{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:56:08Z","timestamp":1792788968146,"version":"4.5.0"},"reference-count":284,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2023,11,26]],"date-time":"2023-11-26T00:00:00Z","timestamp":1700956800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000001","name":"US National Science Foundation","doi-asserted-by":"publisher","award":["2133660"],"award-info":[{"award-number":["2133660"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"US National Science Foundation","doi-asserted-by":"publisher","award":["2R44AT010840"],"award-info":[{"award-number":["2R44AT010840"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"name":"NIH\/NCCIH","award":["2133660"],"award-info":[{"award-number":["2133660"]}]},{"name":"NIH\/NCCIH","award":["2R44AT010840"],"award-info":[{"award-number":["2R44AT010840"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioengineering"],"abstract":"<jats:p>Microbial cell factories offer an eco-friendly alternative for transforming raw materials into commercially valuable products because of their reduced carbon impact compared to conventional industrial procedures. These systems often depend on lignocellulosic feedstocks, mainly pentose and hexose sugars. One major hurdle when utilizing these sugars, especially glucose, is balancing carbon allocation to satisfy energy, cofactor, and other essential component needs for cellular proliferation while maintaining a robust yield. Nearly half or more of this carbon is inevitably lost as CO2 during the biosynthesis of regular metabolic necessities. This loss lowers the production yield and compromises the benefit of reducing greenhouse gas emissions\u2014a fundamental advantage of biomanufacturing. This review paper posits the perspectives of using CO2 from the atmosphere, industrial wastes, or the exhausted gases generated in microbial fermentation as a feedstock for biomanufacturing. Achieving the carbon-neutral or -negative goals is addressed under two main strategies. The one-step strategy uses novel metabolic pathway design and engineering approaches to directly fix the CO2 toward the synthesis of the desired products. Due to the limitation of the yield and efficiency in one-step fixation, the two-step strategy aims to integrate firstly the electrochemical conversion of the exhausted CO2 into C1\/C2 products such as formate, methanol, acetate, and ethanol, and a second fermentation process to utilize the CO2-derived C1\/C2 chemicals or co-utilize C5\/C6 sugars and C1\/C2 chemicals for product formation. The potential and challenges of using CO2 as a feedstock for future biomanufacturing of fuels and chemicals are also discussed.<\/jats:p>","DOI":"10.3390\/bioengineering10121357","type":"journal-article","created":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T03:32:03Z","timestamp":1701055923000},"page":"1357","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Perspectives for Using CO2 as a Feedstock for Biomanufacturing of Fuels and Chemicals"],"prefix":"10.3390","volume":"10","author":[{"given":"Elif","family":"Kurt","sequence":"first","affiliation":[{"name":"Department of Chemical Engineering, University of Massachusetts, Lowell, MA 01854, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiansong","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering, University of Massachusetts, Lowell, MA 01854, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandria","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering, University of Massachusetts, Lowell, MA 01854, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youbo","family":"Zhao","sequence":"additional","affiliation":[{"name":"Physical Sciences Inc., 20 New England Business Ctr., Andover, MA 01810, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3881-7975","authenticated-orcid":false,"given":"Dongming","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering, University of Massachusetts, Lowell, MA 01854, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,11,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"486","DOI":"10.3389\/fmicb.2020.00486","article-title":"CO2-Fixation Strategies in Energy Extremophiles: What Can We Learn from Acetogens?","volume":"11","author":"Lemaire","year":"2020","journal-title":"Front. Microbiol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s11270-022-05581-1","article-title":"Extreme Level of CO2 Accumulation into the Atmosphere Due to the Unequal Global Carbon Emission and Sequestration","volume":"233","author":"Hossain","year":"2022","journal-title":"Water Air Soil Pollut."},{"key":"ref_3","unstructured":"Bhat, P. (2023, November 23). Carbon Needs to Cost at Least $100\/tonne Now to Reach Net Zero by 2050: Reuters Poll. Available online: https:\/\/www.reuters.com\/business\/cop\/carbon-needs-cost-least-100tonne-now-reach-net-zero-by-2050-2021-10-25\/."},{"key":"ref_4","unstructured":"Baylin-Stern, A., and Berghout, N. (2023, November 23). Is Carbon Capture Too Expensive?. Available online: https:\/\/www.iea.org\/commentaries\/is-carbon-capture-too-expensive."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1038\/nrmicro.2016.130","article-title":"Harnessing the power of microbial autotrophy","volume":"14","author":"Claassens","year":"2016","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1038\/s42255-019-0077-0","article-title":"Synergistic substrate cofeeding stimulates reductive metabolism","volume":"1","author":"Park","year":"2019","journal-title":"Nat. Metab."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1038\/nrmicro.2016.32","article-title":"Fuelling the future: Microbial engineering for the production of sustainable biofuels","volume":"14","author":"Liao","year":"2016","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Xie, D. (2022). Continuous biomanufacturing with microbes\u2014Upstream progresses and challenges. Curr. Opin. Biotechnol., 78.","DOI":"10.1016\/j.copbio.2022.102793"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Zhang, C., Ottenheim, C., Weingarten, M., and Ji, L. (2022). Microbial Utilization of Next-Generation Feedstocks for the Biomanufacturing of Value-Added Chemicals and Food Ingredients. Front. Bioeng. Biotechnol., 10.","DOI":"10.3389\/fbioe.2022.874612"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.tibtech.2008.10.009","article-title":"Methanol-based industrial biotechnology: Current status and future perspectives of methylotrophic bacteria","volume":"27","author":"Schrader","year":"2009","journal-title":"Trends Biotechnol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.tibtech.2020.09.004","article-title":"From acetate to bio-based products: Underexploited potential for industrial biotechnology","volume":"39","author":"Kiefer","year":"2021","journal-title":"Trends Biotechnol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1021\/acsenergylett.8b00878","article-title":"Reduction of CO2 to Chemicals and Fuels: A Solution to Global Warming and Energy Crisis","volume":"3","author":"Peter","year":"2018","journal-title":"ACS Energy Lett."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"138349","DOI":"10.1016\/j.electacta.2021.138349","article-title":"Carbon dioxide conversion to C1-C2 compounds in a microbial electrosynthesis cell with in situ electrodeposition of nickel and iron","volume":"383","author":"Bruant","year":"2021","journal-title":"Electrochim. Acta"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Bae, J., Jin, S., Kang, S., Cho, B.-K., and Oh, M.-K. (2022). Recent progress in the engineering of C1-utilizing microbes. Curr. Opin. Biotechnol., 78.","DOI":"10.1016\/j.copbio.2022.102836"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"137","DOI":"10.3390\/microorganisms3020137","article-title":"Interactions of Methylotrophs with Plants and Other Heterotrophic Bacteria","volume":"3","author":"Iguchi","year":"2015","journal-title":"Microorganisms"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1038\/s42255-021-00453-0","article-title":"An orthogonal metabolic framework for one-carbon utilization","volume":"3","author":"Chou","year":"2021","journal-title":"Nat. Metab."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"3992","DOI":"10.1038\/s41467-018-06496-4","article-title":"A modified serine cycle in Escherichia coli coverts methanol and CO2 to two-carbon compounds","volume":"9","author":"Yu","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/j.cell.2020.07.010","article-title":"Converting Escherichia coli to a synthetic methylotroph growing solely on methanol","volume":"182","author":"Chen","year":"2020","journal-title":"Cell"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.cell.2016.05.064","article-title":"Sugar Synthesis from CO2 in Escherichia coli","volume":"166","author":"Antonovsky","year":"2016","journal-title":"Cell"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1021\/acssynbio.6b00167","article-title":"Recycling Carbon Dioxide during Xylose Fermentation by Engineered Saccharomyces cerevisiae","volume":"6","author":"Xia","year":"2017","journal-title":"ACS Synth. Biol."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Xi, Y.-l., Chen, K.-q., Li, J., Fang, X.-j., Zheng, X.-y., Sui, S.-S., Jiang, M., and Wei, P. (2011). Optimization of culture conditions in CO2 fixation for succinic acid production using Actinobacillus succinogenes. J. Ind. Microbiol. Biotechnol., 38.","DOI":"10.1007\/s10295-011-0952-5"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.apenergy.2017.08.193","article-title":"Carbon capture and utilization of fermentation CO2: Integrated ethanol fermentation and succinic acid production as an efficient platform","volume":"206","author":"Zhang","year":"2017","journal-title":"Appl. Energy"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"124584","DOI":"10.1016\/j.cej.2020.124584","article-title":"Recent advances in microbial CO2 fixation and conversion to value-added products","volume":"390","author":"Salehizadeh","year":"2020","journal-title":"Chem. Eng. J."