{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T14:28:28Z","timestamp":1776868108405,"version":"3.51.2"},"reference-count":61,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2024,2,22]],"date-time":"2024-02-22T00:00:00Z","timestamp":1708560000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioengineering"],"abstract":"<jats:p>Ascending aortic aneurysm (AAoA) is a silent disease with high mortality; however, the factors associated with a worse prognosis are not completely understood. The objective of this observational, longitudinal, single-center study was to identify the hemodynamic patterns and their influence on AAoA growth using computational fluid dynamics (CFD), focusing on the effects of geometrical variations on aortic hemodynamics. Personalized anatomic models were obtained from angiotomography scans of 30 patients in two different years (with intervals of one to three years between them), of which 16 (53%) showed aneurysm growth (defined as an increase in the ascending aorta volume by 5% or more). Numerically determined velocity and pressure fields were compared with the outcome of aneurysm growth. Through a statistical analysis, hemodynamic characteristics were found to be associated with aneurysm growth: average and maximum high pressure (superior to 100 Pa); average and maximum high wall shear stress (superior to 7 Pa) combined with high pressure (&gt;100 Pa); and stress load over time (maximum pressure multiplied by the time interval between the exams). This study provides insights into a worse prognosis of this serious disease and may collaborate for the expansion of knowledge about mechanobiology in the progression of AAoA.<\/jats:p>","DOI":"10.3390\/bioengineering11030204","type":"journal-article","created":{"date-parts":[[2024,2,22]],"date-time":"2024-02-22T03:30:26Z","timestamp":1708572626000},"page":"204","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Stress Load and Ascending Aortic Aneurysms: An Observational, Longitudinal, Single-Center Study Using Computational Fluid Dynamics"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4361-5609","authenticated-orcid":false,"given":"Fabiula Schwartz","family":"de Azevedo","sequence":"first","affiliation":[{"name":"Department of Cardiology, Federal University of Rio de Janeiro, Rio de Janeiro 21941-913, RJ, Brazil"},{"name":"Research and Teaching Department, Instituto Nacional de Cardiologia, Rio de Janeiro 22240-006, RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3082-6167","authenticated-orcid":false,"given":"Gabriela de Castro","family":"Almeida","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, Pontifical Catholic University of Rio de Janeiro, Rio de Janeiro 22451-900, RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4788-1496","authenticated-orcid":false,"given":"Bruno","family":"Alvares de Azevedo","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, Pontifical Catholic University of Rio de Janeiro, Rio de Janeiro 22451-900, RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9541-311X","authenticated-orcid":false,"given":"Ivan Fernney","family":"Ibanez Aguilar","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, Pontifical Catholic University of Rio de Janeiro, Rio de Janeiro 22451-900, RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6709-8225","authenticated-orcid":false,"given":"Bruno Nieckele","family":"Azevedo","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, Pontifical Catholic University of Rio de Janeiro, Rio de Janeiro 22451-900, RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5025-7531","authenticated-orcid":false,"given":"Pedro Soares","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Fit Center\u2014Cl\u00ednica de Performance Humana, Niter\u00f3i 24220-331, RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5203-6097","authenticated-orcid":false,"given":"Gabriel Cordeiro","family":"Camargo","sequence":"additional","affiliation":[{"name":"Research and Teaching Department, Instituto Nacional de Cardiologia, Rio de Janeiro 22240-006, RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3446-5741","authenticated-orcid":false,"given":"Marcelo Goulart","family":"Correia","sequence":"additional","affiliation":[{"name":"Research and Teaching Department, Instituto Nacional de Cardiologia, Rio de Janeiro 