{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T12:46:06Z","timestamp":1790858766165,"version":"4.1.0"},"reference-count":150,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2023,5,4]],"date-time":"2023-05-04T00:00:00Z","timestamp":1683158400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioengineering"],"abstract":"<jats:p>The field of dental medicine is constantly evolving and advancing toward minimally invasive techniques. Several studies have demonstrated that bonding to the tooth structure, particularly enamel, yields the most predictable results. In some instances, however, significant tooth loss, pulpal necrosis, or irreversible pulpitis may limit the options available to the restorative dentist. In these cases, placement of a post and core followed by a crown is the preferred treatment option, provided all requirements are met. This literature review provides an overview of the historical development of dental FRC post systems as well as a comprehensive examination of the currently available posts and their bonding requirements. In addition, it offers valuable insights for dental professionals seeking to understand the current state of the field and the prospects of dental FRC post systems.<\/jats:p>","DOI":"10.3390\/bioengineering10050551","type":"journal-article","created":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T02:56:51Z","timestamp":1683255411000},"page":"551","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Dental Fiber-Post Systems: An In-Depth Review of Their Evolution, Current Practice and Future Directions"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8890-8707","authenticated-orcid":false,"given":"Abdulrahman","family":"Alshabib","sequence":"first","affiliation":[{"name":"Department of Restorative Dental Science, College of Dentistry, King Saud University, Riyadh 11545, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5222-3765","authenticated-orcid":false,"given":"Khaled","family":"Abid Althaqafi","sequence":"additional","affiliation":[{"name":"Department of Restorative Dental Department, College of Dentistry, University of Umm Al Qura, Makkah 24211, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6375-5089","authenticated-orcid":false,"given":"Hani S.","family":"AlMoharib","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Community Dentistry, College of Dentistry, King Saud University, Riyadh 11545, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahir","family":"Mirah","sequence":"additional","affiliation":[{"name":"Department of Restorative Dental Science, Dental College, and Hospital, Taibah University, Madinah 42353, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasser F.","family":"AlFawaz","sequence":"additional","affiliation":[{"name":"Department of Restorative Dental Science, College of Dentistry, King Saud University, Riyadh 11545, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamad","family":"Algamaiah","sequence":"additional","affiliation":[{"name":"Department of Restorative Dental Science, College of Dentistry, King Saud University, Riyadh 11545, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,4]]},"reference":[{"key":"ref_1","first-page":"613","article-title":"Restoration of endodontically treated teeth with carbon fibre posts-a prospective study","volume":"66","author":"Glazer","year":"2000","journal-title":"J. Can. Dent. Assoc."},{"key":"ref_2","first-page":"131","article-title":"New concept of coronoradicular reconstruction: The Composipost (1)","volume":"60","author":"Duret","year":"1990","journal-title":"Chir. Dent. Fr."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/S0022-3913(08)60106-7","article-title":"Influence of airborne-particle abrasion on mechanical properties and bond strength of carbon\/epoxy and glass\/bis-GMA fiber-reinforced resin posts","volume":"99","author":"Soares","year":"2008","journal-title":"J. Prosthet. Dent."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"277","DOI":"10.4103\/0970-9290.57357","article-title":"Flexural modulus, flexural strength, and stiffness of fiber-reinforced posts","volume":"20","author":"Novais","year":"2009","journal-title":"Indian J. Dent. Res."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2196519","DOI":"10.1155\/2019\/2196519","article-title":"Fracture strength and stress distribution in premolars restored with cast post-and-cores or glass-fiber posts considering the influence of ferule","volume":"2019","author":"Bacchi","year":"2019","journal-title":"BioMed Res. Int."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"103750","DOI":"10.1016\/j.jdent.2021.103750","article-title":"Is a fiber post better than a metal post for the restoration of endodontically treated teeth? A systematic review and meta-analysis","volume":"112","author":"Martins","year":"2021","journal-title":"J. Dent."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0022-3913(98)70103-9","article-title":"A retrospective study of 236 patients with teeth restored by carbon fiber-reinforced epoxy resin posts","volume":"80","author":"Fredriksson","year":"1998","journal-title":"J. Prosthet. Dent."},{"key":"ref_8","first-page":"9B","article-title":"Retrospective study of the clinical performance of fiber posts","volume":"13","author":"Ferrari","year":"2000","journal-title":"Am. J. Dent."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1067\/mpr.2002.128492","article-title":"Three-year clinical comparison of survival of endodontically treated teeth restored with either full cast coverage or with direct composite restoration","volume":"88","author":"Mannocci","year":"2002","journal-title":"J. Prosthet. Dent."