{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:33:07Z","timestamp":1787027587770,"version":"build-2736575974"},"reference-count":41,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T00:00:00Z","timestamp":1695340800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioengineering"],"abstract":"<jats:p>Maxillary sinus augmentation with a lateral approach (MSA) is a well-established treatment. In this prospective study, we evaluated risk factors for postoperative bone graft displacement and reported the clinical application of long-term resorbable L-lactic acid\/-caprolactone (PLA\/PCL) as a barrier membrane to cover the open window in the lateral wall in MSA. Twenty-four patients underwent MSA according to the relevant criteria; CT data obtained before and 1 week (1 w) and 5\u20136 months (5 m) post-MSA, bone height changes, bone height reduction rates at 1 w and 5 m post-MSA, bone graft displacement measurements, and risk factors were examined. All patients showed bone height increments (p &lt; 0.005). However, no difference was observed between 1 w and 5 m post-MSA. Bone graft displacement was observed in eight patients; the reduction rate from 1 w to 5 m post-MSA was 8.38% \u00b1 4.88%. Sex, septa, maxillary sinus floor\u2013palatal bone distance, and maxillary sinus floor\u2013maxillary ostium distance were associated with bone graft displacement (p &lt; 0.05). The height from the maxillary sinus floor to the palatal bone and the sinus angle influenced the augmentation degree (p &lt; 0.05). The PLA\/PCL membrane is compared favorably with other membranes and may be useful as a barrier membrane for the MSA open window.<\/jats:p>","DOI":"10.3390\/bioengineering10101110","type":"journal-article","created":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T05:32:45Z","timestamp":1695360765000},"page":"1110","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Effectiveness and Practicality of a Novel Barrier Membrane for the Open Window in Maxillary Sinus Augmentation with a Lateral Approach, with Risk Indicators for Bone Graft Displacement and Bone Height Decrease: A Prospective Study in Humans"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3919-9179","authenticated-orcid":false,"given":"Kikue","family":"Yamaguchi","sequence":"first","affiliation":[{"name":"Department of Implant Dentistry, Showa University School of Dentistry, 2-1-1, Kita-senzoku, Ota-ku, Tokyo 1458515, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5085-7991","authenticated-orcid":false,"given":"Motohiro","family":"Munakata","sequence":"additional","affiliation":[{"name":"Department of Implant Dentistry, Showa University School of Dentistry, 2-1-1, Kita-senzoku, Ota-ku, Tokyo 1458515, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Implant Dentistry, Showa University School of Dentistry, 2-1-1, Kita-senzoku, Ota-ku, Tokyo 1458515, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Kataoka","sequence":"additional","affiliation":[{"name":"Department of Dental Education, Showa University School of Dentistry, 1-8-5, Hatanodai, Shinagawa-ku, Tokyo 1428555, Japan"},{"name":"Department of Biomaterials and Engineering, Showa University School of Dentistry, 1-8-5, Hatanodai, Shinagawa-ku, Tokyo 14228555, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryota","family":"Kawamata","sequence":"additional","affiliation":[{"name":"Department of Implant Dentistry, Showa University School of Dentistry, 2-1-1, Kita-senzoku, Ota-ku, Tokyo 1458515, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1097\/ID.0000000000000768","article-title":"Maxillary Sinus Floor Augmentation with Synthetic Bone Substitutes Compared with Other Grafting Materials: A Systematic Review and Meta-analysis","volume":"27","author":"Mordenfeld","year":"2018","journal-title":"Implant Dent."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1111\/j.1600-051X.2008.01272.x","article-title":"A Systematic Review of the Success of Sinus Floor Elevation and Survival of Implants Inserted in Combination with Sinus Floor Elevation","volume":"35","author":"Pjetursson","year":"2008","journal-title":"J. Clin. Periodontol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.ijom.2017.05.001","article-title":"A Systematic Review and Meta-analysis of Long-Term Studies (Five or More Years) Assessing Maxillary Sinus Floor Augmentation","volume":"47","author":"Aludden","year":"2018","journal-title":"Int. J. Oral Maxillofac. Surg."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"773","DOI":"10.11607\/prd.1288","article-title":"Long-term implant survival in the grafted maxillary sinus: A systematic review","volume":"33","author":"Wallace","year":"2013","journal-title":"Int. J. Periodontics Restor. Dent."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.ijom.2011.10.001","article-title":"Maxillary sinus lift with solely autogenous bone compared to a combination of autogenous bone and growth factors or (solely) bone substitutes. A systematic review","volume":"41","author":"Rickert","year":"2012","journal-title":"Int. J. Oral Maxillofac. Surg."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/prd.12286","article-title":"Risk Factors in Lateral Window Sinus Elevation Surgery","volume":"81","author":"Testori","year":"2019","journal-title":"Periodontol. 