22240-006, RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4836-8931","authenticated-orcid":false,"given":"Angela Ourivio","family":"Nieckele","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, Pontifical Catholic University of Rio de Janeiro, Rio de Janeiro 22451-900, RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0737-6188","authenticated-orcid":false,"given":"Glaucia Maria Moraes","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Federal University of Rio de Janeiro, Rio de Janeiro 21941-913, RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2361","DOI":"10.1016\/j.jacc.2022.11.005","article-title":"The Global Burden of Cardiovascular Diseases and Risk","volume":"80","author":"Vaduganathan","year":"2022","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2873","DOI":"10.1093\/eurheartj\/ehu281","article-title":"2014 ESC Guidelines on the Diagnosis and Treatment of Aortic Diseases: Document Covering Acute and Chronic Aortic Diseases of the Thoracic and Abdominal Aorta of the Adult. The Task Force for the Diagnosis and Treatment of Aortic Diseases of the European Society of Cardiology (ESC)","volume":"35","author":"Erbel","year":"2014","journal-title":"Eur. Heart J."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"e334","DOI":"10.1161\/CIR.0000000000001106","article-title":"2022 ACC\/AHA Guideline for the Diagnosis and Management of Aortic Disease: A Report of the American Heart Association\/American College of Cardiology Joint Committee on Clinical Practice Guidelines","volume":"146","author":"Isselbacher","year":"2022","journal-title":"Circulation"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"8355","DOI":"10.1038\/s41598-023-35585-8","article-title":"In-Silico Investigations of Haemodynamic Parameters for a Blunt Thoracic Aortic Injury Case","volume":"13","author":"Dadras","year":"2023","journal-title":"Sci. Rep."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"6214","DOI":"10.1038\/s41598-017-06339-0","article-title":"Bridging the Gap between Measurements and Modelling: A Cardiovascular Functional Avatar","volume":"7","author":"Casas","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"9718","DOI":"10.1038\/s41598-022-12894-y","article-title":"Impact of Extra-Anatomical Bypass on Coarctation Fluid Dynamics Using Patient-Specific Lumped Parameter and Lattice Boltzmann Modeling","volume":"12","author":"Sadeghi","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/j.jacc.2009.08.084","article-title":"Thoracic Aortic Aneurysm Clinically Pertinent Controversies and Uncertainties","volume":"55","author":"Elefteriades","year":"2010","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1007\/s12055-018-0687-2","article-title":"Size and Dissection: What Is the Relation?","volume":"35","author":"Harky","year":"2019","journal-title":"Indian J. Thorac. Cardiovasc. Surg."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1148\/radiol.13122310","article-title":"Aortic Disease in Patients with Marfan Syndrome: Aortic Volume Assessment for Surveillance","volume":"269","author":"Franken","year":"2013","journal-title":"Radiology"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"e87","DOI":"10.1016\/j.ejrad.2011.01.077","article-title":"Aortic Volume as an Indicator of Disease Progression in Patients with Untreated Infrarenal Abdominal Aneurysm","volume":"81","author":"Renapurkar","year":"2012","journal-title":"Eur. J. Radiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1067\/mva.2000.103971","article-title":"Wall Stress Distribution on Three-Dimensionally Reconstructed Models of Human Abdominal Aortic Aneurysm","volume":"31","author":"Raghavan","year":"2000","journal-title":"J. Vasc. Surg."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1148\/radiol.2020192112","article-title":"Combining Volumetric and Wall Shear Stress Analysis from CT to Assess Risk of Abdominal Aortic Aneurysm Progression","volume":"295","author":"Meyrignac","year":"2020","journal-title":"Radiology"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.actbio.2023.06.026","article-title":"Ascending Aortic Volume: A Feasible Indicator for Ascending Aortic Aneurysm Elective Surgery?","volume":"167","author":"Xiao","year":"2023","journal-title":"Acta Biomater."