-344X","authenticated-orcid":false,"given":"Matthew","family":"Mavandi","sequence":"first","affiliation":[{"name":"College of Osteopathic Medicine, Kansas City University, Kansas City, MO 64106, USA"},{"name":"Helzberg School of Management, Rockhurst University, Kansas City, MO 64110, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2399-967X","authenticated-orcid":false,"given":"Jack","family":"Hyler","sequence":"additional","affiliation":[{"name":"College of Osteopathic Medicine, Kansas City University, Kansas City, MO 64106, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Lee","sequence":"additional","affiliation":[{"name":"College of Osteopathic Medicine, Kansas City University, Kansas City, MO 64106, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramanjot","family":"Singh","sequence":"additional","affiliation":[{"name":"College of Osteopathic Medicine, Kansas City University, Kansas City, MO 64106, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8313-1636","authenticated-orcid":false,"given":"De Wet","family":"Swanepoel","sequence":"additional","affiliation":[{"name":"Department of Speech-Language Pathology and Audiology, University of Pretoria, Pretoria 0001, South Africa"},{"name":"Department of Otolaryngology-Head and Neck Surgery, University of Colorado Anschutz School of Medicine, Aurora, CO 80045, USA"},{"name":"Virtual Hearing Lab, Collaborative Initiative University of Colorado School of Medicine, Aurora, CO 80045, USA"},{"name":"Virtual Hearing Lab, Collaborative Initiative, University of Pretoria, Pretoria 00001, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley M.","family":"Nassiri","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, University of Colorado Anschutz School of Medicine, Aurora, CO 80045, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1254-8407","authenticated-orcid":false,"given":"Vinaya","family":"Manchaiah","sequence":"additional","affiliation":[{"name":"Department of Speech-Language Pathology and Audiology, University of Pretoria, Pretoria 0001, South Africa"},{"name":"Department of Otolaryngology-Head and Neck Surgery, University of Colorado Anschutz School of Medicine, Aurora, CO 80045, USA"},{"name":"Virtual Hearing Lab, Collaborative Initiative University of Colorado School of Medicine, Aurora, CO 80045, USA"},{"name":"Virtual Hearing Lab, Collaborative Initiative, University of Pretoria, Pretoria 00001, South Africa"},{"name":"UCHealth Hearing and Balance, University of Colorado Hospital, Aurora, CO 80045, USA"},{"name":"Department of Speech and Hearing, School of Allied Health Sciences, Manipal Academy of Higher Education, Manipal 576104, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/s13643-018-0736-3","article-title":"A protocol for a network meta-analysis of interventions to treat patients with sudden sensorineural hearing loss","volume":"7","author":"Ahmadzai","year":"2018","journal-title":"Syst. Rev."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"242","DOI":"10.2471\/BLT.21.285643","article-title":"The world report on hearing, 2021","volume":"99","author":"Chadha","year":"2021","journal-title":"Bull. World Health Organ."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/S0140-6736(23)01406-X","article-title":"Hearing intervention versus health education control to reduce cognitive decline in older adults with hearing loss in the USA (ACHIEVE): A multicentre, randomised controlled trial","volume":"402","author":"Lin","year":"2023","journal-title":"Lancet"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1159\/000493558","article-title":"Comparison of two different treatment protocols using systemic and intratympanic steroids with and without hyperbaric oxygen therapy in patients with severe to profound idiopathic sudden sensorineural hearing loss: A randomized controlled trial","volume":"23","author":"Cho","year":"2018","journal-title":"Audiol. Neurotol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1097\/MAO.0b013e318297638a","article-title":"Randomized prospective trial of hyperbaric oxygen therapy and intratympanic steroid injection as salvage treatment of sudden sensorineural hearing