{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T01:13:43Z","timestamp":1790903623222,"version":"4.1.0"},"reference-count":272,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T00:00:00Z","timestamp":1709078400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005416","name":"Research Council of Norway","doi-asserted-by":"publisher","award":["231741"],"award-info":[{"award-number":["231741"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005416","name":"Research Council of Norway","doi-asserted-by":"publisher","award":["303218"],"award-info":[{"award-number":["303218"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]},{"name":"SINTEF","award":["231741"],"award-info":[{"award-number":["231741"]}]},{"name":"SINTEF","award":["303218"],"award-info":[{"award-number":["303218"]}]},{"name":"Sigma2\u2014the National Infrastructure for High Performance Computing and Data Storage in Norway","award":["231741"],"award-info":[{"award-number":["231741"]}]},{"name":"Sigma2\u2014the National Infrastructure for High Performance Computing and Data Storage in Norway","award":["303218"],"award-info":[{"award-number":["303218"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioengineering"],"abstract":"<jats:p>Computational rhinology is a specialized branch of biomechanics leveraging engineering techniques for mathematical modelling and simulation to complement the medical field of rhinology. Computational rhinology has already contributed significantly to advancing our understanding of the nasal function, including airflow patterns, mucosal cooling, particle deposition, and drug delivery, and is foreseen as a crucial element in, e.g., the development of virtual surgery as a clinical, patient-specific decision support tool. The current paper delves into the field of computational rhinology from a nasal airflow perspective, highlighting the use of computational fluid dynamics to enhance diagnostics and treatment of breathing disorders. This paper consists of three distinct parts\u2014an introduction to and review of the field of computational rhinology, a review of the published literature on in vitro and in silico studies of nasal airflow, and the presentation and analysis of previously unpublished high-fidelity CFD simulation data of in silico rhinomanometry. While the two first parts of this paper summarize the current status and challenges in the application of computational tools in rhinology, the last part addresses the gross disagreement commonly observed when comparing in silico and in vivo rhinomanometry results. It is concluded that this discrepancy cannot readily be explained by CFD model deficiencies caused by poor choice of turbulence model, insufficient spatial or temporal resolution, or neglecting transient effects. Hence, alternative explanations such as nasal cavity compliance or drag effects due to nasal hair should be investigated.<\/jats:p>","DOI":"10.3390\/bioengineering11030239","type":"journal-article","created":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T09:26:17Z","timestamp":1709112377000},"page":"239","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Computational Rhinology: Unraveling Discrepancies between In Silico and In Vivo Nasal Airflow Assessments for Enhanced Clinical Decision Support"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5362-8908","authenticated-orcid":false,"given":"Sverre Gullikstad","family":"Johnsen","sequence":"first","affiliation":[{"name":"SINTEF, NO-7465 Trondheim, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,28]]},"reference":[{"key":"ref_1","unstructured":"Broschek, B., and Sonora, C.M.G. (2015). Experimental Study of Fluid-Structure Interaction in a Simplified Geometry of the Human Upper Airways. [Master\u2019s Thesis, NTNU]. Available online: https:\/\/bibsys-almaprimo.hosted.exlibrisgroup.com\/permalink\/f\/13q4kuj\/BRAGE11250\/2385338."},{"key":"ref_2","unstructured":"Jordal, M.R. (2016). Patient Specific Numerical Simulation of Flow in the Human Upper Airways. [Master\u2019s Thesis, NTNU]. Available online: https:\/\/bibsys-almaprimo.hosted.exlibrisgroup.com\/permalink\/f\/13q4kuj\/BRAGE11250\/2405975."},{"key":"ref_3","unstructured":"Aasgrav, E. (2017, January 30). CFD Simulations of Turbulent Flow in the Human Upper Airways. Proceedings of the 12th International Conference on CFD in Oil & Gas, Metallurgical and Process Industries, Trondheim, Norway."},{"key":"ref_4","unstructured":"Aasgrav, E. (2017). Investigation of CFD Simulations of Flow in the Upper Airways. [Master\u2019s Thesis, NTNU]. Available online: https:\/\/bibsys-almaprimo.hosted.exlibrisgroup.com\/permalink\/f\/13q4kuj\/BRAGE11250\/2454893."},{"key":"ref_5","unstructured":"Jordal, M.R., Johnsen, S.G., Dahl, S.K., and M\u00fcller, B. (2017, January 30). Patient Specific Numerical Simulation of Flow in the Human Upper Airways for Assessing the Effect of Nasal Surgery. Proceedings of the 12th International Conference on CFD in Oil & Gas, Metallurgical and Process Industries, Trondheim, Norway."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.jbiomech.2017.11.006","article-title":"Palatal Implant Surgery Effectiveness in Treatment of Obstructive Sleep Apnea: A Numerical Method with 3D Patient-Specific Geometries","volume":"66","author":"Liu","year":"2018","journal-title":"J. Biomech."},{"key":"ref_7","unstructured":"Moxness, M.H.S. (2018). The Influence of the Nasal Airway in Obstructive Sleep Apnea. [Ph.D. Thesis, NTNU]."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1002\/lio2.140","article-title":"Simulation of the Upper Airways in Patients with Obstructive Sleep Apnea and Nasal Obstruction: A Novel Finite Element Method: Novel FE Method for OSA and Nasal Obstruction","volume":"3","author":"Moxness","year":"2018","journal-title":"Laryngoscope Investig. Otolaryngol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1002\/fld.4696","article-title":"High-Order Ghost-Point Immersed Boundary Method for Viscous Compressible Flows Based on Summation-by-Parts Operators","volume":"89","author":"Khalili","year":"2019","journal-title":"Int. J. Numer. Methods Fluids"},{"key":"ref_10","unstructured":"Akbar, B. (2022). Mathematical Modelling and Simulation of Flow in Collapsible Tubes. [Master\u2019s Thesis, NTNU]. Available online: https:\/\/bibsys-almaprimo.hosted.exlibrisgroup.com\/permalink\/f\/13q4kuj\/BRAGE11250\/3023112."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Ayyalasomayajula, V., Moxness, M., and Skallerud, B. (2023). Potential of Computational Models in Personalized Treatment of Obstructive Sleep Apnea: A Patient-Specific Partial 3D Finite Element Study. Biomech. Model. Mechanobiol.","DOI":"10.1007\/s10237-023-01788-1"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e6008","DOI":"10.1097\/MD.0000000000006008","article-title":"Apnea\u2013Hypopnea Index Decreased Significantly after Nasal Surgery for Obstructive Sleep Apnea: A Meta-Analysis","volume":"96","author":"Wu","year":"2017","journal-title":"Medicine"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Schoustra, E., Van Maanen, P., Den Haan, C., Ravesloot, M.J.L., and De Vries, N. (2022). The Role of Isolated Nasal Surgery in Obstructive Sleep Apnea Therapy\u2014A Systematic Review. Brain Sci., 12.","DOI":"10.3390\/brainsci12111446"},{"key":"ref_14","unstructured":"Johnsen, S.G. (2023). In Silico Rhinomanometry\u2014A High Fidelity LES CFD Simulation Study [Data Set], Norstore, Sigma2."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2936","DOI":"10.1073\/pnas.1714795115","article-title":"Physical and Geometric Constraints Shape the Labyrinth-like Nasal Cavity","volume":"115","author":"Zwicker","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Cingi, C., and Bayar Muluk, N. (2020). All Around the Nose: Basic Science, Diseases and Surgical Management, Springer International Publishing.","DOI":"10.1007\/978-3-030-21217-9"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"32","DOI":"10.31080\/ASDS.2020.04.0831","article-title":"Mouth Breathing-Its Consequences, Diagnosis & Treatment","volume":"4","author":"Singh","year":"2020","journal-title":"Acta Sci. Dent. Sci."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s11882-007-0009-z","article-title":"The Way the Wind Blows: Implications of Modeling Nasal Airflow","volume":"7","author":"Zhao","year":"2007","journal-title":"Curr. Allergy Asthma Rep."},{"key":"ref_19","first-page":"2","article-title":"The Clinical Implications of Computerised Fluid Dynamic Modelling in Rhinology","volume":"57","author":"Leite","year":"2018","journal-title":"Rhinol. J."},{"key":"ref_20","first-page":"477","article-title":"Comment on the European Position Paper on Diagnostic Tools in Rhinology\u2014Computational Fluid Dynamics","volume":"57","author":"Wong","year":"2019","journal-title":"Rhinol. J."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1177\/2040622315590318","article-title":"Obstructive Sleep Apnoea Syndrome and Its Management","volume":"6","author":"Spicuzza","year":"2015","journal-title":"Ther. Adv. Chronic Dis."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Trosman, I., and Trosman, S.J. (2017). Cognitive and Behavioral Consequences of Sleep Disordered Breathing in Children. Med. Sci., 5.","DOI":"10.3390\/medsci5040030"},{"key":"ref_23","first-page":"142","article-title":"A Comprehensive Review of Obstructive Sleep Apnea","volume":"14","author":"Abbasi","year":"2021","journal-title":"Sleep Sci. Sao Paulo Braz."