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J. Murdock Charitable Trust","award":["P20GM103408"],"award-info":[{"award-number":["P20GM103408"]}]},{"name":"M. J. Murdock Charitable Trust","award":["P20GM109095"],"award-info":[{"award-number":["P20GM109095"]}]},{"name":"M. J. Murdock Charitable Trust","award":["RRID:SCR_019174"],"award-info":[{"award-number":["RRID:SCR_019174"]}]},{"name":"M. J. Murdock Charitable Trust","award":["0619793"],"award-info":[{"award-number":["0619793"]}]},{"name":"M. J. Murdock Charitable Trust","award":["0923535"],"award-info":[{"award-number":["0923535"]}]},{"name":"Lori and Duane Stueckle","award":["P20GM103408"],"award-info":[{"award-number":["P20GM103408"]}]},{"name":"Lori and Duane Stueckle","award":["P20GM109095"],"award-info":[{"award-number":["P20GM109095"]}]},{"name":"Lori and Duane Stueckle","award":["RRID:SCR_019174"],"award-info":[{"award-number":["RRID:SCR_019174"]}]},{"name":"Lori and Duane Stueckle","award":["0619793"],"award-info":[{"award-number":["0619793"]}]},{"name":"Lori and Duane Stueckle","award":["0923535"],"award-info":[{"award-number":["0923535"]}]},{"name":"Idaho State Board of Education","award":["P20GM103408"],"award-info":[{"award-number":["P20GM103408"]}]},{"name":"Idaho State Board of Education","award":["P20GM109095"],"award-info":[{"award-number":["P20GM109095"]}]},{"name":"Idaho State Board of Education","award":["RRID:SCR_019174"],"award-info":[{"award-number":["RRID:SCR_019174"]}]},{"name":"Idaho State Board of Education","award":["0619793"],"award-info":[{"award-number":["0619793"]}]},{"name":"Idaho State Board of Education","award":["0923535"],"award-info":[{"award-number":["0923535"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioengineering"],"abstract":"<jats:p>The extracellular microenvironment regulates many of the mechanical and biochemical cues that direct musculoskeletal development and are involved in musculoskeletal disease. The extracellular matrix (ECM) is a main component of this microenvironment. Tissue engineered approaches towards regenerating muscle, cartilage, tendon, and bone target the ECM because it supplies critical signals for regenerating musculoskeletal tissues. Engineered ECM\u2013material scaffolds that mimic key mechanical and biochemical components of the ECM are of particular interest in musculoskeletal tissue engineering. Such materials are biocompatible, can be fabricated to have desirable mechanical and biochemical properties, and can be further chemically or genetically modified to support cell differentiation or halt degenerative disease progression. In this review, we survey how engineered approaches using natural and ECM-derived materials and scaffold systems can harness the unique characteristics of the ECM to support musculoskeletal tissue regeneration, with a focus on skeletal muscle, cartilage, tendon, and bone. We summarize the strengths of current approaches and look towards a future of materials and culture systems with engineered and highly tailored cell\u2013ECM\u2013material interactions to drive musculoskeletal tissue restoration. The works highlighted in this review strongly support the continued exploration of ECM and other engineered materials as tools to control cell fate and make large-scale musculoskeletal regeneration a reality.<\/jats:p>","DOI":"10.3390\/bioengineering10040453","type":"journal-article","created":{"date-parts":[[2023,4,10]],"date-time":"2023-04-10T03:24:18Z","timestamp":1681097058000},"page":"453","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Engineering Cell\u2013ECM\u2013Material Interactions for Musculoskeletal Regeneration"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7126-1668","authenticated-orcid":false,"given":"Calvin L.","family":"Jones","sequence":"first","affiliation":[{"name":"Department of Mechanical and Biomedical Engineering, Boise State University, 1910 University Dr MS2085, Boise, ID 83725, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian T.","family":"Penney","sequence":"additional","affiliation":[{"name":"Department of Mechanical and Biomedical Engineering, Boise State University, 1910 University Dr MS2085, Boise, ID 83725, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia K.","family":"Theodossiou","sequence":"additional","affiliation":[{"name":"Department of Mechanical and Biomedical Engineering, Boise State University, 1910 University Dr MS2085, Boise, ID 83725, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,7]]},"reference":[{"key":"ref_1","unstructured":"AAOS (2008). United States Bone and Joint Decade: The Burden of Musculoskeletal Diseases in the United States, American Academy of Orthopaedic Surgeons."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"602009","DOI":"10.3389\/fbioe.2020.602009","article-title":"Cell-Derived Extracellular Matrix for Tissue Engineering and Regenerative Medicine","volume":"8","author":"Yiu","year":"2020","journal-title":"Front. Bioeng. Biotechnol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.tibtech.2012.12.004","article-title":"Extracellular matrix scaffolds for cartilage and bone regeneration","volume":"31","author":"Benders","year":"2013","journal-title":"Trends Biotechnol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"5474","DOI":"10.1016\/j.biomaterials.2005.02.002","article-title":"Porosity of 3D biomaterial scaffolds and osteogenesis","volume":"26","author":"Karageorgiou","year":"2005","journal-title":"Biomaterials"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.memsci.2008.04.066","article-title":"Optimizing Collagen Transport through Track-Etched Nanopores","volume":"321","author":"Bueno","year":"2008","journal-title":"J. Memb. Sci."