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1046\/j.1365-2842.2003.01178.x","article-title":"Clinical evaluation of a carbon fibre reinforced carbon endodontic post","volume":"30","author":"King","year":"2003","journal-title":"J. Oral Rehabil."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/sj.bdj.4810405","article-title":"Retention of prefabricated and individually cast root canal posts in vitro","volume":"195","author":"Hedlund","year":"2003","journal-title":"Br. Dent. J."},{"key":"ref_12","first-page":"267","article-title":"Survival of glass fiber post restorations over 5 years","volume":"21","author":"Naumann","year":"2008","journal-title":"Am. J. Dent."},{"key":"ref_13","unstructured":"Schmitter, M., Doz, P., Rammelsberg, P., Gabbert, O., and Ohlmann, B. (2007). Influence of clinical baseline findings on the survival of 2 post systems: A randomized clinical trial. Int. J. Prosthodont., 20."},{"key":"ref_14","first-page":"287","article-title":"Long-term retrospective study of the clinical performance of fiber posts","volume":"20","author":"Ferrari","year":"2007","journal-title":"Am. J. Dent."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1016\/j.joen.2009.07.026","article-title":"Randomized clinical trial comparing the effects of post placement on failure rate of postendodontic restorations: Preliminary results of a mean period of 32 months","volume":"35","author":"Bitter","year":"2009","journal-title":"J. Endod."},{"key":"ref_16","first-page":"843","article-title":"Survival of two post systems\u2014Five-year results of a randomized clinical trial","volume":"42","author":"Schmitter","year":"2011","journal-title":"Quintessence Int. J. Pract. Dent. Engl. Ed."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.joen.2012.01.003","article-title":"10-year survival evaluation for glass-fiber\u2013supported postendodontic restoration: A prospective observational clinical study","volume":"38","author":"Naumann","year":"2012","journal-title":"J. Endod."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"368","DOI":"10.3109\/00016357.2011.603702","article-title":"Fiber post placement with core buildup materials or resin cements\u2014An evaluation of different adhesive approaches","volume":"70","author":"Sterzenbach","year":"2012","journal-title":"Acta Odontol. Scand."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.jdent.2014.02.003","article-title":"Cast metal vs. glass fibre posts: A randomized controlled trial with up to 3 years of follow up","volume":"42","author":"Boscato","year":"2014","journal-title":"J. Dent."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.prosdent.2015.03.011","article-title":"Clinical outcomes and success rates of quartz fiber post restorations: A retrospective study","volume":"114","author":"Parisi","year":"2015","journal-title":"J. Prosthet. Dent."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Cloet, E., Debels, E., and Naert, I. (2017). Controlled Clinical Trial on the Outcome of Glass Fiber Composite Cores Versus Wrought Posts and Cast Cores for the Restoration of Endodontically Treated Teeth: A 5-Year Follow-up Study. Int. J. Prosthodont., 30.","DOI":"10.11607\/ijp.4861"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"128","DOI":"10.2341\/16-278-C","article-title":"A multicenter randomized double-blind controlled clinical trial of fiber post cementation strategies","volume":"43","author":"Bergoli","year":"2018","journal-title":"Oper. Dent."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Perdig\u00e3o, J. (2016). Restoration of Root Canal-Treated Teeth, Springer.","DOI":"10.1007\/978-3-319-15401-5"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"40217","DOI":"10.1002\/app.40217","article-title":"Dynamic mechanical properties of semi-interpenetrating polymer network-based on nitrile rubber and poly (methyl methacrylate-co-butyl acrylate)","volume":"131","author":"Su","year":"2014","journal-title":"J. Appl. Polym. Sci."},{"key":"ref_25","first-page":"93","article-title":"Comparison of carbon fiber and stainless steel root canal posts","volume":"27","author":"Purton","year":"1996","journal-title":"Quintessence Int."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.gien.2018.04.002","article-title":"Removal of fiber posts during endodontic retreatments using ultrasonic tips: A comparison between two different endodontic fiber posts","volume":"32","author":"Capriotti","year":"2018","journal-title":"G. Ital. Di Endod."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"e45","DOI":"10.1016\/j.dental.2012.11.001","article-title":"Mechanical properties and micro-morphology of fiber posts","volume":"29","author":"Zicari","year":"2013","journal-title":"Dent. Mater."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1046\/j.1365-2842.1997.00464.x","article-title":"Curing of a silane coupling agent and its effect on the transverse strength of autopolymerizing polymethylmethacrylate\u2014Glass fibre composite","volume":"24","author":"Vallittu","year":"1997","journal-title":"J. Oral Rehabil."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/j.1834-7819.2010.01298.x","article-title":"Current perspectives on post systems: A literature review","volume":"56","author":"Goracci","year":"2011","journal-title":"Aust. Dent. J."