{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T22:52:51Z","timestamp":1788389571342,"version":"build-2803163510"},"reference-count":83,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"\u201cDepartments of Excellence 2018-2022\u201d Program (Dipartimenti di Eccellenza) of the Italian Ministry of University and Research to DIBAF, University of Tuscia, Project \u201cLandscape 4.0-food, wellbeing and environment"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioengineering"],"abstract":"<jats:p>Aortic dissection is a life-threatening vascular disease associated with high rates of morbidity and mortality, especially in medically underserved communities. Understanding patients\u2019 blood flow patterns is pivotal for informing evidence-based treatment as they greatly influence the disease outcome. The present study investigates the flow patterns in the false lumen of three aorta dissections (fully perfused, partially thrombosed, and fully thrombosed) in the chronic phase, and compares them to a healthy aorta. Three-dimensional geometries of aortic true and false lumens (TLs and FLs) are reconstructed through an ad hoc developed and minimally supervised image analysis procedure. Computational fluid dynamics (CFD) is performed through a finite volume unsteady Reynolds-averaged Navier\u2013Stokes approach assuming rigid wall aortas, Newtonian and homogeneous fluid, and incompressible flow. In addition to flow kinematics, we focus on time-averaged wall shear stress and oscillatory shear index that are recognized risk factors for aneurysmal degeneration. Our analysis shows that partially thrombosed dissection is the most prone to false lumen degeneration. In all dissections, the arteries connected to the false lumen are generally poorly perfused. Further, both true and false lumens present higher turbulence levels than the healthy aorta, and critical stagnation points. Mesh sensitivity and a thorough comparison against literature data together support the reliability of the CFD methodology. Image-based CFD simulations are efficient tools to assess the possibility of aortic dissection to lead to aneurysmal degeneration, and provide new knowledge on the hemodynamic characteristics of dissected versus healthy aortas. Similar analyses should be routinely included in patient-specific hemodynamics investigations, to plan and design tailored therapeutic strategies, and to timely assess their effectiveness.<\/jats:p>","DOI":"10.3390\/bioengineering10030316","type":"journal-article","created":{"date-parts":[[2023,3,2]],"date-time":"2023-03-02T02:10:59Z","timestamp":1677723059000},"page":"316","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Comparative Analysis of Patient-Specific Aortic Dissections through Computational Fluid Dynamics Suggests Increased Likelihood of Degeneration in Partially Thrombosed False Lumen"],"prefix":"10.3390","volume":"10","author":[{"given":"Simona","family":"Moretti","sequence":"first","affiliation":[{"name":"DEIM Department of Economics, Engineering, Society and Business Administration, University of Tuscia, Largo dell\u2019Universit\u00e0, 01100 Viterbo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5176-3492","authenticated-orcid":false,"given":"Flavia","family":"Tauro","sequence":"additional","affiliation":[{"name":"DIBAF Department for Innovation in Biological, Agro-Food and Forest Systems, University of Tuscia, Via San Camillo de Lellis, 01100 Viterbo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Orrico","sequence":"additional","affiliation":[{"name":"Vascular and Endovascular Surgery Unit, San Camillo Forlanini Hospital, Circonvallazione Gianicolense 87, 00149 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Mangialardi","sequence":"additional","affiliation":[{"name":"Vascular and Endovascular Surgery Unit, San Camillo Forlanini Hospital, Circonvallazione Gianicolense 87, 00149 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Facci","sequence":"additional","affiliation":[{"name":"DEIM Department of Economics, Engineering, Society and Business Administration, University of Tuscia, Largo dell\u2019Universit\u00e0, 01100 Viterbo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1001\/jama.283.7.897","article-title":"The International Registry of Acute Aortic Dissection (IRAD): New insights into an old disease","volume":"283","author":"Hagan","year":"2000","journal-title":"JAMA"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.tcm.2021.08.008","article-title":"Update in aortic dissection","volume":"32","author":"Juraszek","year":"2022","journal-title":"Trends Cardiovasc. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"113511","DOI":"10.1016\/j.cma.2020.113511","article-title":"A discrete approach for modeling degraded elastic fibers in aortic dissection","volume":"373","author":"Li","year":"2021","journal-title":"Comput. Methods Appl. Mech. Eng."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0002-8703(81)90666-9","article-title":"Aortic dissection: Anatomy, consequences, and causes","volume":"101","author":"Roberts","year":"1981","journal-title":"Am. Heart J."