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Morales, M., S\u00e1nchez, L., and Revah, S. (2018). The impact of environmental factors on carbon dioxide fixation by microalgae. FEMS Microbiol. Lett., 365.","DOI":"10.1093\/femsle\/fnx262"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Ray, S., Abraham, J., Jordan, N., Lindsay, M., and Chauhan, N. (2022). Synthetic, Photosynthetic, and Chemical Strategies to Enhance Carbon Dioxide Fixation. C, 8.","DOI":"10.3390\/c8010018"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1126\/science.aah5237","article-title":"A synthetic pathway for the fixation of carbon dioxide in vitro","volume":"354","author":"Schwander","year":"2016","journal-title":"Science"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.jare.2022.07.011","article-title":"Natural carbon fixation and advances in synthetic engineering for redesigning and creating new fixation pathways","volume":"47","author":"Schultz","year":"2023","journal-title":"J. Adv. Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"101929","DOI":"10.1016\/j.jcou.2022.101929","article-title":"Bacterial conversion of CO2 to organic compounds","volume":"58","author":"Choi","year":"2022","journal-title":"J. CO2 Util."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.copbio.2017.07.017","article-title":"A short history of Rubisco: The rise and fall (?) of Nature\u2019s predominant CO2 fixing enzyme","volume":"49","author":"Erb","year":"2018","journal-title":"Curr. Opin. Biotechnol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"3365","DOI":"10.1021\/acs.biochem.9b00237","article-title":"Revisiting Trade-offs between Rubisco Kinetic Parameters","volume":"58","author":"Flamholz","year":"2019","journal-title":"Biochemistry"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12934-020-01494-y","article-title":"Engineering the Calvin\u2013Benson\u2013Bassham cycle and hydrogen utilization pathway of Ralstonia eutropha for improved autotrophic growth and polyhydroxybutyrate production","volume":"19","author":"Li","year":"2020","journal-title":"Microb. Cell Factories"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"e104081","DOI":"10.15252\/embj.2019104081","article-title":"Highly active rubiscos discovered by systematic interrogation of natural sequence diversity","volume":"39","author":"Davidi","year":"2020","journal-title":"EMBO J."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.procbio.2023.10.013","article-title":"Functional expression of RuBisCO reduces CO2 emission during fermentation by engineered Saccharomyces cerevisiae","volume":"134","author":"Park","year":"2023","journal-title":"Process Biochem."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.febslet.2011.09.031","article-title":"Hydrogen, metals, bifurcating electrons, and proton gradients: The early evolution of biological energy conservation","volume":"586","author":"Martin","year":"2012","journal-title":"FEBS Lett."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Pu, X., and Han, Y. (2022). Promotion of Carbon Dioxide Biofixation through Metabolic and Enzyme Engineering. Catalysts, 12.","DOI":"10.3390\/catal12040399"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.ymben.2023.04.005","article-title":"Efforts to install a heterologous Wood-Ljungdahl pathway in Clostridium acetobutylicum enable the identification of the native tetrahydrofolate (THF) cycle and result in early induction of solvents","volume":"77","author":"Jang","year":"2023","journal-title":"Metab. Eng."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"6673","DOI":"10.1038\/s41467-023-42166-w","article-title":"Synergistic investigation of natural and synthetic C1-trophic microorganisms to foster a circular carbon economy","volume":"14","author":"Orsi","year":"2023","journal-title":"Nat. Commun."},{"key":"ref_38","unstructured":"Claassens, N.J., Satanowski, A., Bysani, V.R., Dronsella, B., Orsi, E., Rainaldi, V., Yilmaz, S., Wenk, S., and Lindner, S.N. (2022). One-Carbon Feedstocks for Sustainable Bioproduction, Springer."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1021\/acs.biochem.8b00937","article-title":"Nonphotosynthetic Biological CO2 Reduction","volume":"58","author":"Gonzales","year":"2019","journal-title":"Biochemistry"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"7516","DOI":"10.1073\/pnas.1912289117","article-title":"Functional cooperation of the glycine synthase-reductase and Wood\u2013Ljungdahl pathways for autotrophic growth of Clostridium drakei","volume":"117","author":"Song","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.ymben.2023.02.004","article-title":"Paving the way for synthetic C1-Metabolism in Pseudomonas putida through the reductive glycine pathway","volume":"76","author":"Bruinsma","year":"2023","journal-title":"Metab. Eng."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Kim, S., Giraldo, N., Rainaldi, V., Machens, F., Collas, F., Kubis, A., Kensy, F., Bar-Even, A., and Lindner, S.N. (2023). Optimizing E. coli as a formatotrophic platform for bioproduction via the reductive glycine pathway. Front. Bioeng. Biotechnol., 11.","DOI":"10.3389\/fbioe.2023.1091899"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Steffens, L., Pettinato, E., Steiner, T.M., Eisenreich, W., and Berg, I.A. (2022). Tracking the Reversed Oxidative Tricarboxylic Acid Cycle in Bacteria. Bio Protoc, 12.","DOI":"10.21769\/BioProtoc.4364"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Chen, C.-H., Tseng, I.-T., Lo, S.-C., Yu, Z.-R., Pang, J.-J., Chen, Y.-H., Huang, C.-C., and Li, S.-Y. (2020). Manipulating ATP Supply Improve in situ CO2 recycling by reductive TCA cycle in engineered Escherichia coli. 3 Biotech, 10.","DOI":"10.1007\/s13205-020-2116-7"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1146\/annurev-micro-090110-102801","article-title":"Alternative pathways of carbon dioxide fixation: Insights into the early evolution of life?","volume":"65","author":"Fuchs","year":"2011","journal-title":"Annu. Rev. Microbiol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"8466","DOI":"10.1128\/AEM.05702-11","article-title":"Carboxylases in Natural and Synthetic Microbial Pathways","volume":"77","year":"2011","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Zhang, Y., Su, M., Chen, Y., Wang, Z., Nielsen, J., and Liu, Z. (2023). Engineering yeast mitochondrial metabolism for 3-hydroxypropionate production. Biotechnol. Biofuels Bioprod., 16.","DOI":"10.1186\/s13068-023-02309-z"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Min, Z., Zhang, X., Wu, W., Xin, Y., Liu, M., Wang, K., Zhang, X., He, Y., Fan, C., and Wang, Z. (2022). Crystal Structure of an Intramolecular Mesaconyl-coenzyme A Transferase From the 3-Hydroxypropionic Acid Cycle of Roseiflexus castenholzii. Front. Microbiol., 13.","DOI":"10.3389\/fmicb.2022.923367"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1038\/s41929-019-0421-5","article-title":"Third-generation biorefineries as the means to produce fuels and chemicals from CO2","volume":"3","author":"Liu","year":"2020","journal-title":"Nat. Catal."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Liu, L., Schubert, D.M., K\u00f6nneke, M., and Berg, I.A. (2021). (S)-3-Hydroxybutyryl-COA Dehydrogenase From the Autotrophic 3-Hydroxypropionate\/4-Hydroxybutyrate Cycle in Nitrosopumilus maritimus. Front. Microbiol., 12.","DOI":"10.3389\/fmicb.2021.712030"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"eadh4299","DOI":"10.1126\/sciadv.adh4299","article-title":"Exploring alternative pathways for the in vitro establishment of the HOPAC cycle for synthetic CO2 fixation","volume":"9","author":"McLean","year":"2023","journal-title":"Sci. Adv."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"5812","DOI":"10.1038\/s41467-020-19564-5","article-title":"Awakening a latent carbon fixation cycle in Escherichia coli","volume":"11","author":"Satanowski","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1126\/science.abh4049","article-title":"Cell-free chemoenzymatic starch synthesis from carbon dioxide","volume":"373","author":"Cai","year":"2021","journal-title":"Science"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1021\/acscatal.1c04151","article-title":"A minimized synthetic carbon fixation cycle","volume":"12","author":"Xiao","year":"2021","journal-title":"ACS Catal."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"2772","DOI":"10.1038\/s41467-023-38490-w","article-title":"Turn air-captured CO2 with methanol into amino acid and pyruvate in an ATP\/NAD (P) H-free chemoenzymatic system","volume":"14","author":"Liu","year":"2023","journal-title":"Nat. Commun."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"8889","DOI":"10.1073\/pnas.0907176107","article-title":"Design and analysis of synthetic carbon fixation pathways","volume":"107","author":"Noor","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.greenca.2023.09.002","article-title":"Opportunities of CO2-based biorefineries for production of fuels and chemicals","volume":"1","author":"Liu","year":"2023","journal-title":"Green Carbon"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.copbio.2017.12.023","article-title":"Advances in metabolic engineering in the microbial production of fuels and chemicals from C1 gas","volume":"50","author":"Humphreys","year":"2018","journal-title":"Curr. Opin. Biotechnol."