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1016\/j.chest.2017.05.009","article-title":"Obstructive Sleep Apnea and Diabetes","volume":"152","author":"Reutrakul","year":"2017","journal-title":"Chest"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"e56","DOI":"10.1161\/CIR.0000000000000988","article-title":"Obstructive Sleep Apnea and Cardiovascular Disease: A Scientific Statement from the American Heart Association","volume":"144","author":"Yeghiazarians","year":"2021","journal-title":"Circulation"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"66","DOI":"10.4239\/wjd.v9.i4.66","article-title":"Correlation between Metabolic Syndrome and Sleep Apnea","volume":"9","author":"Castaneda","year":"2018","journal-title":"World J. Diabetes"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1183\/13993003.01894-2015","article-title":"New Rules on Driver Licensing for Patients with Obstructive Sleep Apnoea: EU Directive 2014\/85\/EU","volume":"47","author":"Bonsignore","year":"2016","journal-title":"Eur. Respir. J."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"606","DOI":"10.14789\/jmj.JMJ22-0026-OA","article-title":"Changes in Attitudes of Life Insurance Companies Towards Patients with Sleep Apnea Syndrome Undergoing Continuous Positive Airway Pressure in Japan","volume":"68","author":"Sawada","year":"2022","journal-title":"Juntendo Med. J."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"S757","DOI":"10.1016\/S0091-6749(97)70124-6","article-title":"Nasal Obstruction as a Risk Factor for Sleep-Disordered Breathing","volume":"99","author":"Young","year":"1997","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1159\/000084337","article-title":"Nasal Resistance in Patients with Obstructive Sleep Apnea","volume":"67","author":"Li","year":"2005","journal-title":"ORL"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"51","DOI":"10.2500\/ajra.2010.24.3382","article-title":"Pathogenetic Role of Increased Nasal Resistance in Obese Patients with Obstructive Sleep Apnea Syndrome","volume":"24","author":"Tagaya","year":"2010","journal-title":"Am. J. Rhinol. Allergy"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"587","DOI":"10.4193\/Rhino.11.131","article-title":"Impaired Nasal Breathing May Prevent the Beneficial Effect of Weight Loss in the Treatment of OSA","volume":"49","author":"Blomster","year":"2011","journal-title":"Rhinol. J."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1111\/coa.12639","article-title":"Usefulness of Rhinomanometry in the Identification and Treatment of Patients with Obstructive Sleep Apnoea: An Algorithm for Predicting the Relationship between Nasal Resistance and Continuous Positive Airway Pressure. a Retrospective Study","volume":"41","author":"Hueto","year":"2016","journal-title":"Clin. Otolaryngol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"79","DOI":"10.4193\/RHINOL\/20.005","article-title":"Associations between Nasal Characteristics and Sleep Polygraphic Data in Patients Suspected Obstructive Sleep Apnea","volume":"3","author":"Hoven","year":"2020","journal-title":"Rhinol. Online"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.sleep.2020.03.024","article-title":"Impact of Nasal Resistance on the Distribution of Apneas and Hypopneas in Obstructive Sleep Apnea","volume":"71","author":"Hoel","year":"2020","journal-title":"Sleep Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.sleep.2023.01.028","article-title":"Outcome of Nasal Measurements in Patients with OSA\u2014Mounting Evidence of a Nasal Endotype","volume":"103","author":"Hoel","year":"2023","journal-title":"Sleep Med."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Kim, K.B., Movahed, R., Malhotra, R.K., and Stanley, J.J. (2021). Management of Obstructive Sleep Apnea, Springer International Publishing.","DOI":"10.1007\/978-3-030-54146-0"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1001\/jamafacial.2015.0978","article-title":"Evaluation of Improvement in Nasal Obstruction Following Nasal Valve Correction in Patients With a History of Failed Septoplasty","volume":"17","author":"Chambers","year":"2015","journal-title":"JAMA Facial Plast. Surg."},{"key":"ref_39","first-page":"296","article-title":"Nasal Resistance for Determinant Factor of Nasal Surgery in CPAP Failure Patients with Obstructive Sleep Apnea Syndrome","volume":"43","author":"Nakata","year":"2005","journal-title":"Rhinology"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Moxness, M.H.S., and Nordg\u00e5rd, S. (2014). An Observational Cohort Study of the Effects of Septoplasty with or without Inferior Turbinate Reduction in Patients with Obstructive Sleep Apnea. BMC Ear Nose Throat Disord., 14.","DOI":"10.1186\/1472-6815-14-11"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1002\/lio2.452","article-title":"Does Nasal Surgery Improve Multilevel Surgical Outcome in Obstructive Sleep Apnea: A Multicenter Study on 735 Patients","volume":"5","author":"Pang","year":"2020","journal-title":"Laryngoscope Investig. Otolaryngol."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Berger, M., Pillei, M., Mehrle, A., Recheis, W., Kral, F., Kraxner, M., Bardosi, Z., and Freysinger, W. (2021). Nasal Cavity Airflow: Comparing Laser Doppler Anemometry and Computational Fluid Dynamic Simulations. Respir. Physiol. Neurobiol., 283.","DOI":"10.1016\/j.resp.2020.103533"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/j.1398-9995.1997.tb04879.x","article-title":"Measurement of Nasal Patency","volume":"52","author":"Malm","year":"1997","journal-title":"Allergy"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1111\/all.12778","article-title":"Measurements of Nasal Airflow and Patency: A Critical Review with Emphasis on the Use of Peak Nasal Inspiratory Flow in Daily Practice","volume":"71","author":"Ottaviano","year":"2016","journal-title":"Allergy"},{"key":"ref_45","first-page":"1402","article-title":"Measurement of the Nasal Airway","volume":"Volume 1","author":"Eccles","year":"2018","journal-title":"Scott-Brown\u2019s Otorhinolaryngology and Head and Neck Surgery"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4193\/Rhin19.410","article-title":"European Position Paper on Diagnostic Tools in Rhinology","volume":"57","author":"Rimmer","year":"2019","journal-title":"Rhinol. J."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1001\/jamafacial.2013.2473","article-title":"A Systematic Review of Patient-Reported Nasal Obstruction Scores: Defining Normative and Symptomatic Ranges in Surgical Patients","volume":"16","author":"Rhee","year":"2014","journal-title":"JAMA Facial Plast. Surg."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1111\/j.1749-4486.2009.02042.x","article-title":"Correlation between Subjective and Objective Evaluation of the Nasal Airway. A Systematic Review of the Highest Level of Evidence: Subjective and Objective Evaluation of Nasal Patency","volume":"34","author":"Vuyk","year":"2009","journal-title":"Clin. Otolaryngol."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Zhao, K., Blacker, K., Luo, Y., Bryant, B., and Jiang, J. (2011). Perceiving Nasal Patency through Mucosal Cooling Rather than Air Temperature or Nasal Resistance. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0024618"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1177\/0194599816687751","article-title":"Correlation between Subjective Nasal Patency and Intranasal Airflow Distribution","volume":"156","author":"Casey","year":"2017","journal-title":"Otolaryngol. Neck Surg."},{"key":"ref_51","first-page":"313","article-title":"Correlation between Objective and Subjective Assessment of Nasal Patency","volume":"28","author":"Mozzanica","year":"2016","journal-title":"Iran. J. Otorhinolaryngol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1061440","DOI":"10.3389\/fsurg.2022.1061440","article-title":"Unmet Challenges in Septoplasty\u2013Nordic Studies from a Uniform Healthcare and Geographical Area","volume":"9","author":"Hellgren","year":"2022","journal-title":"Front. Surg."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1097\/00020840-199902000-00006","article-title":"Nasal Resistance from the Laboratory to the Clinic","volume":"7","author":"Quine","year":"1999","journal-title":"Curr. Opin. Otolaryngol. Head Neck Surg."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1017\/S002221510009486X","article-title":"The Effect of Menthol in Nasal Resistance to Air Flow","volume":"97","author":"Eccles","year":"1983","journal-title":"J. Laryngol. Otol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1111\/j.2042-7158.1990.tb06625.x","article-title":"The Effects of Oral Administration of (\u2014)-Menthol on Nasal Resistance to Airflow and Nasal Sensation of Airflow in Subjects Suffering from Nasal Congestion Associated with the Common Cold","volume":"42","author":"Eccles","year":"1990","journal-title":"J. Pharm. Pharmacol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1097\/MOO.0000000000000544","article-title":"Update on Empty Nose Syndrome: Disease Mechanisms, Diagnostic Tools, and Treatment Strategies","volume":"27","author":"Gill","year":"2019","journal-title":"Curr. Opin. Otolaryngol. Head Neck Surg."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1007\/s40136-021-00387-x","article-title":"Computational Fluid Dynamics (CFD) Modeling as an Objective Analytical Tool for Nasal\/Upper Airway Breathing","volume":"10","author":"Malik","year":"2022","journal-title":"Curr. Otorhinolaryngol. Rep."