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.biomaterials.2015.04.011","article-title":"pH-responsive scaffolds generate a pro-healing response","volume":"57","author":"You","year":"2015","journal-title":"Biomaterials"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.actbio.2017.11.009","article-title":"Multifunctional pH sensitive 3D scaffolds for treatment and prevention of bone infection","volume":"65","author":"Doadrio","year":"2018","journal-title":"Acta Biomater."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1089\/ten.tea.2021.0137","article-title":"Photoreactive Hydrogel Stiffness Influences Volumetric Muscle Loss Repair","volume":"28","author":"Basurto","year":"2022","journal-title":"Tissue Eng. Part A"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1038\/ncomms1792","article-title":"Stiffening hydrogels to probe short- and long-term cellular responses to dynamic mechanics","volume":"3","author":"Guvendiren","year":"2012","journal-title":"Nat. Commun."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"3058","DOI":"10.1002\/jbm.a.35850","article-title":"Elastic, silk-cardiac extracellular matrix hydrogels exhibit time-dependent stiffening that modulates cardiac fibroblast response","volume":"104","author":"Stoppel","year":"2016","journal-title":"J. Biomed. Mater. Res. Part A"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"119720","DOI":"10.1016\/j.biomaterials.2019.119720","article-title":"Enzymatically crosslinked silk and silk-gelatin hydrogels with tunable T gelation kinetics, mechanical properties and bioactivity for cell culture and encapsulation","volume":"232","author":"Hasturk","year":"2020","journal-title":"Biomaterials"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2537","DOI":"10.1039\/D0BM00104J","article-title":"Injectable hydrogel systems with multiple biophysical and biochemical cues for bone regeneration","volume":"8","author":"Cheng","year":"2020","journal-title":"Biomater. Sci."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1089\/ten.tec.2018.0062","article-title":"Bioinspired Three-Dimensional Human Neuromuscular Junction Development in Suspended Hydrogel Arrays","volume":"24","author":"Dixon","year":"2018","journal-title":"Tissue Eng. Part C Methods"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Guo, X., Badu-Mensah, A., Thomas, M.C., McAleer, C.W., and Hickman, J.J. (2020). Characterization of Functional Human Skeletal Myotubes and Neuromuscular Junction Derived\u2014From the Same Induced Pluripotent Stem Cell Source. Bioengineering, 7.","DOI":"10.3390\/bioengineering7040133"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.jmbbm.2014.01.004","article-title":"3D braid scaffolds for regeneration of articular cartilage","volume":"34","author":"Ahn","year":"2014","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Hao, D., Lopez, J.M., Chen, J., Iavorovschi, A.M., Lelivelt, N.M., and Wang, A. (2022). Engineering Extracellular Microenvironment for Tissue Regeneration. Bioengineering, 9.","DOI":"10.3390\/bioengineering9050202"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"121786","DOI":"10.1016\/j.biomaterials.2022.121786","article-title":"Decellularized extracellular matrix: New promising and challenging biomaterials for regenerative medicine","volume":"289","author":"Brown","year":"2022","journal-title":"Biomaterials"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2376","DOI":"10.1038\/nprot.2017.107","article-title":"Cell-derived matrices for studying cell proliferation and directional migration in a complex 3D microenvironment","volume":"12","author":"Kaukonen","year":"2017","journal-title":"Nat. Protoc."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.actbio.2015.09.038","article-title":"Decellularized human placenta chorion matrix as a favorable source of small-diameter vascular grafts","volume":"29","author":"Schneider","year":"2016","journal-title":"Acta Biomater."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"3233","DOI":"10.1016\/j.biomaterials.2011.01.057","article-title":"An overview of tissue and whole organ decellularization processes","volume":"32","author":"Crapo","year":"2011","journal-title":"Biomaterials"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"621","DOI":"10.2106\/00004623-200703000-00020","article-title":"Degradation and remodeling of small intestinal submucosa in canine Achilles tendon repair","volume":"89","author":"Gilbert","year":"2007","journal-title":"J. Bone Jt. Surg. Am."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"7339","DOI":"10.1016\/j.biomaterials.2005.05.066","article-title":"Effectiveness of three extraction techniques in the development of a decellularized bone-anterior cruciate ligament-bone graft","volume":"26","author":"Woods","year":"2005","journal-title":"Biomaterials"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"234ra58","DOI":"10.1126\/scitranslmed.3008085","article-title":"An Acellular Biologic Scaffold Promotes Skeletal Muscle Formation in Mice and Humans with Volumetric Muscle Loss","volume":"6","author":"Sicari","year":"2014","journal-title":"Sci. Transl. Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.arthro.2006.03.016","article-title":"Rotator Cuff Repair Using an Acellular Dermal Matrix Graft: An In Vivo Study in a Canine Model","volume":"22","author":"Adams","year":"2006","journal-title":"Arthrosc. J. Arthrosc. Relat. Surg."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Bandzerewicz, A., and Gadomska-Gajadhur, A. (2022). Into the Tissues: Extracellular Matrix and Its Artificial Substitutes: Cell Signalling Mechanisms. Cells, 11.","DOI":"10.3390\/cells11050914"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"107421","DOI":"10.1016\/j.biotechadv.2019.107421","article-title":"Extracellular matrix-derived biomaterials in engineering cell function","volume":"42","author":"Xing","year":"2020","journal-title":"Biotechnol. Adv."