{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T09:31:33Z","timestamp":1771147893102,"version":"3.50.1"},"reference-count":60,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,1,19]],"date-time":"2023-01-19T00:00:00Z","timestamp":1674086400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["17GRNT33411154"],"award-info":[{"award-number":["17GRNT33411154"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioengineering"],"abstract":"<jats:p>Single ventricle (SV) anomalies account for one-fourth of all congenital heart disease cases. The existing palliative treatment for this anomaly achieves a survival rate of only 50%. To reduce the trauma associated with surgical management, the hybrid comprehensive stage II (HCSII) operation was designed as an alternative for a select subset of SV patients with the adequate antegrade aortic flow. This study aims to provide better insight into the hemodynamics of HCSII patients utilizing a multiscale Computational Fluid Dynamics (CFD) model and a mock flow loop (MFL). Both 3D-0D loosely coupled CFD and MFL models have been tuned to match baseline hemodynamic parameters obtained from patient-specific catheterization data. The hemodynamic findings from clinical data closely match the in-vitro and in-silico measurements and show a strong correlation (r = 0.9). The geometrical modification applied to the models had little effect on the oxygen delivery. Similarly, the particle residence time study reveals that particles injected in the main pulmonary artery (MPA) have successfully ejected within one cardiac cycle, and no pathological flows were observed.<\/jats:p>","DOI":"10.3390\/bioengineering10020135","type":"journal-article","created":{"date-parts":[[2023,1,19]],"date-time":"2023-01-19T05:06:14Z","timestamp":1674104774000},"page":"135","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["In-Silico and In-Vitro Analysis of the Novel Hybrid Comprehensive Stage II Operation for Single Ventricle Circulation"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7399-3830","authenticated-orcid":false,"given":"Arka","family":"Das","sequence":"first","affiliation":[{"name":"Department of Mechanical Engineering, Embry-Riddle Aeronautical University, Daytona Beach, FL 32114, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1903-5855","authenticated-orcid":false,"given":"Marwan","family":"Hameed","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, American University of Bahrain, Riffa 942, Bahrain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ray","family":"Prather","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, Embry-Riddle Aeronautical University, Daytona Beach, FL 32114, USA"},{"name":"Department of Mechanical and Aerospace Engineering, University of Central Florida, Orlando, FL 32816, USA"},{"name":"The Heart Center at Orlando Health Arnold Palmer Hospital for Children, Orlando, FL 32806, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Farias","sequence":"additional","affiliation":[{"name":"The Heart Center at Orlando Health Arnold Palmer Hospital for Children, Orlando, FL 32806, USA"},{"name":"Department of Clinical Sciences, College of Medicine, University of Central Florida, Orlando, FL 32816, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6699-4402","authenticated-orcid":false,"given":"Eduardo","family":"Divo","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, Embry-Riddle Aeronautical University, Daytona Beach, FL 32114, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alain","family":"Kassab","sequence":"additional","affiliation":[{"name":"Department of Mechanical and Aerospace Engineering, University of Central Florida, Orlando, FL 32816, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Nykanen","sequence":"additional","affiliation":[{"name":"The Heart Center at Orlando Health Arnold Palmer Hospital for Children, Orlando, FL 32806, USA"},{"name":"Department of Clinical Sciences, College of Medicine, University of Central Florida, Orlando, FL 32816, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6254-225X","authenticated-orcid":false,"given":"William","family":"DeCampli","sequence":"additional","affiliation":[{"name":"The Heart Center at Orlando Health Arnold Palmer Hospital for Children, Orlando, FL 32806, USA"},{"name":"Department of Clinical Sciences, College of Medicine, University of Central Florida, Orlando, FL 32816, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1161\/CIRCULATIONAHA.109.881904","article-title":"Mortality in First 5 Years in Infants With Functional Single Ventricle Born in Texas, 1996 to 2003","volume":"121","author":"Fixler","year":"2010","journal-title":"Circulation"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.jacc.2011.09.022","article-title":"Hypoplastic Left Heart Syndrome","volume":"59","author":"Feinstein","year":"2012","journal-title":"J. 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