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Di, M.-Y., Jiang, Z., Gao, Z.-Q., Li, Z., An, Y.-R., and Lv, W. (2013). Numerical Simulation of Airflow Fields in Two Typical Nasal Structures of Empty Nose Syndrome: A Computational Fluid Dynamics Study. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0084243"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"E176","DOI":"10.1002\/lary.26530","article-title":"Computational Fluid Dynamics and Trigeminal Sensory Examinations of Empty Nose Syndrome Patients: Computational and Trigeminal Studies of ENS","volume":"127","author":"Li","year":"2017","journal-title":"Laryngoscope"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1002\/alr.22045","article-title":"Investigation of the Abnormal Nasal Aerodynamics and Trigeminal Functions among Empty Nose Syndrome Patients: Abnormal Nasal Aerodynamics in ENS Patients","volume":"8","author":"Li","year":"2018","journal-title":"Int. Forum Allergy Rhinol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"2634","DOI":"10.1016\/j.jbiomech.2013.08.007","article-title":"Changes in Nasal Airflow and Heat Transfer Correlate with Symptom Improvement after Surgery for Nasal Obstruction","volume":"46","author":"Kimbell","year":"2013","journal-title":"J. Biomech."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1177\/0194599813509776","article-title":"Perception of Better Nasal Patency Correlates with Increased Mucosal Cooling after Surgery for Nasal Obstruction","volume":"150","author":"Sullivan","year":"2014","journal-title":"Otolaryngol. Neck Surg."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1002\/lary.24265","article-title":"Regional Peak Mucosal Cooling Predicts the Perception of Nasal Patency","volume":"124","author":"Zhao","year":"2014","journal-title":"Laryngoscope"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1001\/jamafacial.2016.1445","article-title":"Correlation of Nasal Mucosal Temperature With Subjective Nasal Patency in Healthy Individuals","volume":"19","author":"Bailey","year":"2017","journal-title":"JAMA Facial Plast. Surg."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.resp.2017.01.004","article-title":"Estimates of Nasal Airflow at the Nasal Cycle Mid-Point Improve the Correlation between Objective and Subjective Measures of Nasal Patency","volume":"238","author":"Gaberino","year":"2017","journal-title":"Respir. Physiol. Neurobiol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1111\/coa.13344","article-title":"Correlations between Computational Fluid Dynamics and Clinical Evaluation of Nasal Airway Obstruction Due to Septal Deviation: An Observational Study","volume":"44","author":"Radulesco","year":"2019","journal-title":"Clin. Otolaryngol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s11548-019-02023-y","article-title":"Normative Ranges of Nasal Airflow Variables in Healthy Adults","volume":"15","author":"Borojeni","year":"2020","journal-title":"Int. J. Comput. Assist. Radiol. Surg."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1002\/lary.30327","article-title":"Correlation of Nasal Mucosal Temperature and Nasal Patency\u2014A Computational Fluid Dynamics Study","volume":"133","author":"Tjahjono","year":"2023","journal-title":"Laryngoscope"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"311","DOI":"10.4193\/Rhin12.053","article-title":"Deviated Nasal Septum Hinders Intranasal Sprays: A Computer Simulation Study","volume":"50","author":"Frank","year":"2012","journal-title":"Rhinol. J."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/978-3-642-23154-4_34","article-title":"Analysis of Changes of the Hydraulic Diameter and Determination of the Air Flow Modes in the Nasal Cavity","volume":"Volume 102","year":"2011","journal-title":"Image Processing and Communications Challenges 3"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"R1","DOI":"10.1017\/jfm.2018.303","article-title":"On Turbulent Friction in Straight Ducts with Complex Cross-Section: The Wall Law and the Hydraulic Diameter","volume":"846","author":"Pirozzoli","year":"2018","journal-title":"J. Fluid Mech."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1152\/japplphysiol.01118.2018","article-title":"The Complexities of Nasal Airflow: Theory and Practice","volume":"127","author":"Tolley","year":"2019","journal-title":"J. Appl. Physiol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1108\/HFF-06-2020-0383","article-title":"Numerical Investigation of Friction Laws for Laminar and Turbulent Flow in Undulated Channels","volume":"31","author":"Benim","year":"2021","journal-title":"Int. J. Numer. Methods Heat Fluid Flow"},{"key":"ref_74","first-page":"19","article-title":"Variations in Nasal Resistance in Man: A Rhinomanometric Study of the Nasal Cycle in 50 Human Subjects","volume":"16","author":"Hasegawa","year":"1978","journal-title":"Rhinology"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"590","DOI":"10.3109\/00016489709113443","article-title":"Spontaneous Changes of Unilateral Nasal Airflow in Man. A Re-Examination of the \u2018Nasal Cycle\u2019","volume":"117","author":"Flanagan","year":"1997","journal-title":"Acta Otolaryngol. (Stockh.)"},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Cingi, C., and Bayar Muluk, N. (2020). All Around the Nose, Springer International Publishing.","DOI":"10.1007\/978-3-030-21217-9"},{"key":"ref_77","first-page":"1","article-title":"4-Phase-Rhinomanometry (4PR)\u2014Basics and Practice 2010","volume":"21","author":"Vogt","year":"2010","journal-title":"Rhinol. Suppl."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1055\/s-2007-997964","article-title":"Die Rhinoresistometrie\u2014Eine Weiterentwicklung der Rhinomanometrie","volume":"72","author":"Mlynski","year":"1993","journal-title":"Laryngo-Rhino-Otol."},{"key":"ref_79","first-page":"287","article-title":"An International Comparison of Rhinomanometry between Canada and Japan","volume":"29","author":"Naito","year":"1991","journal-title":"Rhinology"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1111\/j.1749-4486.2011.02279.x","article-title":"Objective Evidence for the Efficacy of Surgical Management of the Deviated Septum as a Treatment for Chronic Nasal Obstruction: A Systematic Review: Objective Evidence for the Efficacy of Surgical Management of the Deviated Septum: A Systematic Review","volume":"36","author":"Moore","year":"2011","journal-title":"Clin. Otolaryngol."},{"key":"ref_81","unstructured":"Blevins, R.D. (1984). Applied Fluid Dynamics Handbook, Van Nostrand Reinhold Co."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1115\/1.3240948","article-title":"Simple and Explicit Formulas for the Friction Factor in Turbulent Pipe Flow","volume":"105","author":"Haaland","year":"1983","journal-title":"J. Fluids Eng."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.jbiomech.2017.08.031","article-title":"Computational Modeling and Validation of Human Nasal Airflow under Various Breathing Conditions","volume":"64","author":"Li","year":"2017","journal-title":"J. Biomech."},{"key":"ref_84","unstructured":"Fletcher, D.F. (2023, January 8). Use of CFD to Stimulate Flow in the Nose and Airway: Best Practices, Quality and Future Perspectives. Proceedings of the SCONA 2023 Conference, Brisbane, Australia."},{"key":"ref_85","unstructured":"Inthavong, K. (2023, January 8). Current State of the Art, Controversies, and the Future of Nose and Airway Simulations. Proceedings of the SCONA 2023 Conference, Brisbane, Australia."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.compbiomed.2018.05.016","article-title":"DigBody\u00ae: A New 3D Modeling Tool for Nasal Virtual Surgery","volume":"98","author":"Burgos","year":"2018","journal-title":"Comput. Biol. Med."},{"key":"ref_87","first-page":"295","article-title":"The Virtual Pediatric Airways Workbench","volume":"220","author":"Quammen","year":"2016","journal-title":"Stud. Health Technol. Inform."},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Sanmiguel-Rojas, E., Burgos, M.A., and Esteban-Ortega, F. (2018). Nasal Surgery Handled by CFD Tools. Int. J. Numer. Methods Biomed. Eng., 34.","DOI":"10.1002\/cnm.3126"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1001\/jamafacial.2017.1554","article-title":"Virtual Surgery for the Nasal Airway: A Preliminary Report on Decision Support and Technology Acceptance","volume":"20","author":"Vanhille","year":"2018","journal-title":"JAMA Facial Plast. Surg."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1007\/s11548-020-02124-z","article-title":"Virtual Septoplasty: A Method to Predict Surgical Outcomes for Patients with Nasal Airway Obstruction","volume":"15","author":"Moghaddam","year":"2020","journal-title":"Int. J. Comput. Assist. Radiol. Surg."},{"key":"ref_91","unstructured":"Patankar, S.V. (1980). Numerical Heat Transfer and Fluid Flow, Hemisphere Publishing Corporation\/Taylor & Francis."},{"key":"ref_92","unstructured":"Anderson, J.D. (1995). Computational Fluid Dynamics: The Basics with Applications, McGraw-Hill."},{"key":"ref_93","unstructured":"Versteeg, H.K., and Malalasekera, W. (2007). An Introduction to Computational Fluid Dynamics: The Finite Volume Method, Pearson Education Ltd."