{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:58:06Z","timestamp":1792789086423,"version":"4.5.0"},"reference-count":167,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2023,12,29]],"date-time":"2023-12-29T00:00:00Z","timestamp":1703808000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"Ministry of Education, Science, and Technology (MEST)","doi-asserted-by":"publisher","award":["NRF-2022R1F1A1073895"],"award-info":[{"award-number":["NRF-2022R1F1A1073895"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"Ministry of Education, Science, and Technology (MEST)","doi-asserted-by":"publisher","award":["2023IL0023"],"award-info":[{"award-number":["2023IL0023"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"Ministry of Education, Science, and Technology (MEST)","doi-asserted-by":"publisher","award":["2023IP0089"],"award-info":[{"award-number":["2023IP0089"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Asan Institute for Life Sciences","award":["NRF-2022R1F1A1073895"],"award-info":[{"award-number":["NRF-2022R1F1A1073895"]}]},{"name":"Asan Institute for Life Sciences","award":["2023IL0023"],"award-info":[{"award-number":["2023IL0023"]}]},{"name":"Asan Institute for Life Sciences","award":["2023IP0089"],"award-info":[{"award-number":["2023IP0089"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioengineering"],"abstract":"<jats:p>Dry eye disease (DED) is an emerging health issue affecting millions of individuals annually. Ocular surface disorders, such as DED, are characterized by inflammation triggered by various factors. This condition can lead to tear deficiencies, resulting in the desiccation of the ocular surface, corneal ulceration\/perforation, increased susceptibility to infections, and a higher risk of severe visual impairment and blindness. Currently, the clinical management of DED primarily relies on supportive and palliative measures, including the frequent and lifelong use of different lubricating agents. While some advancements like punctal plugs, non-steroidal anti-inflammatory drugs, and salivary gland autografts have been attempted, they have shown limited effectiveness. Recently, there have been promising developments in the treatment of DED, including biomaterials such as nano-systems, hydrogels, and contact lenses for drug delivery, cell-based therapies, biological approaches, and tissue-based regenerative therapy. This article specifically explores the different strategies reported so far for treating DED. The aim is to discuss their potential as long-term cures for DED while also considering the factors that limit their feasibility and effectiveness. These advancements offer hope for more effective and sustainable treatment options in the future.<\/jats:p>","DOI":"10.3390\/bioengineering11010039","type":"journal-article","created":{"date-parts":[[2023,12,29]],"date-time":"2023-12-29T06:56:57Z","timestamp":1703833017000},"page":"39","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Current Advances in Regenerative Strategies for Dry Eye Diseases: A Comprehensive Review"],"prefix":"10.3390","volume":"11","author":[{"given":"Basanta","family":"Bhujel","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8374-0453","authenticated-orcid":false,"given":"Se-Heon","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang-Min","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye-Ji","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8735-1684","authenticated-orcid":false,"given":"Ho-Seok","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun-Ah","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8571-8350","authenticated-orcid":false,"given":"Jae-Yong","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1136\/bjophthalmol-2019-315747","article-title":"Modern approach to the treatment of dry eye, a complex multifactorial disease: A PICASSO board review","volume":"105","author":"Aragona","year":"2021","journal-title":"Br. J. Ophthalmol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.jtos.2017.05.008","article-title":"TFOS DEWS II definition and classification report","volume":"15","author":"Craig","year":"2017","journal-title":"Ocul. Surf."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.jtos.2017.05.005","article-title":"TFOS DEWS II Introduction","volume":"15","author":"Nelson","year":"2017","journal-title":"Ocul. Surf."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Rahman, M.M., Kim, D.H., Park, C.-K., and Kim, Y.H. (2021). Experimental Models, Induction Protocols, and Measured Parameters in Dry Eye Disease: Focusing on Practical Implications for Experimental Research. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms222212102"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Thacker, M., Tseng, C.-L., Chang, C.-Y., Jakfar, S., Chen, H.Y., and Lin, F.-H. (2020). Mucoadhesive Bletilla striata polysaccharide-based artificial tears to relieve symptoms and inflammation in rabbit with dry eyes syndrome. Polymers, 12.","DOI":"10.3390\/polym12071465"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"428","DOI":"10.4103\/0974-9233.167818","article-title":"Biomaterials and tissue engineering strategies for conjunctival reconstruction and dry eye treatment","volume":"22","author":"Lu","year":"2015","journal-title":"Middle East Afr. J. Ophthalmol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/sj.eye.6701895","article-title":"Corticosteroid-induced glaucoma: A review of the literature","volume":"20","author":"Kersey","year":"2006","journal-title":"Eye"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.jtos.2014.12.006","article-title":"Efficacy and safety of topical 0.05% cyclosporine eye drops in the treatment of dry eye syndrome: A systematic review and meta-analysis","volume":"13","author":"Wan","year":"2015","journal-title":"Ocul. Surf."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"96","DOI":"10.4140\/TCP.n.2016.96","article-title":"Treatment of dry eye disease","volume":"31","author":"Marshall","year":"2016","journal-title":"Consult. Pharm.