loss","volume":"34","author":"Cvorovic","year":"2013","journal-title":"Otol. Neurotol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.amjoto.2012.12.010","article-title":"Sudden sensorineural hearing loss: Results of intratympanic steroids as salvage treatment","volume":"34","author":"Dispenza","year":"2013","journal-title":"Am. J. Otolaryngol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"422","DOI":"10.4252\/wjsc.v12.i6.422","article-title":"Stem cell-based approaches: Possible route to hearing restoration?","volume":"12","year":"2020","journal-title":"World J. Stem Cells"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1002\/lary.23678","article-title":"Intratympanic steroid therapy in moderate sudden hearing loss: A randomized, triple-blind, placebo-controlled trial","volume":"123","author":"Filipo","year":"2013","journal-title":"Laryngoscope"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.4103\/njcp.njcp_390_19","article-title":"Age-related hearing loss at Gwagwalada area council of federal capital territory, Abuja","volume":"23","author":"Folorunso","year":"2020","journal-title":"Niger. J. Clin. Pract."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"360","DOI":"10.3109\/14992027.2013.769066","article-title":"Why do people fitted with hearing aids not wear them?","volume":"52","author":"McCormack","year":"2013","journal-title":"Int. J. Audiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.heares.2019.03.003","article-title":"Translating animal models to human therapeutics in noise-induced and age-related hearing loss","volume":"377","author":"Kujawa","year":"2019","journal-title":"Hear. Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1097\/00005537-200310000-00012","article-title":"Combining acoustic and electrical hearing","volume":"113","author":"Gantz","year":"2003","journal-title":"Laryngoscope"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1097\/AUD.0b013e3181c6b831","article-title":"Evidence for the expansion of adult cochlear implant candidacy","volume":"31","author":"Gifford","year":"2010","journal-title":"Ear Hear."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Matsunaga, M., and Nakagawa, T. (2023). Future pharmacotherapy for sensorineural hearing loss by protection and regeneration of auditory hair cells. Pharmaceutics, 15.","DOI":"10.3390\/pharmaceutics15030777"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1177\/0194599820976177","article-title":"Trends in use and timing of intratympanic corticosteroid injections for sudden sensorineural hearing loss","volume":"165","author":"Jin","year":"2021","journal-title":"Otolaryngol.-Head Neck Surg."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1007\/s00106-022-01184-8","article-title":"Efficacy and safety of systemic, high-dose glucocorticoid therapy for idiopathic sudden sensorineural hearing loss: Study protocol for a three-armed, randomized, triple-blind, multicenter trial (HODOKORT)","volume":"70","author":"Plontke","year":"2022","journal-title":"HNO"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"467","DOI":"10.7326\/M18-0850","article-title":"PRISMA extension for scoping reviews (PRISMA-ScR)","volume":"169","author":"Tricco","year":"2018","journal-title":"Ann. Intern. Med."},{"key":"ref_18","unstructured":"Mavandi, M., Hyler, J., Lee, E., Singh, R., Nassiri, A., Swanepoel, D.W., and Manchaiah, V. (2024). Scoping review of pharmacotherapeutics in sensorineural hearing loss. MetaArXiv."},{"key":"ref_19","unstructured":"Sound Pharmaceuticals, Incorporated (2026, April 26). A Phase 2, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate The Safety and Efficacy of Spi-1005 in Adults Receiving A Cochlear Implant, Available online: https:\/\/clinicaltrials.gov\/study\/NCT06340633."},{"key":"ref_20","unstructured":"Winthrop, K., and Oregon Health and Science University (2026, April 26). Phase 2 Study of the Efficacy and Safety of ORC-13661 for the Prevention of Drug-Induced Hearing Loss in Patients Receiving Intravenous Amikacin Therapy for Non-Tuberculous Mycobacterium Disease, Available online: https:\/\/clinicaltrials.gov\/study\/NCT05730283."