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"643","DOI":"10.3904\/kjim.2016.015","article-title":"Differences among skeletal muscle mass indices derived from height-, weight-, and body mass index-adjusted models in assessing sarcopenia","volume":"31","author":"Kim","year":"2016","journal-title":"Korean J. Intern. Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"253","DOI":"10.3389\/fphys.2020.00253","article-title":"Skeletal Muscle Extracellular Matrix\u2014What Do We Know About Its Composition, Regulation, and Physiological Roles? A Narrative Review","volume":"11","author":"Csapo","year":"2020","journal-title":"Front. Physiol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1002\/mus.22094","article-title":"Structure and function of the skeletal muscle extracellular matrix","volume":"44","author":"Gillies","year":"2011","journal-title":"Muscle Nerve"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/s13018-016-0421-y","article-title":"Matrix scaffolding for stem cell guidance toward skeletal muscle tissue engineering","volume":"11","author":"Fuoco","year":"2016","journal-title":"J. Orthop. Surg."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"S35","DOI":"10.5435\/00124635-201102001-00007","article-title":"Volumetric muscle loss","volume":"19","author":"Grogan","year":"2011","journal-title":"J. Am. Acad. Orthop. Surg."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1111\/nan.12655","article-title":"Extracellular matrix remodelling is associated with muscle force increase in overloaded mouse plantaris muscle","volume":"47","author":"Stantzou","year":"2021","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"4620","DOI":"10.1038\/s41467-019-12545-3","article-title":"In vivo engineered extracellular matrix scaffolds with instructive niches for oriented tissue regeneration","volume":"10","author":"Zhu","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"120653","DOI":"10.1016\/j.biomaterials.2021.120653","article-title":"Muscle functional recovery is driven by extracellular vesicles combined with muscle extracellular matrix in a volumetric muscle loss murine model","volume":"269","author":"Magarotto","year":"2021","journal-title":"Biomaterials"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.jss.2011.11.1029","article-title":"Biologic Scaffold Remodeling in a Dog Model of Complex Musculoskeletal Injury","volume":"176","author":"Turner","year":"2012","journal-title":"J. Surg. Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"851825","DOI":"10.3389\/fbioe.2022.851825","article-title":"Personalized in vitro Extracellular Matrix Models of Collagen VI-Related Muscular Dystrophies","volume":"10","author":"Almici","year":"2022","journal-title":"Front. Bioeng. Biotechnol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s13036-022-00292-x","article-title":"Extracellular matrix dynamics: Tracking in biological systems and their implications","volume":"16","author":"Hu","year":"2022","journal-title":"J. Biol. Eng."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.matbio.2022.01.003","article-title":"CCN2 participates in overload-induced skeletal muscle hypertrophy","volume":"106","author":"Petrosino","year":"2022","journal-title":"Matrix Biol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1080\/03008207.2020.1834540","article-title":"Comparison between placental and skeletal muscle ECM: In vivo implantation","volume":"62","author":"Carvalho","year":"2021","journal-title":"Connect. Tissue Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"101774","DOI":"10.1016\/j.redox.2020.101774","article-title":"Silencing COX-2 blocks PDK1\/TRAF4-induced AKT activation to inhibit fibrogenesis during skeletal muscle atrophy","volume":"38","author":"Chen","year":"2021","journal-title":"Redox Biol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1038\/s41419-019-2049-4","article-title":"SPARCL1 promotes C2C12 cell differentiation via BMP7-mediated BMP\/TGF-\u03b2 cell signaling pathway","volume":"10","author":"Wang","year":"2019","journal-title":"Cell Death Dis."},{"key":"ref_42","first-page":"e21503","article-title":"Reduced RECK levels accelerate skeletal muscle differentiation, improve muscle regeneration, and decrease fibrosis","volume":"35","author":"Gonzalez","year":"2021","journal-title":"FASEB J."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"2951","DOI":"10.1038\/s41467-021-23217-6","article-title":"FKRP-dependent glycosylation of fibronectin regulates muscle pathology in muscular dystrophy","volume":"12","author":"Wood","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1152\/japplphysiol.00248.2021","article-title":"Diaphragm Muscle Fibrosis Involves Changes in Collagen Organization with Mechanical Implications in Duchenne Muscular Dystrophy","volume":"132","author":"Sahani","year":"2022","journal-title":"J. Appl. Physiol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.matbio.2019.01.002","article-title":"Denervation-Induced Skeletal Muscle Fibrosis Is Mediated by CTGF\/CCN2 Independently of TGF-\u03b2","volume":"82","author":"Rebolledo","year":"2019","journal-title":"Matrix Biol."},{"key":"ref_46","first-page":"23","article-title":"Lysyl Oxidase Inhibition in Primary Myelofibrosis: A Renewed Strategy","volume":"1","author":"Piasecki","year":"2020","journal-title":"Arch. Stem Cell Ther."},{"key":"ref_47","unstructured":"CDC (2023, January 02). Arthritis. Centers for Disease Control and Prevention, Available online: https:\/\/www.cdc.gov\/chronicdisease\/resources\/publications\/factsheets\/arthritis.htm."