{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:34:01Z","timestamp":1787027641316,"version":"build-2736575974"},"reference-count":111,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2024,1,13]],"date-time":"2024-01-13T00:00:00Z","timestamp":1705104000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioengineering"],"abstract":"<jats:p>Biomaterials are used extensively in graft procedures to correct bone defects, interacting with the body without causing adverse reactions. The aim of this pre-clinical study was to analyze the effects of photobiomodulation therapy (PBM) with the use of a low-level laser in the repair process of bone defects filled with inorganic matrix (IM) associated with heterologous fibrin biopolymer (FB). A circular osteotomy of 4 mm in the left tibia was performed in 30 Wistar male adult rats who were randomly divided into three groups: G1 = IM + PBM, G2 = IM + FB and G3 = IM + FB + PBM. PBM was applied at the time of the experimental surgery and three times a week, on alternate days, until euthanasia, with 830 nm wavelength, in two points of the operated site. Five animals from each group were euthanized 14 and 42 days after surgery. In the histomorphometric analysis, the percentage of neoformed bone tissue in G3 (28.4% \u00b1 2.3%) was higher in relation to G1 (24.1% \u00b1 2.91%) and G2 (22.2% \u00b1 3.11%) at 14 days and at 42 days, the percentage in G3 (35.1% \u00b1 2.55%) was also higher in relation to G1 (30.1% \u00b1 2.9%) and G2 (31.8% \u00b1 3.12%). In the analysis of the birefringence of collagen fibers, G3 showed a predominance of birefringence between greenish-yellow in the neoformed bone tissue after 42 days, differing from the other groups with a greater presence of red-orange fibers. Immunohistochemically, in all experimental groups, it was possible to observe immunostaining for osteocalcin (OCN) near the bone surface of the margins of the surgical defect and tartrate-resistant acid phosphatase (TRAP) bordering the newly formed bone tissue. Therefore, laser photobiomodulation therapy contributed to improving the bone repair process in tibial defects filled with bovine biomaterial associated with fibrin biopolymer derived from snake venom.<\/jats:p>","DOI":"10.3390\/bioengineering11010078","type":"journal-article","created":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T08:52:03Z","timestamp":1705308723000},"page":"78","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Photobiomodulation Therapy Improves Repair of Bone Defects Filled by Inorganic Bone Matrix and Fibrin Heterologous Biopolymer"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9151-6990","authenticated-orcid":false,"given":"Maria Fernanda Rossi","family":"Vigliar","sequence":"first","affiliation":[{"name":"Graduate Program in Anatomy of Domestic and Wild Animals, Faculty of Veterinary Medicine and Animal Science, University of Sao Paulo (FMVZ\/USP), Sao Paulo 05508-270, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lais Furlaneto","family":"Marega","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Bauru School of Dentistry, University of Sao Paulo (FOB\/USP), Bauru 17012-901, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3051-737X","authenticated-orcid":false,"given":"Marco Antonio Hungaro","family":"Duarte","sequence":"additional","affiliation":[{"name":"Department of Dentistry, Endodontics and Dental Materials, Bauru School of Dentistry, University of Sao Paulo (FOB\/USP), Bauru 17012-901, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murilo Priori","family":"Alcalde","sequence":"additional","affiliation":[{"name":"Department of Dentistry, Endodontics and Dental Materials, Bauru School of Dentistry, University of Sao Paulo (FOB\/USP), Bauru 17012-901, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelie Priscila de Oliveira","family":"Rosso","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Bauru School of Dentistry, University of Sao Paulo (FOB\/USP), Bauru 17012-901, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6952-0512","authenticated-orcid":false,"given":"Rui Seabra","family":"Ferreira Junior","sequence":"additional","affiliation":[{"name":"Center for the Study of Venoms and Venomous Animals (CEVAP), Sao Paulo State University (University Estadual Paulista, UNESP), Botucatu 18610-307, Brazil"},{"name":"Graduate Programs in Tropical Diseases and Clinical Research, Botucatu Medical School (FMB), Sao Paulo State University (UNESP\u2013University Estadual Paulista), Botucatu 18618-687, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedito","family":"Barraviera","sequence":"additional","affiliation":[{"name":"Center for the Study of Venoms and Venomous Animals (CEVAP), Sao Paulo State University (University Estadual Paulista, UNESP), Botucatu 18610-307, Brazil"},{"name":"Graduate Programs in Tropical Diseases and Clinical Research, Botucatu Medical School (FMB), Sao Paulo State University (UNESP\u2013University Estadual Paulista), Botucatu 18618-687, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Henrique Bertoni","family":"Reis","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Bauru School of Dentistry, University of Sao Paulo (FOB\/USP), Bauru 17012-901, Brazil"},{"name":"Postgraduate Program in Structural and Functional Interactions in Rehabilitation, Postgraduate Department, University of Marilia (UNIMAR), Marilia 17525-902, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9914-1262","authenticated-orcid":false,"given":"Daniela Vieira","family":"Buchaim","sequence":"additional","affiliation":[{"name":"Graduate Program in Anatomy of Domestic and Wild Animals, Faculty of Veterinary Medicine and Animal Science, University of Sao Paulo (FMVZ\/USP), Sao Paulo 05508-270, Brazil"},{"name":"Postgraduate Program in Structural and Functional Interactions in Rehabilitation, Postgraduate Department, University of Marilia (UNIMAR), Marilia 17525-902, Brazil"},{"name":"Medical School, University Center of Adamantina (UNIFAI), Adamantina 17800-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5881-2218","authenticated-orcid":false,"given":"Rogerio Leone","family":"Buchaim","sequence":"additional","affiliation":[{"name":"Graduate Program in Anatomy of Domestic and Wild Animals, Faculty of Veterinary Medicine and Animal Science, University of Sao Paulo (FMVZ\/USP), Sao Paulo 05508-270, Brazil"},{"name":"Department of Biological Sciences, Bauru School of Dentistry, University of Sao Paulo (FOB\/USP), Bauru 17012-901, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,1,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Zhang, X., Wang, X., Lee, Y.-W., Feng, L., Wang, B., Pan, Q., Meng, X., Cao, H., Li, L., and Wang, H. (2022). Bioactive Scaffold Fabricated by 3D Printing for Enhancing Osteoporotic Bone Regeneration. Bioengineering, 9.","DOI":"10.3390\/bioengineering9100525"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1038\/s41580-020-00279-w","article-title":"Mechanisms of Bone Development and Repair","volume":"21","author":"Salhotra","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/j.jdent.2014.05.008","article-title":"Tissue Engineering in Dentistry","volume":"42","author":"Chrzanowski","year":"2014","journal-title":"J. Dent."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Tamaddon, M., Samizadeh, S., Wang, L., Blunn, G., and Liu, C. (2017). Intrinsic Osteoinductivity of Porous Titanium Scaffold for Bone Tissue Engineering. Int. J. Biomater., 2017.","DOI":"10.1155\/2017\/5093063"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Crovace, A.M., Giancamillo, A.D., Gervaso, F., Mangiavini, L., Zani, D., Scalera, F., Palazzo, B., Izzo, D., Agnoletto, M., and Domenicucci, M. (2019). Evaluation of in Vivo Response of Three Biphasic Scaffolds for Osteochondral Tissue Regeneration in a Sheep Model. Vet. Sci., 6.","DOI":"10.3390\/vetsci6040090"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1016\/j.injury.2005.07.019","article-title":"Current Concepts of Molecular Aspects of Bone Healing","volume":"36","author":"Dimitriou","year":"2005","journal-title":"Injury"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Boccaccio, A. (2021). Design of Materials for Bone Tissue Scaffolds. Materials, 14.","DOI":"10.3390\/ma14205985"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Ribeiro, T.P., Flores, M., Madureira, S., Zanotto, F., Monteiro, F.J., and Laranjeira, M.S. (2023). Magnetic Bone Tissue Engineering: Reviewing the Effects of Magnetic Stimulation on Bone Regeneration and Angiogenesis. Pharmaceutics, 15.","DOI":"10.3390\/pharmaceutics15041045"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e39","DOI":"10.1016\/j.oooo.2012.04.018","article-title":"Autogenous Teeth Used for Bone Grafting: A Comparison with Traditional Grafting Materials","volume":"117","author":"Kim","year":"2014","journal-title":"Oral. Surg. Oral. Med. Oral. Pathol. Oral. Radiol."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Reis, C.H.B., Buchaim, D.V., Ortiz, A.D.C., Fideles, S.O.M., Dias, J.A., Miglino, M.A., Teixeira, D.D.B., Pereira, E.D.S.B.M., da Cunha, M.R., and Buchaim, R.L. (2022). Application of Fibrin Associated with Photobiomodulation as a Promising Strategy to Improve Regeneration in Tissue Engineering: A Systematic Review. Polymers, 14.","DOI":"10.3390\/polym14153150"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"de Azambuja Carvalho, P.H., Al-Maawi, S., Dohle, E., Sader, R.A., Pereira-Filho, V.A., and Ghanaati, S. (2022). Cellular Response of Human Osteoblasts to Different Presentations of Deproteinized Bovine Bone. Materials, 15.","DOI":"10.3390\/ma15030999"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e258","DOI":"10.1097\/OI9.0000000000000258","article-title":"Management of Aseptic Nonunions and Severe Bone Defects: Let Us Get This Thing Healed!","volume":"6","author":"Nauth","year":"2023","journal-title":"OTA Int."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Li, J., Jin, F., Wang, R., Shang, X., Yang, P., Zhu, Y., Tsoi, J.K.H., Chan, K., and Wang, S. (2023). Guided Bone Regeneration in a Periodontally Compromised Individual with Autogenous Tooth Bone Graft: A Radiomics Analysis. J. Funct. Biomater., 14.","DOI":"10.3390\/jfb14040220"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.injury.2007.02.012","article-title":"Autologous iliac crest bone graft: Should it still be the gold standard for treating nonunions?","volume":"38","author":"Sen","year":"2007","journal-title":"Injury"},{"key":"ref_15","first-page":"432","article-title":"Tibial pilon fractures: A review of incidence, diagnosis, treatment, and complications","volume":"77","author":"Mauffrey","year":"2011","journal-title":"Acta Orthop. Belg."