},{"key":"ref_30","first-page":"733","article-title":"Biomechanical considerations for the restoration of endodontically treated teeth: A systematic review of the literature-Part 1. Composition and micro-and macrostructure alterations","volume":"38","author":"Dietschi","year":"2007","journal-title":"Quintessence Int."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1097\/00004770-200405000-00001","article-title":"Post placement and restoration of endodontically treated teeth: A literature review","volume":"30","author":"Schwartz","year":"2004","journal-title":"J. Endod."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"275","DOI":"10.17219\/dmp\/94656","article-title":"The effect of fiber post location on fracture resistance of endodontically treated maxillary premolars","volume":"55","author":"Sulaiman","year":"2018","journal-title":"Dent. Med. Probl."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1016\/j.dental.2011.09.009","article-title":"Mechanical behavior of post-restored upper canine teeth: A 3D FE analysis","volume":"27","author":"Ausiello","year":"2011","journal-title":"Dent. Mater."},{"key":"ref_34","first-page":"369","article-title":"A literature review on the prosthetic treatment of structurally compromised teeth","volume":"17","author":"Fransson","year":"2004","journal-title":"Int. J. Prosthodont."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"475","DOI":"10.11607\/ijp.4120","article-title":"Effect of Post Placement on the Restoration of Endodontically Treated Teeth: A Systematic Review","volume":"28","author":"Zhu","year":"2015","journal-title":"Int. J. Prosthodont."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.jdsr.2007.10.001","article-title":"Key factors in achieving firm adhesion in post\u2013core restorations","volume":"44","author":"Hayashi","year":"2008","journal-title":"Jpn. Dent. Sci. Rev."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1111\/j.1532-849X.2010.00647.x","article-title":"A review of failure modes in teeth restored with adhesively luted endodontic dowels","volume":"19","author":"Rasimick","year":"2010","journal-title":"J. Prosthodont.: Implant Esthet. Reconstr. Dent."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1016\/j.joen.2010.06.005","article-title":"Fracture resistance of teeth restored with post-retained restorations: An overview","volume":"36","author":"Mahmoud","year":"2010","journal-title":"J. Endod."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0022-3913(09)60025-1","article-title":"In vitro fracture resistance of glass-fiber and cast metal posts with different lengths","volume":"101","author":"Giovani","year":"2009","journal-title":"J. Prosthet. Dent."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/0022-3913(90)90070-S","article-title":"Ferrule design and fracture resistance of endodontically treated teeth","volume":"63","author":"Sorensen","year":"1990","journal-title":"J. Prosthet. Dent."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.joen.2011.09.024","article-title":"Ferrule effect: A literature review","volume":"38","author":"Juloski","year":"2012","journal-title":"J. Endod."},{"key":"ref_42","first-page":"78","article-title":"The influence of post length and crown ferrule length on the resistance to cyclic loading of bovine teeth with prefabricated titanium posts","volume":"12","author":"Isidor","year":"1999","journal-title":"Int. J. Prosthodont."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0022-3913(09)60159-1","article-title":"Load fatigue of teeth with different ferrule lengths, restored with fiber posts, composite resin cores, and all-ceramic crowns","volume":"102","author":"Ma","year":"2009","journal-title":"J. Prosthet. Dent."},{"key":"ref_44","first-page":"155","article-title":"Load fatigue of teeth restored with cast posts and cores and complete crowns","volume":"8","author":"Libman","year":"1995","journal-title":"Int. J. Prosthodont."},{"key":"ref_45","first-page":"351","article-title":"Effect of tooth type and ferrule on the survival of pulpless teeth restored with fiber posts: A 3-year clinical study","volume":"23","author":"Mancebo","year":"2010","journal-title":"Am. J. Dent."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1046\/j.1365-2591.2001.00351.x","article-title":"An in vitro study into the effect of the ferrule preparation on the fracture resistance of crowned teeth incorporating prefabricated post and composite core restorations","volume":"34","author":"Gutteridge","year":"2001","journal-title":"Int. Endod. J."},{"key":"ref_47","first-page":"483","article-title":"A comparative study of fracture resistance between morphologic dowel and cores and a resin-reinforced dowel system in the intraradicular restoration of structurally compromised roots","volume":"27","author":"Saupe","year":"1996","journal-title":"Quintessence Int."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/sj.bdj.2010.580","article-title":"Rethinking ferrule\u2013a new approach to an old dilemma","volume":"209","author":"Jotkowitz","year":"2010","journal-title":"Br. Dent. J."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1067\/mpr.2002.127909","article-title":"Effect of core stiffness on the in vitro fracture of crowned, endodontically treated teeth","volume":"88","author":"Pilo","year":"2002","journal-title":"J. Prosthet. Dent."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/0022-3913(85)90633-X","article-title":"Resistance to root fracture of dowel channels with various thicknesses of buccal dentin walls","volume":"53","author":"Tjan","year":"1985","journal-title":"J. Prosthet. Dent."