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Kato, Y., Inabe, K., Hidese, R., Kondo, A., and Hasunuma, T. (2022). Metabolomics-based engineering for biofuel and bio-based chemical production in microalgae and cyanobacteria: A review. Bioresour. Technol., 344.","DOI":"10.1016\/j.biortech.2021.126196"},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Farrokh, P., Sheikhpour, M., Kasaeian, A., Asadi, H., and Bavandi, R. (2019). Cyanobacteria as an eco-friendly resource for biofuel production: A critical review. Biotechnol. Prog., 35.","DOI":"10.1002\/btpr.2835"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1021\/acssynbio.5b00043","article-title":"Genome engineering in cyanobacteria: Where we are and where we need to go","volume":"4","author":"Ramey","year":"2015","journal-title":"ACS Synth. Biol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12934-018-0879-x","article-title":"The promising future of microalgae: Current status, challenges, and optimization of a sustainable and renewable industry for biofuels, feed, and other products","volume":"17","author":"Khan","year":"2018","journal-title":"Microb. Cell Factories"},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Gimpel, J.A., Henr\u00edquez, V., and Mayfield, S.P. (2015). In metabolic engineering of eukaryotic microalgae: Potential and challenges come with great diversity. Front. Microbiol., 6.","DOI":"10.3389\/fmicb.2015.01376"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1126\/science.aaf5039","article-title":"Water splitting\u2013biosynthetic system with CO2 reduction efficiencies exceeding photosynthesis","volume":"352","author":"Liu","year":"2016","journal-title":"Science"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1126\/science.1217643","article-title":"Integrated electromicrobial conversion of CO2 to higher alcohols","volume":"335","author":"Li","year":"2012","journal-title":"Science"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.ymben.2015.04.008","article-title":"Metabolic engineering in chemolithoautotrophic hosts for the production of fuels and chemicals","volume":"30","author":"Nybo","year":"2015","journal-title":"Metab. Eng."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s00253-012-4320-9","article-title":"Studies on the production of branched-chain alcohols in engineered Ralstonia eutropha","volume":"96","author":"Lu","year":"2012","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1475-2859-12-107","article-title":"Development of a broad-host synthetic biology toolbox for Ralstonia eutropha and its application to engineering hydrocarbon biofuel production","volume":"12","author":"Bi","year":"2013","journal-title":"Microb. Cell Factories"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1002\/bit.25703","article-title":"Engineering the iron-oxidizing chemolithoautotroph Acidithiobacillus ferrooxidans for biochemical production","volume":"113","author":"Kernan","year":"2016","journal-title":"Biotechnol. Bioeng."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Lee, H., Bae, J., Jin, S., Kang, S., and Cho, B.-K. (2022). Engineering Acetogenic Bacteria for Efficient One-Carbon Utilization. Front. Microbiol., 13.","DOI":"10.3389\/fmicb.2022.865168"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/s41587-021-01195-w","article-title":"Carbon-negative production of acetone and isopropanol by gas fermentation at industrial pilot scale","volume":"40","author":"Liew","year":"2022","journal-title":"Nat. Biotechnol."},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Yoon, J., and Oh, M.-K. (2022). Strategies for Biosynthesis of C1 Gas-derived Polyhydroxyalkanoates: A review. Bioresour. Technol., 344.","DOI":"10.1016\/j.biortech.2021.126307"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1016\/j.cell.2019.11.009","article-title":"Conversion of Escherichia coli to generate all biomass carbon from CO2","volume":"179","author":"Gleizer","year":"2019","journal-title":"Cell"},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Kim, S.R., Kim, S.-J., Kim, S.-K., Seo, S.-O., Park, S., Shin, J., Kim, J.-S., Park, B.-R., Jin, Y.-S., and Chang, P.-S. (2021). Yeast metabolic engineering for carbon dioxide fixation and its application. Bioresour. Technol., 346.","DOI":"10.1016\/j.biortech.2021.126349"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"3634","DOI":"10.1021\/acs.nanolett.5b01254","article-title":"Nanowire\u2013bacteria hybrids for unassisted solar carbon dioxide fixation to value-added chemicals","volume":"15","author":"Liu","year":"2015","journal-title":"Nano Lett."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"3773","DOI":"10.1073\/pnas.1516867113","article-title":"Integrated bioprocess for conversion of gaseous substrates to liquids","volume":"113","author":"Hu","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Meng, X., Liu, L., and Chen, X. (2022). Bacterial photosynthesis: State-of-the-art in light-driven carbon fixation in engineered bacteria. Curr. Opin. Microbiol., 69.","DOI":"10.1016\/j.mib.2022.102174"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1042\/EBC20160016","article-title":"Photosynthesis","volume":"60","author":"Johnson","year":"2016","journal-title":"Essays Biochem."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.ymben.2016.08.002","article-title":"Introducing extra NADPH consumption ability significantly increases the photosynthetic efficiency and biomass production of cyanobacteria","volume":"38","author":"Zhou","year":"2016","journal-title":"Metab. Eng."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1126\/science.aar8313","article-title":"Photochemistry beyond the red limit in chlorophyll f\u2013containing photosystems","volume":"360","author":"Morton","year":"2018","journal-title":"Science"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.copbio.2011.11.022","article-title":"Improving photosynthesis and metabolic networks for the competitive production of phototroph-derived biofuels","volume":"23","author":"Work","year":"2012","journal-title":"Curr. Opin. Biotechnol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1126\/science.aad3317","article-title":"Self-photosensitization of nonphotosynthetic bacteria for solar-to-chemical production","volume":"351","author":"Sakimoto","year":"2016","journal-title":"Science"},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Teng, Y., Xu, Y., Wang, X., and Christie, P. (2019). Function of biohydrogen metabolism and related microbial communities in environmental bioremediation. Front. Microbiol., 10.","DOI":"10.3389\/fmicb.2019.00106"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"4081","DOI":"10.1021\/cr4005814","article-title":"Hydrogenases","volume":"114","author":"Lubitz","year":"2014","journal-title":"Chem. Rev."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/bs.ampbs.2016.02.008","article-title":"The model [NiFe]-hydrogenases of Escherichia coli","volume":"68","author":"Sargent","year":"2016","journal-title":"Adv. Microb. Physiol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/s00203-016-1322-5","article-title":"Design and characterisation of synthetic operons for biohydrogen technology","volume":"199","author":"Lamont","year":"2017","journal-title":"Arch. Microbiol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/bs.ampbs.2016.02.002","article-title":"Mechanisms of bacterial extracellular electron exchange","volume":"68","author":"White","year":"2016","journal-title":"Adv. Microb. Physiol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1038\/nature16459","article-title":"Complete nitrification by a single microorganism","volume":"528","author":"Speth","year":"2015","journal-title":"Nature"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/nrmicro.2018.9","article-title":"The microbial nitrogen-cycling network","volume":"16","author":"Kuypers","year":"2018","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Wang, R., Lin, J.-Q., Liu, X.-M., Pang, X., Zhang, C.-J., Yang, C.-L., Gao, X.-Y., Lin, C.-M., Li, Y.-Q., and Li, Y. (2019). Sulfur oxidation in the acidophilic autotrophic Acidithiobacillus spp.. Front. Microbiol., 9.","DOI":"10.3389\/fmicb.2018.03290"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/bs.aambs.2016.09.004","article-title":"Microbial phosphite oxidation and its potential role in the global phosphorus and carbon cycles","volume":"98","author":"Figueroa","year":"2017","journal-title":"Adv. Appl. Microbiol."},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Butler, C.S., and Lovley, D.R. (2016). How to sustainably feed a microbe: Strategies for biological production of carbon-based commodities with renewable electricity. Front. Microbiol., 7.","DOI":"10.3389\/fmicb.2016.01879"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"12903","DOI":"10.1021\/acs.chemrev.0c00472","article-title":"Fundamentals, applications, and future directions of bioelectrocatalysis","volume":"120","author":"Chen","year":"2020","journal-title":"Chem. Rev."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.jpowsour.2017.04.024","article-title":"Biotransformation of carbon dioxide in bioelectrochemical systems: State of the art and future prospects","volume":"356","author":"Bajracharya","year":"2017","journal-title":"J. Power Sources"},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Liu, Z., Xue, X., Cai, W., Cui, K., Patil, S.A., and Guo, K. (2023). Recent progress on microbial electrosynthesis reactor designs and strategies to enhance the reactor performance. Biochem. Eng. J., 190.","DOI":"10.1016\/j.bej.2022.108745"},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Bhagchandanii, D.D., Babu, R.P., Sonawane, J.M., Khanna, N., Pandit, S., Jadhav, D.A., Khilari, S., and Prasad, R. (2020). A comprehensive understanding of electro-fermentation. Fermentation, 6.","DOI":"10.3390\/fermentation6030092"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.pecs.2017.07.003","article-title":"Microbial electrolysis cell platform for simultaneous waste biorefinery and clean electrofuels generation: Current situation, challenges and future perspectives","volume":"63","author":"Zhen","year":"2017","journal-title":"Prog. Energy Combust. Sci."},{"key":"ref_98","first-page":"484","article-title":"Value added product recovery and carbon dioxide sequestration from biogas using microbial electrosynthesis","volume":"56","author":"Das","year":"2018","journal-title":"Indian J. Exp. Biol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1021\/es303837j","article-title":"Sulfide-driven microbial electrosynthesis","volume":"47","author":"Gong","year":"2013","journal-title":"Environ. Sci. Technol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1128\/AEM.02891-12","article-title":"A genetic system for Clostridium ljungdahlii: A chassis for autotrophic production of biocommodities and a model homoacetogen","volume":"79","author":"Leang","year":"2013","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1039\/C7RE00220C","article-title":"Impact of dissolved carbon dioxide concentration on the process parameters during its conversion to acetate through microbial electrosynthesis","volume":"3","author":"Mohanakrishna","year":"2018","journal-title":"React. Chem. Eng."