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1097\/BOT.0000000000000460","article-title":"Bone Grafting: Sourcing, Timing, Strategies, and Alternatives","volume":"29","author":"Egol","year":"2015","journal-title":"J. Orthop. Trauma."},{"key":"ref_17","first-page":"1272490","article-title":"Minimally Invasive Technique in the Management of Tibial Pilon Fractures: New Approach and Promising Results","volume":"2023","author":"Bassir","year":"2023","journal-title":"Adv. Orthop."},{"key":"ref_18","first-page":"e24655","article-title":"History of Bone Grafts in Spine Surgery","volume":"14","author":"Hampel","year":"2022","journal-title":"Cureus"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.bone.2007.04.189","article-title":"Impaired Osteoinduction in a Rat Model for Chronic Alcohol Abuse","volume":"41","author":"Trevisiol","year":"2007","journal-title":"Bone"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Chinnasami, H., Dey, M.K., and Devireddy, R. (2023). Three-Dimensional Scaffolds for Bone Tissue Engineering. Bioengineering, 10.","DOI":"10.3390\/bioengineering10070759"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Nguyen-Thanh, T., Nguyen-Tran, B.-S., Cruciani, S., Nguyen-Thi, T.-D., Dang-Cong, T., and Maioli, M. (2023). Osteochondral Regeneration Ability of Uncultured Bone Marrow Mononuclear Cells and Platelet-Rich Fibrin Scaffold. Bioengineering, 10.","DOI":"10.3390\/bioengineering10060661"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.progpolymsci.2015.02.004","article-title":"Advancing Biomaterials of Human Origin for Tissue Engineering","volume":"53","author":"Chen","year":"2016","journal-title":"Prog. Polym. Sci."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Rosso, M.P.D.O., Oyadomari, A.T., Pomini, K.T., Della Coletta, B.B., Shindo, J.V.T.C., Ferreira J\u00fanior, R.S., Barraviera, B., Cassaro, C.V., Buchaim, D.V., and Teixeira, D.D.B. (2020). Photobiomodulation Therapy Associated with Heterologous Fibrin Biopolymer and Bovine Bone Matrix Helps to Reconstruct Long Bones. Biomolecules, 10.","DOI":"10.3390\/biom10030383"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Iwase, D., Metoki, Y., Kusumoto, Y., Aikawa, J., Fukushima, K., Takano, S., Mukai, M., Uchida, K., Inoue, G., and Takaso, M. (2022). Using Allogenous Structural Bone Graft for Uncontained Tibial Bone Defects \u2265 10 Mm in Depth in Primary Total Knee Arthroplasty. BMC Musculoskelet. Disord., 23.","DOI":"10.1186\/s12891-022-05491-7"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.tdj.2015.05.003","article-title":"Tissue Engineering in Oral and Maxillofacial Reconstruction","volume":"12","author":"Melek","year":"2015","journal-title":"Tanta Dent. J."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1002\/jbm.a.37170","article-title":"Bone Substitutes and Photobiomodulation in Bone Regeneration: A Systematic Review in Animal Experimental Studies","volume":"109","author":"Magri","year":"2021","journal-title":"J. Biomed. Mater. Res. A"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"da Silva Brum, I., Frigo, L., Lana Devita, R., da Silva Pires, J.L., Hugo Vieira de Oliveira, V., Rosa Nascimento, A.L., and de Carvalho, J.J. (2020). Histomorphometric, Immunohistochemical, Ultrastructural Characterization of a Nano-Hydroxyapatite\/Beta-Tricalcium Phosphate Composite and a Bone Xenograft in Sub-Critical Size Bone Defect in Rat Calvaria. Materials, 13.","DOI":"10.3390\/ma13204598"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1007\/s00586-008-0648-3","article-title":"Donor Site Morbidity Following Iliac Crest Bone Harvesting for Cervical Fusion: A Comparison between Minimally Invasive and Open Techniques","volume":"17","author":"Pollock","year":"2008","journal-title":"Eur. Spine J."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Hanna, R., Dalvi, S., Amaroli, A., De Angelis, N., and Benedicenti, S. (2021). Effects of Photobiomodulation on Bone Defects Grafted with Bone Substitutes: A Systematic Review of in Vivo Animal Studies. J. Biophotonics, 14.","DOI":"10.1002\/jbio.202000267"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Inchingolo, A.M., Patano, A., Di Pede, C., Inchingolo, A.D., Palmieri, G., de Ruvo, E., Campanelli, M., Buongiorno, S., Carpentiere, V., and Piras, F. (2023). Autologous Tooth Graft: Innovative Biomaterial for Bone Regeneration. Tooth Transformer\u00ae and the Role of Microbiota in Regenerative Dentistry. A Systematic Review. J. Funct. Biomater., 14.","DOI":"10.3390\/jfb14030132"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1016\/j.biomaterials.2008.12.024","article-title":"Reconstruction of Calvarial Defect Using a Tricalcium Phosphate-Oligomeric Proanthocyanidins Cross-Linked Gelatin Composite","volume":"30","author":"Chen","year":"2009","journal-title":"Biomaterials"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s13770-021-00333-4","article-title":"Comparison of Autogenous Tooth Materials and Other Bone Grafts","volume":"18","author":"Zhang","year":"2021","journal-title":"Tissue Eng. Regen. Med."