\u00ae"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Bachu, R.D., Chowdhury, P., Al-Saedi, Z.H., Karla, P.K., and Boddu, S.H. (2018). Ocular drug delivery barriers\u2014Role of nanocarriers in the treatment of anterior segment ocular diseases. Pharmaceutics, 10.","DOI":"10.3390\/pharmaceutics10010028"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1089\/jop.2012.0212","article-title":"Contact lenses: Promising devices for ocular drug delivery","volume":"29","author":"Colligris","year":"2013","journal-title":"J. Ocul. Pharmacol. Ther."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.jtos.2017.05.011","article-title":"Tfos dews ii pathophysiology report","volume":"15","author":"Bron","year":"2017","journal-title":"Ocul. Surf."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s10384-011-0002-x","article-title":"Regulation of soluble interleukin-6 (IL-6) receptor release from corneal epithelial cells and its role in the ocular surface","volume":"55","author":"Sugaya","year":"2011","journal-title":"Jpn. J. Ophthalmol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"7648","DOI":"10.1038\/s41598-019-44000-0","article-title":"Meibum expressibility improvement as a therapeutic target of intense pulsed light treatment in meibomian gland dysfunction and its association with tear inflammatory cytokines","volume":"9","author":"Choi","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"7725","DOI":"10.1167\/iovs.11-7266","article-title":"Proinflammatory cytokine profiling of tears from dry eye patients by means of antibody microarrays","volume":"52","author":"Boehm","year":"2011","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1007\/s12016-016-8570-7","article-title":"Significance of interleukin-6\/STAT pathway for the gene expression of REG I\u03b1, a new autoantigen in Sj\u00f6gren\u2019s syndrome patients, in salivary duct epithelial cells","volume":"52","author":"Fujimura","year":"2017","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1038\/eye.2014.38","article-title":"Analysis of Th17-associated cytokines in tears of patients with dry eye syndrome","volume":"28","author":"Tan","year":"2014","journal-title":"Eye"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"S14","DOI":"10.1016\/j.ophtha.2017.08.029","article-title":"Inflammation in dry eye disease: How do we break the cycle?","volume":"124","author":"Rhee","year":"2017","journal-title":"Ophthalmology"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.exer.2005.08.019","article-title":"JNK and ERK MAP kinases mediate induction of IL-1\u03b2, TNF-\u03b1 and IL-8 following hyperosmolar stress in human limbal epithelial cells","volume":"82","author":"Li","year":"2006","journal-title":"Exp. Eye Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"5871","DOI":"10.1167\/iovs.14-14481","article-title":"CCR7 is critical for the induction and maintenance of Th17 immunity in dry eye disease","volume":"55","author":"Kodati","year":"2014","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/mi.2013.20","article-title":"Chronic dry eye disease is principally mediated by effector memory Th17 cells","volume":"7","author":"Chen","year":"2014","journal-title":"Mucosal Immunol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2636","DOI":"10.1002\/eji.200838535","article-title":"Induction, function and regulation of IL-17-producing T cells","volume":"38","author":"Mills","year":"2008","journal-title":"Eur. J. Immunol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1089\/jop.2016.0105","article-title":"LFA-1\/ICAM-1 interaction as a therapeutic target in dry eye disease","volume":"33","author":"Pflugfelder","year":"2017","journal-title":"J. Ocul. Pharmacol. Ther."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.preteyeres.2012.02.003","article-title":"Ocular surface immunity: Homeostatic mechanisms and their disruption in dry eye disease","volume":"31","author":"Barabino","year":"2012","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2553","DOI":"10.1167\/iovs.07-0069","article-title":"Dry eye\u2013induced conjunctival epithelial squamous metaplasia is modulated by interferon-\u03b3","volume":"48","author":"Villarreal","year":"2007","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.4049\/jimmunol.182.3.1247","article-title":"Autoimmunity in dry eye is due to resistance of Th17 to Treg suppression","volume":"182","author":"Chauhan","year":"2009","journal-title":"J. Immunol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.exer.2009.12.009","article-title":"Effect of pro-inflammatory mediators on membrane-associated mucins expressed by human ocular surface epithelial cells","volume":"90","author":"Albertsmeyer","year":"2010","journal-title":"Exp. Eye Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1111\/aos.13844","article-title":"Role of corneal nerves in ocular surface homeostasis and disease","volume":"97","author":"Labetoulle","year":"2019","journal-title":"Acta Ophthalmol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.jtos.2013.07.003","article-title":"Role of hyperosmolarity in the pathogenesis and management of dry eye disease: Proceedings of the OCEAN group meeting","volume":"11","author":"Baudouin","year":"2013","journal-title":"Ocul. Surf."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"815075","DOI":"10.3389\/fmed.2021.815075","article-title":"Current Advances in mechanisms and treatment of Dry eye Disease: Toward Anti-inflammatory and immunomodulatory therapy and traditional Chinese medicine","volume":"8","author":"Ling","year":"2022","journal-title":"Front. Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1089\/jop.2019.0060","article-title":"The immunological basis of dry eye disease and current topical treatment options","volume":"36","author":"Periman","year":"2020","journal-title":"J. Ocul. Pharmacol. Ther."