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40643-018-0195-7","article-title":"Microbial electrosynthesis of organic chemicals from CO2 by Clostridium scatologenes ATCC 25775 T","volume":"5","author":"Liu","year":"2018","journal-title":"Bioresour. Bioprocess."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.bioelechem.2016.09.001","article-title":"Long-term operation of microbial electrosynthesis cell reducing CO2 to multi-carbon chemicals with a mixed culture avoiding methanogenesis","volume":"113","author":"Bajracharya","year":"2017","journal-title":"Bioelectrochemistry"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1021\/acs.estlett.5b00212","article-title":"Integrated Production, Extraction, and concentration of Acetic Acid from CO2 through Microbial Electrosynthesis","volume":"2","author":"Gildemyn","year":"2015","journal-title":"Environ. Sci. Technol. Lett."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"4058","DOI":"10.1039\/C8GC01771A","article-title":"Bio-electrorecycling of carbon dioxide into bioplastics","volume":"20","author":"Sciarria","year":"2018","journal-title":"Green Chem."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3389\/fenrg.2018.00007","article-title":"Critical biofilm growth throughout unmodified carbon felts allows continuous bioelectrochemical chain elongation from CO2 up to caproate at high current density","volume":"6","author":"Jourdin","year":"2018","journal-title":"Front. Energy Res."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.bioelechem.2017.06.004","article-title":"Microbial electrosynthesis of butyrate from carbon dioxide: Production and extraction","volume":"117","author":"Ganigue","year":"2017","journal-title":"Bioelectrochemistry"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.eng.2021.03.025","article-title":"Microbial Electrosynthesis for Producing Medium Chain Fatty Acids","volume":"16","author":"Chu","year":"2022","journal-title":"Engineering"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.bioelechem.2017.05.001","article-title":"Thermophilic Moorella thermoautotrophica-immobilized cathode enhanced microbial electrosynthesis of acetate and formate from CO2","volume":"117","author":"Yu","year":"2017","journal-title":"Bioelectrochemistry"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"55","DOI":"10.3389\/fenrg.2018.00055","article-title":"Sulfate-reducing electroautotrophs and their applications in bioelectrochemical systems","volume":"6","author":"Agostino","year":"2018","journal-title":"Front. Energy Res."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1038\/ismej.2016.149","article-title":"Enhanced microbial electrosynthesis by using defined co-cultures","volume":"11","author":"Deutzmann","year":"2017","journal-title":"ISME J."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.watres.2019.04.053","article-title":"Zinc: A promising material for electrocatalyst-assisted microbial electrosynthesis of carboxylic acids from carbon dioxide","volume":"159","author":"Jiang","year":"2019","journal-title":"Water Res."},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Lee, S.Y., Oh, Y.-K., Lee, S., Fitriana, H.N., Moon, M., Kim, M.-S., Lee, J., Min, K., Park, G.W., and Lee, J.-P. (2021). Recent developments and key barriers to microbial CO2 electrobiorefinery. Bioresour. Technol., 320.","DOI":"10.1016\/j.biortech.2020.124350"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1007\/s10295-019-02166-6","article-title":"Microbial electron uptake in microbial electrosynthesis: A mini-review","volume":"46","author":"Karthikeyan","year":"2019","journal-title":"J. Ind. Microbiol. Biotechnol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.copbio.2019.07.003","article-title":"Mixed carbon substrates: A necessary nuisance or a missed opportunity","volume":"62","author":"Liu","year":"2020","journal-title":"Curr. Opin. Biotechnol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"2423","DOI":"10.1039\/C2CS35360A","article-title":"Catalysis of the electrochemical reduction of carbon dioxide","volume":"42","author":"Costentin","year":"2013","journal-title":"Chem. Soc. Rev."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"101177","DOI":"10.1016\/j.coelec.2022.101177","article-title":"Towards carbon neutral chemicals production: Opportunities for combining fermentation with electrochemical processes","volume":"37","author":"Wood","year":"2023","journal-title":"Curr. Opin. Electrochem."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.copbio.2019.10.002","article-title":"Renewable methanol and formate as microbial feedstocks","volume":"62","author":"Cotton","year":"2020","journal-title":"Curr. Opin. Biotechnol."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.jechem.2020.01.023","article-title":"Current technology development for CO2 utilization into solar fuels and chemicals: A review","volume":"49","author":"Mustafa","year":"2020","journal-title":"J. Energy Chem."},{"key":"ref_120","doi-asserted-by":"crossref","unstructured":"Rayne, S. (2008). Thermal Carbon Dioxide Splitting: A Summary of the Peer-Reviewed Scientific Literature. Nat. Preced.","DOI":"10.1038\/npre.2008.1741.2"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"128138","DOI":"10.1016\/j.cej.2020.128138","article-title":"Transformation technologies for CO2 utilisation: Current status, challenges and future prospects","volume":"409","author":"Kamkeng","year":"2021","journal-title":"Chem. Eng. J."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"131325","DOI":"10.1016\/j.cej.2021.131325","article-title":"Valorization of C1 gases to value-added chemicals using acetogenic biocatalysts","volume":"428","author":"Bae","year":"2022","journal-title":"Chem. Eng. J."},{"key":"ref_123","doi-asserted-by":"crossref","unstructured":"Liew, F., Martin, M.E., Tappel, R.C., Heijstra, B.D., Mihalcea, C., and K\u00f6pke, M. (2016). Gas Fermentation\u2014A Flexible Platform for commercial Scale Production of Low-Carbon-Fuels and Chemicals from Waste and Renewable Feedstocks. Front. Microbiol., 7.","DOI":"10.3389\/fmicb.2016.00694"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.coelec.2020.05.004","article-title":"Co-electrolysis of CO2 and H2O: From electrode reactions to cell-level development","volume":"23","author":"Herranz","year":"2020","journal-title":"Curr. Opin. Electrochem."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/nrmicro1595","article-title":"Distribution, diversity and ecology of aerobic co-oxidizing bacteria","volume":"5","author":"King","year":"2007","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"4149","DOI":"10.1021\/cr400461p","article-title":"Structure, Function, and Mechanism of the Nickel Metalloenzymes, Co Dehydrogenase, and Acetyl-COA Synthase","volume":"114","author":"Can","year":"2014","journal-title":"Chem. Rev."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s00203-008-0382-6","article-title":"Carbon monoxide-dependent energy metabolism in anaerobic bacteria and archaea","volume":"190","author":"Oelgeschlager","year":"2008","journal-title":"Arch Microbiol"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1111\/1751-7915.13270","article-title":"Using gas mixtures of CO, CO2 and H2 as microbial substrates: The do\u2019s and don\u2019ts of successful technology transfer from laboratory to production scale","volume":"11","author":"Takors","year":"2018","journal-title":"Microb. Biotechnol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.ymben.2019.07.006","article-title":"Exploiting Hydrogenophaga pseudoflava for aerobic syngas-based production of chemicals","volume":"55","author":"Grenz","year":"2019","journal-title":"Metab. Eng."},{"key":"ref_130","doi-asserted-by":"crossref","unstructured":"Diender, M., Stams, A.J., and Sousa, D.Z. (2015). Pathways and Bioenergetics of Anaerobic Carbon Monoxide Fermentation. Front. Microbiol., 6.","DOI":"10.3389\/fmicb.2015.01275"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1073\/pnas.86.1.32","article-title":"Cloning and expression of the gene cluster encoding key proteins involved in acetyl-COA synthesis in Clostridium thermoaceticum: Co dehydrogenase, the corrinoid\/Fe-S protein, and methyltransferase","volume":"86","author":"Roberts","year":"1989","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_132","first-page":"e02307","article-title":"Functional Expression of the Clostridium ljungdahlii Acetyl-coenzyme A Synthase in Clostridium acetobutylicum as Demonstrated by a Novel In Vivo CO Exchange Activity En Route to Heterologous Installation of a Functional Wood-Ljungdahl Pathway","volume":"84","year":"2018","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Kang, H., Park, B., Oh, S., Pathiraja, D., Kim, J.-Y., Jung, S., Jeong, J., Cha, M., Park, Z.-Y., and Choi, I.-G. (2021). Metabolism perturbation Causedby the overexpression of carbon monoxide dehydrogenase\/Acetyl-COA synthase gene complex accelerated gas to acetate conversion rate of Eubacterium limosumKIST612. Bioresour. Technol., 341.","DOI":"10.1016\/j.biortech.2021.125879"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"137678","DOI":"10.1016\/j.cej.2022.137678","article-title":"Development of CO gas conversion system using high CO tolerance biocatalyst","volume":"449","author":"Jin","year":"2022","journal-title":"Chem. Eng. J."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.renene.2011.09.006","article-title":"Sources and mitigation of methane emissions by sectors: A critical review","volume":"39","author":"Karakurt","year":"2012","journal-title":"Renew. Energy"},{"key":"ref_136","unstructured":"Krupp, F. (2023, November 23). Reducing Methane Will Help Hit the Brakes on Runaway Global Warming. Available online: https:\/\/www.edf.org\/blog\/2022\/05\/16\/reducing-methane-will-help-hit-brakes-runaway-global-warming."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1111\/j.1574-6976.2010.00212.x","article-title":"Methanotrophs and copper","volume":"34","author":"Semrau","year":"2010","journal-title":"FEMS Microbiol. Rev."