},{"key":"ref_21","unstructured":"Cochlear (2026, April 26). A Pivotal, Prospective, Multi-Centre, Randomised Controlled, 6-Month Blinded Investigation Followed by A 6-Month Open-Label Phase Evaluating the Efficacy of A Dexamethasone Eluting Slim Straight Electrode (Ci622d) in The Reduction of Impedance as Compared to a Standard Slim Straight Electrode (Ci622) in a Newly Implanted Adult Population with Post-Linguistic, Bilateral, Moderately Severe To Profound Sensorineural Hearing Loss, Available online: https:\/\/clinicaltrials.gov\/study\/NCT06424262."},{"key":"ref_22","unstructured":"Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University (2026, April 26). A Pilot Study of Autologous Blood Monocyte Vesicles for the Treatment Of Sudden Deafness, Available online: https:\/\/clinicaltrials.gov\/study\/NCT06707389."},{"key":"ref_23","unstructured":"Northwestern University (2026, April 26). Towards a Self-Administered Hearing Protection Regimen, Available online: https:\/\/clinicaltrials.gov\/study\/NCT04826237."},{"key":"ref_24","unstructured":"Minia University (2026, April 26). Evaluation of the Effect of Statins on the Incidence of Side Effects of Platinum Based Chemotherapy in Patients with Solid Tumors, Available online: https:\/\/clinicaltrials.gov\/study\/NCT06553157."},{"key":"ref_25","unstructured":"Chang Gung Memorial Hospital (2026, April 26). The Role of Migraine Prophylaxis Agent Topiramate in Treating Patients with Sudden Sensorineural Hearing Loss, Available online: https:\/\/clinicaltrials.gov\/study\/NCT05403229."},{"key":"ref_26","unstructured":"Vanderbilt University Medical Center (2026, April 26). Effect of Donepezil on Speech Recognition in Cochlear Implant Users, Available online: https:\/\/clinicaltrials.gov\/study\/NCT05438264."},{"key":"ref_27","unstructured":"Acousia Therapeutics GmbH (2026, April 26). Phase Iia Randomized, Double-Blind, and Placebo-Controlled Multicenter Split Body Trial of Repeated Doses of Acou085 for the Prevention of Hearing Loss in Testicular Cancer Patients Receiving Cisplatin, Available online: https:\/\/clinicaltrials.gov\/study\/NCT06521190."},{"key":"ref_28","unstructured":"Neuracle Science Co., Ltd. (2026, April 26). A Phase 1b\/2a, Double-Blinded, Placebo-Controlled, Multiple Doses, 2 Step-Up Study Evaluating the Safety, Tolerability, Pk\/Pd and Efficacy of Systemic Ns101 in Healthy Volunteers and Ssnhl Patients, Available online: https:\/\/clinicaltrials.gov\/study\/NCT06249919."},{"key":"ref_29","unstructured":"Shanghai Jiao Tong University School of Medicine (2026, April 26). Rct Study of Liuwei Dihuang Pill Preventing and Treating Presbycusis with Shen (Kidney)-Yin Deficiency, Available online: https:\/\/clinicaltrials.gov\/study\/NCT05125081."},{"key":"ref_30","unstructured":"AudioCure Pharma GmbH (2026, April 26). Phase ii, Multi-Center, Randomized, Blinded Study Evaluating the Efficacy, Safety and Tolerability of a Single Intratympanic Dose of Ac102 Compared to Oral Steroids for the Treatment of Idiopathic Sudden Sensorineural Hearing Loss, Available online: https:\/\/clinicaltrials.gov\/study\/NCT05776459."},{"key":"ref_31","unstructured":"Hannover Medical School (2026, April 26). Extracellular Vesicle-Enriched Secretome Fraction (vsf1.01) for the Reduction of Cochlear ImpLANT surgery Related Trauma (escrt). An Open-Label Monocentric Phase i\/iia Clinical Trial to Investigate the Safety of Intracochlear Application of vsf1.01 Enriched with Huc-Msc-Evs in Patients Receiving Cochlear Implantation, Available online: https:\/\/clinicaltrials.gov\/study\/NCT06545175."},{"key":"ref_32","unstructured":"Akouos, Inc. (2026, May 16). A Trial of AAVAnc80-hOTOF Gene Therapy in Individuals with Sensorineural Hearing Loss Due to Otoferlin Gene Mutations, Available online: https:\/\/clinicaltrials.gov\/study\/NCT05821959."},{"key":"ref_33","unstructured":"Regeneron Pharmaceuticals (2026, May 16). A Phase 1\/2, Open-Label, Multicenter Trial with a Single Ascending Dose Cohort with Unilateral Intracochlear Injection Followed by a Bilateral Injection Expansion Cohort to Evaluate the Safety, Tolerability, and Efficacy Of Db-Oto in Children and Infants with Biallelic hOTOF Mutations, Available online: https:\/\/clinicaltrials.gov\/study\/NCT05788536."