},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Rodriguez, S. (2019). Applied Computational Fluid Dynamics and Turbulence Modeling: Practical Tools, Tips and Techniques, Springer International Publishing.","DOI":"10.1007\/978-3-030-28691-0"},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Roychowdhury, D.G. (2020). Computational Fluid Dynamics for Incompressible Flow, CRC Press.","DOI":"10.1201\/9780367809171"},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Inthavong, K., Singh, N., Wong, E., and Tu, J. (2021). Clinical and Biomedical Engineering in the Human Nose, Springer. Biological and Medical Physics, Biomedical Engineering.","DOI":"10.1007\/978-981-15-6716-2"},{"key":"ref_97","unstructured":"DenOtter, T.D., and Schubert, J. (2024, January 01). Hounsfield Unit, StatPearls [Internet], Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK547721\/."},{"key":"ref_98","unstructured":"Dance, D.R. (2014). Diagnostic Radiology Physics: A Handbook for Teachers and Students, International Atomic Energy Agency. Non-serial Publications."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"16","DOI":"10.11648\/j.ijbse.20210902.12","article-title":"Computational Fluid Dynamics Modeling in Respiratory Airways Obstruction: Current Applications and Prospects","volume":"9","author":"Ayodele","year":"2021","journal-title":"Int. J. Biomed. Sci. Eng."},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Cherobin, G.B., Voegels, R.L., Gebrim, E.M.M.S., and Garcia, G.J.M. (2018). Sensitivity of Nasal Airflow Variables Computed via Computational Fluid Dynamics to the Computed Tomography Segmentation Threshold. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0207178"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/s11517-015-1325-4","article-title":"Effects of CT Resolution and Radiodensity Threshold on the CFD Evaluation of Nasal Airflow","volume":"54","author":"Quadrio","year":"2016","journal-title":"Med. Biol. Eng. Comput."},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Inthavong, K., Singh, N., Wong, E., and Tu, J. (2021). Clinical and Biomedical Engineering in the Human Nose, Springer. Biological and Medical Physics, Biomedical Engineering.","DOI":"10.1007\/978-981-15-6716-2"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1089\/jamp.2018.1490","article-title":"High-Efficiency Nose-to-Lung Aerosol Delivery in an Infant: Development of a Validated Computational Fluid Dynamics Method","volume":"32","author":"Bass","year":"2019","journal-title":"J. Aerosol Med. Pulm. Drug Deliv."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"105851","DOI":"10.1016\/j.jaerosci.2021.105851","article-title":"Evaluation of the Polyhedral Mesh Style for Predicting Aerosol Deposition in Representative Models of the Conducting Airways","volume":"159","author":"Thomas","year":"2022","journal-title":"J. Aerosol Sci."},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Inthavong, K., Das, P., Singh, N., and Sznitman, J. (2019). In Silico Approaches to Respiratory Nasal Flows: A Review. J. Biomech., 97.","DOI":"10.1016\/j.jbiomech.2019.109434"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.compbiomed.2018.09.010","article-title":"Examining Mesh Independence for Flow Dynamics in the Human Nasal Cavity","volume":"102","author":"Inthavong","year":"2018","journal-title":"Comput. Biol. Med."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1007\/s11517-022-02592-2","article-title":"Fluid\u2013Structure Interaction Modelling of the Upper Airway with and without Obstructive Sleep Apnea: A Review","volume":"60","author":"Ashraf","year":"2022","journal-title":"Med. Biol. Eng. Comput."},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Tennekes, H., and Lumley, J.L. (1972). A First Course in Turbulence, The MIT Press. Nachdruck des Originals von 1972.","DOI":"10.7551\/mitpress\/3014.001.0001"},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Pope, S.B. (2000). Turbulent Flows, Cambridge University Press. [1st ed.].","DOI":"10.1017\/CBO9780511840531"},{"key":"ref_110","unstructured":"Wilcox, D.C. (2010). Turbulence Modeling for CFD, DCW Industries. [3rd ed.]. 2 print."},{"key":"ref_111","unstructured":"Menter, F.R. (2015). Best Practice: Scale-Resolving Simulations in Ansys CFD, ANSYS, Inc.. ANSYS Rep."},{"key":"ref_112","unstructured":"Menter, F.R., Lechner, R., and Matyushenko, A. (2021). Best Practice: RANS Turbulence Modeling in Ansys CFD, ANSYS, Inc.. ANSYS Rep."},{"key":"ref_113","unstructured":"ANSYS (2023). ANSYS Fluent Theory Guide, ANSYS, Inc."},{"key":"ref_114","unstructured":"Rumsey, C., Smith, B., and Huang, G. (2023, November 11). NASA Turbulence Modeling Resource, Available online: https:\/\/turbmodels.larc.nasa.gov."},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Inthavong, K., Singh, N., Wong, E., and Tu, J. (2021). Clinical and Biomedical Engineering in the Human Nose, Springer. Biological and Medical Physics, Biomedical Engineering.","DOI":"10.1007\/978-981-15-6716-2"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"94","DOI":"10.2500\/ajra.2012.26.3766","article-title":"Computed Nasal Resistance Compared with Patient-Reported Symptoms in Surgically Treated Nasal Airway Passages: A Preliminary Report","volume":"26","author":"Kimbell","year":"2012","journal-title":"Am. J. Rhinol. Allergy"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1177\/1945892420950157","article-title":"Rhinomanometry Versus Computational Fluid Dynamics: Correlated, but Different Techniques","volume":"35","author":"Cherobin","year":"2021","journal-title":"Am. J. Rhinol. Allergy"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1109\/TVCG.2009.198","article-title":"Visual Exploration of Nasal Airflow","volume":"15","author":"Zachow","year":"2009","journal-title":"IEEE Trans. Vis. Comput. Graph."},{"key":"ref_119","unstructured":"Hildebrandt, T. (2011). Das Konzept der Rhinorespiratorischen Hom\u00f6ostase\u2014Ein Neuer Theoretischer Ansatz f\u00fcr die Diskussion Physiologischer und Physikalischer Zusammenh\u00e4nge bei der Nasenatmung. [Ph.D. Thesis, Albert-Ludwigs-Universit\u00e4t]. Available online: https:\/\/freidok.uni-freiburg.de\/data\/8177."},{"key":"ref_120","unstructured":"Hildebrandt, T. Personal communication."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1007\/s11548-022-02699-9","article-title":"Comparison of Rhinomanometric and Computational Fluid Dynamic Assessment of Nasal Resistance with Respect to Measurement Accuracy","volume":"17","author":"Schmidt","year":"2022","journal-title":"Int. J. Comput. Assist. Radiol. Surg."},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Dong, J., Sun, Q., Shang, Y., Zhang, Y., Tian, L., and Tu, J. (2022). Numerical Comparison of Inspiratory Airflow Patterns in Human Nasal Cavities with Distinct Age Differences. Int. J. Numer. Methods Biomed. Eng., 38.","DOI":"10.1002\/cnm.3565"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1002\/tee.22084","article-title":"Patient-Specific Aided Surgery Approach of Deviated Nasal Septum Using Computational Fluid Dynamics","volume":"10","author":"Hemtiwakorn","year":"2015","journal-title":"IEEJ Trans. Electr. Electron. Eng."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1515\/cdbme-2016-0136","article-title":"Assessment of Nasal Resistance Using Computational Fluid Dynamics","volume":"2","author":"Osman","year":"2016","journal-title":"Curr. Dir. Biomed. Eng."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1007\/s11548-021-02332-1","article-title":"Agreement between Rhinomanometry and Computed Tomography-Based Computational Fluid Dynamics","volume":"16","author":"Berger","year":"2021","journal-title":"Int. J. Comput. Assist. Radiol. Surg."},{"key":"ref_126","first-page":"56","article-title":"Numerical Simulation of Nasal Resistance Using Three-Dimensional Models of the Nasal Cavity and Paranasal Sinus","volume":"48","author":"Kaneda","year":"2023","journal-title":"Tokai J. Exp. Clin. Med."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1007\/s11517-022-02716-8","article-title":"Computational Analysis of Human Upper Airway Aerodynamics","volume":"61","author":"Hebbink","year":"2023","journal-title":"Med. Biol. Eng. Comput."},{"key":"ref_128","unstructured":"Computational Fluid Dynamics Committee (1998). Guide: Guide for the Verification and Validation of Computational Fluid Dynamics Simulations (AIAA G-077-1998(2002)), American Institute of Aeronautics and Astronautics, Inc."},{"key":"ref_129","unstructured":"Pawade, A.R. (2021). Computational Modeling of Airflow in a Human Nasal Cavity. [Master\u2019s Thesis, Chalmers University of Technology]."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1089\/fpsam.2020.0576","article-title":"The Virtual Nose: Assessment of Static Nasal Airway Obstruction Using Computational Simulations and 3D-Printed Models","volume":"24","author":"Reid","year":"2022","journal-title":"Facial Plast. Surg. Aesthetic Med."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1177\/0194599814559385","article-title":"Simulating the Nasal Cycle with Computational Fluid Dynamics","volume":"152","author":"Patel","year":"2015","journal-title":"Otolaryngol. Neck Surg."