},{"key":"ref_138","doi-asserted-by":"crossref","unstructured":"Sahoo, K.K., Goswami, G., and Das, D. (2021). Biotransformation of Methane and Carbon Dioxide Into High-Value Products by Methanotrophs: Current State of Art and Future Prospects. Front. Microbiol., 12.","DOI":"10.3389\/fmicb.2021.636486"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s10163-018-00826-w","article-title":"Application and development of methanotrophs in environmental engineering","volume":"21","author":"Park","year":"2019","journal-title":"J. Mater. Cycles Waste Manag."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1016\/j.biotechadv.2014.09.004","article-title":"Biological conversion of methane to liquid fuels: Status and opportunities","volume":"32","author":"Ge","year":"2014","journal-title":"Biotechnol. Adv."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/35036572","article-title":"A marine microbial consortium apparently mediating anaerobic oxidation of methane","volume":"407","author":"Boetius","year":"2000","journal-title":"Nature"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1126\/science.1169984","article-title":"Manganese-and iron-dependent marine methane oxidation","volume":"325","author":"Beal","year":"2009","journal-title":"Science"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1038\/nature12375","article-title":"Anaerobic oxidation of methane coupled to nitrate reduction in a novel archaeal lineage","volume":"500","author":"Haroon","year":"2013","journal-title":"Nature"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1038\/nature08883","article-title":"Nitrite-driven anaerobic methane oxidation by oxygenic bacteria","volume":"464","author":"Ettwig","year":"2010","journal-title":"Nature"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1002\/bbb.1678","article-title":"Metabolic engineering of methanotrophs and its application to production of chemicals and biofuels from methane","volume":"10","author":"Lee","year":"2016","journal-title":"Biofuels Bioprod. Biorefining"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"3071","DOI":"10.1007\/s00253-018-8842-7","article-title":"Biological conversion of methane to chemicals and fuels: Technical challenges and issues","volume":"102","author":"Hwang","year":"2018","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.copbio.2015.03.008","article-title":"C1-carbon sources for chemical and fuel production by microbial gas fermentation","volume":"35","author":"Eikmanns","year":"2015","journal-title":"Curr. Opin. Biotechnol."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.tibtech.2020.07.007","article-title":"Engineered Methanotrophy: A Sustainable Solution for Methane-Based Industrial Biomanufacturing","volume":"39","author":"Nguyen","year":"2021","journal-title":"Trends Biotechnol."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"2720","DOI":"10.1002\/anie.201006587","article-title":"Tuning a P450 Enzyme for Methane Oxidation","volume":"50","author":"Zilly","year":"2011","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1002\/cbic.200500261","article-title":"Direct conversion of Ethane to Ethanol by Engineered Cytochrome P450 BM3","volume":"6","author":"Meinhold","year":"2005","journal-title":"ChemBioChem"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/nature08992","article-title":"Oxidation of methane by a biological dicopper centre","volume":"465","author":"Balasubramanian","year":"2010","journal-title":"Nature"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1038\/s41929-019-0255-1","article-title":"Biological conversion of methane to methanol through genetic reassembly of native catalytic domains","volume":"2","author":"Kim","year":"2019","journal-title":"Nat. Catal."},{"key":"ref_153","doi-asserted-by":"crossref","unstructured":"Bennett, R.K., Nyaradzo, D., Michael, D., Stephanie, J., Kelley, H., Baolong, Z., Noah, H., Derek, G., Elizabeth, C., and Eleftherios, T.P. (2021). Expression of soluble methane monooxygenase in Escherichia coli enables methane conversion. bioRxiv, 2021.2008.2005.455234.","DOI":"10.1101\/2021.08.05.455234"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.3934\/energy.2018.6.1074","article-title":"Methanol-Managing greenhouse gas emissions in the production chain by optimizing the resource base","volume":"6","author":"Raili","year":"2018","journal-title":"AIMS Energy"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1002\/cssc.201501013","article-title":"Research Progress on the Indirect Hydrogenation of Carbon Dioxide to Methanol","volume":"9","author":"Du","year":"2016","journal-title":"ChemSusChem"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.copbio.2015.01.007","article-title":"Synthetic methylotrophy: Engineering the production of biofuels and chemicals based on the biology of aerobic methanol utilization","volume":"33","author":"Whitaker","year":"2015","journal-title":"Curr. Opin. Biotechnol."},{"key":"ref_157","doi-asserted-by":"crossref","unstructured":"Chen, A.Y., and Lan, E.I. (2020). Chemical Production from Methanol Using Natural and Synthetic Methylotrophs. Biotechnol. J., 15.","DOI":"10.1002\/biot.201900356"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1002\/bbb.1773","article-title":"Methanol as carbon substrate in the bio-economy: Metabolic engineering of aerobic methylotrophic bacteria for production of value-added chemicals","volume":"11","author":"Pfeifenschneider","year":"2017","journal-title":"Biofuels Bioprod. Biorefining"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.copbio.2019.07.001","article-title":"Synthetic methylotrophy: Strategies to assimilate methanol for growth and chemicals production","volume":"59","author":"Antoniewicz","year":"2019","journal-title":"Curr. Opin. Biotechnol."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"197","DOI":"10.21775\/cimb.033.197","article-title":"Methylotrophic yeasts: Current understanding of their C1-metabolism and its regulation by sensing methanol for survival on plant leaves","volume":"33","author":"Yurimoto","year":"2019","journal-title":"Curr. Issues Mol. Biol."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1016\/j.tibtech.2016.04.010","article-title":"Metabolic Engineering for Expanding the Substrate Range of Yarrowia lipolytica","volume":"34","author":"Nicaud","year":"2016","journal-title":"Trends Biotechnol."},{"key":"ref_162","doi-asserted-by":"crossref","unstructured":"Lv, X., Yu, W., Zhang, C., Ning, P., Li, J., Liu, Y., Du, G., and Liu, L. (2023). C1-based biomanufacturing: Advances, challenges and perspectives. Bioresour. Technol., 367.","DOI":"10.1016\/j.biortech.2022.128259"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"3655","DOI":"10.1002\/bit.27862","article-title":"Strategies and challenges with the microbial conversion of methanol to high-value chemicals","volume":"118","author":"Zhan","year":"2021","journal-title":"Biotechnol. Bioeng."},{"key":"ref_164","doi-asserted-by":"crossref","unstructured":"Kremp, F., and M\u00fcller, V. (2021). Methanol and methyl group conversion in acetogenic bacteria: Biochemistry, physiology and application. FEMS Microbiol. Rev., 45.","DOI":"10.1093\/femsre\/fuaa040"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.ymben.2021.09.005","article-title":"Recent advances toward the bioconversion of methane and methanol in synthetic methylotrophs","volume":"71","author":"Gregory","year":"2022","journal-title":"Metab. Eng."},{"key":"ref_166","unstructured":"Song, Y., Bae, J., Shin, J., Jin, S., Kang, S., Lee, H., Cho, S., and Cho, B.-K. (2022). One-Carbon Feedstocks for Sustainable Bioproduction, Springer."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.copbio.2017.11.010","article-title":"Engineering the bioconversion of methane and methanol to fuels and chemicals in native and synthetic methylotrophs","volume":"50","author":"Bennett","year":"2018","journal-title":"Curr. Opin. Biotechnol."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.gce.2022.10.005","article-title":"Engineering the native methylotrophs for the bioconversion of methanol to value-added chemicals: Current status and future perspectives","volume":"4","author":"Wang","year":"2023","journal-title":"Green Chem. Eng."},{"key":"ref_169","doi-asserted-by":"crossref","unstructured":"Schultenk\u00e4mper, K., G\u00fctle, D.D., L\u00f3pez, M.G., Keller, L.B., Zhang, L., Einsle, O., Jacquot, J.-P., and Wendisch, V.F. (2021). Interrogating the Role of the Two Distinct Fructose-Bisphosphate Aldolases of Bacillus methanolicus by Site-Directed Mutagenesis of Key Amino Acids and Gene Repression by CRISPR Interference. Front. Microbiol., 12.","DOI":"10.3389\/fmicb.2021.669220"},{"key":"ref_170","doi-asserted-by":"crossref","unstructured":"Lim, C.K., Villada, J.C., Chalifour, A., Duran, M.F., Lu, H., and Lee, P.K. (2019). Designing and engineering Methylorubrum extorquens AM1 for itaconic acid production. Front. Microbiol., 10.","DOI":"10.3389\/fmicb.2019.01027"},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"e2201711119","DOI":"10.1073\/pnas.2201711119","article-title":"Methanol biotransformation toward high-level production of fatty acid derivatives by engineering the industrial yeast Pichia pastoris","volume":"119","author":"Cai","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1038\/s42255-022-00601-0","article-title":"Rescuing yeast from cell death enables overproduction of fatty acids from sole methanol","volume":"4","author":"Gao","year":"2022","journal-title":"Nat. Metab."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.jbiotec.2021.12.005","article-title":"Constructing a methanol-dependent Bacillus subtilis by engineering the methanol metabolism","volume":"343","author":"Gao","year":"2022","journal-title":"J. Biotechnol."},{"key":"ref_174","doi-asserted-by":"crossref","unstructured":"Zhu, T., Zhao, T., Bankefa, O.E., and Li, Y. (2020). Engineering unnatural methylotrophic cell factories for methanol-based biomanufacturing: Challenges and opportunities. Biotechnol. Adv., 39.","DOI":"10.1016\/j.biotechadv.2019.107467"},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.copbio.2021.12.001","article-title":"Synthetic or natural? Metabolic engineering for assimilation and valorization of methanol","volume":"74","author":"Sanford","year":"2022","journal-title":"Curr. Opin. Biotechnol."