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"19476035221081466","DOI":"10.1177\/19476035221081466","article-title":"Stiffness- and Bioactive Factor-Mediated Protection of Self-Assembled Cartilage against Macrophage Challenge in a Novel Co-Culture System","volume":"13","author":"Donahue","year":"2022","journal-title":"Cartilage"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1600967","DOI":"10.1002\/adhm.201600967","article-title":"Instructing Human Macrophage Polarization by Stiffness and Glycosaminoglycan Functionalization in 3D Collagen Networks","volume":"6","author":"Friedemann","year":"2017","journal-title":"Adv. Healthc. Mater."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1038\/nrrheum.2016.136","article-title":"Low-grade inflammation as a key mediator of the pathogenesis of osteoarthritis","volume":"12","author":"Robinson","year":"2016","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Previtera, M.L., and Sengupta, A. (2015). Substrate Stiffness Regulates Proinflammatory Mediator Production through TLR4 Activity in Macrophages. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0145813"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1002\/jbm.a.34104","article-title":"The effects of substrate stiffness on the in vitro activation of macrophages and in vivo host response to poly(ethylene glycol)-based hydrogels","volume":"100","author":"Blakney","year":"2012","journal-title":"J. Biomed. Mater. Res. A"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"284873","DOI":"10.1155\/2013\/284873","article-title":"The Role of Changes in Extracellular Matrix of Cartilage in the Presence of Inflammation on the Pathology of Osteoarthritis","volume":"2013","author":"Maldonado","year":"2013","journal-title":"BioMed Res. Int."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.matbio.2018.05.008","article-title":"Osteoarthritis as a disease of the cartilage pericellular matrix","volume":"71\u201372","author":"Guilak","year":"2018","journal-title":"Matrix Biol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1002\/1529-0131(200201)46:1<114::AID-ART10025>3.0.CO;2-P","article-title":"Crosslinking by advanced glycation end products increases the stiffness of the collagen network in human articular cartilage: A possible mechanism through which age is a risk factor for osteoarthritis","volume":"46","author":"Verzijl","year":"2002","journal-title":"Arthritis Rheum."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1016\/j.drudis.2019.07.010","article-title":"Targeted cell delivery for articular cartilage regeneration and osteoarthritis treatment","volume":"24","author":"Nasiri","year":"2019","journal-title":"Drug Discov. Today"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1146\/annurev-matsci-062910-100431","article-title":"Nanomechanics of the Cartilage Extracellular Matrix","volume":"41","author":"Han","year":"2011","journal-title":"Annu. Rev. Mater. Res."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.wear.2014.11.033","article-title":"Investigation of the nano-mechanical properties and surface topographies of wear particles and human knee cartilages","volume":"324\u2013325","author":"Wang","year":"2015","journal-title":"Wear"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.yexcr.2018.04.005","article-title":"Reduced Substrate Stiffness Promotes M2-like Macrophage Activation and Enhances Peroxisome Proliferator-Activated Receptor \u03b3 Expression","volume":"367","author":"Okamoto","year":"2018","journal-title":"Exp. Cell Res."},{"key":"ref_60","first-page":"a004978","article-title":"The Collagen Family","volume":"3","year":"2011","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"177","DOI":"10.3390\/jdb3040177","article-title":"Role of Chondrocytes in Cartilage Formation, Progression of Osteoarthritis and Cartilage Regeneration","volume":"3","author":"Akkiraju","year":"2015","journal-title":"J. Dev. Biol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"120555","DOI":"10.1016\/j.biomaterials.2020.120555","article-title":"The Regulation of Cartilage Extracellular Matrix Homeostasis in Joint Cartilage Degeneration and Regeneration","volume":"268","author":"Peng","year":"2021","journal-title":"Biomaterials"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"5408","DOI":"10.1111\/jcmm.15204","article-title":"Mechanotransduction pathways in the regulation of cartilage chondrocyte homoeostasis","volume":"24","author":"Zhao","year":"2020","journal-title":"J. Cell. Mol. Med."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1186\/1479-5876-12-88","article-title":"Extracellular matrix production in vitro in cartilage tissue engineering","volume":"12","author":"Chen","year":"2014","journal-title":"J. Transl. Med."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1042\/BST0350677","article-title":"Influence of the extracellular matrix on the frictional properties of tissue-engineered cartilage","volume":"35","author":"Hatton","year":"2007","journal-title":"Biochem. Soc. Trans."