},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Cingi, C., Bayar Muluk, N., Scadding, G.K., and Mladina, R. (2021). Challenges in Rhinology, Springer International Publishing.","DOI":"10.1007\/978-3-030-50899-9"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1177\/000348948209100125","article-title":"Nasal Cycle and Postural Variations in Nasal Resistance","volume":"91","author":"Hasegawa","year":"1982","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"key":"ref_134","first-page":"1","article-title":"Unilateral Nasal Resistance and Asymmetrical Body Pressure","volume":"16","author":"Haight","year":"1986","journal-title":"J. Otolaryngol. Suppl."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1152\/japplphysiol.00625.2004","article-title":"Inspiratory Flow in the Nose: A Model Coupling Flow and Vasoerectile Tissue Distensibility","volume":"98","author":"Fodil","year":"2005","journal-title":"J. Appl. Physiol."},{"key":"ref_136","first-page":"53","article-title":"An Overview of Numerical Modelling of Nasal Airflow","volume":"44","author":"Bailie","year":"2006","journal-title":"Rhinology"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"81","DOI":"10.4193\/RHINOL\/18.086","article-title":"Nasal Valve Elastography: Quantitative Determination of the Mobility of the Nasal Valve","volume":"2","author":"Akmenkalne","year":"2019","journal-title":"Rhinol. Online"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1097\/MOO.0b013e32834e6306","article-title":"Airway Assessment by Four-Phase Rhinomanometry in Septal Surgery","volume":"20","author":"Vogt","year":"2012","journal-title":"Curr. Opin. Otolaryngol. Head Neck Surg."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1007\/s00405-015-3723-5","article-title":"Four-Phase Rhinomanometry: A Multicentric Retrospective Analysis of 36,563 Clinical Measurements","volume":"273","author":"Vogt","year":"2016","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"ref_140","first-page":"126520","article-title":"A Fluid Mechanical Interpretation of Hysteresis in Rhinomanometry","volume":"2011","author":"Peters","year":"2011","journal-title":"ISRN Otolaryngol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1007\/s11548-014-1134-5","article-title":"Automatic Segmentation of the Nasal Cavity and Paranasal Sinuses from Cone-Beam CT Images","volume":"10","author":"Bui","year":"2015","journal-title":"Int. J. Comput. Assist. Radiol. Surg."},{"key":"ref_142","unstructured":"Aanderaa, L.\u00d8. (2021). Experimental Investigation of Rhinomanometry. [Master\u2019s Thesis, NTNU]."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"131","DOI":"10.2500\/105065899782106689","article-title":"Reproducibility of Acoustic Rhinometry and Rhinomanometry in Normal Subjects","volume":"13","author":"Silkoff","year":"1999","journal-title":"Am. J. Rhinol."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1046\/j.1365-2273.2000.00384.x","article-title":"Reliable and Reproducible Anterior Active Rhinomanometry for the Assessment of Unilateral Nasal Resistance","volume":"25","author":"Carney","year":"2000","journal-title":"Clin. Otolaryngol. Allied Sci."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"46","DOI":"10.4193\/Rhino10.027","article-title":"Can We Always Trust Rhinomanometry?","volume":"49","author":"Thulesius","year":"2011","journal-title":"Rhinol. J."},{"key":"ref_146","unstructured":"ERCOFTAC (2000). Best Practice Guidelines, Industrial Computational Fluid Dynamics of Single-Phase Flows, ERCOFTAC."},{"key":"ref_147","doi-asserted-by":"crossref","unstructured":"Andersson, B., Andersson, R., H\u00e5kansson, L., Mortensen, M., Sudiyo, R., and Van Wachem, B. (2011). Computational Fluid Dynamics for Engineers, Cambridge University Press.","DOI":"10.1017\/CBO9781139093590"},{"key":"ref_148","doi-asserted-by":"crossref","unstructured":"Schillaci, A., and Quadrio, M. (2022). Importance of the Numerical Schemes in the CFD of the Human Nose. J. Biomech., 138.","DOI":"10.1016\/j.jbiomech.2022.111100"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1177\/000348945106000216","article-title":"Air Currents in the Upper Respiratory Tract and Their Clinical Importance","volume":"60","author":"Proetz","year":"1951","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1152\/jappl.1991.71.3.983","article-title":"Steady and Oscillatory Transnasal Pressure-Flow Relationships in Healthy Adults","volume":"71","author":"Sullivan","year":"1991","journal-title":"J. Appl. Physiol."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1152\/jappl.1993.75.5.2273","article-title":"Velocity Profiles Measured for Airflow through a Large-Scale Model of the Human Nasal Cavity","volume":"75","author":"Hahn","year":"1993","journal-title":"J. Appl. Physiol."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1115\/1.2794204","article-title":"Numerical Simulation of Airflow in the Human Nasal Cavity","volume":"117","author":"Keyhani","year":"1995","journal-title":"J. Biomech. Eng."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1115\/1.2244574","article-title":"Laminar Airflow and Nanoparticle or Vapor Deposition in a Human Nasal Cavity Model","volume":"128","author":"Shi","year":"2006","journal-title":"J. Biomech. Eng."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/j.jbiomech.2009.12.008","article-title":"On the Assumption of Steadiness of Nasal Cavity Flow","volume":"43","author":"Meinke","year":"2010","journal-title":"J. Biomech."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1113\/jphysiol.1955.sp005276","article-title":"Method for the Calculation of Velocity, Rate of Flow and Viscous Drag in Arteries When the Pressure Gradient Is Known","volume":"127","author":"Womersley","year":"1955","journal-title":"J. Physiol."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1006\/jtbi.1997.0564","article-title":"The Use of the Dimensionless Womersley Number to Characterize the Unsteady Nature of Internal Flow","volume":"191","author":"Loudon","year":"1998","journal-title":"J. Theor. Biol."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.resp.2008.07.027","article-title":"Mechanics of Airflow in the Human Nasal Airways","volume":"163","author":"Doorly","year":"2008","journal-title":"Respir. Physiol. Neurobiol."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"030085","DOI":"10.1063\/1.4964027","article-title":"Influence of the Respiratory Cycle Structure on the Flow Field in Human Nasal Cavity at a Fixed Level of Breath Depth","volume":"1770","author":"Bosykh","year":"2016","journal-title":"AIP Conf. Proc."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"115103","DOI":"10.1063\/5.0112223","article-title":"New Insights into the Breathing Physiology from Transient Respiratory Nasal Simulation","volume":"34","author":"Bradshaw","year":"2022","journal-title":"Phys. Fluids"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"3980","DOI":"10.1038\/s41598-023-31166-x","article-title":"Numerical Analysis of the Ostiomeatal Complex Aeration Using the CFD Method","volume":"13","author":"Tretiakow","year":"2023","journal-title":"Sci. Rep."},{"key":"ref_161","unstructured":"Koeppen, B.M., and Stanton, B.A. (2018). Berne & Levy Physiology, Elsevier. [7th ed.]."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1017\/jfm.2014.698","article-title":"Transition of Transient Channel Flow after a Change in Reynolds Number","volume":"764","author":"He","year":"2015","journal-title":"J. Fluid Mech."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"A43","DOI":"10.1017\/jfm.2021.303","article-title":"Transient Dynamics of Accelerating Turbulent Pipe Flow","volume":"917","author":"Guerrero","year":"2021","journal-title":"J. Fluid Mech."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"A44","DOI":"10.1017\/jfm.2023.294","article-title":"Transient Behaviour of Decelerating Turbulent Pipe Flows","volume":"962","author":"Guerrero","year":"2023","journal-title":"J. Fluid Mech."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1161\/01.RES.19.4.791","article-title":"Laminar-Turbulent Transition Process in Pulsatile Flow","volume":"19","author":"Yellin","year":"1966","journal-title":"Circ. Res."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1299\/jsmeb.42.384","article-title":"Present State of Art on Pulsatile Flow Theory. Part 1. Laminar and Transitional Flow Regimes","volume":"42","year":"1999","journal-title":"JSME Int. J. Ser. B"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1299\/jsmeb.42.398","article-title":"Present State of Art on Pulsatile Flow Theory. Part 2. Turbulent Flow Regime","volume":"42","year":"1999","journal-title":"JSME Int. J. Ser. B"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1017\/jfm.2017.620","article-title":"Transition to Turbulence in Pulsating Pipe Flow","volume":"831","author":"Xu","year":"2017","journal-title":"J. Fluid Mech."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"114103","DOI":"10.1063\/1.4767537","article-title":"Large Eddy Simulation of Controlled Transition to Turbulence","volume":"24","author":"Sayadi","year":"2012","journal-title":"Phys. Fluids"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"637","DOI":"10.3109\/00016489.2011.651228","article-title":"Airflow and Temperature Distribution inside the Maxillary Sinus: A Computational Fluid Dynamics Simulation","volume":"132","author":"Zang","year":"2012","journal-title":"Acta Otolaryngol. (Stockh.)"},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.jbiomech.2012.11.022","article-title":"Patient Specific CFD Models of Nasal Airflow: Overview of Methods and Challenges","volume":"46","author":"Kim","year":"2013","journal-title":"J. Biomech."