{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T15:25:46Z","timestamp":1777044346883,"version":"3.51.4"},"reference-count":14,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T00:00:00Z","timestamp":1695859200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000009","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5R21AR080388-02"],"award-info":[{"award-number":["5R21AR080388-02"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioengineering"],"abstract":"<jats:p>Diabetic foot ulcer (DFU) is associated with neuropathy and\/or peripheral artery disease of the lower limb in diabetic patients, affecting quality of life and leading to repeated hospitalizations and infections [...]<\/jats:p>","DOI":"10.3390\/bioengineering10101140","type":"journal-article","created":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T05:55:54Z","timestamp":1695880554000},"page":"1140","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Mesenchymal Stem\/Stromal Cell-Derived Small Extracellular Vesicles (MSC-sEVs): A Promising Treatment Modality for Diabetic Foot Ulcer"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3892-9013","authenticated-orcid":false,"given":"Dimitrios","family":"Kouroupis","sequence":"first","affiliation":[{"name":"Department of Orthopaedics, UHealth Sports Medicine Institute, Miller School of Medicine, University of Miami, Miami, FL 33146, USA"},{"name":"Diabetes Research Institute & Cell Transplant Center, Miller School of Medicine, University of Miami, Miami, FL 33136, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lee D.","family":"Kaplan","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, UHealth Sports Medicine Institute, Miller School of Medicine, University of Miami, Miami, FL 33146, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camillo","family":"Ricordi","sequence":"additional","affiliation":[{"name":"Diabetes Research Institute & Cell Transplant Center, Miller School of Medicine, University of Miami, Miami, FL 33136, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas M.","family":"Best","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, UHealth Sports Medicine Institute, Miller School of Medicine, University of Miami, Miami, FL 33146, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e3281","DOI":"10.1002\/dmrr.3281","article-title":"Diagnosis of infection in the foot in diabetes: A systematic review","volume":"36","author":"Senneville","year":"2020","journal-title":"Diabetes Metab. Res. Rev."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1016\/S0140-6736(05)67699-4","article-title":"Treatment for diabetic foot ulcers","volume":"366","author":"Cavanagh","year":"2005","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.stem.2011.06.008","article-title":"The MSC: An Injury Drugstore","volume":"9","author":"Caplan","year":"2011","journal-title":"Cell Stem Cell"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"59","DOI":"10.5966\/sctm.2011-0017","article-title":"Concise review: Mesenchymal stem cells for diabetes","volume":"1","author":"Lanzoni","year":"2012","journal-title":"Stem Cells Transl. Med."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Rai, V., Moellmer, R., and Agrawal, D.K. (2022). Stem Cells and Angiogenesis: Implications and Limitations in Enhancing Chronic Diabetic Foot Ulcer Healing. Cells, 11.","DOI":"10.3390\/cells11152287"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.stem.2013.09.006","article-title":"Mesenchymal Stromal Cells: Sensors and Switchers of Inflammation","volume":"13","author":"Bernardo","year":"2013","journal-title":"Cell Stem Cell"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Mahmoudvand, G., Rouzbahani, A.K., Razavi, Z.S., Mahjoor, M., and Afkhami, H. (2023). Mesenchymal stem cell therapy for non-healing diabetic foot ulcer infection: New insight. Front. Bioeng. Biotechnol., 11.","DOI":"10.3389\/fbioe.2023.1158484"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"10864","DOI":"10.1038\/s41598-019-47391-2","article-title":"Infrapatellar fat pad-derived MSC response to inflammation and fibrosis induces an immunomodulatory phenotype involving CD10-mediated Substance P degradation","volume":"9","author":"Kouroupis","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"109882","DOI":"10.1016\/j.diabres.2022.109882","article-title":"Mechanism and application of exosomes in the wound healing process in diabetes mellitus","volume":"187","author":"Li","year":"2022","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"e13337","DOI":"10.1111\/acel.13337","article-title":"Mesenchymal stem cell-derived extracellular vesicles reduce senescence and extend health span in mouse models of aging","volume":"20","author":"Dorronsoro","year":"2021","journal-title":"Aging Cell"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"3609","DOI":"10.1038\/s41598-022-07569-7","article-title":"Human infrapatellar fat pad mesenchymal stem cells show immunomodulatory exosomal signatures","volume":"12","author":"Kouroupis","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Kouroupis, D., Kaplan, L.D., Huard, J., and Best, T.M. (2023). CD10-Bound Human Mesenchymal Stem\/Stromal Cell-Derived Small Extracellular Vesicles Possess Immunomodulatory Cargo and Maintain Cartilage Homeostasis under Inflammatory Conditions. Cells, 12.","DOI":"10.20944\/preprints202305.1465.v1"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Le\u00f1ero, C., Kaplan, L.D., Best, T.M., and Kouroupis, D. (2022). CD146+ Endometrial-Derived Mesenchymal Stem\/Stromal Cell Subpopulation Possesses Exosomal Secretomes with Strong Immunomodulatory miRNA Attributes. Cells, 11.","DOI":"10.3390\/cells11244002"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/j.omtn.2023.05.002","article-title":"Extracellular vesicle-based biovectors in chronic wound healing: Biogenesis and delivery approaches","volume":"32","author":"Garima","year":"2023","journal-title":"Mol. Ther.\u2014Nucleic Acids"}],"container-title":["Bioengineering"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2306-5354\/10\/10\/1140\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:00:47Z","timestamp":1760130047000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2306-5354\/10\/10\/1140"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,28]]},"references-count":14,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2023,10]]}},"alternative-id":["bioengineering10101140"],"URL":"https:\/\/doi.org\/10.3390\/bioengineering10101140","relation":{},"ISSN":["2306-5354"],"issn-type":[{"value":"2306-5354","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,28]]}}}