},{"key":"ref_32","first-page":"71","article-title":"The pathophysiology, diagnosis, and treatment of dry eye disease","volume":"112","author":"Messmer","year":"2015","journal-title":"Dtsch. \u00c4rzteblatt Int."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Mondal, H., Kim, H.-J., Mohanto, N., and Jee, J.-P. (2023). A Review on Dry Eye Disease Treatment: Recent Progress, Diagnostics, and Future Perspectives. Pharmaceutics, 15.","DOI":"10.3390\/pharmaceutics15030990"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2515841420905740","DOI":"10.1177\/2515841420905740","article-title":"Promising therapeutic drug delivery systems for glaucoma: A comprehensive review","volume":"12","author":"Singh","year":"2020","journal-title":"Ther. Adv. Ophthalmol."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Choi, S.W., and Kim, J. (2018). Therapeutic contact lenses with polymeric vehicles for ocular drug delivery: A review. Materials, 11.","DOI":"10.3390\/ma11071125"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1136\/bjo.2004.044347","article-title":"Autologous serum eye drops for ocular surface disorders","volume":"88","author":"Geerling","year":"2004","journal-title":"Br. J. Ophthalmol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"DES121","DOI":"10.1167\/iovs.17-23760","article-title":"Autologous serum and serum components","volume":"59","author":"Higuchi","year":"2018","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Lekhanont, K., Jongkhajornpong, P., Choubtum, L., and Chuckpaiwong, V. (2013). Topical 100% serum eye drops for treating corneal epithelial defect after ocular surgery. BioMed Res. Int., 2013.","DOI":"10.1155\/2013\/521315"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"106206","DOI":"10.1016\/j.ejps.2022.106206","article-title":"Current trends in pharmaceutical treatment of dry eye disease: A review","volume":"175","author":"Mohamed","year":"2022","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1136\/bjo.83.4.390","article-title":"Treatment of dry eye by autologous serum application in Sj\u00f6gren\u2019s syndrome","volume":"83","author":"Tsubota","year":"1999","journal-title":"Br. J. Ophthalmol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/sj.bmt.1703862","article-title":"Autologous serum eye drops for the treatment of severe dry eye in patients with chronic graft-versus-host disease","volume":"31","author":"Ogawa","year":"2003","journal-title":"Bone Marrow Transplant."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/j.ophtha.2003.10.019","article-title":"Autologous serum application in the treatment of neurotrophic keratopathy","volume":"111","author":"Matsumoto","year":"2004","journal-title":"Ophthalmology"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1142\/S1682648518500051","article-title":"Effects of autologous serum eye drops for treatment of keratoconjunctivitis sicca in dogs","volume":"44","author":"Lin","year":"2018","journal-title":"Taiwan Vet. J."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Semeraro, F., Forbice, E., Braga, O., Bova, A., Di Salvatore, A., and Azzolini, C. (2014). Evaluation of the efficacy of 50% autologous serum eye drops in different ocular surface pathologies. BioMed Res. Int., 2014.","DOI":"10.1155\/2014\/826970"},{"key":"ref_45","first-page":"948","article-title":"Toxicity of natural tear substitutes in a fully defined culture model of human corneal epithelial cells","volume":"42","author":"Geerling","year":"2001","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.4103\/IJO.IJO_2756_22","article-title":"Autologous serum eye drops in dry eye disease: Preferred practice pattern guidelines","volume":"71","author":"Vazirani","year":"2023","journal-title":"Indian J. Ophthalmol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1111\/aos.12801","article-title":"Improving the anti-inflammatory effect of serum eye drops using allogeneic serum permissive for regulatory T cell induction","volume":"93","author":"Stenwall","year":"2015","journal-title":"Acta Ophthalmol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.transci.2016.01.022","article-title":"Quality standards, safety and efficacy of blood-derived serum eye drops: A review","volume":"54","author":"Seghatchian","year":"2016","journal-title":"Transfus. Apher. Sci."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"979258","DOI":"10.1155\/2009\/979258","article-title":"Cytokines and cytokine profiles in human autoimmune diseases and animal models of autoimmunity","volume":"2009","author":"Kunz","year":"2009","journal-title":"Mediat. Inflamm."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Belinskaia, D.A., Voronina, P.A., Shmurak, V.I., Jenkins, R.O., and Goncharov, N.V. (2021). Serum albumin in health and disease: Esterase, antioxidant, transporting and signaling properties. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms221910318"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1097\/ICU.0000000000000169","article-title":"Eye platelet-rich plasma in the treatment of ocular surface disorders","volume":"26","author":"Alio","year":"2015","journal-title":"Curr. Opin. Ophthalmol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1160\/TH03-07-0440","article-title":"Autologous platelets as a source of proteins for healing and tissue regeneration","volume":"91","author":"Anitua","year":"2004","journal-title":"Thromb. Haemost."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"e000071","DOI":"10.1136\/bmjsem-2015-000071","article-title":"Normal platelet function in platelet concentrates requires non-platelet cells: A comparative in vitro evaluation of leucocyte-rich (type 1a) and leucocyte-poor (type 3b) platelet concentrates","volume":"2","author":"Parrish","year":"2016","journal-title":"BMJ Open Sport Exerc. Med."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.jos.2016.07.009","article-title":"Leukocyte concentration and composition in platelet-rich plasma (PRP) influences the growth factor and protease concentrations","volume":"21","author":"Kobayashi","year":"2016","journal-title":"J. Orthop. Sci."