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"e181281","DOI":"10.1001\/jamanetworkopen.2018.1281","article-title":"Association of Mortality and Acute Aortic Events with Ascending Aortic Aneurysm: A Systematic Review and Meta-Analysis","volume":"1","author":"Guo","year":"2018","journal-title":"JAMA Netw. Open"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e001513","DOI":"10.1161\/JAHA.114.001513","article-title":"Risk Profiles for Aortic Dissection and Ruptured or Surgically Treated Aneurysms: A Prospective Cohort Study","volume":"4","author":"Landenhed","year":"2015","journal-title":"J. Am. Heart Assoc."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1136\/heartjnl-2015-308044","article-title":"Computational Fluid Dynamics Modelling in Cardiovascular Medicine","volume":"102","author":"Morris","year":"2016","journal-title":"Heart"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1007\/s10439-014-1093-6","article-title":"CFD for Evaluation and Treatment Planning of Aneurysms: Review of Proposed Clinical Uses and Their Challenges","volume":"43","author":"Chung","year":"2015","journal-title":"Ann. Biomed. Eng."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1007\/s10439-023-03175-4","article-title":"The Influence of Minor Aortic Branches in Patient-Specific Flow Simulations of Type-B Aortic Dissection","volume":"51","author":"Stokes","year":"2023","journal-title":"Ann. Biomed. Eng."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2950","DOI":"10.1007\/s10439-020-02603-z","article-title":"A Combined In Vivo, In Vitro, In Silico Approach for Patient-Specific Haemodynamic Studies of Aortic Dissection","volume":"48","author":"Bonfanti","year":"2020","journal-title":"Ann. Biomed. Eng."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Moretti, S., Tauro, F., Orrico, M., Mangialardi, N., and Facci, A.L. (2023). Comparative Analysis of Patient-Specific Aortic Dissections through Computational Fluid Dynamics Suggests Increased Likelihood of Degeneration in Partially Thrombosed False Lumen. Bioengineering, 10.","DOI":"10.3390\/bioengineering10030316"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"58","DOI":"10.22468\/cvia.2018.00073","article-title":"Computational Fluid Dynamics Modeling in Aortic Diseases","volume":"2","author":"Ueda","year":"2018","journal-title":"Cardiovasc. Imaging Asia"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.avsg.2019.04.032","article-title":"Computational Fluid Dynamics Modeling of Hemodynamic Parameters in the Human Diseased Aorta: A Systematic Review","volume":"63","author":"Ong","year":"2020","journal-title":"Ann. Vasc. Surg."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Aghilinejad, A., Wei, H., Magee, G.A., and Pahlevan, N.M. (2022). Model-Based Fluid-Structure Interaction Approach for Evaluation of Thoracic Endovascular Aortic Repair Endograft Length in Type B Aortic Dissection. Front. Bioeng. Biotechnol., 10.","DOI":"10.3389\/fbioe.2022.825015"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Al-Jumaily, A.M., Embong, A.H.B., AL-Rawi, M., Mahadevan, G., and Sugita, S. (2023). Aneurysm Rupture Prediction Based on Strain Energy-CFD Modelling. Bioengineering, 10.","DOI":"10.3390\/bioengineering10101231"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Sim\u00e3o, M., Ferreira, J., Tom\u00e1s, A.C., Fragata, J., and Ramos, H. (2017). Aorta Ascending Aneurysm Analysis Using CFD Models towards Possible Anomalies. Fluids, 2.","DOI":"10.3390\/fluids2020031"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"448","DOI":"10.36660\/abc.20200926","article-title":"Computational Fluid Dynamics to Assess the Future Risk of Ascending Aortic Aneurysms","volume":"118","author":"Almeida","year":"2022","journal-title":"Arq. Bras. Cardiol."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Salmasi, M.Y., Pirola, S., Mahuttanatan, S., Fisichella, S.M., Sengupta, S., Jarral, O.A., Oo, A., O\u2019Regan, D., Xu, X.Y., and Athanasiou, T. (2023). Geometry and Flow in Ascending Aortic Aneurysms Are Influenced by Left Ventricular Outflow Tract Orientation: Detecting Increased Wall Shear Stress on the Outer Curve of Proximal Aortic Aneurysms. J. Thorac. Cardiovasc. Surg., 166.","DOI":"10.1016\/j.jtcvs.2021.06.014"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Salmasi, M.Y., Pirola, S., Sasidharan, S., Fisichella, S.M., Redaelli, A., Jarral, O.A., O\u2019Regan, D.P., Oo, A.Y., Moore, J.E., and Xu, X.Y. (2021). High Wall Shear Stress Can Predict Wall Degradation in Ascending Aortic Aneurysms: An Integrated