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0140-6736(08)60994-0","article-title":"Acute aortic dissection","volume":"372","author":"Golledge","year":"2008","journal-title":"Lancet"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"e001513","DOI":"10.1161\/JAHA.114.001513","article-title":"Risk profiles for aortic dissection and ruptured or surgically treated aneurysms: A prospective cohort study","volume":"4","author":"Landenhed","year":"2015","journal-title":"J. Am. Heart Assoc."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1161\/CIRCULATIONAHA.108.799908","article-title":"Aortic dissection","volume":"118","author":"Juang","year":"2008","journal-title":"Circulation"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/j.jtcvs.2009.11.014","article-title":"Role of age in acute type A aortic dissection outcome: Report from the international registry of Acute Aortic Dissection (IRAD)","volume":"140","author":"Trimarchi","year":"2010","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"ref_9","first-page":"1","article-title":"Ascending aortic dissection in the developing world; Case report","volume":"12","author":"Kumtap","year":"2018","journal-title":"Jos J. Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.amjcard.2022.01.026","article-title":"Relation of Community-Level Socioeconomic Status to Delayed Diagnosis of Acute Type A Aortic Dissection","volume":"170","author":"Lim","year":"2022","journal-title":"Am. J. Cardiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1016\/j.jtcvs.2020.09.031","article-title":"Commentary: Lack of screening makes primary prevention most effective to reduce the mortality of aortic dissection","volume":"161","author":"Hughes","year":"2021","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/S0022-5223(19)34288-6","article-title":"Surgical treatment of aneurysm and\/or dissection of the ascending aorta, transverse aortic arch, and ascending aorta and transverse aortic arch. Factors influencing survival in 717 patients","volume":"98","author":"Crawford","year":"1989","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"ref_13","first-page":"1118","article-title":"Dissection and dissecting aneurysms of the aorta: Twenty-year follow-up of five hundred twenty-seven patients treated surgically","volume":"92","author":"DeBakey","year":"1982","journal-title":"Surgery"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.jvs.2019.11.013","article-title":"Society for Vascular Surgery (SVS) and Society of Thoracic Surgeons (STS) reporting standards for type B aortic dissections","volume":"71","author":"Lombardi","year":"2020","journal-title":"J. Vasc. Surg."},{"key":"ref_15","first-page":"1060","article-title":"Aortic dissection","volume":"2","author":"Nienaber","year":"2016","journal-title":"Nat. Rev. Dis. Prim."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2841","DOI":"10.1002\/jcp.22629","article-title":"Characterization of the differential response of endothelial cells exposed to normal and elevated laminar shear stress","volume":"226","author":"White","year":"2011","journal-title":"J. Cell. Physiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"104385","DOI":"10.1016\/j.compbiomed.2021.104385","article-title":"Geometrically induced wall shear stress variability in CFD-MRI coupled simulations of blood flow in the thoracic aortas","volume":"133","author":"Juffermans","year":"2021","journal-title":"Comput. Biol. Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1115\/1.4000964","article-title":"Analysis of flow patterns in a patient-specific aortic dissection model","volume":"132","author":"Cheng","year":"2010","journal-title":"J. Biomech. Eng."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s10237-021-01534-5","article-title":"An integrated fluid\u2013structure interaction and thrombosis model for type B aortic dissection","volume":"21","author":"Chong","year":"2022","journal-title":"Biomech. Model. Mechanobiol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.ejvs.2017.06.012","article-title":"Elevated Wall Shear Stress in aortic type B dissection may relate to retrograde aortic type A dissection: A computational fluid dynamics pilot study","volume":"54","author":"Osswald","year":"2017","journal-title":"Eur. J. Vasc. Endovasc. Surg."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s10439-014-1075-8","article-title":"Geometric and flow features of type B aortic dissection: Initial findings and comparison of medically treated and stented cases","volume":"43","author":"Cheng","year":"2015","journal-title":"Ann. Biomed. Eng."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.ijcard.2016.02.099","article-title":"A systematic review of computational fluid dynamics in type B aortic dissection","volume":"210","author":"Sun","year":"2016","journal-title":"Int. J. Cardiol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"106508","DOI":"10.1016\/j.cmpb.2021.106508","article-title":"Hemodynamic simulation of Abdominal Aortic Aneurysm on idealised models: Investigation of stress parameters during disease progression","volume":"213","author":"Philip","year":"2021","journal-title":"Comput. Methods Programs Biomed."