{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T17:17:42Z","timestamp":1778260662148,"version":"3.51.4"},"reference-count":70,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T00:00:00Z","timestamp":1713830400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Canadian Institutes of Health Research","award":["19NASAHER3"],"award-info":[{"award-number":["19NASAHER3"]}]},{"name":"FQRS","award":["19NASAHER3"],"award-info":[{"award-number":["19NASAHER3"]}]},{"name":"IVADO","award":["19NASAHER3"],"award-info":[{"award-number":["19NASAHER3"]}]},{"name":"NASA","award":["19NASAHER3"],"award-info":[{"award-number":["19NASAHER3"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioengineering"],"abstract":"<jats:p>This study investigated the effect of intraocular pressure (IOP) reduction on pulsatile displacement within the optic nerve head (ONH) in primary open-angle glaucoma (POAG) patients with and without axial myopia. Forty-one POAG patients (19 without myopia, 9 with axial myopia and 13 glaucoma with no intervention) participated. Swept-source optical coherence tomography (OCT) videos of the ONH were obtained before and after IOP-lowering treatment (medical or surgical) achieving a minimum IOP drop of 3 mmHg. A demons registration-based algorithm measured local pulsatile displacement maps within the ONH. Results demonstrated a significant 14% decrease in pulsatile tissue displacement in the non-myopic glaucoma cohort after intervention (p = 0.03). However, glaucoma patients with axial myopia exhibited no statistically significant change. There were no significant changes in the pulsatile ONH deformation in the control group. These findings suggest a potential link between IOP reduction and reduced pulsatile displacement within the ONH in POAG patients without myopia, offering new insights into the disease\u2019s pathophysiology and warranting further investigation into underlying mechanisms and clinical implications.<\/jats:p>","DOI":"10.3390\/bioengineering11050411","type":"journal-article","created":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T05:28:06Z","timestamp":1713850086000},"page":"411","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Optic Nerve Head Pulsatile Displacement in Open-Angle Glaucoma after Intraocular Pressure Reduction Measured by Optical Coherence Tomography: A Pilot Study"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1055-669X","authenticated-orcid":false,"given":"Mariss\u00e9","family":"Mas\u00eds Solano","sequence":"first","affiliation":[{"name":"Maisonneuve-Rosemont Hospital Research Center, 5415 Assumption Blvd, Montreal, QC H1T 2M4, Canada"},{"name":"Department of Ophthalmology, Universit\u00e9 de Montr\u00e9al, 5415 Assumption Blvd, Montreal, QC H1T 2M4, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuelle","family":"Richer","sequence":"additional","affiliation":[{"name":"Maisonneuve-Rosemont Hospital Research Center, 5415 Assumption Blvd, Montreal, QC H1T 2M4, Canada"},{"name":"\u00c9cole Polytechnique de Montr\u00e9al, 2500 Chemin de Polytechnique, Montreal, QC H3T 1J4, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2454-2635","authenticated-orcid":false,"given":"Santiago","family":"Costantino","sequence":"additional","affiliation":[{"name":"Maisonneuve-Rosemont Hospital Research Center, 5415 Assumption Blvd, Montreal, QC H1T 2M4, Canada"},{"name":"Department of Ophthalmology, Universit\u00e9 de Montr\u00e9al, 5415 Assumption Blvd, Montreal, QC H1T 2M4, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark R.","family":"Lesk","sequence":"additional","affiliation":[{"name":"Maisonneuve-Rosemont Hospital Research Center, 5415 Assumption Blvd, Montreal, QC H1T 2M4, Canada"},{"name":"Department of Ophthalmology, Universit\u00e9 de Montr\u00e9al, 5415 Assumption Blvd, Montreal, QC H1T 2M4, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.ajo.2011.06.004","article-title":"An Assessment of the Health and Economic Burdens of Glaucoma","volume":"152","author":"Varma","year":"2011","journal-title":"Am. 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