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.oftal.2016.03.001","article-title":"Platelet rich plasma in ocular surface","volume":"91","author":"Riestra","year":"2016","journal-title":"Arch. Soc. Esp. Oftalmol. (Engl. Ed.)"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.jtos.2017.01.003","article-title":"Autologous method for ex vivo expansion of human limbal epithelial progenitor cells based on plasma rich in growth factors technology","volume":"15","author":"Riestra","year":"2017","journal-title":"Ocul. Surf."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1097\/ICO.0b013e3181a81820","article-title":"Plasma rich in growth factors as a therapeutic agent for persistent corneal epithelial defects","volume":"29","author":"Morales","year":"2010","journal-title":"Cornea"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1159\/000444496","article-title":"Safety and efficacy of autologous plasma rich in growth factors eye drops for the treatment of evaporative dry eye","volume":"56","author":"Riestra","year":"2016","journal-title":"Ophthalmic Res."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s40123-017-0100-z","article-title":"Treatment of dry eye disease with autologous platelet-rich plasma: A prospective, interventional, non-randomized study","volume":"6","author":"Alio","year":"2017","journal-title":"Ophthalmol. Ther."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"82","DOI":"10.4068\/cmj.2014.50.3.82","article-title":"Use of umbilical cord serum in ophthalmology","volume":"50","author":"Yoon","year":"2014","journal-title":"Chonnam Med. J."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1167\/iovs.09-4170","article-title":"Evaluation of umbilical cord serum therapy in acute ocular chemical burns","volume":"52","author":"Sharma","year":"2011","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.ajo.2007.03.016","article-title":"Comparison of autologous serum and umbilical cord serum eye drops for dry eye syndrome","volume":"144","author":"Yoon","year":"2007","journal-title":"Am. J. Ophthalmol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/nrg3763","article-title":"Non-viral vectors for gene-based therapy","volume":"15","author":"Yin","year":"2014","journal-title":"Nat. Rev. Genet."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Sarkar, S., Panikker, P., D\u2019Souza, S., Shetty, R., Mohan, R.R., and Ghosh, A. (2023). Corneal Regeneration Using Gene Therapy Approaches. Cells, 12.","DOI":"10.3390\/cells12091280"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1740-2557-2-6","article-title":"Expression of TNF inhibitor gene in the lacrimal gland promotes recovery of tear production and tear stability and reduced immunopathology in rabbits with induced autoimmune dacryoadenitis","volume":"2","author":"Trousdale","year":"2005","journal-title":"J. Autoimmune Dis."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"5137","DOI":"10.1167\/iovs.10-5423","article-title":"Adeno-associated virus\u2013mediated IL-10 gene transfer suppresses lacrimal gland immunopathology in a rabbit model of autoimmune dacryoadenitis","volume":"51","author":"Thomas","year":"2010","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"5694","DOI":"10.1073\/pnas.1601992113","article-title":"Aquaporin gene therapy corrects Sj\u00f6gren\u2019s syndrome phenotype in mice","volume":"113","author":"Lai","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.2147\/OPTH.S364200","article-title":"Ocular gene therapy: A literature review with special focus on immune and inflammatory responses","volume":"16","author":"Ghoraba","year":"2022","journal-title":"Clin. Ophthalmol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1089\/jop.2018.0032","article-title":"Comparison of 0.1%, 0.18%, and 0.3% hyaluronic acid eye drops in the treatment of experimental dry eye","volume":"34","author":"You","year":"2018","journal-title":"J. Ocul. Pharmacol. Ther."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"871","DOI":"10.3109\/02713683.2014.884595","article-title":"Effects of eye drops containing a mixture of omega-3 essential fatty acids and hyaluronic acid on the ocular surface in desiccating stress-induced murine dry eye","volume":"39","author":"Li","year":"2014","journal-title":"Curr. Eye Res."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.jtos.2017.05.006","article-title":"TFOS DEWS II management and therapy report","volume":"15","author":"Jones","year":"2017","journal-title":"Ocul. Surf."},{"key":"ref_72","first-page":"1447","article-title":"Managing Sj\u00f6gren\u2019s Syndrome and non-Sj\u00f6gren Syndrome dry eye with anti-inflammatory therapy","volume":"8","author":"Coursey","year":"2014","journal-title":"Clin. Ophthalmol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1097\/01.ico.0000176611.88579.0a","article-title":"Efficacy of commercially available topical cyclosporine A 0.05% in the treatment of meibomian gland dysfunction","volume":"25","author":"Perry","year":"2006","journal-title":"Cornea"},{"key":"ref_74","unstructured":"Gilbard, J.P. (2000). Ophtalmic Solution with Tetracycline for Topical Treatment of Dry Eye Disease. (W02000007601A1), Google Patents."