},{"key":"ref_51","first-page":"49","article-title":"Fracture resistance of endodontically treated teeth: Three walls versus four walls of remaining coronal tooth structure","volume":"18","author":"Arunpraditkul","year":"2009","journal-title":"J. Prosthodont. Implant Esthet. Reconstr. Dent."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1080\/00016350500331120","article-title":"Effect of incomplete crown ferrules on load capacity of endodontically treated maxillary incisors restored with fiber posts, composite buildups, and all-ceramic crowns: An in vitro evaluation after chewing simulation","volume":"64","author":"Naumann","year":"2006","journal-title":"Acta Odontol. Scand."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"62","DOI":"10.5005\/jcdp-8-7-62","article-title":"Evaluation of the effect of different ferrule designs on the fracture resistance of endodontically treated maxillary central incisors incorporating fiber posts, composite cores and crown restorations","volume":"8","author":"Ozel","year":"2007","journal-title":"J. Contemp. Dent. Pract."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.prosdent.2005.01.013","article-title":"In vitro fracture resistance of endodontically treated central incisors with varying ferrule heights and configurations","volume":"93","author":"Tan","year":"2005","journal-title":"J. Prosthet. Dent."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1046\/j.1365-2591.2002.00596.x","article-title":"An in vitro investigation into the effects of retained coronal dentine on the strength of a tooth restored with a cemented post and partial core restoration","volume":"35","author":"Gutteridge","year":"2002","journal-title":"Int. Endod. J."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.prosdent.2006.02.026","article-title":"Influence of remaining coronal tooth structure location on the fracture resistance of restored endodontically treated anterior teeth","volume":"95","author":"Ng","year":"2006","journal-title":"J. Prosthet. Dent."},{"key":"ref_57","first-page":"164","article-title":"Effect of dowel length on the retention of 2 different prefabricated posts","volume":"38","author":"Borer","year":"2007","journal-title":"Quintessence Int."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.jdent.2012.01.006","article-title":"Effect of fibre post length and adhesive strategy on fracture resistance of endodontically treated teeth after fatigue loading","volume":"40","author":"Zicari","year":"2012","journal-title":"J. Dent."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1111\/j.1365-2591.2008.01492.x","article-title":"Influence of post fit and post length on fracture resistance","volume":"42","author":"Krastl","year":"2009","journal-title":"Int. Endod. J."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S0099-2399(75)80211-1","article-title":"Frequency, location, and direction of the lateral, secondary, and accessory canals","volume":"1","year":"1975","journal-title":"J. Endod."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.tripleo.2010.02.036","article-title":"The effect of the gap between the post restoration and the remaining root canal filling on the periradicular status in a Turkish subpopulation","volume":"110","author":"Kayahan","year":"2010","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endodontol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.dental.2005.01.012","article-title":"The fit of tapered posts in root canals luted with zinc phosphate cement: A histological study","volume":"21","author":"Schmage","year":"2005","journal-title":"Dent. Mater."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S0022-3913(96)90028-1","article-title":"Restoration of pulpless teeth: Application of traditional principles in present and future contexts","volume":"75","author":"Morgano","year":"1996","journal-title":"J. Prosthet. Dent."},{"key":"ref_64","first-page":"290","article-title":"Resin cement thickness in oval-shaped canals: Oval vs. circular fiber posts in combination with different tips\/drills for post space preparation","volume":"22","author":"Carvalho","year":"2009","journal-title":"Am. J. Dent."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1111\/j.1365-2842.2006.01720.x","article-title":"Influence of prefabricated post dimensions on restored maxillary central incisors","volume":"34","year":"2007","journal-title":"J. Oral Rehabil."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"101","DOI":"10.3109\/00016357.2010.536909","article-title":"Different scanning electron microscopic evaluation methods of cement interface homogeneity of adhesively luted glass fiber posts","volume":"69","author":"Watzke","year":"2011","journal-title":"Acta Odontol. Scand."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.ijadhadh.2016.03.014","article-title":"Strategies to stabilise dentine-bonded interfaces through remineralising operative approaches\u2013State of The Art","volume":"69","author":"Sauro","year":"2016","journal-title":"Int. J. Adhes. Adhes."},{"key":"ref_68","first-page":"17","article-title":"A review of polymerization contraction: The influence of stress development versus stress relief","volume":"21","author":"Carvalho","year":"1996","journal-title":"Oper. Dent."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1111\/jerd.12537","article-title":"Moist vs over-dried etched dentin: FE-SEM\/TEM and bond strength evaluation of resin-dentin interfaces produced by universal adhesives","volume":"32","author":"Kumagai","year":"2020","journal-title":"J. Esthet. Restor. Dent."