{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:33:58Z","timestamp":1787027638772,"version":"build-2736575974"},"reference-count":112,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,2,27]],"date-time":"2023-02-27T00:00:00Z","timestamp":1677456000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioengineering"],"abstract":"<jats:p>Assisted reproductive technology (ART) is used to enhance pregnancy in infertile women. In this technique, the eggs are removed from the ovary and fertilized and injected with sperm to make embryos. Unfortunately, embryo implantation failures still occur in many of these women. Platelet-rich plasma (PRP) therapies use a patient\u2019s own platelets to promote tissue healing and growth, including endometrium. The growth factors provided by the platelets play a criterial role on the regenerative ability of PRP. In the last years, PRP treatments have been gaining a lot of popularity to treat women with repeated ART failures. In this study, we collected and summarized all information published in the scientific literature to assess the evidence of the PRP effect on pregnancy. We only considered randomized controlled trials (RCT), a type of study designed to be unbiased and considered at the highest level of evidence. Our analysis indicates that PRP therapies might be an effective treatment in cases of poor responsiveness to conventional ART. However, additional studies (well-designed) are necessary to confirm this beneficial effect of PRP.<\/jats:p>","DOI":"10.3390\/bioengineering10030303","type":"journal-article","created":{"date-parts":[[2023,2,28]],"date-time":"2023-02-28T02:01:51Z","timestamp":1677549711000},"page":"303","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Efficacy of Platelet-Rich Plasma in Women with a History of Embryo Transfer Failure: A Systematic Review and Meta-Analysis with Trial Sequential Analysis"],"prefix":"10.3390","volume":"10","author":[{"given":"Eduardo","family":"Anitua","sequence":"first","affiliation":[{"name":"Regenerative Medicine Department, BTI Biotechnology Institute, 01007 Vitoria-Gasteiz, Spain"},{"name":"Clinical Research, University Institute for Regenerative Medicine and Oral Implantology (UIRMI), 01007 Vitoria-Gasteiz, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikel","family":"Allende","sequence":"additional","affiliation":[{"name":"Regenerative Medicine Department, BTI Biotechnology Institute, 01007 Vitoria-Gasteiz, Spain"},{"name":"Clinical Research, University Institute for Regenerative Medicine and Oral Implantology (UIRMI), 01007 Vitoria-Gasteiz, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6820-1517","authenticated-orcid":false,"given":"Mar\u00eda","family":"de la Fuente","sequence":"additional","affiliation":[{"name":"Regenerative Medicine Department, BTI Biotechnology Institute, 01007 Vitoria-Gasteiz, Spain"},{"name":"Clinical Research, University Institute for Regenerative Medicine and Oral Implantology (UIRMI), 01007 Vitoria-Gasteiz, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7144-0984","authenticated-orcid":false,"given":"Massimo","family":"Del Fabbro","sequence":"additional","affiliation":[{"name":"Department of Biomedical, Surgical and Dental Sciences, University of Milan, 20122 Milan, Italy"},{"name":"Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4422-4527","authenticated-orcid":false,"given":"Mohammad Hamdan","family":"Alkhraisat","sequence":"additional","affiliation":[{"name":"Regenerative Medicine Department, BTI Biotechnology Institute, 01007 Vitoria-Gasteiz, Spain"},{"name":"Clinical Research, University Institute for Regenerative Medicine and Oral Implantology (UIRMI), 01007 Vitoria-Gasteiz, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Mascarenhas, M.N., Flaxman, S.R., Boerma, T., Vanderpoel, S., and Stevens, G.A. 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