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"3","DOI":"10.4103\/2211-5056.369606","article-title":"Dry eye disease: A review of anti-inflammatory therapies","volume":"13","author":"Nguyen","year":"2023","journal-title":"Taiwan J. Ophthalmol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/S0002-9394(00)00620-6","article-title":"Efficacy and tolerability outcomes after punctal occlusion with silicone plugs in dry eye syndrome","volume":"131","author":"Balaram","year":"2001","journal-title":"Am. J. Ophthalmol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"105","DOI":"10.2165\/00002512-200825020-00003","article-title":"Pharmacological management of dry eye in the elderly patient","volume":"25","author":"Foulks","year":"2008","journal-title":"Drugs Aging"},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Pflugfelder, S.C., and Stern, M.E. (2004). Dry Eye and Ocular Surface Disorders, CRC Press.","DOI":"10.1201\/b14144"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.ophtha.2015.09.029","article-title":"Topical fluorometholone protects the ocular surface of dry eye patients from desiccating stress: A randomized controlled clinical trial","volume":"123","author":"Stern","year":"2016","journal-title":"Ophthalmology"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S1542-0124(12)70081-2","article-title":"The definition and classification of dry eye disease","volume":"5","author":"Lemp","year":"2007","journal-title":"Ocul. Surf."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.sjopt.2014.06.004","article-title":"Essential fatty acids in the treatment of dry eye syndrome: A myth or reality?","volume":"28","year":"2014","journal-title":"Saudi J. Ophthalmol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1093\/ajcn\/82.4.887","article-title":"Relation between dietary n\u22123 and n\u22126 fatty acids and clinically diagnosed dry eye syndrome in women","volume":"82","author":"Trivedi","year":"2005","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1001\/archophthalmol.2007.61","article-title":"Topical omega-3 and omega-6 fatty acids for treatment of dry eye","volume":"126","author":"Rashid","year":"2008","journal-title":"Arch. Ophthalmol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1136\/bjophthalmol-2013-304801","article-title":"Comparative role of 20% cord blood serum and 20% autologous serum in dry eye associated with Hansen\u2019s disease: A tear proteomic study","volume":"99","author":"Mukhopadhyay","year":"2015","journal-title":"Br. J. Ophthalmol."},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Noda-Tsuruya, T., Asano-Kato, N., Toda, I., and Tsubota, K. (2006). Autologous Serum Eye Drops for Dry Eye after LASIK, Slack Incorporated.","DOI":"10.3928\/1081-597X-20060101-13"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1136\/bjophthalmol-2018-312072","article-title":"Randomised, prospective clinical trial of platelet-rich plasma injection in the management of severe dry eye","volume":"103","author":"Avila","year":"2019","journal-title":"Br. J. Ophthalmol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"4207","DOI":"10.2147\/OPTH.S391536","article-title":"Effect of Autologous Platelet-Rich Plasma Drops in the Treatment of Ocular Surface Disease","volume":"16","author":"Nadelmann","year":"2022","journal-title":"Clin. Ophthalmol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1215848","DOI":"10.3389\/fopht.2023.1215848","article-title":"Use of allogeneic platelet-rich plasma for the treatment of autoimmune ocular surface disorders: Case series","volume":"3","author":"Mancini","year":"2023","journal-title":"Front. Ophthalmol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"3347","DOI":"10.1007\/s40123-023-00827-5","article-title":"Allogeneic Serum Eye Drops: A Randomized Clinical Trial to Evaluate the Clinical Effectiveness of Two Drop Sizes","volume":"12","author":"Vermeulen","year":"2023","journal-title":"Ophthalmol. Ther."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1089\/jop.2012.0002","article-title":"Allogeneic serum eye drops for the treatment of dry eye patients with chronic graft-versus-host disease","volume":"28","author":"Na","year":"2012","journal-title":"J. Ocul. Pharmacol. Ther."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1097\/ICO.0000000000001257","article-title":"Efficacy of 2-month treatment with cord blood serum eye drops in ocular surface disease: An in vivo confocal microscopy study","volume":"36","author":"Giannaccare","year":"2017","journal-title":"Cornea"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1136\/bjophthalmol-2019-314859","article-title":"Blood derived treatment from two allogeneic sources for severe dry eye associated to keratopathy: A multicentre randomised cross over clinical trial","volume":"104","author":"Campos","year":"2020","journal-title":"Br. J. Ophthalmol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"3638","DOI":"10.1167\/iovs.11-9311","article-title":"Kinetics and function of mesenchymal stem cells in corneal injury","volume":"53","author":"Lan","year":"2012","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_94","first-page":"2237","article-title":"Mesenchymal stem cells and corneal reconstruction","volume":"19","author":"Yao","year":"2013","journal-title":"Mol. Vis."},{"key":"ref_95","first-page":"3142","article-title":"Allogeneic mesenchymal stem cell treatment alleviates experimental and clinical Sj\u00f6gren syndrome","volume":"120","author":"Xu","year":"2012","journal-title":"Blood J. Am. Soc. Hematol."},{"key":"ref_96","first-page":"250230","article-title":"Efficacy of topical mesenchymal stem cell therapy in the treatment of experimental dry eye syndrome model","volume":"2014","author":"Acar","year":"2014","journal-title":"Stem Cells Int."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"18299","DOI":"10.1038\/s41598-019-54840-5","article-title":"MSC transplantation improves lacrimal gland regeneration after surgically induced dry eye disease in mice","volume":"9","author":"Dietrich","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jtos.2020.11.013","article-title":"Safety and feasibility of mesenchymal stem cell therapy in patients with aqueous deficient dry eye disease","volume":"19","author":"Larsen","year":"2021","journal-title":"Ocul. Surf."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"eabj9617","DOI":"10.1126\/sciadv.abj9617","article-title":"miR-204\u2013containing exosomes ameliorate GVHD-associated dry eye disease","volume":"8","author":"Zhou","year":"2022","journal-title":"Sci. Adv."