Biomechanics Study. Front. Bioeng. Biotechnol., 9.","DOI":"10.3389\/fbioe.2021.750656"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1161\/HYPERTENSIONAHA.120.16249","article-title":"Aortic Stiffness, Central Blood Pressure, and Pulsatile Arterial Load Predict Future Thoracic Aortic Aneurysm Expansion","volume":"77","author":"Boczar","year":"2021","journal-title":"Hypertension"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"11521","DOI":"10.1038\/s41598-021-91079-5","article-title":"Association of Hemodynamic Factors and Progressive Aortic Dilatation Following Type A Aortic Dissection Surgical Repair","volume":"11","author":"Zhu","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: An Open-Source Platform for Biological-Image Analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat. Methods"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"O195","DOI":"10.1111\/aor.13883","article-title":"Effect of Percutaneous Aortic Valve Position on Stress Map in Ascending Aorta: A Fluid-Structure Interaction Analysis","volume":"45","author":"Ibanez","year":"2021","journal-title":"Artif. Organs"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"10060","DOI":"10.1073\/pnas.0402937101","article-title":"Microviscometry Reveals Reduced Blood Viscosity and Altered Shear Rate and Shear Stress Profiles in Microvessels after Hemodilution","volume":"101","author":"Long","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.protcy.2016.05.045","article-title":"Blood Flow in Human Arterial System-A Review","volume":"24","author":"Thomas","year":"2016","journal-title":"Procedia Technol."},{"key":"ref_35","unstructured":"Almeida, G.C., Azevedo, B.N., Silva, J.A., Ibanez, I.F.A., de Azevedo, B.A., Nieckele, A.O., Azevedo, F.S., and Oliveira, G.M.M. (2021, January 22\u201326). Impact of Viscosity on Blood Flow in Ascending Aortic Aneurysm. Proceedings of the 26th International Congress of Mechanical Engineering, Florian\u00f3polis, Brazil."},{"key":"ref_36","unstructured":"Perocco, E.L.M. (2022). Analysis of the Blood Flow during the Cardiac Cycle in the Ascending Aorta. [Master\u2019s Thesis, Pontifical Catholic University of Rio de Janeiro]."},{"key":"ref_37","first-page":"597","article-title":"Computational Fluid Dynamics of the Ascending Aorta before the Onset of Type A Aortic Dissection","volume":"51","author":"Malvindi","year":"2017","journal-title":"Eur. J. Cardio-Thorac. Surg."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/aor.12955","article-title":"Hemodynamic Evaluation of a Biological and Mechanical Aortic Valve Prosthesis Using Patient-Specific MRI-Based CFD","volume":"42","author":"Hellmeier","year":"2018","journal-title":"Artif. Organs"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1097\/01.mat.0000201961.97981.e9","article-title":"Effect of Left Ventricular Assist Device Outflow Conduit Anastomosis Location on Flow Patterns in the Native Aorta","volume":"52","author":"Hillen","year":"2006","journal-title":"ASAIO J."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Geers, A.J., Larrabide, I., Morales, H.G., and Frangi, A.F. (2010, January 31). Comparison of Steady-State and Transient Blood Flow Simulations of Intracranial Aneurysms. Proceedings of the 2010 Annual International Conference of the IEEE Engineering in Medicine and Biology, Buenos Aires, Argentina. Available online: https:\/\/academia.edu\/download\/53011957\/Comparison_of_Steady-State_and_Transient20170505-3483-z401k3.pdf.","DOI":"10.1109\/IEMBS.2010.5626609"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1007\/s10237-020-01395-4","article-title":"The Influence of Inlet Velocity Profile on Predicted Flow in Type B Aortic Dissection","volume":"20","author":"Armour","year":"2021","journal-title":"Biomech. Model. Mechanobiol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"15492","DOI":"10.1038\/s41598-020-72309-8","article-title":"Physiologic Blood Flow Is Turbulent","volume":"10","author":"Saqr","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.2514\/3.12149","article-title":"Two-Equation Eddy-Viscosity Turbulence Models for Engineering Applications","volume":"32","author":"Menter","year":"1994","journal-title":"AIAA J."},{"key":"ref_44","unstructured":"Celis, D.F.T. (2017). Numerical Study of the Influence of Tilt Valve Angle on Blood Flow in an Aortic Model. [Master\u2019s Thesis, Pontifical Catholic University of Rio de Janeiro]."