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"777","DOI":"10.18869\/acadpub.jafm.73.240.25348","article-title":"CFD Transient Simulation of a Breathing Cycle in an Oral-Nasal Extrathoracic Model","volume":"10","author":"Paz","year":"2017","journal-title":"J. Appl. Fluid Mech."},{"key":"ref_173","doi-asserted-by":"crossref","unstructured":"Chen, S., Wang, J., Liu, D., Lei, L., Wu, W., Liu, Z., and Lee, C. (2021). Open Oral Cavity Has Little Effects on Upper Airway Aerodynamics in Children with Obstructive Sleep Apnea Syndrome: A Computational Fluid Dynamics Study Based on Patient-Specific Models. J. Biomech., 121.","DOI":"10.1016\/j.jbiomech.2021.110383"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"373","DOI":"10.2500\/ajra.2015.29.4209","article-title":"The Effect of Vibrissae on Subjective and Objective Measures of Nasal Obstruction","volume":"29","author":"Stoddard","year":"2015","journal-title":"Am. J. Rhinol. Allergy"},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"327","DOI":"10.4015\/S1016237212500251","article-title":"Numerical Study of Mucous Layer Effects on Nasal Airflow","volume":"24","author":"Lee","year":"2012","journal-title":"Biomed. Eng. Appl. Basis Commun."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1089\/jamp.2014.1188","article-title":"Influence of Mesh Density on Airflow and Particle Deposition in Sinonasal Airway Modeling","volume":"29","author":"Wofford","year":"2016","journal-title":"J. Aerosol Med. Pulm. Drug Deliv."},{"key":"ref_177","unstructured":"Launder, B.E., and Spalding, D.B. (1972). Lectures in Mathematical Models of Turbulence, Academic Press."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1007\/BF01448839","article-title":"\u00dcber die partiellen Differenzengleichungen der mathematischen Physik","volume":"100","author":"Courant","year":"1928","journal-title":"Math. Ann."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1147\/rd.112.0215","article-title":"On the Partial Difference Equations of Mathematical Physics","volume":"11","author":"Courant","year":"1967","journal-title":"IBM J. Res. Dev."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1098\/rsif.2009.0306","article-title":"Inflow Boundary Profile Prescription for Numerical Simulation of Nasal Airflow","volume":"7","author":"Taylor","year":"2010","journal-title":"J. R. Soc. Interface"},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s11427-018-9373-y","article-title":"Direct Visualizations of Air Flow in the Human Upper Airway Using In-Vitro Models","volume":"62","author":"Wu","year":"2019","journal-title":"Sci. China Life Sci."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1177\/0194599815606435","article-title":"Clinical Consensus Statement: Septoplasty with or without Inferior Turbinate Reduction","volume":"153","author":"Han","year":"2015","journal-title":"Otolaryngol. Neck Surg."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s40136-022-00395-5","article-title":"Key Points on Functional Rhinoplasty Patient Evaluation","volume":"10","author":"Puccia","year":"2022","journal-title":"Curr. Otorhinolaryngol. Rep."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s40675-020-00186-8","article-title":"Overview of Recent Advances in Surgical Treatments for OSA","volume":"6","author":"Urban","year":"2020","journal-title":"Curr. Sleep Med. Rep."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/s11548-021-02524-9","article-title":"Toward Automatic Atlas-Based Surgical Planning for Septoplasty","volume":"17","author":"Vicory","year":"2022","journal-title":"Int. J. Comput. Assist. Radiol. Surg."},{"key":"ref_186","doi-asserted-by":"crossref","unstructured":"Cingi, C., and Bayar Muluk, N. (2020). All Around the Nose, Springer International Publishing.","DOI":"10.1007\/978-3-030-21217-9"},{"key":"ref_187","doi-asserted-by":"crossref","unstructured":"Tu, J., Inthavong, K., and Ahmadi, G. (2012). Computational Fluid and Particle Dynamics in the Human Respiratory System, Springer. Biological and Medical Physics, Biomedical Engineering.","DOI":"10.1007\/978-94-007-4488-2"},{"key":"ref_188","doi-asserted-by":"crossref","unstructured":"Inthavong, K., Singh, N., Wong, E., and Tu, J. (2021). Clinical and Biomedical Engineering in the Human Nose: A Computational Fluid Dynamics Approach, Springer. Biological and Medical Physics, Biomedical Engineering.","DOI":"10.1007\/978-981-15-6716-2"},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"139","DOI":"10.4193\/Rhin09.133","article-title":"A Review of the Implications of Computational Fluid Dynamic Studies on Nasal Airflow and Physiology","volume":"48","author":"Leong","year":"2010","journal-title":"Rhinol. J."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1111\/coa.13396","article-title":"Functional Relevance of Computational Fluid Dynamics in the Field of Nasal Obstruction: A Literature Review","volume":"44","author":"Radulesco","year":"2019","journal-title":"Clin. Otolaryngol."},{"key":"ref_191","doi-asserted-by":"crossref","unstructured":"Faizal, W.M., Ghazali, N.N.N., Khor, C.Y., Badruddin, I.A., Zainon, M.Z., Yazid, A.A., Ibrahim, N.B., and Razi, R.M. (2020). Computational Fluid Dynamics Modelling of Human Upper Airway: A Review. Comput. Methods Programs Biomed., 196.","DOI":"10.1016\/j.cmpb.2020.105627"},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"3121","DOI":"10.1007\/s00405-017-4611-y","article-title":"New CFD Tools to Evaluate Nasal Airflow","volume":"274","author":"Burgos","year":"2017","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"ref_193","doi-asserted-by":"crossref","unstructured":"Pugachev, A., Arnold, M., Burgmann, S., Janoske, U., Bics\u00e1k, \u00c1., Abel, D., Linssen, J., and Bonitz, L. (2020). Application of Patient-specific Simulation Workflow for Obstructive Sleep Apnea Diagnosis and Treatment with a Mandibular Advancement Device. Int. J. Numer. Methods Biomed. Eng., 36.","DOI":"10.1002\/cnm.3350"},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1007\/s00405-020-06428-3","article-title":"Three-Dimensional Modeling and Automatic Analysis of the Human Nasal Cavity and Paranasal Sinuses Using the Computational Fluid Dynamics Method","volume":"278","author":"Tretiakow","year":"2021","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s11517-021-02446-3","article-title":"An Effective Simulation- and Measurement-Based Workflow for Enhanced Diagnostics in Rhinology","volume":"60","author":"Waldmann","year":"2022","journal-title":"Med. Biol. Eng. Comput."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1007\/s00405-013-2742-3","article-title":"Review of Computational Fluid Dynamics in the Assessment of Nasal Air Flow and Analysis of Its Limitations","volume":"271","author":"Quadrio","year":"2014","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"e14099","DOI":"10.14814\/phy2.14099","article-title":"Airflow Limitation in a Collapsible Model of the Human Pharynx: Physical Mechanisms Studied with Fluid-structure Interaction Simulations and Experiments","volume":"7","author":"Le","year":"2019","journal-title":"Physiol. Rep."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s00162-023-00638-1","article-title":"Direct Numerical Simulations and Flow-Pressure Acoustic Analyses of Flapping-Uvula-Induced Flow Evolutions within Normal and Constricted Pharynx","volume":"37","author":"Xi","year":"2023","journal-title":"Theor. Comput. Fluid Dyn."},{"key":"ref_199","doi-asserted-by":"crossref","unstructured":"Larimi, M.M., Babamiri, A., Biglarian, M., Ramiar, A., Tabe, R., Inthavong, K., and Farnoud, A. (2023). Numerical and Experimental Analysis of Drug Inhalation in Realistic Human Upper Airway Model. Pharmaceuticals, 16.","DOI":"10.3390\/ph16030406"},{"key":"ref_200","unstructured":"Stuiver, M. (1958). Biophysics of the Sense of Smell. [Ph.D. Thesis, University of Groningen]."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/BF00440941","article-title":"Investigations about the Course of Flow in the Nose Model","volume":"189","author":"Masing","year":"1967","journal-title":"Arch Klin Exp Ohr Nas Kehlkopf"},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1001\/archotol.1987.01860020061013","article-title":"Airflow Patterns in a Human Nasal Model","volume":"113","author":"Hornung","year":"1987","journal-title":"Arch. Otolaryngol. Head Neck Surg."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1152\/jappl.2000.89.1.323","article-title":"Detailed Flow Patterns in the Nasal Cavity","volume":"89","author":"Kelly","year":"2000","journal-title":"J. Appl. Physiol."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1016\/j.jbiomech.2009.03.035","article-title":"Validation of Computational Fluid Dynamics Methodology Used for Human Upper Airway Flow Simulations","volume":"42","author":"Mylavarapu","year":"2009","journal-title":"J. Biomech."},{"key":"ref_205","doi-asserted-by":"crossref","unstructured":"Ormiskangas, J., Valtonen, O., Kivek\u00e4s, I., Dean, M., Poe, D., J\u00e4rnstedt, J., Lekkala, J., Harju, T., Saarenrinne, P., and Rautiainen, M. (2020). Assessment of PIV Performance in Validating CFD Models from Nasal Cavity CBCT Scans. Respir. Physiol. Neurobiol., 282.","DOI":"10.1016\/j.resp.2020.103508"},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"011907","DOI":"10.1063\/5.0036095","article-title":"Pressure Distribution and Flow Dynamics in a Nasal Airway Using a Scale Resolving Simulation","volume":"33","author":"Shrestha","year":"2021","journal-title":"Phys. Fluids"},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1002\/alr.21319","article-title":"What Is Normal Nasal Airflow? A Computational Study of 22 Healthy Adults: Normal Human Nasal Airflow","volume":"4","author":"Zhao","year":"2014","journal-title":"Int. Forum Allergy Rhinol."