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"704","DOI":"10.4103\/0366-6999.226889","article-title":"Effects of adipose-derived mesenchymal stem cell exosomes on corneal stromal fibroblast viability and extracellular matrix synthesis","volume":"131","author":"Shen","year":"2018","journal-title":"Chin. Med. J."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1159\/000519458","article-title":"Exosomes derived from mouse adipose-derived mesenchymal stem cells alleviate benzalkonium chloride-induced mouse dry eye model via inhibiting NLRP3 inflammasome","volume":"65","author":"Wang","year":"2022","journal-title":"Ophthalmic Res."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1002\/sctm.18-0297","article-title":"Mesenchymal stem cells reduce corneal fibrosis and inflammation via extracellular vesicle-mediated delivery of miRNA","volume":"8","author":"Shojaati","year":"2019","journal-title":"Stem Cells Transl. Med."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"5194","DOI":"10.1167\/iovs.18-24803","article-title":"Effect of human corneal mesenchymal stromal cell-derived exosomes on corneal epithelial wound healing","volume":"59","author":"Samaeekia","year":"2018","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Bhujel, B., Oh, S.-H., Kim, C.-M., Yoon, Y.-J., Kim, Y.-J., Chung, H.-S., Ye, E.-A., Lee, H., and Kim, J.-Y. (2023). Mesenchymal Stem Cells and Exosomes: A Novel Therapeutic Approach for Corneal Diseases. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241310917"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"09636897221133818","DOI":"10.1177\/09636897221133818","article-title":"Mesenchymal Stromal Cell\u2013Based Therapy for Dry Eye: Current Status and Future Perspectives","volume":"31","author":"Jiang","year":"2022","journal-title":"Cell Transplant."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/mt.2014.159","article-title":"Mesenchymal stem\/stromal cells protect the ocular surface by suppressing inflammation in an experimental dry eye","volume":"23","author":"Lee","year":"2015","journal-title":"Mol. Ther."},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Guo, R., Liang, Q., He, Y., Wang, C., Jiang, J., Chen, T., Zhang, D., and Hu, K. (2022). Mesenchymal stromal cells-derived extracellular vesicles regulate dendritic cell functions in dry eye disease. Cells, 12.","DOI":"10.2139\/ssrn.4197800"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"107905","DOI":"10.1016\/j.exer.2019.107905","article-title":"Human umbilical cord mesenchymal stem cells alleviate ongoing autoimmune dacryoadenitis in rabbits via polarizing macrophages into an anti-inflammatory phenotype","volume":"191","author":"Lu","year":"2020","journal-title":"Exp. Eye Res."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.1038\/mt.2012.208","article-title":"Mesenchymal stromal cells treatment attenuates dry eye in patients with chronic graft-versus-host disease","volume":"20","author":"Weng","year":"2012","journal-title":"Mol. Ther."},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"M\u00f8ller-Hansen, M. (2023). Mesenchymal Stem Cell Therapy in Aqueous Deficient Dry Eye Disease, Wiley Online Library.","DOI":"10.1111\/aos.15739"},{"key":"ref_111","unstructured":"Zhang, X., and Williams, D. (2019). Definitions of Biomaterials for the Twenty-First Century, Elsevier."},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Williams, D. (2014). Essential Biomaterials Science, Cambridge University Press.","DOI":"10.1017\/CBO9781139026086"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1039\/C6LC01554A","article-title":"Organ-on-a-chip devices advance to market","volume":"17","author":"Zhang","year":"2017","journal-title":"Lab Chip"},{"key":"ref_114","first-page":"3872","article-title":"Human blinking \u2018eye-on-a-chip\u2019","volume":"57","author":"Seo","year":"2016","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Heidari, M., Noorizadeh, F., Wu, K., Inomata, T., and Mashaghi, A. (2019). Dry eye disease: Emerging approaches to disease analysis and therapy. J. Clin. Med., 8.","DOI":"10.3390\/jcm8091439"},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Khiev, D., Mohamed, Z.A., Vichare, R., Paulson, R., Bhatia, S., Mohapatra, S., Lobo, G.P., Valapala, M., Kerur, N., and Passaglia, C.L. (2021). Emerging nano-formulations and nanomedicines applications for ocular drug delivery. Nanomaterials, 11.","DOI":"10.3390\/nano11010173"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s40089-014-0094-7","article-title":"Nanomedicine and drug delivery: A mini review","volume":"4","author":"Mirza","year":"2014","journal-title":"Int. Nano Lett."},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Lynch, C., Kondiah, P.P., Choonara, Y.E., du Toit, L.C., Ally, N., and Pillay, V. (2019). Advances in biodegradable nano-sized polymer-based ocular drug delivery. Polymers, 11.","DOI":"10.3390\/polym11081371"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"109339","DOI":"10.1016\/j.exer.2022.109339","article-title":"Biomaterials for dry eye disease treatment: Current overview and future perspectives","volume":"226","author":"Thacker","year":"2023","journal-title":"Exp. Eye Res."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"7251","DOI":"10.2147\/IJN.S173198","article-title":"Gelatin\u2013epigallocatechin gallate nanoparticles with hyaluronic acid decoration as eye drops can treat rabbit dry-eye syndrome effectively via inflammatory relief","volume":"13","author":"Huang","year":"2018","journal-title":"Int. J. Nanomed."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"5580","DOI":"10.1039\/C9NR00376B","article-title":"Synergistically dual-functional nano eye-drops for simultaneous anti-inflammatory and anti-oxidative treatment of dry eye disease","volume":"11","author":"Li","year":"2019","journal-title":"Nanoscale"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1007\/s11095-020-02872-2","article-title":"A novel eyes topical drug delivery system: CsA-LNC for the treatment of DED","volume":"37","author":"Zhang","year":"2020","journal-title":"Pharm. Res."