2000"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1016\/j.joms.2015.01.039","article-title":"Risk factors of membrane perforation and postoperative complications in sinus floor elevation surgery: Review of 407 augmentation procedures","volume":"73","author":"Schwarz","year":"2015","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1016\/j.joms.2013.11.023","article-title":"Complication rate in 200 consecutive sinus lift procedures: Guidelines for prevention and treatment","volume":"72","author":"Gil","year":"2014","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"140","DOI":"10.2174\/1874210601711010140","article-title":"Complications during maxillary sinus augmentation associated with interfering septa: A new classification of septa","volume":"11","author":"Irinakis","year":"2017","journal-title":"Open Dent. J."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1111\/prd.12414","article-title":"Complications in sinus lifting procedures: Classification and management","volume":"88","author":"Molina","year":"2022","journal-title":"Periodontol. 2000"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1111\/j.1600-051X.2005.00656.x","article-title":"The Amount of Newly Formed Bone in Sinus Grafting Procedures Depends on Tissue Depth as Well as the Type and Residual Amount of the Grafted Material","volume":"32","author":"Artzi","year":"2005","journal-title":"J. Clin. Periodontol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1097\/ID.0b013e3182691959","article-title":"Predictive Factors for Maxillary Sinus Augmentation Outcomes: A Case Series Analysis","volume":"21","author":"Mesa","year":"2012","journal-title":"Implant Dent."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1111\/j.1708-8208.2010.00274.x","article-title":"Maxillary Sinus Augmentation Using Prehydrated Corticocancellous Porcine Bone: Hystomorphometric Evaluation After 6 Months","volume":"14","author":"Barone","year":"2012","journal-title":"Clin. Implant Dent. Relat. Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.jcms.2012.10.015","article-title":"Comparison of Two Different Absorbable Membranes for the Coverage of Lateral Osteotomy Sites in Maxillary Sinus Augmentation: A Preliminary Study","volume":"41","author":"Gassling","year":"2013","journal-title":"J. Craniomaxillofac. Surg."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1111\/j.1600-051X.2008.01268.x","article-title":"Advances in Bone Augmentation to Enable Dental Implant Placement: Consensus Report of the Sixth European Workshop on Periodontology","volume":"35","author":"Tonetti","year":"2008","journal-title":"J. Clin. Periodontol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1902\/annals.2003.8.1.328","article-title":"Effect of Maxillary Sinus Augmentation on the Survival of Endosseous Dental Implants. A Systematic Review","volume":"8","author":"Wallace","year":"2003","journal-title":"Ann. Periodontol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1097\/ID.0b013e3182310b3d","article-title":"Sinus Lift with Autologous Bone Alone or in Addition to Equine Bone: An Immunohistochemical Study in Man","volume":"20","author":"Artese","year":"2011","journal-title":"Implant Dent."},{"key":"ref_18","first-page":"227","article-title":"Residual Lateral Wall Defects Following Sinus Grafting with Recombinant Human Osteogenic Protein-1 or Bio-Oss in the Chimpanzee","volume":"18","author":"McAllister","year":"1998","journal-title":"Int. J. Periodontics Restor. Dent."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S1532-3382(12)70030-1","article-title":"Maxillary Sinus Elevation by Lateral Window Approach: Evolution of Technology and Technique","volume":"12","author":"Wallace","year":"2012","journal-title":"J. Evid. Based Dent. Pract."},{"key":"ref_20","first-page":"117","article-title":"Histologic and Clinical Comparison of Bilateral Sinus Floor Elevations with and Without Barrier Membrane Placement in 12 Patients: Part 3 of an Ongoing Prospective Study","volume":"20","author":"Tarnow","year":"2000","journal-title":"Int. J. Periodontics Restor. Dent."},{"key":"ref_21","first-page":"713","article-title":"Sinus Floor Elevation Using a Bovine Bone Mineral (Bio-Oss) With or Without the Concomitant Use of a Bilayered Collagen Barrier (Bio-Gide): A Clinical Report of Immediate and Delayed Implant Placement","volume":"16","author":"Tawil","year":"2001","journal-title":"Int. J. Oral Maxillofac. Implant."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"681","DOI":"10.11607\/jomi.6940","article-title":"Bone Graft Displacement After Maxillary Sinus Floor Augmentation with or Without Covering Barrier Membrane: A Retrospective Computed Tomographic Image Evaluation","volume":"34","author":"Ohayon","year":"2019","journal-title":"Int. J. Oral Maxillofac. Implant."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Ishikawa, K., Miyamoto, Y., Tsuchiya, A., Hayashi, K., Tsuru, K., and Ohe, G. (2018). Physical and Histological Comparison of Hydroxyapatite, Carbonate Apatite, and \u03b2-Tricalcium Phosphate Bone Substitutes. Materials, 11.","DOI":"10.3390\/ma11101993"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/j.dental.2020.03.013","article-title":"Fabrication of Novel Poly(Lactic Acid\/Caprolactone) Bilayer Membrane for GBR Application","volume":"36","author":"Abe","year":"2020","journal-title":"Dent. Mater."},{"key":"ref_25","first-page":"587","article-title":"Evaluation of Guided Bone Regeneration with Poly(Lactic Acid-co-Glycolic Acid-co-\u03b5-Caprolactone) Porous Membrane in Lateral Bone Defects of the Canine Mandible","volume":"27","author":"Matsumoto","year":"2012","journal-title":"Int. J. Oral Maxillofac. Implant."