{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T17:41:52Z","timestamp":1793122912845,"version":"4.5.0"},"reference-count":34,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T00:00:00Z","timestamp":1700438400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioengineering"],"abstract":"<jats:p>We aimed to investigate the diagnostic accuracy of Screening Corneal Objective Risk of Ectasia (SCORE) Analyzer software using ANTERION, a swept-source optical coherence tomography device, for keratoconus diagnosis in an Asian population. A total of 151 eyes of 151 patients were included in this retrospective study as follows: 60, 45, and 46 keratoconus, keratoconus suspects, and normal control eyes, respectively. Parameters in the SCORE calculation, including six indices, were compared for the three groups. The receiver operating characteristic curve analysis and cut-off value were estimated to assess the diagnostic ability to differentiate keratoconus and keratoconus suspect eyes from the normal group. The SCORE value and six indices were significantly correlated\u2014\u201cAntK max\u201d (R = 0.864), \u201cAntK oppoK\u201d (R = 0.866), \u201cAnt inf supK\u201d (R = 0.943), \u201cAnt irre 3mm\u201d (R = 0.741), \u201cpost elevation at the thinnest point\u201d (R = 0.943), and \u201cminimum corneal thickness\u201d (R = \u22120.750). The SCORE value showed high explanatory power (98.1%), sensitivity of 81.9%, and specificity of 78.3% (cut-off value: 0.25) in diagnosing normal eyes from the keratoconus suspect and keratoconus eyes. The SCORE Analyzer was found to be valid and consistent, showing good sensitivity and specificity for keratoconus detection in an Asian population.<\/jats:p>","DOI":"10.3390\/bioengineering10111335","type":"journal-article","created":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T10:32:32Z","timestamp":1700476352000},"page":"1335","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Diagnostic Validation of the Screening Corneal Objective Risk of Ectasia Analyzer Evaluated by Swept Source Optical Coherence Tomography for Keratoconus in an Asian Population"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4752-3098","authenticated-orcid":false,"given":"Kookyoung","family":"Kim","sequence":"first","affiliation":[{"name":"Nuri Eye Hospital, Daejeon 35233, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyungmin","family":"Koh","sequence":"additional","affiliation":[{"name":"Kim\u2019s Eye Hospital, Seoul 07301, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8473-4383","authenticated-orcid":false,"given":"Seongjun","family":"Lee","sequence":"additional","affiliation":[{"name":"Nuri Eye Hospital, Daejeon 35233, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1642-0248","authenticated-orcid":false,"given":"Yongwoo","family":"Lee","sequence":"additional","affiliation":[{"name":"Departement of Ophthalmology, Kangwon National University Hopsital, Kangwon National University School of Medicine, Chuncheon, Gangwon 24289, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,11,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1016\/j.jcrs.2017.07.021","article-title":"New perspectives on the detection and progression of keratoconus","volume":"43","author":"Pinero","year":"2017","journal-title":"J. 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