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ymben.2019.10.004","article-title":"Genome-scale evaluation of core one-carbon metabolism in gammaproteobacterial methanotrophs grown on methane and methanol","volume":"57","author":"Nguyen","year":"2020","journal-title":"Metab. Eng."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.ymben.2014.12.008","article-title":"Engineering Escherichia coli for methanol conversion","volume":"28","author":"Meyer","year":"2015","journal-title":"Metab. Eng."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"12691","DOI":"10.1073\/pnas.1601797113","article-title":"Scaffoldless engineered enzyme assembly for enhanced methanol utilization","volume":"113","author":"Price","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1038\/s41467-018-04795-4","article-title":"Improving formaldehyde consumption drives methanol assimilation in engineered E. coli","volume":"9","author":"Woolston","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1038\/s41467-018-03937-y","article-title":"Methanol-essential growth of Escherichia coli","volume":"9","author":"Meyer","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"5564","DOI":"10.1038\/s41467-020-19390-9","article-title":"Adaptive laboratory evolution of native methanol assimilation in Saccharomyces cerevisiae","volume":"11","author":"Espinosa","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"3537","DOI":"10.1021\/acssynbio.1c00464","article-title":"Engineering Yeast Yarrowia lipolytica for Methanol Assimilation","volume":"10","author":"Wang","year":"2021","journal-title":"ACS Synth. Biol."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1038\/s41589-021-00836-0","article-title":"Metabolic engineering strategies to enable microbial utilization of C1 feedstocks","volume":"17","author":"Jiang","year":"2021","journal-title":"Nat. Chem. Biol."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cbpa.2016.07.005","article-title":"The formate bio-economy","volume":"35","author":"Yishai","year":"2016","journal-title":"Curr. Opin. Chem. Biol."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/j.bbabio.2012.10.013","article-title":"Design and analysis of metabolic pathways supporting formatotrophic growth for electricity-dependent cultivation of microbes","volume":"1827","author":"Noor","year":"2013","journal-title":"Biochim. Biophys. Acta (BBA)-Bioenerg."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1016\/j.bbabio.2012.05.002","article-title":"Thermodynamic constraints shape the structure of carbon fixation pathways","volume":"1817","author":"Flamholz","year":"2012","journal-title":"Biochim. Et Biophys. Acta (BBA)-Bioenerg."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1111\/1751-7915.12149","article-title":"Kinetic and stoichiometric characterization of organoautotrophic growth of Ralstonia eutropha on formic acid in fed-batch and continuous cultures","volume":"8","author":"Grunwald","year":"2015","journal-title":"Microb. Biotechnol."},{"key":"ref_188","doi-asserted-by":"crossref","unstructured":"Qiao, W., Xu, S., Liu, Z., Fu, X., Zhao, H., and Shi, S. (2022). Challenges and opportunities in C1-based biomanufacturing. Bioresour. Technol., 364.","DOI":"10.1016\/j.biortech.2022.128095"},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"237","DOI":"10.21775\/cimb.033.237","article-title":"Synthetic Methanol and Formate Assimilation Via Modular Engineering and Selection Strategies","volume":"33","author":"Claassens","year":"2019","journal-title":"Curr. Issues Mol. Biol."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"3851","DOI":"10.1021\/acs.biochem.6b00495","article-title":"Formate Assimilation: The Metabolic Architecture of Natural and Synthetic Pathways","volume":"55","year":"2016","journal-title":"Biochemistry"},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.tibtech.2021.02.005","article-title":"Reductive Glycine Pathway: A Versatile Route for One-Carbon Biotech","volume":"39","author":"Claassens","year":"2021","journal-title":"Trends Biotechnol."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.ymben.2020.08.004","article-title":"Replacing the Calvin cycle with the reductive glycine pathway in Cupriavidus necator","volume":"62","author":"Claassens","year":"2020","journal-title":"Metab. Eng."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"5090","DOI":"10.1038\/s41467-020-18906-7","article-title":"The reductive glycine pathway allows autotrophic growth of Desulfovibrio desulfuricans","volume":"11","author":"Guedes","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1002\/bit.27658","article-title":"Introduction of glycine synthase enables uptake of exogenous formate and strongly impacts the metabolism in Clostridium pasteurianum","volume":"118","author":"Hong","year":"2021","journal-title":"Biotechnol. Bioeng."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1021\/acssynbio.7b00086","article-title":"Engineered assimilation of exogenous and endogenous formate in Escherichia coli","volume":"6","author":"Yishai","year":"2017","journal-title":"ACS Synth. Biol."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1021\/acssynbio.8b00131","article-title":"In vivo assimilation of one-carbon via a synthetic reductive glycine pathway in Escherichia coli","volume":"7","author":"Yishai","year":"2018","journal-title":"ACS Synth. Biol."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"E9271","DOI":"10.1073\/pnas.1810386115","article-title":"Assimilation of formic acid and CO2 by engineered Escherichia coli equipped with reconstructed one-carbon assimilation pathways","volume":"115","author":"Bang","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1038\/s41564-020-00793-9","article-title":"Escherichia coli is engineered to grow on CO2 and formic acid","volume":"5","author":"Bang","year":"2020","journal-title":"Nat. Microbiol."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.ymben.2018.03.015","article-title":"Electrical-biological hybrid system for CO2 reduction","volume":"47","author":"Tashiro","year":"2018","journal-title":"Metab. Eng."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1038\/s41589-020-0473-5","article-title":"Growth of E. coli on formate and methanol via the reductive glycine pathway","volume":"16","author":"Kim","year":"2020","journal-title":"Nat. Chem. Biol."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1021\/acssynbio.8b00464","article-title":"core Catalysis of the Reductive Glycine Pathway Demonstrated in Yeast","volume":"8","author":"Machens","year":"2019","journal-title":"ACS Synth. Biol."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.ymben.2021.09.004","article-title":"A quantitative metabolic analysis reveals Acetobacterium woodii as a flexible and robust host for formate-based bioproduction","volume":"68","author":"Neuendorf","year":"2021","journal-title":"Metab. Eng."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"4214","DOI":"10.1111\/1462-2920.15598","article-title":"Formate metabolism in the acetogenic bacterium Acetobacterium woodii","volume":"23","author":"Moon","year":"2021","journal-title":"Environ. Microbiol."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1111\/1751-7915.13963","article-title":"High methanol-to-formate ratios induce butanol production in Eubacterium limosum","volume":"15","author":"Wood","year":"2022","journal-title":"Microb. Biotechnol."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/0006-291X(75)90856-6","article-title":"Formate as an inhibitor of cytochrome c oxidase","volume":"67","author":"Nicholls","year":"1975","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/1475-2859-4-25","article-title":"Organic acid toxicity, tolerance, and production in Escherichia coli biorefining applications","volume":"4","author":"Warnecke","year":"2005","journal-title":"Microb. Cell Factories"},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1002\/yea.856","article-title":"Functional analysis of structural genes for NAD+-dependent formate dehydrogenase in Saccharomyces cerevisiae","volume":"19","author":"Overkamp","year":"2002","journal-title":"Yeast"},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"2686","DOI":"10.1111\/1751-7915.13779","article-title":"Butyrate production in the acetogen Eubacterium limosum is dependent on the carbon and energy source","volume":"14","author":"Litty","year":"2021","journal-title":"Microb. Biotechnol."},{"key":"ref_209","doi-asserted-by":"crossref","unstructured":"Du, C., Li, Y., Xiang, R., and Yuan, W. (2022). Formate dehydrogenase improves the resistance to formic acid and acetic acid simultaneously in Saccharomyces cerevisiae. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23063406"},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1002\/elsc.200900027","article-title":"The Auxiliary Substrate concept: From simple considerations to heuristically valuable knowledge","volume":"9","author":"Babel","year":"2009","journal-title":"Eng. Life Sci."},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1016\/j.cell.2016.02.004","article-title":"Engineering Cellular Metabolism","volume":"164","author":"Nielsen","year":"2016","journal-title":"Cell"},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"3998","DOI":"10.1021\/acs.jafc.8b00458","article-title":"Rediscovering Acetate Metabolism: Its Potential Sources and Utilization for Biobased Transformation into Value-Added Chemicals","volume":"66","author":"Lim","year":"2018","journal-title":"J. Agric. Food Chem."