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Minetti, E., Palermo, A., Savadori, P., Patano, A., Inchingolo, A.D., Rapone, B., Malcangi, G., Inchingolo, F., Dipalma, G., and Tartaglia, F.C. (2023). Socket Preservation Using Dentin Mixed with Xenograft Materials: A Pilot Study. Materials, 16.","DOI":"10.3390\/ma16144945"},{"key":"ref_34","first-page":"103","article-title":"Characterization physical-chemical and biological the bovine Characterization physical-chemical and biological the bovine bone graft, Bonefill in biogical assays\u2014Part 1","volume":"7","author":"Carbonari","year":"2010","journal-title":"ImplantNews"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Chisci, G., Hatia, A., Chisci, E., Chisci, D., Gennaro, P., and Gabriele, G. (2023). Socket Preservation after Tooth Extraction: Particulate Autologous Bone vs. Deproteinized Bovine Bone. Bioengineering, 10.","DOI":"10.3390\/bioengineering10040421"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Pietruszka, P., Chru\u015bcicka, I., Du\u015b-Ilnicka, I., and Paradowska-Stolarz, A. (2021). PRP and PRF\u2014Subgroups and Divisions When Used in Dentistry. J. Pers. Med., 11.","DOI":"10.3390\/jpm11100944"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Morello, G., Polini, A., Scalera, F., Rizzo, R., Gigli, G., and Gervaso, F. (2021). Preparation and Characterization of Salt-Mediated Injectable Thermosensitive Chitosan\/Pectin Hydrogels for Cell Embedding and Culturing. Polymers, 13.","DOI":"10.3390\/polym13162674"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/978-1-0716-2716-7_7","article-title":"Advances in Regenerative Medicine and Biomaterials","volume":"2575","year":"2023","journal-title":"Methods Mol. Biol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"168","DOI":"10.4055\/cios20079","article-title":"Treatment of 10-Mm-Deep or Greater Uncontained Tibial Bone Defects in Primary Total Knee Reconstruction without Metal Augmentation: Autologous Oblique Structural Peg Bone and Cancellous Chip Bone Grafting","volume":"13","author":"Chon","year":"2021","journal-title":"CiOS Clin. Orthop. Surg."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Fernandes, Y., Mantovani, R., Reino, D., Novaes, A., Messora, M., Gustavo Sousa, L., Palioto, D., and Scombatti de Souza, S. (2022). Evaluation of a New Porcine Bone Graft on the Repair of Surgically Created Critical Bone Defects in Rat Calvaria: Histomorphometric and Microtomographic Study. J. Funct. Biomater., 13.","DOI":"10.3390\/jfb13030124"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"German, I.J.S., Pomini, K.T., Bighetti, A.C.C., Andreo, J.C., Reis, C.H.B., Shinohara, A.L., Rosa, G.M., de Bortoli Teixeira, D., de Oliveira Rosso, M.P., and Buchaim, D.V. (2020). Evaluation of the Use of an Inorganic Bone Matrix in the Repair of Bone Defects in Rats Submitted to Experimental Alcoholism. Materials, 13.","DOI":"10.3390\/ma13030695"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Francisco, I., Bas\u00edlio, \u00c2., Ribeiro, M.P., Nunes, C., Travassos, R., Marques, F., Pereira, F., Paula, A.B., Carrilho, E., and Marto, C.M. (2023). Three-Dimensional Impression of Biomaterials for Alveolar Graft: Scoping Review. J. Funct. Biomater., 14.","DOI":"10.3390\/jfb14020076"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1111\/j.1600-0501.2010.01918.x","article-title":"Alveolar ridge preservation with guided bone regeneration and a synthetic bone substitute or a bovine-derived xenograft: A randomized, controlled clinical trial","volume":"21","author":"Mardas","year":"2010","journal-title":"Clin. Oral. Implant. Res."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Gao, X., Cheng, H., Sun, X., Lu, A., Ruzbarsky, J.J., Wang, B., and Huard, J. (2021). Comparison of Autologous Blood Clots with Fibrin Sealant as Scaffolds for Promoting Human Muscle-Derived Stem Cell-Mediated Bone Regeneration. Biomedicines, 9.","DOI":"10.3390\/biomedicines9080983"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.blre.2013.02.001","article-title":"Blood-Derived Biomaterials and Platelet Growth Factors in Regenerative Medicine","volume":"27","author":"Burnouf","year":"2013","journal-title":"Blood Rev."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1007\/s10103-016-1939-2","article-title":"The New Heterologous Fibrin Sealant in Combination with Low-Level Laser Therapy (LLLT) in the Repair of the Buccal Branch of the Facial Nerve","volume":"31","author":"Buchaim","year":"2016","journal-title":"Lasers Med. Sci."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"627541","DOI":"10.3389\/fimmu.2021.627541","article-title":"Treatment of Chronic Venous Ulcers with Heterologous Fibrin Sealant: A Phase I\/II Clinical Trial","volume":"12","author":"Abbade","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s40409-017-0109-8","article-title":"Heterologous Fibrin Sealant Derived from Snake Venom: From Bench to Bedside\u2014An Overview","volume":"23","author":"Ferreira","year":"2017","journal-title":"J. Venom. Anim. Toxins Incl. Trop. Dis."