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1177\/1947603515612190","article-title":"Superficial Zone Extracellular Matrix Extracts Enhance Boundary Lubrication of Self-Assembled Articular Cartilage","volume":"7","author":"Peng","year":"2016","journal-title":"Cartilage"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"103580","DOI":"10.1016\/j.jmbbm.2019.103580","article-title":"A method for the assessment of the coefficient of friction of articular cartilage and a replacement biomaterial","volume":"103","author":"Mahmood","year":"2020","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"119821","DOI":"10.1016\/j.biomaterials.2020.119821","article-title":"Decellularized tissue engineered hyaline cartilage graft for articular cartilage repair","volume":"235","author":"Nie","year":"2020","journal-title":"Biomaterials"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"2378","DOI":"10.1016\/j.biomaterials.2008.01.037","article-title":"A cartilage ECM-derived 3-D porous acellular matrix scaffold for in vivo cartilage tissue engineering with PKH26-labeled chondrogenic bone marrow-derived mesenchymal stem cells","volume":"29","author":"Yang","year":"2008","journal-title":"Biomaterials"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"581972","DOI":"10.3389\/fcell.2020.581972","article-title":"Potential of Soluble Decellularized Extracellular Matrix for Musculoskeletal Tissue Engineering\u2014Comparison of Various Mesenchymal Tissues","volume":"8","author":"Hanai","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.actbio.2017.12.043","article-title":"Mesenchymal stem cell-derived extracellular matrix enhances chondrogenic phenotype of and cartilage formation by encapsulated chondrocytes in vitro and in vivo","volume":"69","author":"Yang","year":"2018","journal-title":"Acta Biomater."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1016\/j.bioactmat.2020.12.009","article-title":"Hierarchical macro-microporous WPU-ECM scaffolds combined with Microfracture Promote in Situ Articular Cartilage Regeneration in Rabbits","volume":"6","author":"Chen","year":"2021","journal-title":"Bioact. Mater."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Rim, Y.A., and Ju, J.H. (2020). The Role of Fibrosis in Osteoarthritis Progression. Life, 11.","DOI":"10.3390\/life11010003"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"e475","DOI":"10.1002\/ctm2.475","article-title":"Extracellular matrix and Hippo signaling as therapeutic targets of antifibrotic compounds for uterine fibroids","volume":"11","author":"Islam","year":"2021","journal-title":"Clin. Transl. Med."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"5318","DOI":"10.1080\/21655979.2022.2036899","article-title":"The anti-fibrotic agent nintedanib protects chondrocytes against tumor necrosis factor-\u03b1 (TNF-\u03b1)-induced extracellular matrix degradation","volume":"13","author":"Wang","year":"2022","journal-title":"Bioengineered"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"770655","DOI":"10.3389\/fbioe.2021.770655","article-title":"Strategies for Articular Cartilage Repair and Regeneration","volume":"9","author":"Liu","year":"2021","journal-title":"Front. Bioeng. Biotechnol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"e0121966","DOI":"10.1371\/journal.pone.0121966","article-title":"Decellularized Cartilage May Be a Chondroinductive Material for Osteochondral Tissue Engineering","volume":"10","author":"Sutherland","year":"2015","journal-title":"PLoS ONE"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1002\/bit.25145","article-title":"The potential of encapsulating \u201craw materials\u201d in 3D osteochondral gradient scaffolds: Chondroitin Sulfate and Bioactive Glass as Raw Materials","volume":"111","author":"Mohan","year":"2014","journal-title":"Biotechnol. Bioeng."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.actbio.2021.08.032","article-title":"Impact of perlecan, a core component of basement membrane, on regeneration of cartilaginous tissues","volume":"135","author":"Gao","year":"2021","journal-title":"Acta Biomater."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"101547","DOI":"10.1016\/j.apmt.2022.101547","article-title":"Study on bioactive PEGDA\/ECM hybrid bi-layered hydrogel scaffolds fabricated by electro-writing for cartilage regeneration","volume":"28","author":"Han","year":"2022","journal-title":"Appl. Mater. Today"},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Beketov, E.E., Isaeva, E.V., Yakovleva, N.D., Demyashkin, G.A., Arguchinskaya, N.V., Kisel, A.A., Lagoda, T.S., Malakhov, E.P., Kharlov, V.I., and Osidak, E.O. (2021). Bioprinting of Cartilage with Bioink Based on High-Concentration Collagen and Chondrocytes. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms222111351"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"101457","DOI":"10.1016\/j.mtla.2022.101457","article-title":"3D Bioprinting of human Mesenchymal Stem Cells in a novel tunic decellularized ECM bioink for Cartilage Tissue Engineering","volume":"23","author":"Govindharaj","year":"2022","journal-title":"Materialia"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1002\/jor.22818","article-title":"Tendon Functional Extracellular Matrix","volume":"33","author":"Screen","year":"2015","journal-title":"J. Orthop. Res. Off. Publ. Orthop. Res. Soc."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1007\/s11999-008-0286-4","article-title":"The Basic Science of Tendinopathy","volume":"466","author":"Xu","year":"2008","journal-title":"Clin. Orthop."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1111\/iep.12027","article-title":"The role of the non-collagenous matrix in tendon function","volume":"94","author":"Thorpe","year":"2013","journal-title":"Int. J. Exp. Pathol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.actbio.2006.05.008","article-title":"The influence of swelling and matrix degradation on the microstructural integrity of tendon","volume":"2","author":"Screen","year":"2006","journal-title":"Acta Biomater."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"119488","DOI":"10.1016\/j.biomaterials.2019.119488","article-title":"Subcutaneously engineered autologous extracellular matrix scaffolds with aligned microchannels for enhanced tendon regeneration","volume":"224","author":"Li","year":"2019","journal-title":"Biomaterials"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1038\/nrrheum.2010.43","article-title":"The pathogenesis of tendinopathy: Balancing the response to loading","volume":"6","author":"Magnusson","year":"2010","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s42490-019-0029-5","article-title":"Models of tendon development and injury","volume":"1","author":"Theodossiou","year":"2019","journal-title":"BMC Biomed. Eng."