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.jdsr.2020.08.004","article-title":"Current perspectives on dental adhesion: (1) Dentin adhesion\u2013not there yet","volume":"56","year":"2020","journal-title":"Jpn. Dent. Sci. Rev."},{"key":"ref_71","first-page":"215","article-title":"Buonocore memorial lecture. Adhesion to enamel and dentin: Current status and","volume":"28","author":"Yoshida","year":"2003","journal-title":"Oper. Dent."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.dental.2010.10.016","article-title":"State of the art etch-and-rinse adhesives","volume":"27","author":"Pashley","year":"2011","journal-title":"Dent. Mater."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/jerd.12016","article-title":"Dentin adhesion and MMPs: A comprehensive review","volume":"25","author":"Reis","year":"2013","journal-title":"J. Esthet. Restor. Dent."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/0030-4220(72)90351-9","article-title":"Determination of the moisture content of vital and pulpless teeth","volume":"34","author":"Helfer","year":"1972","journal-title":"Oral Surg. Oral Med. Oral Pathol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1023\/A:1013894432622","article-title":"Effects of sodium hypochlorite solution on root dentine composition","volume":"13","author":"Driscoll","year":"2002","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"ref_76","first-page":"939","article-title":"An in vitro evaluation of the visco-elastic behaviour and composition of dentine matrix soaked in EDTA and NaOC1 independently and in combination","volume":"36","author":"Reddington","year":"2003","journal-title":"Int. Endod. J."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/sj.bdj.2013.106","article-title":"Minimal intervention dentistry: Part 7. Minimally invasive operative caries management: Rationale and techniques","volume":"214","author":"Banerjee","year":"2013","journal-title":"Br. Dent. J."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1016\/j.dental.2021.09.004","article-title":"An in-vitro study investigating the effect of air-abrasion bioactive glasses on dental adhesion, cytotoxicity and odontogenic gene expression","volume":"37","author":"Spagnuolo","year":"2021","journal-title":"Dent. Mater."},{"key":"ref_79","first-page":"176","article-title":"Influence of tooth preparation burs on the roughness and bond strength of adhesives to human dentin surfaces","volume":"24","author":"Ayad","year":"2011","journal-title":"Am. J. Dent."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/j.jdent.2012.07.004","article-title":"One-bottle self-etching adhesives applied to dentine air-abraded using bioactive glasses containing polyacrylic acid: An in vitro microtensile bond strength and confocal microscopy study","volume":"40","author":"Sauro","year":"2012","journal-title":"J. Dent."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1111\/j.1600-0722.2012.00939.x","article-title":"Influence of air-abrasion executed with polyacrylic acid-Bioglass 45S5 on the bonding performance of a resin-modified glass ionomer cement","volume":"120","author":"Sauro","year":"2012","journal-title":"Eur. J. Oral Sci."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1111\/j.1708-8240.1991.tb00808.x","article-title":"Dentin bonding: Overview of the substrate with respect to adhesive material","volume":"3","author":"Pashley","year":"1991","journal-title":"J. Esthet. Restor. Dent."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.jmbbm.2018.10.029","article-title":"Dentin pretreatment with 45S5 and niobophosphate bioactive glass: Effects on pH, antibacterial, mechanical properties of the interface and microtensile bond strength","volume":"90","author":"Bauer","year":"2019","journal-title":"J. Mech. Behav. Mater."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/j.dental.2012.04.011","article-title":"The inhibitory effects of silver diamine fluoride at different concentrations on matrix metalloproteinases","volume":"28","author":"Mei","year":"2012","journal-title":"Dent. Mater."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1177\/154405910708600608","article-title":"In vivo preservation of the hybrid layer by chlorhexidine","volume":"86","author":"Carrilho","year":"2007","journal-title":"J. Dent. Res."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1177\/0022034511435329","article-title":"Chlorhexidine inhibits the activity of dental cysteine cathepsins","volume":"91","author":"Scaffa","year":"2012","journal-title":"J. Dent. Res."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.prosdent.2007.02.014","article-title":"Microtensile bond strength between crown and root dentin and two adhesive systems","volume":"97","author":"Giannini","year":"2007","journal-title":"J. Prosthet. Dent."},{"key":"ref_88","first-page":"127","article-title":"Effect of adhesive system type and tooth region on the bond strength to dentin","volume":"10","author":"Galhano","year":"2008","journal-title":"J. Adhes. Dent."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1046\/j.1365-2591.2001.00393.x","article-title":"The structure of dentine in the apical region of human teeth","volume":"34","author":"Smith","year":"2001","journal-title":"Int. Endod. J."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.jdent.2004.04.006","article-title":"Single-bottle adhesives behave as permeable membranes after polymerization. I. In vivo evidence","volume":"32","author":"Tay","year":"2004","journal-title":"J. Dent."