{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T04:20:05Z","timestamp":1772252405227,"version":"3.50.1"},"reference-count":30,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2023,7,17]],"date-time":"2023-07-17T00:00:00Z","timestamp":1689552000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioengineering"],"abstract":"<jats:p>Mechanical properties of an aneurysmatic thoracic aorta are potential markers of future growth and remodelling and can help to estimate the risk of rupture. Aortic geometries obtained from routine medical imaging do not display wall stress distribution and mechanical properties. Mechanical properties for a given vessel may be determined from medical images at different physiological pressures using inverse finite element analysis. However, without considering pre-stresses, the estimation of mechanical properties will lack accuracy. In the present paper, we propose and evaluate a mechanical parameter identification technique, which recovers pre-stresses by determining the zero-pressure configuration of the aortic geometry. We first validated the method on a cylindrical geometry and subsequently applied it to a realistic aortic geometry. The verification of the assessed parameters was performed using synthetically generated reference data for both geometries. The method was able to estimate the true mechanical properties with an accuracy ranging from 98% to 99%.<\/jats:p>","DOI":"10.3390\/bioengineering10070846","type":"journal-article","created":{"date-parts":[[2023,7,18]],"date-time":"2023-07-18T01:46:02Z","timestamp":1689644762000},"page":"846","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Biomechanical Characterisation of Thoracic Ascending Aorta with Preserved Pre-Stresses"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6151-1651","authenticated-orcid":false,"given":"Shaiv","family":"Parikh","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering, CARIM School for Cardiovascular Diseases, Maastricht University, 6229 ER Maastricht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"Moerman","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, University of Galway, H91 TK33 Galway, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitch","family":"Ramaekers","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Heart & Vascular Centre, Maastricht University Medical Centre, 6229 HX Maastricht, The Netherlands"},{"name":"Department of Radiology and Nuclear Medicine, Maastricht University Medical Centre, 6229 HX Maastricht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Schalla","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Heart & Vascular Centre, Maastricht University Medical Centre, 6229 HX Maastricht, The Netherlands"},{"name":"Department of Radiology and Nuclear Medicine, Maastricht University Medical Centre, 6229 HX Maastricht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elham","family":"Bidar","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Heart & Vascular Centre, Maastricht University Medical Centre, 6229 HX Maastricht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6897-9700","authenticated-orcid":false,"given":"Tammo","family":"Delhaas","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, CARIM School for Cardiovascular Diseases, Maastricht University, 6229 ER Maastricht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2354-883X","authenticated-orcid":false,"given":"Koen","family":"Reesink","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, CARIM School for Cardiovascular Diseases, Maastricht University, 6229 ER Maastricht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wouter","family":"Huberts","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, CARIM School for Cardiovascular Diseases, Maastricht University, 6229 ER Maastricht, The Netherlands"},{"name":"Department of Biomedical Engineering, Cardiovascular Biomechanics, Eindhoven University of Technology, 5612 AE Eindhoven, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"20121004","DOI":"10.1098\/rsif.2012.1004","article-title":"Elastin and collagen fibre microstructure of the human aorta in ageing and disease: A review","volume":"10","author":"Tsamis","year":"2013","journal-title":"J. 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