},{"key":"ref_213","doi-asserted-by":"crossref","unstructured":"Kim, Y., Lama, S., Agrawal, D., Kumar, V., and Park, S. (2021). Acetate as a potential feedstock for the production of value-added chemicals: Metabolism and applications. Biotechnol. Adv., 49.","DOI":"10.1016\/j.biotechadv.2021.107736"},{"key":"ref_214","doi-asserted-by":"crossref","unstructured":"Mutyala, S., and Kim, J.R. (2022). Recent advances and challenges in the bioconversion of acetate to value-added chemicals. Bioresour. Technol., 364.","DOI":"10.1016\/j.biortech.2022.128064"},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.biortech.2018.03.064","article-title":"Strategies for enhancing microbial tolerance to inhibitors for biofuel production: A review","volume":"258","author":"Wang","year":"2018","journal-title":"Bioresour. Technol."},{"key":"ref_216","doi-asserted-by":"crossref","unstructured":"Kutscha, R., and Pflugl, S. (2020). Microbial Upgrading of Acetate into Value-Added Products-Examining Microbial Diversity, Bioenergetic constraints and Metabolic Engineering Approaches. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21228777"},{"key":"ref_217","doi-asserted-by":"crossref","unstructured":"Zhou, S., Lama, S., Jiang, J., Sankaranarayanan, M., and Park, S. (2020). Use of acetate for the production of 3-hydroxypropionic acid by metabolically-engineered Pseudomonas denitrificans. Bioresour. Technol., 307.","DOI":"10.1016\/j.biortech.2020.123194"},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.ymben.2020.09.005","article-title":"Adaptive laboratory evolution of Escherichia coli lacking cellular byproduct formation for enhanced acetate utilization through compensatory ATP consumption","volume":"62","author":"Seong","year":"2020","journal-title":"Metab. Eng."},{"key":"ref_219","doi-asserted-by":"crossref","unstructured":"Gong, G., Wu, B., Liu, L., Li, J., Zhu, Q., He, M., and Hu, G. (2022). Metabolic engineering using acetate as a promising building block for the production of bio-based chemicals. Eng. Microbiol., 2.","DOI":"10.1016\/j.engmic.2022.100036"},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.ymben.2018.02.008","article-title":"Balancing the carbon flux distributions between the TCA cycle and glyoxylate shunt to produce glycolate at high yield and titer in Escherichia coli","volume":"46","author":"Deng","year":"2018","journal-title":"Metab. Eng."},{"key":"ref_221","doi-asserted-by":"crossref","unstructured":"Lama, S., Kim, Y., Nguyen, D.T., Im, C.H., Sankaranarayanan, M., and Park, S. (2021). Production of 3-hydroxypropionic acid from acetate using metabolically-engineered and glucose-grown Escherichia coli. Bioresour. Technol., 320.","DOI":"10.1016\/j.biortech.2020.124362"},{"key":"ref_222","doi-asserted-by":"crossref","unstructured":"Chang, Z., Dai, W., Mao, Y., Cui, Z., Zhang, Z., Wang, Z., Ma, H., and Chen, T. (2022). Enhanced 3-hydroxypropionic acid production from acetate via the malonyl-COA pathway in corynebacterium glutamicum. Front. Bioeng. Biotechnol., 9.","DOI":"10.3389\/fbioe.2021.808258"},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1007\/s10295-019-02159-5","article-title":"Production of medium chain length polyhydroxyalkanoate from acetate by engineered Pseudomonas putida KT2440","volume":"46","author":"Yang","year":"2019","journal-title":"J. Ind. Microbiol. Biotechnol."},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"2580","DOI":"10.1038\/ncomms3580","article-title":"Enhanced biofuel production through coupled acetic acid and xylose Consumption by engineered yeast","volume":"4","author":"Wei","year":"2013","journal-title":"Nat. Commun."},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.biortech.2017.09.096","article-title":"Enhancement of extracellular lipid production by oleaginous yeast through preculture and sequencing batch culture strategy with acetic acid","volume":"247","author":"Huang","year":"2018","journal-title":"Bioresour. Technol."},{"key":"ref_226","doi-asserted-by":"crossref","unstructured":"Gong, G., Zhang, X., and Tan, T. (2020). Simultaneously enhanced intracellular lipogenesis and \u03b2-carotene biosynthesis of Rhodotorula glutinis by light exposure with sodium acetate as the substrate. Bioresour. Technol., 295.","DOI":"10.1016\/j.biortech.2019.122274"},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"3129","DOI":"10.1021\/acssynbio.1c00405","article-title":"Increased lipid production in Yarrowia lipolytica from acetate through metabolic engineering and cosubstrate fermentation","volume":"10","author":"Chen","year":"2021","journal-title":"ACS Synth. Biol."},{"key":"ref_228","first-page":"1","article-title":"Acetate as substrate for l-malic acid production with Aspergillus oryzae DSM 1863","volume":"14","author":"Umpfenbach","year":"2021","journal-title":"Biotechnol. Biofuels"},{"key":"ref_229","doi-asserted-by":"crossref","unstructured":"Sun, S., Ding, Y., Liu, M., Xian, M., and Zhao, G. (2020). Comparison of glucose, acetate and ethanol as carbon resource for production of poly (3-hydroxybutyrate) and other acetyl-COA derivatives. Front. Bioeng. Biotechnol., 8.","DOI":"10.3389\/fbioe.2020.00833"},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12934-019-1106-0","article-title":"Precise tuning of the glyoxylate cycle in Escherichia coli for efficient tyrosine production from acetate","volume":"18","author":"Jo","year":"2019","journal-title":"Microb. Cell Factories"},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"E5308","DOI":"10.1073\/pnas.1703321114","article-title":"Application of metabolic controls for the maximization of lipid production in semicontinuous fermentation","volume":"114","author":"Xu","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"7488","DOI":"10.1038\/ncomms8488","article-title":"Two-dimensional isobutyl acetate production pathways to improve carbon yield","volume":"6","author":"Tashiro","year":"2015","journal-title":"Nat. Commun."},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12934-016-0475-x","article-title":"Engineering Escherichia coli to convert acetic acid to \u03b2-caryophyllene","volume":"15","author":"Yang","year":"2016","journal-title":"Microb. Cell Factories"},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"eabf7613","DOI":"10.1126\/sciadv.abf7613","article-title":"Engineered yeast tolerance enables efficient production from toxified lignocellulosic feedstocks","volume":"7","author":"Lam","year":"2021","journal-title":"Sci. Adv."},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.tibtech.2006.10.004","article-title":"Bio-ethanol\u2013the fuel of tomorrow from the residues of today","volume":"24","author":"Galbe","year":"2006","journal-title":"Trends Biotechnol."},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.ymben.2020.11.010","article-title":"Constructing an ethanol utilization pathway in Escherichia coli to produce acetyl-COA derived compounds","volume":"65","author":"Liang","year":"2021","journal-title":"Metab. Eng."},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.ymben.2019.05.001","article-title":"Engineered ethanol-driven biosynthetic system for improving production of acetyl-COA derived drugs in Crabtree-negative yeast","volume":"54","author":"Liu","year":"2019","journal-title":"Metab. Eng."},{"key":"ref_238","doi-asserted-by":"crossref","unstructured":"Cao, Y., Mu, H., Guo, J., Liu, H., Zhang, R., Liu, W., Xian, M., and Liu, H. (2020). Metabolic engineering of Escherichia coli for the utilization of ethanol. J. Biol. Res., 27.","DOI":"10.1186\/s40709-020-0111-0"},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"E111","DOI":"10.1073\/pnas.1110740109","article-title":"Production of amorphadiene in yeast, and its conversion to dihydroartemisinic acid, precursor to the antimalarial agent artemisinin","volume":"109","author":"Westfall","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0079-6603(01)69047-0","article-title":"Ethanol catabolism in Aspergillus nidulans: A model system for studying gene regulation","volume":"69","author":"Felenbok","year":"2001","journal-title":"Prog. Nucleic Acid. Res. Mol. Biol."},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1111\/1751-7915.14172","article-title":"Leveraging substrate flexibility and product selectivity of acetogens in two-stage systems for chemical production","volume":"16","author":"Ricci","year":"2023","journal-title":"Microb. Biotechnol."},{"key":"ref_242","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.egypro.2013.07.068","article-title":"Influence of the biomass gasification processes on the final composition of syngas","volume":"36","author":"Couto","year":"2013","journal-title":"Energy Procedia"},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.jechem.2015.11.005","article-title":"Biomass gasification technology: The state of the art overview","volume":"25","author":"Molino","year":"2016","journal-title":"J. Energy Chem."},{"key":"ref_244","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1016\/j.rser.2015.09.030","article-title":"Assessing the gasification performance of biomass: A review on biomass gasification process conditions, optimization and economic evaluation","volume":"53","author":"Ahmad","year":"2016","journal-title":"Renew. Sustain. Energy Rev."},{"key":"ref_245","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1002\/ep.11613","article-title":"Fuel and chemical products from biomass syngas: A comparison of gas fermentation to thermochemical onversion routes","volume":"31","author":"Griffin","year":"2012","journal-title":"Environ. Prog. Sustain. Energy"},{"key":"ref_246","doi-asserted-by":"crossref","first-page":"5372","DOI":"10.3390\/en5125372","article-title":"Commercial biomass syngas fermentation","volume":"5","author":"Daniell","year":"2012","journal-title":"Energies"},{"key":"ref_247","doi-asserted-by":"crossref","first-page":"7294","DOI":"10.1021\/acs.energyfuels.8b01678","article-title":"A combined overview of combustion, pyrolysis, and gasification of biomass","volume":"32","author":"Akhtar","year":"2018","journal-title":"Energy Fuels"},{"key":"ref_248","doi-asserted-by":"crossref","unstructured":"Phillips, J.R., Huhnke, R.L., and Atiyeh, H.K. (2017). Syngas fermentation: A microbial conversion process of gaseous substrates to various products. Fermentation, 3.","DOI":"10.3390\/fermentation3020028"},{"key":"ref_249","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.ymben.2019.01.003","article-title":"Systems-level engineering and characterisation of Clostridium autoethanogenum through heterologous production of poly-3-hydroxybutyrate (PHB)","volume":"53","author":"Lemgruber","year":"2019","journal-title":"Metab. Eng."