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1111\/iep.12226","article-title":"Low-Level Laser Therapy (780 Nm) Combined with Collagen Sponge Scaffold Promotes Repair of Rat Cranial Critical-Size Defects and Increases TGF-\u03b2, FGF-2, OPG\/RANK and Osteocalcin Expression","volume":"98","author":"Barboza","year":"2017","journal-title":"Int. J. Exp. Pathol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"e48","DOI":"10.34172\/jlms.2022.48","article-title":"Bone Neoformation Induced by Low-Level Laser and Methylene Blue Suggests Early Ossification in Rats","volume":"13","author":"Nagato","year":"2022","journal-title":"J. Lasers Med. Sci."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1007\/s10103-023-03762-w","article-title":"Effects of Photobiomodulation Therapy (PBMT) over Endothelial Function in Healthy Individuals: A Preliminary Crossover Clinical Trial","volume":"38","author":"Hauck","year":"2023","journal-title":"Lasers Med. Sci."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"S101","DOI":"10.5005\/jp-journals-10005-1966","article-title":"Benefits of Using Low-Level Laser Therapy in the Rapid Maxillary Expansion: A Systematic Review","volume":"14","author":"Lai","year":"2021","journal-title":"Int. J. Clin. Pediatr. Dent."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"3379","DOI":"10.1007\/s10103-022-03649-2","article-title":"Efficacy of Photobiomodulation Therapy on Healing of Ionizing Irradiated Bone: A Systematic Review of in Vivo Animal Studies","volume":"37","author":"Amorim","year":"2022","journal-title":"Lasers Med. Sci."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.jphotobiol.2015.08.002","article-title":"The Effects of Combined Low Level Laser Therapy and Mesenchymal Stem Cells on Bone Regeneration in Rabbit Calvarial Defects","volume":"151","author":"Fekrazad","year":"2015","journal-title":"J. Photochem. Photobiol. B"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"du Sert, N.P., Hurst, V., Ahluwalia, A., Alam, S., Avey, M.T., Baker, M., Browne, W.J., Clark, A., Cuthill, I.C., and Dirnagl, U. (2020). The ARRIVE Guidelines 2.0: Updated Guidelines for Reporting Animal Research. PLoS Biol., 18.","DOI":"10.1371\/journal.pbio.3000410"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"du Sert, N.P., Ahluwalia, A., Alam, S., Avey, M.T., Baker, M., Browne, W.J., Clark, A., Cuthill, I.C., Dirnagl, U., and Emerson, M. (2020). Reporting Animal Research: Explanation and Elaboration for the ARRIVE Guidelines 2.0. PLoS Biol., 18.","DOI":"10.1371\/journal.pbio.3000411"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1007\/s00198-008-0609-z","article-title":"Sex Hormones, Their Receptors and Bone Health","volume":"19","author":"Venken","year":"2008","journal-title":"Osteoporos. Int."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1749-6632.2011.06360.x","article-title":"A Crosstalk between Bone and Gonads","volume":"1260","author":"Oury","year":"2012","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Pomini, K.T., Buchaim, D.V., Andreo, J.C., Rosso, M.P.D.O., Della Coletta, B.B., German, \u00cd.J.S., Biguetti, A.C.C., Shinohara, A.L., Rosa, G.M., and Cosin Shindo, J.V.T. (2019). Fibrin Sealant Derived from Human Plasma as a Scaffold for Bone Grafts Associated with Photobiomodulation Therapy. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20071761"},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Pomini, K.T., Buchaim, D.V., Bighetti, A.C.C., Hamz\u00e9, A.L., Reis, C.H.B., Duarte, M.A.H., Alcalde, M.P., Barraviera, B., J\u00fanior, R.S.F., and de Souza, A.T. (2023). Tissue Bioengineering with Fibrin Scaffolds and Deproteinized Bone Matrix Associated or Not with the Transoperative Laser Photobiomodulation Protocol. Molecules, 28.","DOI":"10.3390\/molecules28010407"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1080\/10937400903442514","article-title":"A New Fibrin Sealant from Crotalus Durissus Terrificus Venom: Applications in Medicine","volume":"12","author":"Barros","year":"2009","journal-title":"J. Toxicol. Env. Health B Crit. Rev."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.jphotobiol.2016.07.023","article-title":"Effects of low-level laser therapy on autogenous bone graft stabilized with a new heterologous fibrin sealant","volume":"162","author":"Buchaim","year":"2016","journal-title":"J. Photochem. Photobiol. B"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.jphotobiol.2016.08.040","article-title":"Effects of Low-Level Laser Therapy on Bone Healing of Critical-Size Defects Treated with Bovine Bone Graft","volume":"163","author":"Bosco","year":"2016","journal-title":"J. Photochem. Photobiol. B"},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Freitas, N.R.D., Guerrini, L.B., Esper, L.A., Sbrana, M.C., Santos, C.C.V.D., and Almeida, A.L.P.F.D. (2023). Photobiomodulation and Inorganic Bovine Bone in Guided Bone Regeneration: Histomorphometric Analysis in Rats. J. Funct. Biomater., 14.","DOI":"10.3390\/jfb14050281"},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"de Lima Barbosa, R., Stellet Louren\u00e7o, E., de Azevedo dos Santos, J.V., Rodrigues Santiago Rocha, N., Mour\u00e3o, C.F., and Alves, G.G. (2023). The