},{"key":"ref_45","first-page":"231","article-title":"Influence of the Tilt Angle of Percutaneous Aortic Prosthesis on Velocity and Shear Stress Fields","volume":"109","author":"Camargo","year":"2017","journal-title":"Arq. Bras. Cardiol."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Madhavan, S., and Kemmerling, E.M.C. (2018). The Effect of Inlet and Outlet Boundary Conditions in Image-Based CFD Modeling of Aortic Flow. BioMed. Eng. OnLine, 17.","DOI":"10.1186\/s12938-018-0497-1"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"20160073","DOI":"10.1098\/rsif.2016.0073","article-title":"On the Impact of Modelling Assumptions in Multi-Scale, Subject-Specific Models of Aortic Haemodynamics","volume":"13","author":"Alastruey","year":"2016","journal-title":"J. R. Soc. Interface"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1007\/s10237-012-0444-1","article-title":"Helical Flows and Asymmetry of Blood Jet in Dilated Ascending Aorta with Normally Functioning Bicuspid Valve","volume":"12","author":"Faggiano","year":"2013","journal-title":"Biomech. Model. Mechanobiol."},{"key":"ref_49","unstructured":"ANSYS, Inc (2020). Ansys\u00ae Fluent, Release 1, Help System; User Guide Full 2020, ANSYS, Inc."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"078001","DOI":"10.1115\/1.2960953","article-title":"Procedure of Estimation and Reporting of Uncertainty Due to Discretization in CFD Applications\u2013ScienceOpen","volume":"130","author":"Celik","year":"2008","journal-title":"J. Fluids Eng."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s11517-020-02287-6","article-title":"Numerical Investigation of Patient-Specific Thoracic Aortic Aneurysms and Comparison with Normal Subject via Computational Fluid Dynamics (CFD)","volume":"59","author":"Etli","year":"2021","journal-title":"Med. Biol. Eng. Comput."},{"key":"ref_52","unstructured":"Rosner, B. (2015). Fundamentals of Biostatistics, Cengage Learning. [8th ed.]."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"72","DOI":"10.2307\/1412159","article-title":"The Proof and Measurement of Association between Two Things","volume":"15","author":"Spearman","year":"1904","journal-title":"Am. J. Psychol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1161\/01.CIR.64.6.1227","article-title":"Comparative Reproducibility and Validity of Systems for Assessing Cardiovascular Functional Class: Advantages of a New Specific Activity Scale","volume":"64","author":"Goldman","year":"1981","journal-title":"Circulation"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"7126532","DOI":"10.1155\/2018\/7126532","article-title":"Wall Shear Stress Estimation of Thoracic Aortic Aneurysm Using Computational Fluid Dynamics","volume":"2018","author":"Febina","year":"2018","journal-title":"Comput. Math. Methods Med."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1038\/ncpcardio1397","article-title":"Hemodynamic Shear Stress and the Endothelium in Cardiovascular Pathophysiology","volume":"6","author":"Davies","year":"2009","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1007\/s10439-014-1095-4","article-title":"Change of Direction in the Biomechanics of Atherosclerosis","volume":"43","author":"Mohamied","year":"2015","journal-title":"Ann. Biomed. Eng."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s13239-013-0146-6","article-title":"A Review on Computational Fluid Dynamics Modelling in Human Thoracic Aorta","volume":"2","author":"Caballero","year":"2013","journal-title":"Cardiovasc. Eng. Technol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"187","DOI":"10.3233\/THC-219002","article-title":"Computational Analysis of Aortic Haemodynamics in the Presence of Ascending Aortic Aneurysm","volume":"30","author":"Petuchova","year":"2022","journal-title":"Technol. Health Care"},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Taebi, A. (2022). Deep Learning for Computational Hemodynamics: A Brief Review of Recent Advances. Fluids, 7.","DOI":"10.3390\/fluids7060197"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1109\/RBME.2022.3142058","article-title":"Hemodynamic Modeling, Medical Imaging, and Machine Learning and Their Applications to Cardiovascular Interventions","volume":"16","author":"Kadem","year":"2023","journal-title":"IEEE Rev. Biomed. 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