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1021\/nn506599f","article-title":"Ocular drug delivery nanowafer with enhanced therapeutic efficacy","volume":"9","author":"Yuan","year":"2015","journal-title":"ACS Nano"},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"Agarwal, P., Craig, J.P., and Rupenthal, I.D. (2021). Formulation considerations for the management of dry eye disease. Pharmaceutics, 13.","DOI":"10.3390\/pharmaceutics13020207"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1016\/j.ophtha.2005.05.013","article-title":"Phase III safety evaluation of cyclosporine 0.1% ophthalmic emulsion administered twice daily to dry eye disease patients for up to 3 years","volume":"112","author":"Barber","year":"2005","journal-title":"Ophthalmology"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1016\/j.ophtha.2019.03.050","article-title":"A phase 3, randomized, double-masked study of OTX-101 ophthalmic solution 0.09% in the treatment of dry eye disease","volume":"126","author":"Goldberg","year":"2019","journal-title":"Ophthalmology"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/j.ijbiomac.2017.11.090","article-title":"Nanogel-based natural polymers as smart carriers for the controlled delivery of Timolol Maleate through the cornea for glaucoma","volume":"109","author":"Ilka","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1167\/iovs.16-20843","article-title":"Therapeutic efficacy of nanocomplex of poly (ethylene glycol) and catechin for dry eye disease in a mouse model","volume":"58","author":"Lee","year":"2017","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.jconrel.2019.10.039","article-title":"A cerium oxide loaded glycol chitosan nano-system for the treatment of dry eye disease","volume":"315","author":"Yu","year":"2019","journal-title":"J. Control. Release"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/gt.2012.56","article-title":"A nanomedicine to treat ocular surface inflammation: Performance on an experimental dry eye murine model","volume":"20","author":"Zorzi","year":"2013","journal-title":"Gene Ther."},{"key":"ref_131","doi-asserted-by":"crossref","unstructured":"Yu, Y., Chow, D.W.Y., Lau, C.M.L., Zhou, G., Back, W., Xu, J., Carim, S., and Chau, Y. (2021). A bioinspired synthetic soft hydrogel for the treatment of dry eye. Bioeng. Transl. Med., 6.","DOI":"10.1002\/btm2.10227"},{"key":"ref_132","first-page":"979","article-title":"Novel multiarm PEG-based hydrogels for tissue engineering","volume":"92","author":"Tan","year":"2010","journal-title":"J. Biomed. Mater. Res. Part A Off. J. Soc. Biomater. Jpn. Soc. Biomater. Aust. Soc. Biomater. Korean Soc. Biomater."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"1800225","DOI":"10.1002\/adhm.201800225","article-title":"Thermoreversible Hyaluronic Acid-PNIPAAm Hydrogel Systems for 3D Stem Cell Culture","volume":"7","author":"Ekerdt","year":"2018","journal-title":"Adv. Healthc. Mater."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"3124304","DOI":"10.1155\/2020\/3124304","article-title":"Poly(vinyl alcohol boric acid)-diclofenac sodium salt drug delivery systems: Experimental and theoretical studies","volume":"2020","author":"Ailincai","year":"2020","journal-title":"J. Immunol. Res."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.jconrel.2014.03.052","article-title":"Hydrogels in a historical perspective: From simple networks to smart materials","volume":"190","author":"Buwalda","year":"2014","journal-title":"J. Control. Release"},{"key":"ref_136","doi-asserted-by":"crossref","unstructured":"Williams, D.L., and Mann, B.K. (2014). Efficacy of a crosslinked hyaluronic acid-based hydrogel as a tear film supplement: A masked controlled study. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0099766"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.jtos.2018.05.004","article-title":"Subconjunctival dendrimer-drug therapy for the treatment of dry eye in a rabbit model of induced autoimmune dacryoadenitis","volume":"16","author":"Lin","year":"2018","journal-title":"Ocul. Surf."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"5125","DOI":"10.2147\/IJN.S192407","article-title":"Photothermal conversion hydrogel based mini-eye patch for relieving dry eye with long-term use of the light-emitting screen","volume":"14","author":"Pang","year":"2019","journal-title":"Int. J. Nanomed."},{"key":"ref_139","doi-asserted-by":"crossref","unstructured":"Williams, D.L., and Mann, B.K. (2013). A crosslinked HA-based hydrogel ameliorates dry eye symptoms in dogs. Int. J. Biomater., 2013.","DOI":"10.1155\/2013\/460437"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"111095","DOI":"10.1016\/j.msec.2020.111095","article-title":"Long-acting mucoadhesive thermogels for improving topical treatments of dry eye disease","volume":"115","author":"Luo","year":"2020","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_141","first-page":"77","article-title":"Effectiveness of an ocular adhesive polyhedral oligomeric silsesquioxane hybrid thermo-responsive FK506 hydrogel in a murine model of dry eye","volume":"9","author":"Han","year":"2022","journal-title":"Bioact. Mater."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.clae.2021.02.007","article-title":"BCLA CLEAR\u2013Contact lens technologies of the future","volume":"44","author":"Jones","year":"2021","journal-title":"Contact Lens Anterior Eye"},{"key":"ref_143","doi-asserted-by":"crossref","unstructured":"Toffoletto, N., Saramago, B., and Serro, A.P. (2020). Therapeutic ophthalmic lenses: A review. Pharmaceutics, 13.","DOI":"10.3390\/pharmaceutics13010036"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1080\/09205063.2015.1072902","article-title":"Extended release of hyaluronic acid from hydrogel contact lenses for dry eye syndrome","volume":"26","author":"Maulvi","year":"2015","journal-title":"J. Biomater. Sci. Polym. Ed."