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1177\/00220345840630021001","article-title":"Relaxation of polymerization contraction stresses by flow in dental composites","volume":"63","author":"Davidson","year":"1984","journal-title":"J. Dent. Res."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1097\/01.don.0000168891.23486.de","article-title":"Geometric factors affecting dentin bonding in root canals: A theoretical modeling approach","volume":"31","author":"Tay","year":"2005","journal-title":"J. Endod."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1177\/0022034511431251","article-title":"Meta-analytical review of parameters involved in dentin bonding","volume":"91","author":"Mine","year":"2012","journal-title":"J. Dent. Res."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1111\/j.1600-0722.2004.00146.x","article-title":"The adhesion between fiber posts and root canal walls: Comparison between microtensile and push-out bond strength measurements","volume":"112","author":"Goracci","year":"2004","journal-title":"Eur. J. Oral Sci."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"e78","DOI":"10.1016\/j.dental.2009.12.002","article-title":"Direct comparison of the bond strength results of the different test methods: A critical literature review","volume":"26","author":"Scherrer","year":"2010","journal-title":"Dent. Mater."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1177\/00220345010800070301","article-title":"Concise review biomaterials & bioengineering: Meta-analytical review of factors involved in dentin adherence","volume":"80","author":"Leloup","year":"2001","journal-title":"J. Dent. Res."},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Bitter, K., Gl\u00e4ser, C., Neumann, K., Blunck, U., and Frankenberger, R. (2014). Analysis of resin-dentin interface morphology and bond strength evaluation of core materials for one stage post-endodontic restorations. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0086294"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1111\/j.1600-0722.2009.00623.x","article-title":"Morphological and bond strength evaluation of different resin cements to root dentin","volume":"117","author":"Bitter","year":"2009","journal-title":"Eur. J. Oral Sci."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1111\/j.1600-0722.2012.00974.x","article-title":"Bioactive effects of a calcium\/sodium phosphosilicate on the resin\u2013dentine interface: A microtensile bond strength, scanning electron microscopy, and confocal microscopy study","volume":"120","author":"Profeta","year":"2012","journal-title":"Eur. J. Oral Sci."},{"key":"ref_100","first-page":"160","article-title":"Comparative SEM and TEM observations of nanoleakage within the hybrid layer","volume":"20","author":"Sano","year":"1995","journal-title":"Oper. Dent."},{"key":"ref_101","first-page":"245","article-title":"Microleakage of multi-step and simplified-step bonding systems","volume":"9","author":"Castelnuovo","year":"1996","journal-title":"Am. J. Dent."},{"key":"ref_102","first-page":"255","article-title":"Clinical evaluation of adhesively placed Cerec endo-crowns after 2 years-preliminary results","volume":"1","author":"Bindl","year":"1999","journal-title":"J. Adhes. Dent."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1111\/j.1600-0722.2009.00656.x","article-title":"Push-out stress for fibre posts luted using different adhesive strategies","volume":"117","author":"Mazzoni","year":"2009","journal-title":"Eur. J. Oral Sci."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1111\/j.1600-0722.2008.00577.x","article-title":"Evaluation of the adhesion of fiber posts cemented using different adhesive approaches","volume":"116","author":"Radovic","year":"2008","journal-title":"Eur. J. Oral Sci."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/j.dental.2007.11.011","article-title":"Bonding effectiveness and sealing ability of fiber-post bonding","volume":"24","author":"Zicari","year":"2008","journal-title":"Dent. Mater."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.dental.2010.10.023","article-title":"State of the art of self-etch adhesives","volume":"27","author":"Yoshihara","year":"2011","journal-title":"Dent. Mater."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.dental.2007.02.009","article-title":"Dental adhesion review: Aging and stability of the bonded interface","volume":"24","author":"Breschi","year":"2008","journal-title":"Dent. Mater."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"E103","DOI":"10.2341\/12-258-LIT","article-title":"Overview of clinical alternatives to minimize the degradation of the resin-dentin bonds","volume":"38","author":"Reis","year":"2013","journal-title":"Oper. Dent."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1177\/0022034510382547","article-title":"Nanoleakage inhibition within hybrid layer using new protective chemicals and their effect on adhesion","volume":"90","year":"2011","journal-title":"J. Dent. Res."},{"key":"ref_110","first-page":"173","article-title":"Aging affects the adhesive interface of posts luted with self-adhesive cements: A 1-year study","volume":"15","author":"Marchesi","year":"2013","journal-title":"J Adhes Dent"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1163\/156856109X440957","article-title":"Adhesion to intraradicular dentin: A review","volume":"23","author":"Breschi","year":"2009","journal-title":"J. Adhes. Sci. Technol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.jdent.2008.11.016","article-title":"Effect of sodium sulfinate salts on the polymerization characteristics of dual-cured resin cement systems exposed to attenuated light-activation","volume":"37","author":"Arrais","year":"2009","journal-title":"J. Dent."