},{"key":"ref_34","unstructured":"Shu, Y., and Eye & ENT Hospital of Fudan University (2026, May 16). A Study on the Safety, Tolerability, and Preliminary Efficacy of Eh002 in the Treatment of Dfnb9 Congenital Deafness, Available online: https:\/\/clinicaltrials.gov\/study\/NCT06722170."},{"key":"ref_35","unstructured":"Otovia Therapeutics (2026, May 16). An Investigator Initiated Study Evaluating the Safety, Tolerability, and Efficacy of Otov101n+Otov101c Injection in Treating Patients with Otof Mutation-Related Deafness, Available online: https:\/\/clinicaltrials.gov\/study\/NCT05901480."},{"key":"ref_36","unstructured":"Sensorion (2026, May 16). A Phase I\/Ii, Open-Ended, Adaptative, Open Label Dose Escalation and Expansion Clinical Trial to Evaluate the Efficacy and Safety of Unilateral Intracochlear Injection of Sens-501 Using an Injection System in Children with Severe to Profound Hearing Loss Due to Otoferlin Gene Mutations, Available online: https:\/\/clinicaltrials.gov\/study\/NCT06370351."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"e31479","DOI":"10.1002\/pbc.31479","article-title":"Otoprotective effects of sodium thiosulfate by demographic and clinical characteristics: A report from Children\u2019s Oncology Group study ACCL0431","volume":"72","author":"Ohlsen","year":"2025","journal-title":"Pediatr. Blood Cancer"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1097\/MAO.0000000000001427","article-title":"Emerging therapies for sensorineural hearing loss","volume":"38","author":"Crowson","year":"2017","journal-title":"Otol. Neurotol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"2376","DOI":"10.1056\/NEJMoa1801109","article-title":"Sodium Thiosulfate for protection from Cisplatin-induced hearing loss","volume":"378","author":"Brock","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S1470-2045(16)30625-8","article-title":"Effects of sodium thiosulfate versus observation on development of cisplatin-induced hearing loss in children with cancer (ACCL0431): A multicentre, randomised, controlled, open-label, phase 3 trial","volume":"18","author":"Freyer","year":"2017","journal-title":"Lancet Oncol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"4073","DOI":"10.1093\/ndt\/gfr211","article-title":"Protective effect of N-acetylcysteine from drug-induced ototoxicity in uraemic patients with CAPD peritonitis","volume":"26","author":"Tokgoz","year":"2011","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"2611","DOI":"10.1007\/s00405-014-3207-z","article-title":"Preventing amikacin related ototoxicity with N-acetylcysteine in patients undergoing peritoneal dialysis","volume":"272","author":"Kocyigit","year":"2015","journal-title":"Eur. Arch. Oto-Rhino-Laryngol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.heares.2010.07.005","article-title":"N-Acetyl-cysteine against noise-induced temporary threshold shift in male workers","volume":"269","author":"Lin","year":"2010","journal-title":"Hear. Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1080\/00016489.2016.1214981","article-title":"N-acetylcysteine as a single therapy for sudden deafness","volume":"137","author":"Chen","year":"2017","journal-title":"Acta Oto-Laryngol."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Bai, X., Chen, S., Xu, K., Jin, Y., Niu, X., Xie, L., Qiu, Y., Liu, X.-Z., and Sun, Y. (2021). N-Acetylcysteine combined with Dexamethasone treatment improves sudden sensorineural hearing loss and attenuates hair cell death caused by ROS stress. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.659486"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.3109\/00016481003727590","article-title":"Water-soluble coenzyme Q10 formulation (Q-TER\u00ae) in the treatment of presbycusis","volume":"130","author":"Salami","year":"2010","journal-title":"Acta Oto-Laryngol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"512","DOI":"10.3109\/00016489.2010.539261","article-title":"Water-soluble coenzyme Q10 formulation in presbycusis: Long-term effects","volume":"131","author":"Guastini","year":"2011","journal-title":"Acta Oto-Laryngol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1111\/j.1749-4486.2010.02201.x","article-title":"Coenzyme