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"105124","DOI":"10.1016\/j.cmpb.2019.105124","article-title":"Quantifying hemodynamics within an aneurysm exposed to prolonged exercise levels","volume":"184","author":"Varshney","year":"2020","journal-title":"Comput. Methods Programs Biomed."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s13239-013-0146-6","article-title":"A Review on computational fluid dynamics modelling in human thoracic aorta","volume":"4","author":"Caballero","year":"2013","journal-title":"Cardiovasc. Eng. Technol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1136\/heartjnl-2015-308044","article-title":"Computational fluid dynamics modelling in cardiovascular medicine","volume":"102","author":"Morris","year":"2016","journal-title":"Heart"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.compbiomed.2018.10.014","article-title":"Computational simulation of TEVAR in the ascending aorta for optimal endograft selection: A patient-specific case study","volume":"103","author":"Romarowski","year":"2018","journal-title":"Comput. Biol. Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"104652","DOI":"10.1016\/j.compbiomed.2021.104652","article-title":"Efficient parallel simulation of hemodynamics in patient-specific abdominal aorta with aneurysm","volume":"136","author":"Qin","year":"2021","journal-title":"Comput. Biol. Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"4","DOI":"10.14797\/mdcj-12-1-4","article-title":"Minimally invasive cardiovascular surgery: Incisions and approaches","volume":"12","author":"Langer","year":"2016","journal-title":"Methodist Debakey Cardiovasc. J."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1475-925X-5-25","article-title":"Stress analysis in a layered aortic arch model under pulsatile blood flow","volume":"5","author":"Gao","year":"2006","journal-title":"Biomed. Eng. Online"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"35S","DOI":"10.1016\/j.jvs.2012.07.061","article-title":"Initial findings and potential applicability of computational simulation of the aorta in acute type B dissection","volume":"57","author":"Cheng","year":"2013","journal-title":"J. Vasc. Surg."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.crad.2022.12.001","article-title":"Advanced risk prediction for aortic dissection patients using imaging-based computational flow analysis","volume":"78","author":"Zhu","year":"2023","journal-title":"Clin. Radiol."},{"key":"ref_33","first-page":"377","article-title":"3D Modeling of Blood Flow in Simulated Abdominal Aortic Aneurysm","volume":"55","author":"Mendoza","year":"2021","journal-title":"Vasc. Endovasc. Surg."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.jvs.2012.12.071","article-title":"Efficacy of thoracic endovascular stent repair for chronic type B aortic dissection with aneurysmal degeneration","volume":"58","author":"Scali","year":"2013","journal-title":"J. Vasc. Surg."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"061001","DOI":"10.1115\/1.4043289","article-title":"Numerical investigation of turbulence in abdominal aortic aneurysms","volume":"141","author":"Rawat","year":"2019","journal-title":"J. Biomech. Eng."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Pedley, T.J. (1980). The Fluid Mechanics of Large Blood Vessels, Cambridge University Press.","DOI":"10.1017\/CBO9780511896996"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/j.jbiomech.2010.12.014","article-title":"Investigation of hemodynamics in the development of dissecting aneurysm within patient-specific dissecting aneurismal aortas using computational fluid dynamics (CFD) simulations","volume":"44","author":"Tse","year":"2011","journal-title":"J. Biomech."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1016\/j.medengphy.2014.07.006","article-title":"Predicting flow in aortic dissection: Comparison of computational model with PC-MRI velocity measurements","volume":"36","author":"Cheng","year":"2014","journal-title":"Med. Eng. Phys."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"861627","DOI":"10.1155\/2015\/861627","article-title":"A review of computational methods to predict the risk of rupture of abdominal aortic aneurysms","volume":"2015","author":"Canchi","year":"2015","journal-title":"Biomed Res. Int."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/0141-5425(90)90107-X","article-title":"Numerical 3D-simulation of pulsatile wall shear stress in an arterial T-bifurcation model","volume":"12","author":"Perktold","year":"1990","journal-title":"J. Biomed. Eng."