},{"key":"ref_113","unstructured":"Sakaguchi, R.L., and Powers, J.M. (2012). Craig\u2019s Restorative Dental Materials-e-Book, Elsevier Health Sciences."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1590\/1516-1439.022115","article-title":"The influence of a translucent fiberglass post on the polymerization of dual cure resin cement analyzed by electron paramagnetic resonance","volume":"18","author":"Vicentin","year":"2015","journal-title":"Mater. Res."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.jdent.2008.02.014","article-title":"Effect of curing mode on the polymerization characteristics of dual-cured resin cement systems","volume":"36","author":"Arrais","year":"2008","journal-title":"J. Dent."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1046\/j.1365-2842.2001.00809.x","article-title":"Comparison of photo-activation versus chemical or dual-curing of resin-based luting cements regarding flexural strength, modulus and surface hardness","volume":"28","author":"Hofmann","year":"2001","journal-title":"J. Oral Rehabil."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"92","DOI":"10.2341\/10-145-LR","article-title":"Monomer conversion in dual-cured core buildup materials","volume":"36","author":"Kournetas","year":"2011","journal-title":"Oper. Dent."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"3795","DOI":"10.1016\/S0142-9612(03)00262-X","article-title":"In vitro degradation of resin\u2013dentin bonds analyzed by microtensile bond test, scanning and transmission electron microscopy","volume":"24","author":"Hashimoto","year":"2003","journal-title":"Biomaterials"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1016\/j.dental.2021.09.016","article-title":"Influence of curing modes on thermal stability, hardness development and network integrity of dual-cure resin cements","volume":"37","author":"Aldhafyan","year":"2021","journal-title":"Dent. Mater."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1177\/08959374970110040901","article-title":"Fact and artefact in confocal microscopy","volume":"11","author":"Watson","year":"1997","journal-title":"Adv. Dent. Res."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/j.1365-2842.2010.02148.x","article-title":"Self-adhesive resin cements\u2013chemistry, properties and clinical considerations","volume":"38","author":"Ferracane","year":"2011","journal-title":"J. Oral Rehabil."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"E31","DOI":"10.2341\/13-070-LIT","article-title":"The role of resin cement on bond strength of glass-fiber posts luted into root canals: A systematic review and meta-analysis of in vitro studies","volume":"39","author":"Skupien","year":"2014","journal-title":"Oper. Dent."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0022-3913(11)60037-1","article-title":"Influence of different surface conditioning protocols on microtensile bond strength of self-adhesive resin cements to dentin","volume":"105","author":"Erhardt","year":"2011","journal-title":"J. Prosthet. Dent."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1111\/j.1365-2591.2004.00888.x","article-title":"A confocal laser scanning microscope investigation of different dental adhesives bonded to root canal dentine","volume":"37","author":"Bitter","year":"2004","journal-title":"Int. Endod. J."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s00784-014-1263-9","article-title":"Damage of lithium-disilicate all-ceramic restorations by an experimental self-adhesive resin cement used as core buildups","volume":"19","author":"Sterzenbach","year":"2015","journal-title":"Clin. Oral Investig."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1111\/j.1365-2591.2008.01378.x","article-title":"Influence of endodontic sealer cement on fibreglass post bond strength to root dentine","volume":"41","author":"Menezes","year":"2008","journal-title":"Int. Endod. J."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/S0099-2399(98)80079-4","article-title":"Effects of eugenol and noneugenol endodontic sealer cements on post retention","volume":"24","author":"Schwartz","year":"1998","journal-title":"J. Endod."},{"key":"ref_128","first-page":"15","article-title":"Diffusion behavior of eugenol from zinc oxide-eugenol mixtures through human and bovine dentin in vitro","volume":"22","author":"Kielbassa","year":"1997","journal-title":"Oper. Dent."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"103766","DOI":"10.1016\/j.jdent.2021.103766","article-title":"Effects of dentine surface cleaning on bonding of a self-etch adhesive to root canal sealer-contaminated dentine","volume":"112","author":"Tian","year":"2021","journal-title":"J. Dent."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/j.joen.2021.03.009","article-title":"Impact of conservative endodontic cavities on root canal preparation and biomechanical behavior of upper premolars restored with different materials","volume":"47","author":"Pereira","year":"2021","journal-title":"J. Endod."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1111\/iej.13391","article-title":"Current status on minimal access cavity preparations: A critical analysis and a proposal for a universal nomenclature","volume":"53","author":"Silva","year":"2020","journal-title":"Int. Endod. J."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"618","DOI":"10.2341\/12-395-L","article-title":"Bulk-fill resin-based composites: An in vitro assessment of their mechanical performance","volume":"38","author":"Ilie","year":"2013","journal-title":"Oper. Dent."