Q10 in combination with steroid therapy for treatment of sudden sensorineural hearing loss: A controlled prospective study","volume":"35","author":"Ahn","year":"2010","journal-title":"Clin. Otolaryngol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1080\/00016480510037032","article-title":"Radical scavengers: A remedy for presbyacusis. A pilot study","volume":"125","author":"Takumida","year":"2005","journal-title":"Acta Oto-Laryngol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"2631","DOI":"10.1007\/s00405-012-2294-y","article-title":"Effect of high dose intravenous vitamin C on idiopathic sudden sensorineural hearing loss: A prospective single-blind randomized controlled trial","volume":"270","author":"Kang","year":"2013","journal-title":"Eur. Arch. Oto-Rhino-Laryngol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1186\/s13063-020-04522-9","article-title":"Randomized placebo-controlled clinical trial investigating the effect of antioxidants and a vasodilator on overall safety and residual hearing preservation in cochlear implant patients","volume":"21","author":"Scheper","year":"2020","journal-title":"Trials"},{"key":"ref_52","unstructured":"Sound Pharmaceuticals, Incorporated (2026, April 26). A Phase 2, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of SPI-1005 in Cystic Fibrosis (CF) Patients with Acute Pulmonary Exacerbation (Ape) Receiving iv Tobramycin at Risk for Ototoxicity, Available online: https:\/\/clinicaltrials.gov\/study\/NCT02819856."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"108209","DOI":"10.1016\/j.heares.2021.108209","article-title":"Development of ebselen for the treatment of sensorineural hearing loss and tinnitus","volume":"413","author":"Kil","year":"2022","journal-title":"Hear. Res."},{"key":"ref_54","unstructured":"Sound Pharmaceuticals, Incorporated (2026, April 26). A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Multi-Center Study to Evaluate the Safety and Efficacy of Spi-1005 In Menieres Disease and Open Label Extension Study to Evaluate the Chronic Safety of Spi-1005, Available online: https:\/\/clinicaltrials.gov\/study\/NCT04677972."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1159\/000508124","article-title":"Efficacy of various corticosteroid treatment modalities for the initial treatment of idiopathic sudden hearing loss: A prospective randomized controlled trial","volume":"26","author":"Tong","year":"2021","journal-title":"Audiol. Neurotol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"182","DOI":"10.5604\/01.3001.0014.1652","article-title":"The Use of Combined Pharmacotherapy and Hyperbaricoxygen in the Treatment of Sudden Sensorineural Hearing Loss","volume":"74","author":"Zjawiony","year":"2020","journal-title":"Postep. Hig. Med. Dosw."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"475","DOI":"10.3109\/00016489.2011.647360","article-title":"Hyperbaric oxygen therapy with short duration intratympanic steroid therapy for sudden hearing loss","volume":"132","author":"Filipo","year":"2012","journal-title":"Acta Oto-Laryngol."},{"key":"ref_58","first-page":"115","article-title":"A comparative study on efficacy of fludrocortisones versus glucocorticoids and vasodilators in the treatment of idiopathic sensorineural cochlear hearing loss","volume":"4","year":"2015","journal-title":"Indian J. Otolaryngol. Head Neck Surg."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Okada, M., Ogawa, H., Takagi, T., Nishihara, E., Yoshida, T., Hyodo, J., Shinomori, Y., Honda, N., Fujiwara, T., and Teraoka, M. (2022). A double-blinded, randomized controlled clinical trial of hydrogen inhalation therapy for idiopathic sudden sensorineural hearing loss. Front. Neurosci., 16.","DOI":"10.3389\/fnins.2022.1024634"},{"key":"ref_60","first-page":"207","article-title":"The use of herbal medicine in sudden sensorineural hearing loss in diabetic patients","volume":"35","author":"Tajdini","year":"2023","journal-title":"Iran. J. Otorhinolaryngol."},{"key":"ref_61","first-page":"160","article-title":"Role of Ginkgo biloba extract in sensorineural hearing loss: A randomised prospective clinical study","volume":"13","author":"Sharma","year":"2021","journal-title":"Int. J. Pharm. Clin. Res."