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.ijheatfluidflow.2007.03.004","article-title":"Vortex identification: New requirements and limitations","volume":"28","year":"2007","journal-title":"Int. J. Heat Fluid Flow"},{"key":"ref_42","unstructured":"OpenFoam (2023, January 23). User Guide-CFD Direct. Available online: https:\/\/doc.cfd.direct\/openfoam\/user-guide-v7\/index."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Pianykh, O.S. (2012). Digital Imaging and Communications in Medicine (DICOM) A Practical Introduction and Survival Guide, Springer.","DOI":"10.1007\/978-3-642-10850-1"},{"key":"ref_44","unstructured":"Gonzalez, R.C., Woods, R.E., and Eddins, S.L. (2004). Digital Image Processing Using MATLAB, Pearson Prentice-Hall."},{"key":"ref_45","unstructured":"Mcneel, R. (2023, January 23). Rhinoceros 5 User \u2019 S Guide Table of Contents Section I: Introduction. Available online: https:\/\/www.rhino3d.com\/eu\/download\/rhino\/5.0\/UsersGuide."},{"key":"ref_46","unstructured":"Mesh2surface (2023, January 23). Mesh2Surface Help. Available online: http:\/\/mesh2surface.com\/help\/Helpfile.pdf."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1007\/BF01176300","article-title":"Interface between CAD and rapid prototyping systems. Part 1: A study of existing interfaces","volume":"13","author":"Kai","year":"1997","journal-title":"Int. J. Adv. Manuf. Technol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1016\/j.medengphy.2011.12.002","article-title":"Quantifying turbulent wall shear stress in a subject specific human aorta using large eddy simulation","volume":"34","author":"Lantz","year":"2012","journal-title":"Med. Eng. Phys."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Ferziger, J.H., Peri\u0107, M., and Street, R.L. (2002). Computational Methods for Fluid Dynamics, Springer.","DOI":"10.1007\/978-3-642-56026-2"},{"key":"ref_50","unstructured":"Wilcox, D. (1993). Turbulence Modeling for CFD, DCW Industries, Inc."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0094-4548(74)90150-7","article-title":"Application of the energy-dissipation model of turbulence to the calculation of flow near a spinning disc","volume":"1","author":"Launder","year":"1974","journal-title":"Lett. Heat Mass Transf."},{"key":"ref_52","unstructured":"Hedlund, A. (2023, January 23). Evaluation of RANS Turbulence Models for the Simulation of Channel Flow. Technical Report. Available online: http:\/\/urn.kb.se\/resolve?urn=urn:nbn:se:uu:diva-238649."},{"key":"ref_53","unstructured":"Abreu, H., E\u00e7a, L., Saraiva, G., and Vaz, G. (June, January 31). Pros and Cons of Wall Functions. Proceedings of the ASME 2015 34th International Conference on Ocean, Offshore and Arctic Engineering, St. John\u2019s, NL, Canada."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1002\/(SICI)1097-0363(19990930)31:2<431::AID-FLD884>3.0.CO;2-T","article-title":"High resolution NVD differencing scheme for arbitrarily unstructured meshes","volume":"31","author":"Jasak","year":"1999","journal-title":"Int. J. Numer. Methods Fluids"},{"key":"ref_55","unstructured":"The OpenFOAM Foundation (2023, January 23). OpenFoam. Available online: https:\/\/openfoam.org\/."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/0021-9991(86)90099-9","article-title":"Solution of the implicitly discretised fluid flow equations by operator-splitting","volume":"62","author":"Issa","year":"1986","journal-title":"J. Comput. Phys."},{"key":"ref_57","unstructured":"ESI-OpenCFD (2023, January 23). The Toolbox CFD Open Source, User Guide. Available online: https:\/\/www.openfoam.com\/."},{"key":"ref_58","unstructured":"Frigo, M., and Johnson, S. (1998, January 15). FFTW: An adaptive software architecture for the FFT. Proceedings of the 1998 IEEE International Conference on Acoustics, Speech and Signal Processing, ICASSP, Seattle, WA, USA."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.cma.2016.05.031","article-title":"Integrated Heart\u2014Coupling multiscale and multiphysics models for the simulation of the cardiac function","volume":"314","author":"Quarteroni","year":"2017","journal-title":"Comput. Methods Appl. Mech. Eng."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1097\/00004728-200407000-00005","article-title":"Time-resolved 3-dimensional velocity mapping in the thoracic aorta","volume":"28","author":"Markl","year":"2004","journal-title":"J. Comput. Assist. Tomogr."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"3049","DOI":"10.1016\/j.cma.2006.10.015","article-title":"Simulation of high-Reynolds number vascular flows","volume":"196","author":"Fischer","year":"2007","journal-title":"Comput. Methods Appl. Mech. Eng."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.cma.2016.01.007","article-title":"Geometric multiscale modeling of the cardiovascular system, between theory and practice","volume":"302","author":"Quarteroni","year":"2016","journal-title":"Comput. Methods Appl. Mech. Eng."