Effects of Platelet-Rich Fibrin in the Behavior of Mineralizing Cells Related to Bone Tissue Regeneration\u2014A Scoping Review of In Vitro Evidence. J. Funct. Biomater., 14.","DOI":"10.3390\/jfb14100503"},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Della Coletta, B.B., Jacob, T.B., Moreira, L.A.D.C., Pomini, K.T., Buchaim, D.V., Eleut\u00e9rio, R.G., Pereira, E.D.S.B.M., Roque, D.D., Rosso, M.P.D.O., and Shindo, J.V.T.C. (2021). Photobiomodulation Therapy on the Guided Bone Regeneration Process in Defects Filled by Biphasic Calcium Phosphate Associated with Fibrin Biopolymer. Molecules, 26.","DOI":"10.3390\/molecules26040847"},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Ramires, G.A.D., Helena, J.T., De Oliveira, J.C.S., Faverani, L.P., and Bassi, A.P.F. (2021). Evaluation of Guided Bone Regeneration in Critical Defects Using Bovine and Porcine Collagen Membranes: Histomorphometric and Immunohistochemical Analyses. Int. J. Biomater., 2021.","DOI":"10.1155\/2021\/8828194"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1111\/j.1600-0501.2012.02431.x","article-title":"Histological Results after Maxillary Sinus Augmentation with Straumann\u00ae BoneCeramic, Bio-Oss\u00ae, Puros\u00ae, and Autologous Bone. A Randomized Controlled Clinical Trial","volume":"24","author":"Schmitt","year":"2013","journal-title":"Clin. Oral. Implant. Res."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.21873\/invivo.11719","article-title":"Comparison of Material-Mediated Bone Regeneration Capacities of Sintered and Non-Sintered Xenogeneic Bone Substitutes via 2D and 3D Data","volume":"33","author":"Kapogianni","year":"2019","journal-title":"In Vivo"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/978-1-0716-1028-2_11","article-title":"MicroCT for Scanning and Analysis of Mouse Bones","volume":"2230","author":"Kim","year":"2021","journal-title":"Methods Mol. Biol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/jmi.12745","article-title":"Optimization of Digital Volume Correlation Computation in SR-MicroCT Images of Trabecular Bone and Bone-Biomaterial Systems","volume":"272","author":"Barber","year":"2018","journal-title":"J. Microsc."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1111\/jmi.12844","article-title":"Applications of X-Ray Computed Tomography for the Evaluation of Biomaterial-Mediated Bone Regeneration in Critical-Sized Defects","volume":"277","author":"Witte","year":"2020","journal-title":"J. Microsc."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1097\/ID.0000000000000572","article-title":"Bone Healing Evaluation in Critical-Size Defects Treated with Xenogenous Bone Plus Porcine Collagen","volume":"26","author":"Maciel","year":"2017","journal-title":"Implant. Dent."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Reis, C.H.B., Buchaim, R.L., Pomini, K.T., Hamz\u00e9, A.L., Zattiti, I.V., Duarte, M.A.H., Alcalde, M.P., Barraviera, B., Ferreira J\u00fanior, R.S., and Pontes, F.M.L. (2022). Effects of a Biocomplex Formed by Two Scaffold Biomaterials, Hydroxyapatite\/Tricalcium Phosphate Ceramic and Fibrin Biopolymer, with Photobiomodulation, on Bone Repair. Polymers, 14.","DOI":"10.3390\/polym14102075"},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Bueno, C.R.D.S., Tonin, M.C.C., Buchaim, D.V., Barraviera, B., Ferreira Junior, R.S., Santos, P.S.D.S., Reis, C.H.B., Pastori, C.M., Pereira, E.D.S.B.M., and Nogueira, D.M.B. (2023). Morphofunctional Improvement of the Facial Nerve and Muscles with Repair Using Heterologous Fibrin Biopolymer and Photobiomodulation. Pharmaceuticals, 16.","DOI":"10.3390\/ph16050653"},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Ferreira, M.M., Brito, A.F., Brazete, D., Pereira, I.C., Carrilho, E., Abrantes, A.M., Pires, A.S., Aguiar, M.J., Carvalho, L., and Botelho, M.F. (2019). Doping \u03b2-TCP as a Strategy for Enhancing the Regenerative Potential of Composite \u03b2-TCP\u2014Alkali-Free Bioactive Glass Bone Grafts. Experimental Study in Rats. Materials, 12.","DOI":"10.3390\/ma12010004"},{"key":"ref_77","first-page":"12","article-title":"Biocompatibility of anioniccollagen matrices and its influence on the orientation of cellular growth","volume":"10","author":"Buchaim","year":"2007","journal-title":"Braz. Dent. Sci."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1089\/pho.2010.2771","article-title":"Laser Photobiomodulation of Proliferation of Cells in Culture: A Review of Human and Animal Studies","volume":"28","author":"Peplow","year":"2010","journal-title":"Photomed. Laser Surg."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"e542","DOI":"10.4317\/jced.60594","article-title":"A Randomised Trial of the Bone Formation after Maxillary Sinus Floor Augmentation with Bovine Hydroxyapatite (Cerabone\u00ae) and Photobiomodulation: Histomorphometric and Immunohistochemical Analysis","volume":"15","author":"Klassmann","year":"2023","journal-title":"J. Clin. Exp. Dent."