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"2433","DOI":"10.1007\/s00405-015-3821-4","article-title":"The efficacy and safety of systemic injection of Ginkgo biloba extract, EGb761, in idiopathic sudden sensorineural hearing loss: A randomized placebo-controlled clinical trial","volume":"273","author":"Koo","year":"2016","journal-title":"Eur. Arch. Oto-Rhino-Laryngol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.amjoto.2011.12.001","article-title":"Radix astragali injection enhances recovery from sudden deafness","volume":"33","author":"Xiong","year":"2012","journal-title":"Am. J. Otolaryngol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1002\/ccr3.510","article-title":"Concurrent hyperbaric oxygen therapy and intratympanic steroid application as salvage therapy after severe sudden sensorineural hearing loss","volume":"4","author":"Lamm","year":"2016","journal-title":"Clin. Case Rep."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1097\/AUD.0000000000001338","article-title":"Comparison of intratympanic steroid and hyperbaric oxygen salvage therapy hearing outcomes in idiopathic sudden sensorineural hearing loss: A retrospective study","volume":"44","author":"Ajduk","year":"2023","journal-title":"Ear Hear."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"77","DOI":"10.5606\/kbbihtisas.2015.65768","article-title":"Efficacy of multimodality approach to sudden hearing loss","volume":"25","author":"Verim","year":"2015","journal-title":"Kulak Burun Bogaz Ihtis Derg"},{"key":"ref_67","first-page":"177","article-title":"Is there any effect of addition of hyperbaric oxygen or intratympanic steroid to systemic steroids in idiopathic sudden sensorineural hearing loss treatment?","volume":"50","author":"Uluat","year":"2020","journal-title":"Turk. J. Med. Sci."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/s00405-003-0688-6","article-title":"Should hyperbaric oxygen be added to treatment in idiopathic sudden sensorineural hearing loss?","volume":"261","author":"Topuz","year":"2004","journal-title":"Eur. Arch. Oto-Rhino-Laryngol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"38","DOI":"10.5005\/jp-journals-10003-1438","article-title":"Role of platelet-rich plasma in sensory neural hearing loss","volume":"15","author":"Kanaujia","year":"2023","journal-title":"Int. J. Otorhinolaryngol. Clin."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1007\/s11789-012-0044-8","article-title":"Fibrinogen\/LDL apheresis is a promising rescue therapy for sudden sensorineural hearing loss","volume":"7","author":"Canis","year":"2012","journal-title":"Clin. Res. Cardiol. Suppl."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1007\/s00405-008-0823-5","article-title":"Rheopheresis for idiopathic sudden hearing loss: Results from a large prospective, multicenter, randomized, controlled clinical trial","volume":"266","author":"Heibges","year":"2009","journal-title":"Eur. Arch. Oto-Rhino-Laryngol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"271","DOI":"10.3109\/00016489.2015.1104723","article-title":"Prognostic predictors of sudden sensorineural hearing loss in defibrinogenation therapy","volume":"136","author":"Oya","year":"2016","journal-title":"Acta Oto-Laryngol."},{"key":"ref_73","first-page":"83","article-title":"Sodium enoxaparin and venovenous hemofiltration in treating sudden sensorineural hearing loss and tinnitus","volume":"12","author":"Mora","year":"2006","journal-title":"Int. Tinnitus J."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1007\/s12013-013-9536-5","article-title":"Clinical investigation on the beneficial effects of the Chinese medicinal herb Gushen Pian on sensorineural deafness and tinnitus","volume":"67","author":"Zhai","year":"2013","journal-title":"Cell Biochem. Biophys."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1097\/01.mao.0000231502.54157.ad","article-title":"Hemodilution therapy with Hydroxyethyl starch solution (130\/0.4) in unilateral idiopathic sudden sensorineural hearing loss: A dose-finding, double-blind, placebo-controlled, international multicenter trial with 210 patients","volume":"28","author":"Klemm","year":"2007","journal-title":"Otol. Neurotol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/s40463-017-0228-9","article-title":"Rheopheresis in treatment of idiopathic sensorineural sudden hearing loss","volume":"46","author":"Kostal","year":"2017","journal-title":"J. Otolaryngol.