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1007\/s10237-015-0729-2","article-title":"Multi-modality image-based computational analysis of haemodynamics in aortic dissection","volume":"15","author":"Noorani","year":"2016","journal-title":"Biomech. Model. Mechanobiol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jbiomech.2017.06.005","article-title":"On the choice of outlet boundary conditions for patient-specific analysis of aortic flow using computational fluid dynamics","volume":"60","author":"Pirola","year":"2017","journal-title":"J. Biomech."},{"key":"ref_65","unstructured":"Systems, B.C. (2023, January 23). ANSA Version 20.1.x User Guide. Available online: https:\/\/www.beta-cae.com\/."},{"key":"ref_66","unstructured":"(2023, January 23). Symscape. Available online: https:\/\/www.symscape.com\/."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.jfluidstructs.2015.03.018","article-title":"Assessment of PIV-based analysis of water entry problems through synthetic numerical datasets","volume":"55","author":"Facci","year":"2015","journal-title":"J. Fluids Struct."},{"key":"ref_68","unstructured":"Anderson, S. (2012). 11th International Conference on Pressure Surges, Virtual PiE Led t\/a BHR Group."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1002\/cnm.2598","article-title":"A systematic comparison between 1-D and 3-D hemodynamics in compliant arterial models","volume":"30","author":"Xiao","year":"2014","journal-title":"Int. J. Numer. Methods Biomed. Eng."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/j.compbiomed.2006.09.012","article-title":"Pseudo-organ boundary conditions applied to a computational fluid dynamics model of the human aorta","volume":"37","author":"Sun","year":"2007","journal-title":"Comput. Biol. Med."},{"key":"ref_71","first-page":"CD012992","article-title":"Endovascular versus open surgical repair for complicated chronic type B aortic dissection","volume":"2018","author":"Fitzgibbon","year":"2018","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1007\/s10237-020-01291-x","article-title":"Computational modeling of the fluid flow in type B aortic dissection using a modified finite element embedded formulation","volume":"19","author":"Zorrilla","year":"2020","journal-title":"Biomech. Model. Mechanobiol."},{"key":"ref_73","first-page":"81","article-title":"Computational fluid dynamics study of blood flow in aorta using OpenFOAM","volume":"43","author":"Zakaria","year":"2018","journal-title":"J. Adv. Res. Fluid Mech. Therm. Sci."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/S0166-218X(03)00180-X","article-title":"On variations of P4-sparse graphs","volume":"129","author":"Mosca","year":"2003","journal-title":"Discret. Appl. Math."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.avsg.2019.04.032","article-title":"Computational fluid dynamics modeling of hemodynamic parameters in the human diseased aorta: A systematic review","volume":"63","author":"Ong","year":"2020","journal-title":"Ann. Vasc. Surg."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.compbiomed.2017.07.029","article-title":"Numerical analysis of wall shear stress in ascending aorta before tearing in type A aortic dissection","volume":"89","author":"Chi","year":"2017","journal-title":"Comput. Biol. Med."},{"key":"ref_77","unstructured":"Polanczyk, A., Piechota-Polanczyk, A., Neumayer, C., and Huk, I. (2019). Proceedings of the IUTAM Symposium on Recent Advances in Moving Boundary Problems in Mechanics, Springer International Publishing."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1114\/1.1467679","article-title":"Image-based computational fluid dynamics modeling in realistic arterial geometries","volume":"30","author":"Steinman","year":"2002","journal-title":"Ann. Biomed. Eng."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/978-1-4020-5690-1_4","article-title":"An Overview of Some Mathematical Models of Blood Rheology","volume":"29","author":"Sequeira","year":"2007","journal-title":"Portrait-State-Art Res. Tech. Univ. Lisbon"},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Febina, J., Sikkandar, M.Y., and Sudharsan, N.M. (2018). Wall Shear Stress estimation of thoracic aortic aneurysm using computational fluid dynamics. Comput. Math. Methods Med., 2018.","DOI":"10.1155\/2018\/7126532"},{"key":"ref_81","first-page":"197","article-title":"A critical -review-on blood flow in large arteries","volume":"20","author":"Yilmaz","year":"2008","journal-title":"Korea-Aust. Rheol. J."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1136\/neurintsurg-2011-010089","article-title":"Newtonian viscosity model could overestimate wall shear stress in intracranial aneurysm domes and underestimate rupture risk","volume":"20","author":"Xiang","year":"2012","journal-title":"J. Neurointerventional Surg."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"7609","DOI":"10.15282\/jmes.14.4.2020.25.0599","article-title":"A perspective review: Technical study of combining phase contrast magnetic resonance imaging and computational fluid dynamics for blood flow on carotid bifurcation artery","volume":"14","author":"Abdullah","year":"2020","journal-title":"J. Mech. Eng. 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