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.jbiomech.2016.01.009","article-title":"A Computational Analysis of Nasal Vestibule Morphologic Variabilities on Nasal Function","volume":"49","author":"Ramprasad","year":"2016","journal-title":"J. Biomech."},{"key":"ref_209","doi-asserted-by":"crossref","unstructured":"Sanmiguel-Rojas, E., Burgos, M.A., del Pino, C., Sevilla-Garc\u00eda, M.A., and Esteban-Ortega, F. (2018). Robust Nondimensional Estimators to Assess the Nasal Airflow in Health and Disease: Mathematical Estimators to Assess Nasal Airflow. Int. J. Numer. Methods Biomed. Eng., 34.","DOI":"10.1002\/cnm.2906"},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1159\/000516243","article-title":"Aerodynamics Analysis of the Impact of Nasal Surgery on Patients with Obstructive Sleep Apnea and Nasal Obstruction","volume":"84","author":"Li","year":"2022","journal-title":"ORL"},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"4923","DOI":"10.1007\/s00405-023-08058-x","article-title":"Computational Fluid Dynamics Calculations in Inferior Turbinate Surgery: A Cohort Study","volume":"280","author":"Ormiskangas","year":"2023","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1080\/21681163.2020.1858968","article-title":"Patient-Specific CFD Simulation of Aerodynamics for Nasal Pathology: A Combined Computational and Experimental Study","volume":"9","author":"Sagandykova","year":"2021","journal-title":"Comput. Methods Biomech. Biomed. Eng. Imaging Vis."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"1009640","DOI":"10.3389\/fmech.2022.1009640","article-title":"Nasal Airflow Patterns in a Patient with Septal Deviation and Comparison with a Healthy Nasal Cavity Using Computational Fluid Dynamics","volume":"8","author":"Corda","year":"2022","journal-title":"Front. Mech. Eng."},{"key":"ref_214","unstructured":"Brain, J.D., Proctor, D.F., and Reid, L.M. (1977). Respiratory Defense Mechanisms, Part I, Marcel Dekker."},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1152\/jappl.1993.75.4.1767","article-title":"Correlations between Flow Resistance and Geometry in a Model of the Human Nose","volume":"75","author":"Schreck","year":"1993","journal-title":"J. Appl. Physiol."},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1001\/archotol.125.9.1015","article-title":"A Dynamic and Direct Visualization Model for the Study of Nasal Airflow","volume":"125","author":"Simmen","year":"1999","journal-title":"Arch. Otolaryngol. Neck Surg."},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.euromechflu.2015.08.014","article-title":"Effects of Nostril Orientation on Airflow Dynamics, Heat Exchange, and Particle Depositions in Human Noses","volume":"55","author":"Xi","year":"2016","journal-title":"Eur. J. Mech. BFluids"},{"key":"ref_218","doi-asserted-by":"crossref","unstructured":"Inthavong, K., Singh, N., Wong, E., and Tu, J. (2021). Clinical and Biomedical Engineering in the Human Nose, Springer. Biological and Medical Physics, Biomedical Engineering.","DOI":"10.1007\/978-981-15-6716-2"},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1007\/s10439-008-9556-2","article-title":"Effects of Differences in Nasal Anatomy on Airflow Distribution: A Comparison of Four Individuals at Rest","volume":"36","author":"Segal","year":"2008","journal-title":"Ann. Biomed. Eng."},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.buildenv.2015.10.002","article-title":"Investigation of Flow Pattern in Upper Human Airway Including Oral and Nasal Inhalation by PIV and CFD","volume":"94","author":"Phuong","year":"2015","journal-title":"Build. Environ."},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"012010","DOI":"10.1088\/1742-6596\/882\/1\/012010","article-title":"Velocity Measurements in Nasal Cavities by Means of Stereoscopic PIV\u2014Preliminary Tests","volume":"882","author":"Cozzi","year":"2017","journal-title":"J. Phys. Conf. Ser."},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"379","DOI":"10.2500\/ajr.2006.20.2890","article-title":"Nasal Airflow during Respiratory Cycle","volume":"20","author":"Chung","year":"2006","journal-title":"Am. J. Rhinol."},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"3007","DOI":"10.1007\/s10439-016-1604-8","article-title":"An Experimental and Numerical Investigation of CO2 Distribution in the Upper Airways During Nasal High Flow Therapy","volume":"44","author":"Storey","year":"2016","journal-title":"Ann. Biomed. Eng."},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"106121","DOI":"10.1016\/j.jaerosci.2022.106121","article-title":"Development of Computational Fluid Dynamics Methodology for Characterization of Exhalation Delivery System Performance in a Nasal Airway with Draf-III Surgery","volume":"169","author":"Kleven","year":"2023","journal-title":"J. Aerosol Sci."},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1080\/089583798197772","article-title":"Computational Fluid Dynamics Simulations of Inspiratory Airflow in the Human Nose and Nasopharynx","volume":"10","author":"Subramaniam","year":"1998","journal-title":"Inhal. Toxicol."},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1093\/chemse\/bjj008","article-title":"Numerical Modeling of Turbulent and Laminar Airflow and Odorant Transport during Sniffing in the Human and Rat Nose","volume":"31","author":"Zhao","year":"2006","journal-title":"Chem. Senses"},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1001\/archfaci.2012.182","article-title":"Role of Virtual Surgery in Preoperative Planning: Assessing the Individual Components of Functional Nasal Airway Surgery","volume":"14","author":"Rhee","year":"2012","journal-title":"Arch. Facial Plast. Surg."},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"093","DOI":"10.1055\/s-0033-1341591","article-title":"Evaluation of the Intranasal Flow Field through Computational Fluid Dynamics","volume":"29","author":"Hildebrandt","year":"2013","journal-title":"Facial Plast. Surg."},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1080\/10255842.2012.670850","article-title":"Inspirational Airflow Patterns in Deviated Noses: A Numerical Study","volume":"16","author":"Zhu","year":"2013","journal-title":"Comput. Methods Biomech. Biomed. Engin."},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.matcom.2012.11.008","article-title":"Assessment of Surgical Effects on Patients with Obstructive Sleep Apnea Syndrome Using Computational Fluid Dynamics Simulations","volume":"106","author":"Cheng","year":"2014","journal-title":"Math. Comput. Simul."},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1016\/j.jbiomech.2016.03.051","article-title":"The Relationship between Nasal Resistance to Airflow and the Airspace Minimal Cross-Sectional Area","volume":"49","author":"Garcia","year":"2016","journal-title":"J. Biomech."},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.clinbiomech.2017.10.006","article-title":"Geometry and Airflow Dynamics Analysis in the Nasal Cavity during Inhalation","volume":"66","author":"Inthavong","year":"2019","journal-title":"Clin. Biomech."},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"3755","DOI":"10.1038\/s41598-020-60755-3","article-title":"Characterization of the Airflow within an Average Geometry of the Healthy Human Nasal Cavity","volume":"10","author":"Hildebrandt","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_234","doi-asserted-by":"crossref","unstructured":"Ormiskangas, J., Valtonen, O., Harju, T., Rautiainen, M., and Kivek\u00e4s, I. (2022). Computational Fluid Dynamics Assessed Changes of Nasal Airflow after Inferior Turbinate Surgery. Respir. Physiol. Neurobiol., 302.","DOI":"10.1016\/j.resp.2022.103917"},{"key":"ref_235","doi-asserted-by":"crossref","unstructured":"Siu, J., Inthavong, K., Dong, J., Shang, Y., and Douglas, R.G. (2021). Nasal Air Conditioning Following Total Inferior Turbinectomy Compared to Inferior Turbinoplasty\u2014A Computational Fluid Dynamics Study. Clin. Biomech., 81.","DOI":"10.1016\/j.clinbiomech.2020.105237"},{"key":"ref_236","doi-asserted-by":"crossref","unstructured":"Corda, J.V., Shenoy, B.S., Ahmad, K.A., Lewis, L., Khader, S.M.A., and Zuber, M. (2022). Nasal Airflow Comparison in Neonates, Infant and Adult Nasal Cavities Using Computational Fluid Dynamics. Comput. Methods Programs Biomed., 214.","DOI":"10.1016\/j.cmpb.2021.106538"},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.1016\/j.jbiomech.2008.04.013","article-title":"Large Eddy Simulation and Reynolds-Averaged Navier\u2013Stokes Modeling of Flow in a Realistic Pharyngeal Airway Model: An Investigation of Obstructive Sleep Apnea","volume":"41","author":"Mihaescu","year":"2008","journal-title":"J. Biomech."},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1097\/MLG.0b013e31815937c1","article-title":"Computational Modeling of Upper Airway Before and After Adenotonsillectomy for Obstructive Sleep Apnea","volume":"118","author":"Mihaescu","year":"2008","journal-title":"Laryngoscope"},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1016\/j.matcom.2011.02.006","article-title":"Patient-Specific Geometry Modeling and Mesh Generation for Simulating Obstructive Sleep Apnea Syndrome Cases by Maxillomandibular Advancement","volume":"81","author":"Ito","year":"2011","journal-title":"Math. Comput. Simul."