},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Nogueira, D.M.B., Figadoli, A.L.D.F., Alcantara, P.L., Pomini, K.T., Santos German, I.J., Reis, C.H.B., Rosa J\u00fanior, G.M., Rosso, M.P.D.O., Santos, P.S.D.S., and Zangrando, M.S.R. (2022). Biological Behavior of Xenogenic Scaffolds in Alcohol-Induced Rats: Histomorphometric and Picrosirius Red Staining Analysis. Polymers, 14.","DOI":"10.3390\/polym14030584"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1007\/s10103-014-1580-x","article-title":"New LLLT Protocol to Speed up the Bone Healing Process-Histometric and Immunohistochemical Analysis in Rat Calvarial Bone Defect","volume":"30","author":"Marques","year":"2015","journal-title":"Lasers Med. Sci."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"e53","DOI":"10.34172\/jlms.2021.53","article-title":"The Effect of Photobiomodulation Therapy in Different Doses on Bone Repair of Critical Size Defects in Rats: A Histomorphometric Study","volume":"12","author":"Torquato","year":"2021","journal-title":"J. Lasers Med. Sci."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1002\/vms3.1071","article-title":"Photobiomodulation Therapy Combined with Static Magnetic Field in Tibial Fracture Healing of a Dog: A Case Report","volume":"9","author":"Morga","year":"2023","journal-title":"Vet. Med. Sci."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1186\/s13000-014-0221-9","article-title":"Different Approaches for Interpretation and Reporting of Immunohistochemistry Analysis Results in the Bone Tissue\u2014A Review","volume":"9","author":"Fedchenko","year":"2014","journal-title":"Diagn. Pathol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1159\/000442389","article-title":"Comprehensive Immunohistochemistry: Digital, Analytical and Integrated","volume":"83","author":"Laurinavicius","year":"2016","journal-title":"Pathobiology"},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Pires, J.L.D.S., de Carvalho, J.J., Pereira, M.J.D.S., Brum, I.D.S., Nascimento, A.L.R., dos Santos, P.G.P., Frigo, L., and Fischer, R.G. (2021). Repair of Critical Size Bone Defects Using Synthetic Hydroxyapatite or Xenograft with or without the Bone Marrow Mononuclear Fraction: A Histomorphometric and Immunohistochemical Study in Rat Calvaria. Materials, 14.","DOI":"10.3390\/ma14112854"},{"key":"ref_87","first-page":"447","article-title":"Sintered Anorganic Bone Graft Increases Autocrine Expression of VEGF, MMP-2 and MMP-9 during Repair of Critical-Size Bone Defects","volume":"45","author":"Rocha","year":"2014","journal-title":"J. Mol. Histol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"e33","DOI":"10.34172\/jlms.2022.33","article-title":"Effect of Photobiomodulation Therapy Associated withBiphasic Phosphate Calcium on Bone Repair: A Histomorphometric Study in Rats","volume":"13","year":"2022","journal-title":"J. Lasers Med. Sci."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Silva, S.K., Plepis, A.M.G., Martins, V.d.C.A., Horn, M.M., Buchaim, D.V., Buchaim, R.L., Pelegrine, A.A., Silva, V.R., Kudo, M.H.M., and Fernandes, J.F.R. (2022). Suitability of Chitosan Scaffolds with Carbon Nanotubes for Bone Defects Treated with Photobiomodulation. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23126503"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.1016\/j.biomaterials.2008.12.055","article-title":"The Stimulation of Healing within a Rat Calvarial Defect by MPCL-TCP\/Collagen Scaffolds Loaded with RhBMP-2","volume":"30","author":"Sawyer","year":"2009","journal-title":"Biomaterials"},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Yazdanpanah, Z., Johnston, J.D., Cooper, D.M.L., and Chen, X. (2022). 3D Bioprinted Scaffolds for Bone Tissue Engineering: State-Of-The-Art and Emerging Technologies. Front. Bioeng. Biotechnol., 10.","DOI":"10.3389\/fbioe.2022.824156"},{"key":"ref_92","first-page":"468","article-title":"Influence of the Ratio of Particulate Autogenous Bone Graft\/Platelet-Rich Plasma on Bone Healing in Critical-Size Defects: A Histologic and Histometric Study in Rat Calvaria","volume":"28","author":"Nagata","year":"2010","journal-title":"J. Orthop. Res."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/s41413-020-0099-y","article-title":"Molecular Mechanosensors in Osteocytes","volume":"8","author":"Qin","year":"2020","journal-title":"Bone Res."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1080\/08916930701694667","article-title":"Tartrate-Resistant Acid Phosphatase (TRAP) and the Osteoclast\/Immune Cell Dichotomy","volume":"41","author":"Hayman","year":"2008","journal-title":"Autoimmunity"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.acthis.2015.03.006","article-title":"da A New Heterologous Fibrin Sealant as Scaffold to Recombinant Human Bone Morphogenetic Protein-2 (RhBMP-2) and Natural Latex Proteins for the Repair of Tibial Bone Defects","volume":"117","author":"Machado","year":"2015","journal-title":"Acta Histochem."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"258","DOI":"10.3390\/macromol2030018","article-title":"Antimicrobial Activity of Composites-Based on Biopolymers","volume":"2","author":"Bucio","year":"2022","journal-title":"Macromol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"e20210056","DOI":"10.1590\/1678-9199-jvatitd-2021-0056","article-title":"A Biocomplex to Repair Experimental Critical Size Defects Associated with Photobiomodulation Therapy","volume":"28","author":"Buchaim","year":"2022","journal-title":"J. Venom. Anim. Toxins Incl. Trop. Dis."