{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T16:41:31Z","timestamp":1792168891607,"version":"4.4.0"},"reference-count":32,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioengineering"],"abstract":"<jats:p>Spinocerebellar ataxia 38 (SCA 38) is a rare autosomal neurological disease whose clinical features include, among others, severe gait disturbances that have not yet been fully characterized. In this study, we employed a computerized 3D gait analysis to obtain spatio-temporal parameters of gait and the kinematics in the sagittal plane in the hip, knee, and ankle joints of seven individuals with SCA 38, which were then compared with those of twenty unaffected individuals matched for age, sex, and anthropometric features. The results show that, in comparison with unaffected individuals, those with SCA 38 are characterized by a significantly reduced speed, stride length, and duration of the swing phase, as well as an increased step width and stance and double support phase durations. The point-by-point comparison of the angular trends at the hip, knee, and ankle joints revealed significant alterations during most part of the stance phase for hip joint and at pre-swing\/swing phases for knee and ankle joints. For these latter joints, a significantly reduced dynamic range of motion was also found. Such findings provide some new insights into hip and knee kinematics for this specific form of ataxia and may be useful for monitoring the disease\u2019s progression and designing specific, tailored rehabilitative interventions.<\/jats:p>","DOI":"10.3390\/bioengineering10070788","type":"journal-article","created":{"date-parts":[[2023,7,3]],"date-time":"2023-07-03T01:03:02Z","timestamp":1688346182000},"page":"788","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Quantitative Characterization of Gait Patterns in Individuals with Spinocerebellar Ataxia 38"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9835-3629","authenticated-orcid":false,"given":"Massimiliano","family":"Pau","sequence":"first","affiliation":[{"name":"Department of Mechanical, Chemical and Materials Engineering, University of Cagliari, 09124 Cagliari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3835-6507","authenticated-orcid":false,"given":"Micaela","family":"Porta","sequence":"additional","affiliation":[{"name":"Department of Mechanical, Chemical and Materials Engineering, University of Cagliari, 09124 Cagliari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Pau","sequence":"additional","affiliation":[{"name":"Department of Mechanical, Chemical and Materials Engineering, University of Cagliari, 09124 Cagliari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Tacconi","sequence":"additional","affiliation":[{"name":"Multiple Sclerosis Center, Binaghi Hospital, ASL Cagliari, 09126 Cagliari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Sanna","sequence":"additional","affiliation":[{"name":"U.O.C. Neurology, S.S. Trinit\u00e0 Hospital, ASL Cagliari, 09121 Cagliari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.ajhg.2014.07.001","article-title":"ELOVL5 mutations cause spinocerebellar ataxia 38","volume":"95","author":"Borroni","year":"2014","journal-title":"Am. J. Hum. Genet."},{"key":"ref_2","unstructured":"Adam, M.P., Mirzaa, G.M., and Pagon, R.A. (2023, June 29). Spinocerebellar Ataxia Type 38, GeneReviews, Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK543515\/."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.parkreldis.2016.04.030","article-title":"Clinical and neuroradiological features of spinocerebellar ataxia 38 (SCA38)","volume":"28","author":"Borroni","year":"2016","journal-title":"Park. Relat. 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