},{"key":"ref_90","unstructured":"Theodossiou, S.K., Pancheri, N.M., Bozeman, A.L., Brumley, M.R., Raveling, A.R., and Schiele, N.R. (2019, January 11\u201314). Spinal Cord Transection Disrupts Neonatal Locomotion and Tendon Mechanical Properties. Proceedings of the Biomedical Engineering Society (BMES) Annual Meeting (2019), Philadelphia, PA, USA."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1080\/03008207.2021.1925663","article-title":"The role of the tendon ECM in mechanotransduction: Disruption and repair following overuse","volume":"63","author":"Chatterjee","year":"2022","journal-title":"Connect. Tissue Res."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"e38069","DOI":"10.7554\/eLife.38069","article-title":"Mechanical force regulates tendon extracellular matrix organization and tenocyte morphogenesis through TGFbeta signaling","volume":"7","author":"Subramanian","year":"2018","journal-title":"eLife"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1083\/jcb.103.1.231","article-title":"Extracellular compartments in tendon morphogenesis: Collagen fibril, bundle, and macroaggregate formation","volume":"103","author":"Birk","year":"1986","journal-title":"J. Cell Biol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1113\/jphysiol.2003.050179","article-title":"Elasticity in extracellular matrix \u201cshape modules\u201d of tendon, cartilage, etc. A sliding proteoglycan-filament model","volume":"553","author":"Scott","year":"2003","journal-title":"J. Physiol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.matbio.2004.03.004","article-title":"Characterisation of proteoglycans and their catabolic products in tendon and explant cultures of tendon","volume":"23","author":"Samiric","year":"2004","journal-title":"Matrix Biol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.matbio.2009.08.002","article-title":"Evidence against proteoglycan mediated collagen fibril load transmission and dynamic viscoelasticity in tendon","volume":"28","author":"Fessel","year":"2009","journal-title":"Matrix Biol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"12","DOI":"10.32098\/mltj.01.2013.04","article-title":"Specialisation of extracellular matrix for function in tendons and ligaments","volume":"3","author":"Birch","year":"2013","journal-title":"Muscles Ligaments Tendons J."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/j.bbrc.2018.12.023","article-title":"TGF\u03b22-induced tenogenesis impacts cadherin and connexin cell-cell junction proteins in mesenchymal stem cells","volume":"508","author":"Theodossiou","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1186\/s13287-022-03038-0","article-title":"Tenogenic induction of human adipose-derived stem cells by soluble tendon extracellular matrix: Composition and transcriptomic analyses","volume":"13","author":"Rao","year":"2022","journal-title":"Stem Cell Res. Ther."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1111\/j.1469-7580.2006.00549.x","article-title":"Extracellular matrix adaptation of tendon and skeletal muscle to exercise","volume":"208","author":"Kjaer","year":"2006","journal-title":"J. Anat."},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Kiyotake, E.A., Cheng, M.E., Thomas, E.E., and Detamore, M.S. (2022). The Rheology and Printability of Cartilage Matrix-Only Biomaterials. Biomolecules, 12.","DOI":"10.3390\/biom12060846"},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Hauptstein, J., Forster, L., Nadernezhad, A., Groll, J., Te\u00dfmar, J., and Blunk, T. (2022). Tethered TGF-\u03921 in a Hyaluronic Acid-Based Bioink for Bioprinting Cartilaginous Tissues. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23020924"},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Behan, K., Dufour, A., Garcia, O., and Kelly, D. (2022). Methacrylated Cartilage ECM-Based Hydrogels as Injectables and Bioinks for Cartilage Tissue Engineering. Biomolecules, 12.","DOI":"10.3390\/biom12020216"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.actbio.2008.09.020","article-title":"Effect of Pore Size on ECM Secretion and Cell Growth in Gelatin Scaffold for Articular Cartilage Tissue Engineering","volume":"5","author":"Lien","year":"2009","journal-title":"Acta Biomater."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.actbio.2021.07.038","article-title":"Decellularized tendon matrix membranes prevent post-surgical tendon adhesion and promote functional repair","volume":"134","author":"Tao","year":"2021","journal-title":"Acta Biomater."},{"key":"ref_106","first-page":"2354325","article-title":"Biological Amnion Prevents Flexor Tendon Adhesion in Zone II: A Controlled, Multicentre Clinical Trial","volume":"2019","author":"Liu","year":"2019","journal-title":"BioMed Res. Int."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"e28630","DOI":"10.1097\/MD.0000000000028630","article-title":"Prevention of postoperative adhesions after flexor tendon repair with acellular dermal matrix in Zones III, IV, and V of the hand: A randomized controlled (CONSORT-compliant) trial","volume":"101","author":"Lee","year":"2022","journal-title":"Medicine"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"890","DOI":"10.12968\/jowc.2021.30.11.890","article-title":"Preventing postoperative adhesions after hand tendon repair using acellular dermal matrix","volume":"30","author":"Shim","year":"2021","journal-title":"J. Wound Care"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"050801","DOI":"10.1115\/1.4053086","article-title":"The Role of the Non-Collagenous Extracellular Matrix in Tendon and Ligament Mechanical Behavior: A Review","volume":"144","author":"Eisner","year":"2022","journal-title":"J. Biomech. Eng."