{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:45:28Z","timestamp":1760132728850,"version":"build-2065373602"},"reference-count":44,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T00:00:00Z","timestamp":1697500800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ohio Research Challenge Grant","award":["667099"],"award-info":[{"award-number":["667099"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioengineering"],"abstract":"<jats:p>Even though total ankle replacement has emerged as an alternative treatment to arthrodesis, the long-term clinical results are unsatisfactory. Proper design of the ankle device is required to achieve successful arthroplasty results. Therefore, a quantitative knowledge of the ankle joint is necessary. In this pilot study, imaging data of 22 subjects (with both females and males and across three age groups) was used to measure the morphological parameters of the ankle joint. A total of 40 measurements were collected by creating sections in the sagittal and coronal planes for the tibia and talus. Statistical analyses were performed to compare genders, age groups, and image acquisition techniques used to generate 3D models. About 13 measurements derived for parameters (TiAL, SRTi, TaAL, SRTa, TiW, TaW, and TTL) that are very critical for the implant design showed significant differences (p-value &lt; 0.05) between males and females. Young adults showed a significant difference (p-value &lt; 0.05) compared to adults for 15 measurements related to critical tibial and talus parameters (TiAL, TiW, TML, TaAL, SRTa, TaW, and TTL), but no significant differences were observed between young adults and older adults, and between adults and older adults for most of the parameters. A positive correlation (r &gt; 0.70) was observed between tibial and talar width values and between the sagittal radius values. When compared with morphological parameters obtained in this study, the sizes of current total ankle replacement devices can only fit a very limited group of people in this study. This pilot study contributes to the comprehensive understanding of the effects of gender and age group on ankle joint morphology and the relationship between tibial and talus parameters that can be used to plan and design ankle devices.<\/jats:p>","DOI":"10.3390\/bioengineering10101212","type":"journal-article","created":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T08:08:33Z","timestamp":1697530113000},"page":"1212","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Anthropomorphic Characterization of Ankle Joint"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5134-1663","authenticated-orcid":false,"given":"Dinesh","family":"Gundapaneni","sequence":"first","affiliation":[{"name":"Department of Biomedical, Industrial and Human Factors Engineering, Wright State University, Dayton, OH 45435, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James T.","family":"Tsatalis","sequence":"additional","affiliation":[{"name":"Department of Radiology, Miami Valley Hospital, Dayton, OH 45409, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard T.","family":"Laughlin","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Sports Medicine and Rehabilitation, Miami Valley Hospital, Dayton, OH 45409, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6739-8162","authenticated-orcid":false,"given":"Tarun","family":"Goswami","sequence":"additional","affiliation":[{"name":"Department of Biomedical, Industrial and Human Factors Engineering, Wright State University, Dayton, OH 45435, USA"},{"name":"Department of Orthopedic Surgery, Sports Medicine and Rehabilitation, Miami Valley Hospital, Dayton, OH 45409, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.jmbbm.2014.01.020","article-title":"Finite element analysis of stress and wear characterization in total ankle replacements","volume":"34","author":"Elliot","year":"2014","journal-title":"J. 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