},{"key":"ref_145","doi-asserted-by":"crossref","unstructured":"Akbari, E., Imani, R., Shokrollahi, P., and Heidari Keshel, S. (2021). Preparation of Nanoparticle-Containing Ring-Implanted Poly(Vinyl Alcohol) Contact Lens for Sustained Release of Hyaluronic Acid. Macromol. Biosci., 21.","DOI":"10.1002\/mabi.202100043"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1080\/02713683.2018.1563702","article-title":"The efficiency of cyclosporine a-eluting contact lenses for the treatment of dry eye","volume":"44","author":"Choi","year":"2019","journal-title":"Curr. Eye Res."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.jconrel.2010.07.119","article-title":"Extended release of dexamethasone from silicone-hydrogel contact lenses containing vitamin E","volume":"148","author":"Kim","year":"2010","journal-title":"J. Control. Release"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.jconrel.2011.06.028","article-title":"Extended cyclosporine delivery by silicone\u2013hydrogel contact lenses","volume":"154","author":"Peng","year":"2011","journal-title":"J. Control. Release"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.actbio.2017.01.063","article-title":"Design and optimization of a novel implantation technology in contact lenses for the treatment of dry eye syndrome: In vitro and in vivo evaluation","volume":"53","author":"Maulvi","year":"2017","journal-title":"Acta Biomater."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"18148","DOI":"10.1021\/acsomega.0c01764","article-title":"Novel poly (vinylpyrrolidone)-coated silicone contact lenses to improve tear volume during lens wear: In vitro and in vivo studies","volume":"5","author":"Maulvi","year":"2020","journal-title":"ACS Omega"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.clae.2019.04.011","article-title":"Extended delivery of non-steroidal anti-inflammatory drugs through contact lenses loaded with Vitamin E and cationic surfactants","volume":"42","author":"Hu","year":"2019","journal-title":"Contact Lens Anterior Eye"},{"key":"ref_152","doi-asserted-by":"crossref","unstructured":"Jia, Z., Lv, Y., Zhang, W., Zhang, X., Li, F., Lu, X., and Zhao, S. (2022). Mesenchymal stem cell derived exosomes-based immunological signature in a rat model of corneal allograft rejection therapy. Front. Biosci.-Landmark, 27.","DOI":"10.31083\/j.fbl2703086"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"829","DOI":"10.2147\/OPTH.S1409","article-title":"Treatment of chronic dry eye: Focus on cyclosporine","volume":"2","author":"Kymionis","year":"2008","journal-title":"Clin. Ophthalmol."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"16578","DOI":"10.1039\/C9RA02858G","article-title":"Drug-eluting contact lens containing cyclosporine-loaded cholesterol-hyaluronate micelles for dry eye syndrome","volume":"9","author":"Mun","year":"2019","journal-title":"RSC Adv."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"121414","DOI":"10.1016\/j.ijpharm.2021.121414","article-title":"In vitro and in vivo evaluation of cyclosporine-graphene oxide laden hydrogel contact lenses","volume":"613","author":"Desai","year":"2022","journal-title":"Int. J. Pharm."},{"key":"ref_156","doi-asserted-by":"crossref","unstructured":"Banica, F.-G. (2012). Chemical Sensors and Biosensors: Fundamentals and Applications, John Wiley & Sons.","DOI":"10.1002\/9781118354162"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.snb.2017.04.088","article-title":"Highly sensitive and wide-dynamic-range side-polished fiber-optic taste sensor","volume":"249","author":"Khalilian","year":"2017","journal-title":"Sens. Actuators B Chem."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"2000263","DOI":"10.1002\/aisy.202000263","article-title":"Smart contact lenses for biosensing applications","volume":"3","author":"Ma","year":"2021","journal-title":"Adv. Intell. Syst."},{"key":"ref_159","doi-asserted-by":"crossref","unstructured":"Ferraz, M.P. (2022). Biomaterials for Ophthalmic Applications. Appl. Sci., 12.","DOI":"10.3390\/app12125886"},{"key":"ref_160","first-page":"18","article-title":"Contact lens materials","volume":"2","author":"Tighe","year":"2006","journal-title":"Contact Lenses"},{"key":"ref_161","doi-asserted-by":"crossref","unstructured":"Musgrave, C.S.A., and Fang, F. (2019). Contact lens materials: A materials science perspective. Materials, 12.","DOI":"10.3390\/ma12020261"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"110770","DOI":"10.1016\/j.msec.2020.110770","article-title":"pHEMA@ AGMNA-1: A novel material for the development of antibacterial contact lens","volume":"111","author":"Rossos","year":"2020","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_163","doi-asserted-by":"crossref","unstructured":"Franco, P., and De Marco, I. (2021). Contact lenses as ophthalmic drug delivery systems: A review. Polymers, 13.","DOI":"10.3390\/polym13071102"},{"key":"ref_164","first-page":"704946","article-title":"A comprehensive review on dry eye disease: Diagnosis, medical management, recent developments, and future challenges","volume":"2015","author":"Phadatare","year":"2015","journal-title":"Adv. Pharm."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.4103\/IJO.IJO_2806_22","article-title":"Newer approaches to dry eye therapy: Nanotechnology, regenerative medicine, and tissue engineering","volume":"71","author":"Joshi","year":"2023","journal-title":"Indian J. Ophthalmol."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"114582","DOI":"10.1016\/j.addr.2022.114582","article-title":"Novel drug delivery systems for the management of dry eye","volume":"191","author":"Nagai","year":"2022","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"885780","DOI":"10.3389\/fmed.2022.885780","article-title":"Current approaches for the regeneration and reconstruction of ocular surface in dry eye","volume":"9","author":"Singh","year":"2022","journal-title":"Front. 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