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1038\/nm1630","article-title":"Identification of tendon stem\/progenitor cells and the role of the extracellular matrix in their niche","volume":"13","author":"Bi","year":"2007","journal-title":"Nat. Med."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"3674647","DOI":"10.1155\/2019\/3674647","article-title":"Tendon Stem\/Progenitor Cells and Their Interactions with Extracellular Matrix and Mechanical Loading","volume":"2019","author":"Zhang","year":"2019","journal-title":"Stem Cells Int."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.actbio.2023.02.018","article-title":"Rejuvenation of tendon stem\/progenitor cells for functional tendon regeneration through platelet-derived exosomes loaded with recombinant Yap1","volume":"161","author":"Lu","year":"2023","journal-title":"Acta Biomater."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"a007997","DOI":"10.1101\/cshperspect.a007997","article-title":"Wnt Signaling in Bone Development and Disease: Making Stronger Bone with Wnts","volume":"4","author":"Regard","year":"2012","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1007\/s11914-012-0105-4","article-title":"Osteocyte Signaling in Bone","volume":"10","author":"Schaffler","year":"2012","journal-title":"Curr. Osteoporos Rep."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1186\/s13018-021-02772-0","article-title":"The global prevalence of osteoporosis in the world: A comprehensive systematic review and meta-analysis","volume":"16","author":"Salari","year":"2021","journal-title":"J. Orthop. Surg."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"5452","DOI":"10.3390\/ijms16035452","article-title":"A Polymorphism at the Translation Start Site of the Vitamin D Receptor Gene Is Associated with the Response to Anti-Osteoporotic Therapy in Postmenopausal Women from Southern Italy","volume":"16","author":"Conti","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"ref_117","first-page":"9","article-title":"ECM-receptor interaction as a prognostic indicator for clinical outcome of primary osteoporosis","volume":"9","author":"Yan","year":"2016","journal-title":"Int. J. Clin. Exp. Med."},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Prakoso, A.T., Basri, H., Adanta, D., Yani, I., Ammarullah, M.I., Akbar, I., Ghazali, F.A., Syahrom, A., and Kamarul, T. (2023). The Effect of Tortuosity on Permeability of Porous Scaffold. Biomedicines, 11.","DOI":"10.3390\/biomedicines11020427"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"168","DOI":"10.22203\/eCM.v038a12","article-title":"Biofabrication of multiscale bone extracellular matrix scaffolds for bone tissue engineering","volume":"38","author":"Freeman","year":"2019","journal-title":"Eur. Cell Mater."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"44140","DOI":"10.1038\/srep44140","article-title":"Treatment of rabbit growth plate injuries with oriented ECM scaffold and autologous BMSCs","volume":"7","author":"Li","year":"2017","journal-title":"Sci Rep."},{"key":"ref_121","unstructured":"Research Progress Related to Growth Plate Injuries (2023, January 20). Growth Plate Injuries, Available online: https:\/\/www.niams.nih.gov\/health-topics\/growth-plate-injuries."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"4163","DOI":"10.1016\/j.bioactmat.2021.04.013","article-title":"In situ bone regeneration with sequential delivery of aptamer and BMP2 from an ECM-based scaffold fabricated by cryogenic free-form extrusion","volume":"6","author":"Sun","year":"2021","journal-title":"Bioact. Mater."},{"key":"ref_123","doi-asserted-by":"crossref","unstructured":"Putra, R.U., Basri, H., Prakoso, A.T., Chandra, H., Ammarullah, M.I., Akbar, I., Syahrom, A., and Kamarul, T. (2023). Level of Activity Changes Increases the Fatigue Life of the Porous Magnesium Scaffold, as Observed in Dynamic Immersion Tests, over Time. Sustainability, 15.","DOI":"10.3390\/su15010823"},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"Kim, D.-S., Lee, J.-K., Jung, J.-W., Baek, S.-W., Kim, J.H., Heo, Y., Kim, T.-H., and Han, D.K. (2021). Promotion of Bone Regeneration Using Bioinspired PLGA\/MH\/ECM Scaffold Combined with Bioactive PDRN. Materials, 14.","DOI":"10.3390\/ma14154149"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"108653","DOI":"10.1016\/j.matdes.2020.108653","article-title":"Functionalization of extracellular matrix (ECM) on multichannel biphasic calcium phosphate (BCP) granules for improved bone regeneration","volume":"192","author":"Ventura","year":"2020","journal-title":"Mater. Des."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"eabd6495","DOI":"10.1126\/sciadv.abd6495","article-title":"Trabecular bone organoid model for studying the regulation of localized bone remodeling","volume":"7","author":"Park","year":"2021","journal-title":"Sci. Adv."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.matbio.2022.02.002","article-title":"O-fucosylation of thrombospondin type 1 repeats is essential for ECM remodeling and signaling during bone development","volume":"107","author":"Neupane","year":"2022","journal-title":"Matrix Biol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.bioactmat.2022.03.036","article-title":"The PCK2-glycolysis axis assists three-dimensional-stiffness maintaining stem cell osteogenesis","volume":"18","author":"Li","year":"2022","journal-title":"Bioact. Mater."