\u2014Head Neck Surg."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"242","DOI":"10.3892\/etm.2022.11167","article-title":"Effects of alprostadil combined with hyperbaric oxygen on hearing recovery and hemorheology in patients with sudden sensorineural hearing loss and analysis of related influencing factors","volume":"23","author":"Feng","year":"2022","journal-title":"Exp. Ther. Med."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1111\/j.1464-5491.2006.01993.x","article-title":"Lipo-prostaglandin E1 in combination with steroid therapy is effective for treatment of sudden sensorineural hearing loss in Korean patients with Type 2 diabetes","volume":"23","author":"Ahn","year":"2006","journal-title":"Diabet. Med."},{"key":"ref_79","first-page":"38","article-title":"Sodium enoxaparin treatment of sensorineural hearing loss: An immune-mediated response?","volume":"11","author":"Mora","year":"2005","journal-title":"Int. Tinnitus J."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"114674","DOI":"10.1016\/j.biopha.2023.114674","article-title":"Statins protect mice from high-decibel noise-induced hearing loss","volume":"163","author":"Czech","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"e19763","DOI":"10.1097\/MD.0000000000019763","article-title":"A phase I\/IIa double blind single institute trial of low dose sirolimus for Pendred syndrome\/DFNB4","volume":"99","author":"Fujioka","year":"2020","journal-title":"Medicine"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"104480","DOI":"10.1016\/j.amjoto.2024.104480","article-title":"Efficacy and safety of SENS-401 in sudden sensorineural hearing loss: The AUDIBLE-S randomized placebo-controlled phase IIb trial","volume":"45","author":"Braverman","year":"2024","journal-title":"Am. J. Otolaryngol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1097\/MAO.0000000000000466","article-title":"Efficacy and safety of AM-111 in the treatment of acute sensorineural hearing loss: A double-blind, randomized, placebo-controlled phase II study","volume":"35","author":"Suckfuell","year":"2014","journal-title":"Otol. Neurotol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1097\/MAO.0000000000002229","article-title":"Efficacy and safety of AM-111 in the treatment of acute unilateral sudden deafness\u2014A double-blind, randomized, placebo-controlled phase 3 Study","volume":"40","author":"Staecker","year":"2019","journal-title":"Otol. Neurotol."},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Nakagawa, T., Kumakawa, K., Usami, S.-I., Hato, N., Tabuchi, K., Takahashi, M., Fujiwara, K., Sasaki, A., Komune, S., and Sakamoto, T. (2014). A randomized controlled clinical trial of topical insulin-like growth factor-1 therapy for sudden deafness refractory to systemic corticosteroid treatment. BMC Med., 12.","DOI":"10.1186\/s12916-014-0219-x"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"207","DOI":"10.5152\/iao.2021.8549","article-title":"Effects of insulin-like growth factor (IGF-1) in patients with sensorineural hearing loss","volume":"17","author":"Dave","year":"2021","journal-title":"J. Int. Adv. Otol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.1038\/s41467-024-45784-0","article-title":"A phase I\/IIa safety and efficacy trial of intratympanic gamma-secretase inhibitor as a regenerative drug treatment for sensorineural hearing loss","volume":"15","author":"Schilder","year":"2024","journal-title":"Nat. Commun."