},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Egorikhina, M.N., Bronnikova, I.I., Rubtsova, Y.P., Charykova, I.N., Bugrova, M.L., Linkova, D.D., and Aleynik, D.Y. (2021). Aspects of In Vitro Biodegradation of Hybrid Fibrin\u2013Collagen Scaffolds. Polymers, 13.","DOI":"10.3390\/polym13203470"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1007\/s12663-013-0554-z","article-title":"Comparative, Histological and Histomorphometric Analysis of Three Anorganic Bovine Xenogenous Bone Substitutes: Bio-Oss, Bone-Fill and Gen-Ox Anorganic","volume":"13","author":"Manfro","year":"2014","journal-title":"J. Maxillofac. Oral. Surg."},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Grossi-Oliveira, G., Faverani, L.P., Mendes, B.C., Braga Polo, T.O., Batista Mendes, G.C., De Lima, V.N., Ribeiro J\u00fanior, P.D., Okamoto, R., and Magro-Filho, O. (2020). Comparative Evaluation of Bone Repair with Four Different Bone Substitutes in Critical Size Defects. Int. J. Biomater., 2020.","DOI":"10.1155\/2020\/5182845"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"841146","DOI":"10.3389\/fphys.2022.841146","article-title":"Optimal Parameters of Laser Therapy to Improve Critical Calvarial Defects","volume":"13","author":"Santos","year":"2022","journal-title":"Front. Physiol."},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Dipalma, G., Inchingolo, A.M., Patano, A., Palumbo, I., Guglielmo, M., Trilli, I., Netti, A., Ferrara, I., Viapiano, F., and Inchingolo, A.D. (2023). Photobiomodulation and Growth Factors in Dentistry: A Systematic Review. Photonics, 10.","DOI":"10.3390\/photonics10101095"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"e13","DOI":"10.34172\/jlms.2022.13","article-title":"Effect of Low-Level Laser Therapy on Bone Formation in Rapid Palatal Expansion: A Systematic Review","volume":"13","author":"Farzan","year":"2022","journal-title":"J. Lasers Med. Sci."},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Berni, M., Brancato, A.M., Torriani, C., Bina, V., Annunziata, S., Cornella, E., Trucchi, M., Jannelli, E., Mosconi, M., and Gastaldi, G. (2023). The Role of Low-Level Laser Therapy in Bone Healing: Systematic Review. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24087094"},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Pan, L.-C., Hang, N.-L.-T., Colley, M.M.S., Chang, J., Hsiao, Y.-C., Lu, L.-S., Li, B.-S., Chang, C.-J., and Yang, T.-S. (2022). Single Cell Effects of Photobiomodulation on Mitochondrial Membrane Potential and Reactive Oxygen Species Production in Human Adipose Mesenchymal Stem Cells. Cells, 11.","DOI":"10.3390\/cells11060972"},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Ahmad, M.A., Moganan, M., Hamid, M.S.A., Sulaiman, N., Moorthy, U., Hasnan, N., and Yusof, A. (2023). Comparison between Low-Level and High-Intensity Laser Therapy as an Adjunctive Treatment for Knee Osteoarthritis: A Randomized, Double-Blind Clinical Trial. Life, 13.","DOI":"10.20944\/preprints202305.0686.v1"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"713","DOI":"10.7863\/ultra.33.4.713","article-title":"Effect of low-intensity pulsed ultrasound on bone regeneration: Biochemical and radiologic analyses","volume":"33","author":"Pomini","year":"2014","journal-title":"J. Ultrasound Med."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.ultsonch.2019.04.032","article-title":"Sonochemical time standardization for bioactive materials used in periimplantar defects filling","volume":"56","author":"Okamoto","year":"2019","journal-title":"Ultrason. Sonochem"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1590\/S0004-27302005000600006","article-title":"Evidences of physical agents action on bone metabolism and their potential clinical use","volume":"49","author":"Lirani","year":"2005","journal-title":"Arq. Bras. Endocrinol. Metabol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1590\/s0102-865020180040000004","article-title":"Action of a deproteinized xenogenic biomaterial in the process of bone repair in rats submitted to inhalation of cigarette smoke","volume":"33","author":"Buchaim","year":"2018","journal-title":"Acta Cir. Bras."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1111\/clr.12825","article-title":"Healing at implants installed concurrently to maxillary sinus floor elevation with Bio-Oss\u00ae or autologous bone grafts. A histo-morphometric study in rabbits","volume":"28","author":"Lang","year":"2017","journal-title":"Clin. Oral Implants Res."}],"container-title":["Bioengineering"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2306-5354\/11\/1\/78\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T13:46:11Z","timestamp":1760103971000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2306-5354\/11\/1\/78"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,13]]},"references-count":111,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,1]]}},"alternative-id":["bioengineering11010078"],"URL":"https:\/\/doi.org\/10.3390\/bioengineering11010078","relation":{},"ISSN":["2306-5354"],"issn-type":[{"value":"2306-5354","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,13]]}}}