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"5444","DOI":"10.1172\/JCI136142","article-title":"Immobilization after injury alters extracellular matrix and stem cell fate","volume":"130","author":"Huber","year":"2020","journal-title":"J. Clin. Investig."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"e66107","DOI":"10.7554\/eLife.66107","article-title":"Modeling the ACVR1R206H mutation in human skeletal muscle stem cells","volume":"10","author":"Barruet","year":"2021","journal-title":"eLife"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"8884922","DOI":"10.1155\/2021\/8884922","article-title":"Mechanosensitive Ion Channel Piezo1 Activated by Matrix Stiffness Regulates Oxidative Stress-Induced Senescence and Apoptosis in Human Intervertebral Disc Degeneration","volume":"2021","author":"Wang","year":"2021","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"973886","DOI":"10.3389\/fbioe.2022.973886","article-title":"Research on the osteogenesis and biosafety of ECM\u2013Loaded 3D\u2013Printed Gel\/SA\/58sBG scaffolds","volume":"10","author":"Tan","year":"2022","journal-title":"Front. Bioeng. Biotechnol."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1007\/s10439-019-02337-7","article-title":"ECM in Differentiation: A Review of Matrix Structure, Composition and Mechanical Properties","volume":"48","author":"Padhi","year":"2020","journal-title":"Ann. Biomed. Eng."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1038\/nrm3896","article-title":"Mechanotransduction and extracellular matrix homeostasis","volume":"15","author":"Humphrey","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1083\/jcb.201609037","article-title":"Integrin-mediated mechanotransduction","volume":"215","author":"Sun","year":"2016","journal-title":"J. Cell Biol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.yexcr.2015.10.037","article-title":"Nanoscale and mechanical properties of the physiological cell\u2013ECM microenvironment","volume":"343","author":"Young","year":"2016","journal-title":"Exp. Cell Res."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"377","DOI":"10.4161\/cam.4.3.11747","article-title":"Understanding the effect of mean pore size on cell activity in collagen-glycosaminoglycan scaffolds","volume":"4","author":"Murphy","year":"2010","journal-title":"Cell Adhes. Migr."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1515\/esp-2017-0002","article-title":"A review of electrospinning manipulation techniques to direct fiber deposition and maximize pore size","volume":"1","author":"Feltz","year":"2017","journal-title":"Electrospinning"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"2950","DOI":"10.1039\/C4CP04427D","article-title":"Atomic force microscopy in biomaterials surface science","volume":"17","author":"Variola","year":"2015","journal-title":"Phys. Chem. Chem. Phys."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"2418","DOI":"10.1038\/s41596-021-00495-4","article-title":"Measuring the elastic modulus of soft culture surfaces and three-dimensional hydrogels using atomic force microscopy","volume":"16","author":"Norman","year":"2021","journal-title":"Nat. Protoc."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1038\/s41563-020-0783-8","article-title":"ILC1 drive intestinal epithelial and matrix remodelling","volume":"20","author":"Jowett","year":"2021","journal-title":"Nat. Mater."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.joca.2011.12.010","article-title":"Sliding motion modulates stiffness and friction coefficient at the surface of tissue engineered cartilage","volume":"20","author":"Grad","year":"2012","journal-title":"Osteoarthr. Cartil."},{"key":"ref_143","first-page":"015017","article-title":"3D-bioprinted, phototunable hydrogel models for studying adventitial fibroblast activation in pulmonary arterial hypertension","volume":"15","author":"Thomas","year":"2022","journal-title":"Biofabrication"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"035029","DOI":"10.1088\/1758-5090\/ab9492","article-title":"The Effect of BMP-Mimetic Peptide Tethering Bioinks on the Differentiation of Dental Pulp Stem Cells (DPSCs) in 3D Bioprinted Dental Constructs","volume":"12","author":"Park","year":"2020","journal-title":"Biofabrication"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1089\/ten.tea.2008.0419","article-title":"Macrophage Participation in the Degradation and Remodeling of Extracellular Matrix Scaffolds","volume":"15","author":"Valentin","year":"2009","journal-title":"Tissue Eng. Part A"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.ajpath.2020.09.008","article-title":"Mechanical Feed-Forward Loops Contribute to Idiopathic Pulmonary Fibrosis","volume":"191","author":"Freeberg","year":"2021","journal-title":"Am. J. Pathol."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.trsl.2019.02.002","article-title":"The Cellular Basis of Fibrotic Tendon Healing: Challenges and Opportunities","volume":"209","author":"Nichols","year":"2019","journal-title":"Transl. Res."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.addr.2018.02.002","article-title":"Scarring vs. Functional Repair: Matrix-Based Strategies to Regulate Tissue Healing","volume":"129","author":"Keane","year":"2018","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1007\/s00018-011-0663-0","article-title":"Matrix Control of Scarring","volume":"68","author":"Yates","year":"2011","journal-title":"Cell Mol. Life Sci."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"13582","DOI":"10.1038\/s41598-022-17852-2","article-title":"Matrix Stiffness and Architecture Drive Fibro-Adipogenic Progenitors\u2019 Activation into Myofibroblasts","volume":"12","author":"Loomis","year":"2022","journal-title":"Sci. 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