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"e12094","DOI":"10.1002\/jev2.12094","article-title":"First-in-human intracochlear application of human stromal cell-derived extracellular vesicles","volume":"10","author":"Warnecke","year":"2021","journal-title":"J. Extracell. Vesicles"},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Lewis, M.A., Schulte, J., Matthews, L., Vaden, K.I., Steves, C.J., Williams, F.M.K., Schulte, B.A., Dubno, J.R., and Steel, K.P. (2023). Accurate phenotypic classification and exome sequencing allow identification of novel genes and variants associated with adult-onset hearing loss. PLoS Genet., 19.","DOI":"10.1101\/2023.04.27.23289040"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1016\/S0140-6736(23)02874-X","article-title":"AAV1-hOTOF gene therapy for autosomal recessive deafness 9: A single-arm trial","volume":"403","author":"Lv","year":"2024","journal-title":"Lancet"},{"key":"ref_91","unstructured":"Chinese Clinical Trial Registry (2026, May 16). The Safety, Tolerability, and Preliminary Efficacy of RRG-003 AAV in the Treatment of DFNB9 Congenital Deafness. Chinese Clinical Trial Registry. Available online: https:\/\/www.chictr.org.cn\/showprojEN.html?proj=194989."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1056\/NEJMoa2400521","article-title":"DB-OTO gene therapy for inherited deafness","volume":"394","author":"Valayannopoulos","year":"2026","journal-title":"N. Engl. J. Med."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1517\/17460441.2011.562887","article-title":"The design and screening of drugs to prevent acquired sensorineural hearing loss","volume":"6","author":"Mukherjea","year":"2011","journal-title":"Expert Opin. Drug Discov."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"4909237","DOI":"10.1155\/2021\/4909237","article-title":"Hair Cell Protection from Ototoxic Drugs","volume":"2021","author":"Wu","year":"2021","journal-title":"Neural Plast."},{"key":"ref_95","first-page":"S1","article-title":"Clinical practice guideline: Sudden hearing loss (update)","volume":"161","author":"Chandrasekhar","year":"2019","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1002\/lary.28618","article-title":"Adjuvant migraine medications in the treatment of sudden sensorineural hearing loss","volume":"131","author":"Abouzari","year":"2021","journal-title":"Laryngoscope"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1038\/s41586-026-10393-y","article-title":"Multicentre gene therapy for OTOF-related deafness followed up to 2.5 years","volume":"653","author":"Jiang","year":"2026","journal-title":"Nature"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"2343","DOI":"10.1016\/j.ymthe.2024.11.012","article-title":"The rise of cochlear gene therapy","volume":"33","author":"Landegger","year":"2025","journal-title":"Mol. Ther."},{"key":"ref_99","first-page":"777","article-title":"CRISPR-Cas9: A history of its discovery and ethical considerations of its use in genome editing","volume":"87","author":"Gostimskaya","year":"2022","journal-title":"Biochemistry"},{"key":"ref_100","unstructured":"U.S. Food and Drug Administration (2026, May 21). FDA approves First-Ever Gene Therapy for Treatment of Genetic Hearing Loss Under National Priority Voucher Program, Available online: https:\/\/www.fda.gov\/news-events\/press-announcements\/fda-approves-first-ever-gene-therapy-treatment-genetic-hearing-loss-under-national-priority-voucher."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"e2117946119","DOI":"10.1073\/pnas.2117946119","article-title":"In vivo real-time imaging reveals megalin as the aminoglycoside gentamicin transporter into cochlea whose inhibition is otoprotective","volume":"119","author":"Kim","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1080\/10717544.2021.1943059","article-title":"Drug distribution along the cochlea is strongly enhanced by low-frequency round window micro vibrations","volume":"28","author":"Flaherty","year":"2021","journal-title":"Drug Deliv."}],"container-title":["Audiology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2039-4349\/16\/3\/91\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T04:19:36Z","timestamp":1781842776000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2039-4349\/16\/3\/91"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,14]]},"references-count":102,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,6]]}},"alternative-id":["audiolres16030091"],"URL":"https:\/\/doi.org\/10.3390\/audiolres16030091","relation":{},"ISSN":["2039-4349"],"issn-type":[{"value":"2039-4349","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,14]]}}}