},{"key":"ref_133","first-page":"4","article-title":"Fracture resistance of endodontically treated teeth restored with a bulkfill flowable material and a resin composite","volume":"7","author":"Isufi","year":"2016","journal-title":"Ann. Di Stomatol."},{"key":"ref_134","first-page":"231","article-title":"Effect of air, dentin and resin-based composite thickness on light intensity reduction","volume":"12","author":"Prati","year":"1999","journal-title":"Am. J. Dent."},{"key":"ref_135","first-page":"91","article-title":"Factors affecting cure at depths within light-activated resin composites","volume":"6","author":"Rueggeberg","year":"1993","journal-title":"Am. J. Dent."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1111\/j.1365-2591.2010.01797.x","article-title":"Self-adhesive cements as core buildups for one-stage post-endodontic restorations?","volume":"44","author":"Naumann","year":"2011","journal-title":"Int. Endod. J."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/S0109-5641(02)00003-9","article-title":"Adhesive post-endodontic restorations with fiber posts: Push-out tests and SEM observations","volume":"18","author":"Pest","year":"2002","journal-title":"Dent. Mater."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.joen.2006.10.009","article-title":"Monoblocks in root canals: A hypothetical or a tangible goal","volume":"33","author":"Tay","year":"2007","journal-title":"J. Endod."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1177\/0022034509342851","article-title":"Influence of luting material filler content on post cementation","volume":"88","author":"Ferrari","year":"2009","journal-title":"J. Dent. Res."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1177\/00220345870660110601","article-title":"Setting stress in composite resin in relation to configuration of the restoration","volume":"66","author":"Feilzer","year":"1987","journal-title":"J. Dent. Res."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"396","DOI":"10.2341\/16-243-L","article-title":"Ferrule-effect dominates over use of a fiber post when restoring endodontically treated incisors: An in vitro study","volume":"42","author":"Magne","year":"2017","journal-title":"Oper. Dent."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.joen.2017.09.020","article-title":"\u201cFerrule comes first. Post is second!\u201d Fake news and alternative facts? A systematic review","volume":"44","author":"Naumann","year":"2018","journal-title":"J. Endod."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1902\/jop.2009.080454","article-title":"A novel decision-making process for tooth retention or extraction","volume":"80","author":"Avila","year":"2009","journal-title":"J. Periodontol."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1067\/mpr.2000.107583","article-title":"Effect of crown lengthening and ferrule placement on static load failure of cemented cast post-cores and crowns","volume":"84","author":"Gegauff","year":"2000","journal-title":"J. Prosthet. Dent."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"220S","DOI":"10.1177\/0022034515589710","article-title":"The impact of the crown-root ratio on survival of abutment teeth for dentures","volume":"94","author":"Tada","year":"2015","journal-title":"J. Dent. Res."},{"key":"ref_146","doi-asserted-by":"crossref","unstructured":"Thomas, R.M., Kelly, A., Tagiyeva, N., and Kanagasingam, S. (2020). Comparing endocrown restorations on permanent molars and premolars: A systematic review and meta-analysis. Br. Dent. J., 1\u20139.","DOI":"10.1038\/s41415-020-2279-y"},{"key":"ref_147","first-page":"415.e411","article-title":"Survival and success of endocrowns: A systematic review and meta-analysis","volume":"125","year":"2021","journal-title":"J. Prosthet. Dent."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"600.e601","DOI":"10.1016\/j.prosdent.2021.11.027","article-title":"Biomechanical behavior of endocrown restorations with different cavity design and CAD-CAM materials under a static and vertical load: A finite element analysis","volume":"127","author":"Abtahi","year":"2022","journal-title":"J. Prosthet. Dent."},{"key":"ref_149","doi-asserted-by":"crossref","unstructured":"Tribst, J.P.M., Lo Giudice, R., Dos Santos, A.F.C., Borges, A.L.S., Silva-Conc\u00edlio, L.R., Amaral, M., and Lo Giudice, G. (2021). Lithium disilicate ceramic endocrown biomechanical response according to different pulp chamber extension angles and filling materials. Materials, 14.","DOI":"10.3390\/ma14051307"},{"key":"ref_150","doi-asserted-by":"crossref","unstructured":"Zheng, Z., Sun, J., Jiang, L., Wu, Y., He, J., Ruan, W., and Yan, W. (2022). Influence of margin design and restorative material on the stress distribution of endocrowns: A 3D finite element analysis. BMC Oral Health, 22.","DOI":"10.1186\/s12903-022-02063-y"}],"container-title":["Bioengineering"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2306-5354\/10\/5\/551\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:28:57Z","timestamp":1760124537000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2306-5354\/10\/5\/551"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,4]]},"references-count":150,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2023,5]]}},"alternative-id":["bioengineering10050551"],"URL":"https:\/\/doi.org\/10.3390\/bioengineering10050551","relation":{},"ISSN":["2306-5354"],"issn-type":[{"value":"2306-5354","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,4]]}}}