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"607","DOI":"10.11607\/jomi.3886","article-title":"Effect of Barrier Membranes on the Outcomes of Maxillary Sinus Floor Augmentation: A Meta-analysis of Histomorphometric Outcomes","volume":"30","author":"Catena","year":"2015","journal-title":"Int. J. Oral Maxillofac. Implant."},{"key":"ref_27","first-page":"73","article-title":"The Effects of Resorbable Membrane on Human Maxillary Sinus Graft: A Pilot Study","volume":"24","author":"Choi","year":"2009","journal-title":"Int. J. Oral Maxillofac. Implant."},{"key":"ref_28","first-page":"635","article-title":"A Clinical and Histologic Evaluation of Implant Integration in the Posterior Maxilla After Sinus Floor Augmentation with Autogenous Bone, Bovine Hydroxyapatite, or a 20:80 Mixture","volume":"17","author":"Hallman","year":"2002","journal-title":"Int. J. Oral Maxillofac. Implant."},{"key":"ref_29","first-page":"1230","article-title":"Influence of Lateral Window Dimensions on Vital Bone Formation Following Maxillary Sinus Augmentation","volume":"27","author":"Wang","year":"2012","journal-title":"Int. J. Oral Maxillofac. Implant."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1111\/j.1600-0501.2011.02270.x","article-title":"Analysis of the Influence of Residual Alveolar Bone Height on Sinus Augmentation Outcomes","volume":"23","author":"Neiva","year":"2012","journal-title":"Clin. Oral Implant. Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1902\/jop.2010.090686","article-title":"The Influence of the Bucco-Palatal Distance on Sinus Augmentation Outcomes","volume":"81","author":"Avila","year":"2010","journal-title":"J. Periodontol."},{"key":"ref_32","first-page":"e1","article-title":"Maxillary Sinus Floor Augmentation with or without Barrier Membrane Coverage of the Lateral Window: A Systematic Review and Meta-Analysis","volume":"10","author":"Deluiz","year":"2019","journal-title":"J. Oral Maxillofac. Res."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"325","DOI":"10.5051\/jpis.2105560278","article-title":"Effect of the size of the bony access window and the collagen barrier over the window in sinus floor elevation: A preclinical investigation in a rabbit sinus model","volume":"52","author":"Sim","year":"2022","journal-title":"J. Periodontal Implant. Sci."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"382","DOI":"10.5051\/jpis.2019.49.6.382","article-title":"Application of Low-Crystalline Carbonate Apatite Granules in 2-Stage Sinus Floor Augmentation: A Prospective Clinical Trial and Histomorphometric Evaluation","volume":"49","author":"Nakagawa","year":"2019","journal-title":"J. Periodontal Implant. Sci."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s40729-021-00303-4","article-title":"Comparison of the Performances of Low-Crystalline Carbonate Apatite and Bio-Oss in Sinus Augmentation Using Three-Dimensional Image Analysis","volume":"7","author":"Nagata","year":"2021","journal-title":"Int. J. Implant. Dent."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1111\/odi.13059","article-title":"Sex hormone replacement therapy in periodontology\u2014A systematic review","volume":"26","author":"Chaves","year":"2020","journal-title":"Oral Dis."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s40729-022-00415-5","article-title":"Effects of Missing Teeth and Nasal Septal Deviation on Maxillary Sinus Volume: A Pilot Study","volume":"8","author":"Yamaguchi","year":"2022","journal-title":"Int. J. Implant. Dent."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"e12362","DOI":"10.1111\/jicd.12362","article-title":"Influence of the position of the antrostomy in sinus floor elevation assessed with cone-beam computed tomography: A randomized clinical trial","volume":"9","author":"Kawakami","year":"2018","journal-title":"J. Investig. Clin. Dent."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"223","DOI":"10.11607\/jomi.7112","article-title":"Influence of the height of the antrostomy in sinus floor elevation assessed by cone beam computed tomography\u2014A randomized clinical trial","volume":"34","author":"Kawakami","year":"2019","journal-title":"Int. J. Oral Maxillofac. Implant."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1007\/s00405-019-05383-y","article-title":"Three-dimensional evaluation of maxillary sinus volume in different age and sex groups using CBCT","volume":"276","author":"Colak","year":"2019","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"187","DOI":"10.11607\/prd.3722","article-title":"A Retrospective Evaluation of Factors Influencing the Volume of Healthy Maxillary Sinuses Based on CBCT Imaging","volume":"39","author":"Bornstein","year":"2019","journal-title":"Int. J. Periodontics Restor. Dent."}],"container-title":["Bioengineering"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2306-5354\/10\/10\/1110\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:55:45Z","timestamp":1760129745000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2306-5354\/10\/10\/1110"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,22]]},"references-count":41,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2023,10]]}},"alternative-id":["bioengineering10101110"],"URL":"https:\/\/doi.org\/10.3390\/bioengineering10101110","relation":{},"ISSN":["2306-5354"],"issn-type":[{"value":"2306-5354","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,22]]}}}