{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:36:35Z","timestamp":1787319395226,"version":"build-2736575974"},"reference-count":25,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T00:00:00Z","timestamp":1693267200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Indian Council of Medical Research (ICMR)","award":["3\/1\/3\/PDF (5)\/2012-HRD"],"award-info":[{"award-number":["3\/1\/3\/PDF (5)\/2012-HRD"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioengineering"],"abstract":"<jats:p>Arterial thrombosis (AT) originates through platelet-mediated thrombus formation in the blood vessel and can lead to heart attack, stroke, and peripheral vascular diseases. Restricting the thrombus growth and its simultaneous monitoring by visualisation is an unmet clinical need for a better AT prognosis. As a proof-of-concept, we have engineered a nanoparticle-based theranostic (combined therapy and monitoring) platform that has the potential to monitor and restrain the growth of a thrombus concurrently. The theranostic nanotool is fabricated using biocompatible super-paramagnetic iron oxide nanoparticles (SPIONs) as a core module tethered with the anti-platelet agent Abciximab (ReoPro) on its surface. Our in vitro feasibility results indicate that ReoPro-conjugated SPIONS (Tx@ReoPro) can effectively prevent thrombus growth by inhibiting fibrinogen receptors (GPIIbIIIa) on the platelet surface, and simultaneously, it can also be visible through non-invasive magnetic resonance imaging (MRI) for potential reporting of the real-time thrombus status.<\/jats:p>","DOI":"10.3390\/bioengineering10091020","type":"journal-article","created":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T10:46:00Z","timestamp":1693305960000},"page":"1020","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Self-Reporting Theranostic: Nano Tool for Arterial Thrombosis"],"prefix":"10.3390","volume":"10","author":[{"given":"Suryyani","family":"Deb","sequence":"first","affiliation":[{"name":"Department of Biotechnology, Maulana Abul Kalam Azad University of Technology, Haringhata 741249, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Azharuddin","sequence":"additional","affiliation":[{"name":"Cambridge Display Technology Ltd., Huntingdon PE29 2XG, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1920-3962","authenticated-orcid":false,"given":"Sofia","family":"Ramstr\u00f6m","sequence":"additional","affiliation":[{"name":"School of Medical Sciences, Orebro University, 701 82 \u00d6rebro, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0645-6565","authenticated-orcid":false,"given":"Kanjaksha","family":"Ghosh","sequence":"additional","affiliation":[{"name":"National Institute of Immunohaematology, KEM Hospital Campus, Mumbai 400012, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santiswarup","family":"Singha","sequence":"additional","affiliation":[{"name":"National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi 110067, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0607-9795","authenticated-orcid":false,"given":"Thobias","family":"Romu","sequence":"additional","affiliation":[{"name":"Centre for Medical Image Science and Visualization (CMIV), Department of Biomedical Engineering (IMT), Link\u00f6ping University, 581 85 Link\u00f6ping, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6142-5489","authenticated-orcid":false,"given":"Hirak Kumar","family":"Patra","sequence":"additional","affiliation":[{"name":"Department of Surgical Biotechnology, UCL Division of Surgery and Interventional Sciences, University College London, London NW3 2PF, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"285","DOI":"10.4103\/0971-5916.156557","article-title":"Nanoimaging in cardiovascular diseases: Current state of the art","volume":"141","author":"Deb","year":"2015","journal-title":"Indian J. 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