},{"key":"ref_250","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.ymben.2022.01.015","article-title":"Advances in systems metabolic engineering of autotrophic carbon oxide-fixing biocatalysts towards a circular economy","volume":"71","author":"Pavan","year":"2022","journal-title":"Metab. Eng."},{"key":"ref_251","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.renene.2016.08.069","article-title":"Steam gasification of biomass with subsequent syngas adjustment using shift reaction for syngas production: An Aspen Plus model","volume":"101","author":"Pala","year":"2017","journal-title":"Renew. Energy"},{"key":"ref_252","doi-asserted-by":"crossref","first-page":"110950","DOI":"10.1016\/j.rser.2021.110950","article-title":"A critical review on biofilm-based reactor systems for enhanced syngas fermentation processes","volume":"143","author":"Gunes","year":"2021","journal-title":"Renew. Sustain. Energy Rev."},{"key":"ref_253","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1002\/cite.201900118","article-title":"Syngas Fermentation to Alcohols: Reactor Technology and Application Perspective","volume":"92","author":"Stoll","year":"2020","journal-title":"Chem. Ing. Tech."},{"key":"ref_254","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.copbio.2020.02.017","article-title":"Pollution to products: Recycling of \u2018above ground\u2019carbon by gas fermentation","volume":"65","author":"Simpson","year":"2020","journal-title":"Curr. Opin. Biotechnol."},{"key":"ref_255","doi-asserted-by":"crossref","unstructured":"Marcellin, E., Angenent, L.T., Nielsen, L.K., and Molitor, B. (2022). Recycling Carbon for Sustainable Protein Production Using Gas Fermentation. Curr. Opin. Biotechnol., 76.","DOI":"10.1016\/j.copbio.2022.102723"},{"key":"ref_256","doi-asserted-by":"crossref","first-page":"4635","DOI":"10.1007\/s13762-022-04303-8","article-title":"A review of recent advances in engineering bacteria for enhanced CO2 capture and utilization","volume":"20","author":"Onyeaka","year":"2023","journal-title":"Int. J. Environ. Sci. Technol."},{"key":"ref_257","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1146\/annurev-chembioeng-120120-021122","article-title":"Stepping on the Gas to a Circular Economy: Accelerating Development of Carbon-Negative Chemical Production from Gas Fermentation","volume":"12","author":"Fackler","year":"2021","journal-title":"Annu. Rev. Chem. Biomol. Eng."},{"key":"ref_258","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1089\/ind.2020.29217.ern","article-title":"Using waste carbon feedstocks to produce chemicals","volume":"16","author":"Nesbitt","year":"2020","journal-title":"Ind. Biotechnol."},{"key":"ref_259","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/s41929-017-0005-1","article-title":"Technical photosynthesis involving CO2 electrolysis and fermentation","volume":"1","author":"Haas","year":"2018","journal-title":"Nat. Catal."},{"key":"ref_260","unstructured":"(2023, November 19). Air Protein. Available online: https:\/\/www.airprotein.com\/."},{"key":"ref_261","unstructured":"(2023, November 19). Deep Branch Biotechnology. Available online: https:\/\/deepbranch.com\/."},{"key":"ref_262","unstructured":"(2023, November 19). Kiverdi. Available online: https:\/\/www.kiverdi.om\/."},{"key":"ref_263","unstructured":"(2023, November 19). Solar Foods. Available online: https:\/\/solarfoods.com\/science\/."},{"key":"ref_264","unstructured":"(2023, November 19). NovoNutrients. Available online: https:\/\/www.novonutrients.com\/."},{"key":"ref_265","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1038\/s41586-022-04662-9","article-title":"Alternative photosynthesis pathways drive the algal CO2-concentrating mechanism","volume":"605","author":"Burlacot","year":"2022","journal-title":"Nature"},{"key":"ref_266","doi-asserted-by":"crossref","first-page":"155510","DOI":"10.1149\/1945-7111\/abb836","article-title":"Review\u2014Microbial Electrosynthesis: A Way Towards The Production of Electro-ommodities Through Carbon Sequestration with Microbes as Biocatalysts","volume":"167","author":"Das","year":"2020","journal-title":"J. Electrochem. Soc."},{"key":"ref_267","doi-asserted-by":"crossref","first-page":"3633","DOI":"10.1038\/s41467-020-17403-1","article-title":"Electrochemical CO2 reduction to high-concentration pure formic acid solutions in an all-solid-state reactor","volume":"11","author":"Fan","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_268","doi-asserted-by":"crossref","first-page":"2821","DOI":"10.1038\/s41467-023-38506-5","article-title":"Aqueous phase conversion of CO2 into acetic acid over thermally transformed MIL-88B catalyst","volume":"14","author":"Ahmad","year":"2023","journal-title":"Nat. Commun."},{"key":"ref_269","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.jbiotec.2021.11.010","article-title":"Advanced PHB fermentation strategies with CO2-derived organic acids","volume":"343","author":"Vlaeminck","year":"2022","journal-title":"J. Biotechnol."},{"key":"ref_270","doi-asserted-by":"crossref","first-page":"2529","DOI":"10.1002\/bit.28159","article-title":"Metabolic engineering of oleaginous yeast Rhodotorula toruloides for overproduction of triacetic acid lactone","volume":"119","author":"Cao","year":"2022","journal-title":"Biotechnol. Bioeng."},{"key":"ref_271","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.ymben.2020.10.005","article-title":"Machine learning for metabolic engineering: A review","volume":"63","author":"Lawson","year":"2021","journal-title":"Metab. Eng."},{"key":"ref_272","doi-asserted-by":"crossref","first-page":"e00149","DOI":"10.1016\/j.mec.2020.e00149","article-title":"Systems biology approaches integrated with artificial intelligence for optimized metabolic engineering","volume":"11","author":"Helmy","year":"2020","journal-title":"Metab. Eng. Commun."},{"key":"ref_273","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/s41586-021-03819-2","article-title":"Highly accurate protein structure prediction with AlphaFold","volume":"596","author":"Jumper","year":"2021","journal-title":"Nature"},{"key":"ref_274","doi-asserted-by":"crossref","first-page":"112276","DOI":"10.1016\/j.foodres.2022.112276","article-title":"Redox cofactor metabolism in Saccharomyces cerevisiae and its impact on the production of alcoholic fermentation end-products","volume":"163","author":"Duncan","year":"2023","journal-title":"Food Res. Int."},{"key":"ref_275","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1128\/AEM.02429-15","article-title":"Metabolic Impact of Redox Cofactor Perturbations on the Formation of Aroma Compounds in Saccharomyces cerevisiae","volume":"82","author":"Bloem","year":"2016","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_276","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.biotechadv.2012.11.005","article-title":"Redox potential control and applications in microaerobic and anaerobic fermentations","volume":"31","author":"Liu","year":"2013","journal-title":"Biotechnol. Adv."},{"key":"ref_277","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1128\/AEM.02040-09","article-title":"Metabolic impact of increased NADH availability in Saccharomyces cerevisiae","volume":"76","author":"Hou","year":"2010","journal-title":"Appl Env. Microbiol"},{"key":"ref_278","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/nbt.3763","article-title":"Lipid production in Yarrowia lipolytica is maximized by engineering cytosolic redox metabolism","volume":"35","author":"Qiao","year":"2017","journal-title":"Nat. Biotechnol."},{"key":"ref_279","doi-asserted-by":"crossref","first-page":"15820","DOI":"10.1038\/s41598-018-34210-3","article-title":"Rerouting of NADPH synthetic pathways for increased protopanaxadiol production in Saccharomyces cerevisiae","volume":"8","author":"Kim","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_280","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.ymben.2015.02.005","article-title":"Engineering lipid overproduction in the oleaginous yeast Yarrowia lipolytica","volume":"29","author":"Qiao","year":"2015","journal-title":"Metab. Eng."},{"key":"ref_281","doi-asserted-by":"crossref","unstructured":"Kajla, S., Kumari, R., and Nagi, G.K. (2022). Microbial CO2 fixation and biotechnology in reducing industrial CO2 emissions. Arch. Microbiol., 204.","DOI":"10.1007\/s00203-021-02677-w"},{"key":"ref_282","doi-asserted-by":"crossref","first-page":"140200","DOI":"10.1016\/j.cej.2022.140200","article-title":"Chemolithoautotrophic reduction of CO2 to acetic acid in gas and gas-electro fermentation systems: Enrichment, microbial dynamics, and sustainability assessment","volume":"454","author":"Tharak","year":"2023","journal-title":"Chem. Eng. J."},{"key":"ref_283","doi-asserted-by":"crossref","first-page":"100074","DOI":"10.1016\/j.mtadv.2020.100074","article-title":"Electrocatalytic carbon dioxide reduction: From fundamental principles to catalyst design","volume":"7","author":"Zhang","year":"2020","journal-title":"Mater. Today Adv."},{"key":"ref_284","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.copbio.2021.11.007","article-title":"Coupling electrochemical CO2 reduction to microbial product generation\u2013identification of the gaps and opportunities","volume":"74","author":"Claassens","year":"2022","journal-title":"Curr. Opin. Biotechnol."}],"container-title":["Bioengineering"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2306-5354\/10\/12\/1357\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:30:43Z","timestamp":1760131843000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2306-5354\/10\/12\/1357"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,26]]},"references-count":284,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2023,12]]}},"alternative-id":["bioengineering10121357"],"URL":"https:\/\/doi.org\/10.3390\/bioengineering10121357","relation":{},"ISSN":["2306-5354"],"issn-type":[{"value":"2306-5354","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,26]]}}}