},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"3708","DOI":"10.1016\/j.jbiomech.2007.06.022","article-title":"Functional Imaging Using Computational Fluid Dynamics to Predict Treatment Success of Mandibular Advancement Devices in Sleep-Disordered Breathing","volume":"40","author":"Vanderveken","year":"2007","journal-title":"J. Biomech."},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1002\/lary.20585","article-title":"Assessment of Septal Deviation Effects on Nasal Air Flow: A Computational Fluid Dynamics Model","volume":"119","author":"Chen","year":"2009","journal-title":"Laryngoscope"},{"key":"ref_242","doi-asserted-by":"crossref","unstructured":"Cingi, C., Bayar Muluk, N., Scadding, G.K., and Mladina, R. (2021). Challenges in Rhinology, Springer International Publishing.","DOI":"10.1007\/978-3-030-50899-9"},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1016\/j.jbiomech.2013.06.016","article-title":"Planning Human Upper Airway Surgery Using Computational Fluid Dynamics","volume":"46","author":"Mylavarapu","year":"2013","journal-title":"J. Biomech."},{"key":"ref_244","doi-asserted-by":"crossref","first-page":"59","DOI":"10.2478\/pjmpe-2023-0008","article-title":"Accuracy of Virtual Rhinomanometry","volume":"29","author":"Karbowski","year":"2023","journal-title":"Pol. J. Med. Phys. Eng."},{"key":"ref_245","first-page":"43","article-title":"Turbulent Kinetic Energy of Flow during Inhale and Exhale to Characterize the Severity of Obstructive Sleep Apnea Patient","volume":"136","author":"Faizal","year":"2023","journal-title":"Comput. Model. Eng. Sci."},{"key":"ref_246","doi-asserted-by":"crossref","unstructured":"Wakayama, T., Suzuki, M., and Tanuma, T. (2016). Effect of Nasal Obstruction on Continuous Positive Airway Pressure Treatment: Computational Fluid Dynamics Analyses. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0150951"},{"key":"ref_247","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.compfluid.2017.08.003","article-title":"Numerical Investigation of Turbulent Airflow and Microparticle Deposition in a Realistic Model of Human Upper Airway Using LES","volume":"157","author":"Ghahramani","year":"2017","journal-title":"Comput. Fluids"},{"key":"ref_248","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.procs.2014.05.050","article-title":"Large Eddy Simulation of Flow in Realistic Human Upper Airways with Obstructive Sleep","volume":"29","author":"Lu","year":"2014","journal-title":"Procedia Comput. Sci."},{"key":"ref_249","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.compbiomed.2015.12.003","article-title":"Large-Scale CFD Simulations of the Transitional and Turbulent Regime for the Large Human Airways during Rapid Inhalation","volume":"69","author":"Calmet","year":"2016","journal-title":"Comput. Biol. Med."},{"key":"ref_250","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1080\/10255842.2020.1833865","article-title":"Computational Modelling of Nasal Respiratory Flow","volume":"24","author":"Calmet","year":"2021","journal-title":"Comput. Methods Biomech. Biomed. Engin."},{"key":"ref_251","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.resp.2013.12.009","article-title":"On Locating the Obstruction in the Upper Airway via Numerical Simulation","volume":"193","author":"Wang","year":"2014","journal-title":"Respir. Physiol. Neurobiol."},{"key":"ref_252","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1016\/j.compbiomed.2013.09.003","article-title":"Fluid Mechanics Based Classification of the Respiratory Efficiency of Several Nasal Cavities","volume":"43","author":"Lintermann","year":"2013","journal-title":"Comput. Biol. Med."},{"key":"ref_253","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1007\/s10278-021-00501-x","article-title":"Effects of the Nasal Cavity Complexity on the Pharyngeal Airway Fluid Mechanics: A Computational Study","volume":"34","author":"Aljawad","year":"2021","journal-title":"J. Digit. Imaging"},{"key":"ref_254","unstructured":"(2024, January 01). Otopront. Available online: https:\/\/www.otopront.de."},{"key":"ref_255","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1016\/j.neuroimage.2006.01.015","article-title":"User-Guided 3D Active Contour Segmentation of Anatomical Structures: Significantly Improved Efficiency and Reliability","volume":"31","author":"Yushkevich","year":"2006","journal-title":"NeuroImage"},{"key":"ref_256","unstructured":"(2024, January 01). ANSYS. Available online: https:\/\/www.ansys.com."},{"key":"ref_257","unstructured":"ANSYS (2023). ANSYS Fluent User\u2019s Guide, ANSYS, Inc."},{"key":"ref_258","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/0045-7930(94)00032-T","article-title":"A New K-\u03f5 Eddy Viscosity Model for High Reynolds Number Turbulent Flows","volume":"24","author":"Shih","year":"1995","journal-title":"Comput. Fluids"},{"key":"ref_259","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1023\/A:1009995426001","article-title":"Subgrid-Scale Stress Modelling Based on the Square of the Velocity Gradient Tensor","volume":"62","author":"Nicoud","year":"1999","journal-title":"Flow Turbul. Combust."},{"key":"ref_260","doi-asserted-by":"crossref","first-page":"2200","DOI":"10.1016\/j.camwa.2009.08.060","article-title":"Investigation of the LES WALE Turbulence Model within the Lattice Boltzmann Framework","volume":"59","author":"Weickert","year":"2010","journal-title":"Comput. Math. Appl."},{"key":"ref_261","unstructured":"Patton, K.T., and Thibodeau, G.A. (2013). Anatomy & Physiology, Mosby\/Elsevier. [8th ed.]."},{"key":"ref_262","doi-asserted-by":"crossref","first-page":"064603","DOI":"10.1103\/PhysRevFluids.3.064603","article-title":"Effects of Finite Spatial and Temporal Resolution in Direct Numerical Simulations of Incompressible Isotropic Turbulence","volume":"3","author":"Yeung","year":"2018","journal-title":"Phys. Rev. Fluids"},{"key":"ref_263","first-page":"9","article-title":"The Local Structure of Turbulence in Incompressible Viscous Fluid for Very Large Reynolds Numbers","volume":"434","author":"Kolmogorov","year":"1991","journal-title":"Proc. R. Soc. Lond."},{"key":"ref_264","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.taml.2017.09.010","article-title":"\u201cEquilibrium\u201d and \u201cNon-Equilibrium\u201d Turbulence","volume":"7","author":"Rubinstein","year":"2017","journal-title":"Theor. Appl. Mech. Lett."},{"key":"ref_265","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1177\/000348948609500304","article-title":"The Nasal Valve: A Rhinomanometric Evaluation of Maximum Nasal Inspiratory Flow and Pressure Curves","volume":"95","author":"McCaffrey","year":"1986","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"key":"ref_266","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1177\/194589240401800109","article-title":"Nasal Dyspnea: The Place of Rhinomanometry in Its Objective Assessment","volume":"18","author":"Schumacher","year":"2004","journal-title":"Am. J. Rhinol."},{"key":"ref_267","doi-asserted-by":"crossref","first-page":"118710","DOI":"10.1016\/j.powtec.2023.118710","article-title":"Exploring the Role of Nasal Hair in Inhaled Airflow and Coarse Dust Particle Dynamics in a Nasal Cavity: A CFD-DEM Study","volume":"427","author":"Haghnegahdar","year":"2023","journal-title":"Powder Technol."},{"key":"ref_268","unstructured":"OSASMOD (2024, January 01). PI: M\u00fcller, B. Grant Title: Modeling of Obstructive Sleep Apnea by Fluid-Structure Interaction in the Upper Airways. Grant Number: 231741. Funding Body: The Research Council of Norway. Start-End Dates: 2014\u20132018. Available online: https:\/\/prosjektbanken.forskningsradet.no\/project\/FORISS\/231741."},{"key":"ref_269","unstructured":"VIRTUOSA (2024, January 01). PI: Skallerud, B.H. Grant Title: Virtual Surgery in the Upper Airways\u2014New Solutions to Obstructive Sleep Apnea Treatment. Grant Number: 303218. Funding Body: The Research Council of Norway. Start-End Dates: 2020\u20132024. Available online: https:\/\/prosjektbanken.forskningsradet.no\/project\/FORISS\/303218."},{"key":"ref_270","unstructured":"(2024, January 01). SINTEF. Available online: http:\/\/www.sintef.no."},{"key":"ref_271","unstructured":"(2024, January 01). Sigma2\u2014The National Infrastructure for High Performance Computing and Data Storage in Norway. Available online: https:\/\/www.sigma2.no."},{"key":"ref_272","unstructured":"Norwegian Research Infrastructure Services (NRIS) (2024, January 01). NIRD Research Data Archive. Available online: https:\/\/archive.sigma2.no\/."}],"container-title":["Bioengineering"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2306-5354\/11\/3\/239\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:06:34Z","timestamp":1760105194000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2306-5354\/11\/3\/239"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,28]]},"references-count":272,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2024,3]]}},"alternative-id":["bioengineering11030239"],"URL":"https:\/\/doi.org\/10.3390\/bioengineering11030239","relation":{},"ISSN":["2306-5354"],"issn-type":[{"value":"2306-5354","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,28]]}}}