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Limited research has focused on preventive measures, prompting exploration into the efficacy of raised toe box running shoes. Purpose: This study aimed to investigate the effect of running shoes with raised toe boxes on preventing toe injuries caused by distance running. Methods: A randomized crossover design involved 25 male marathon runners (height: 1.70 \u00b1 0.02 m, weight: 62.6 + 4.5 kg) wearing both raised toe box (extended by 8 mm along the vertical axis and 3 mm along the sagittal axis) and regular toe box running shoes. Ground reaction force (GRF), in-shoe displacement, and degree of toe deformation (based on the distance change between the toe and the metatarsal head) were collected. Results: Wearing raised toe box shoes resulted in a significant reduction in vertical (p = 0.001) and antero\u2013posterior (p = 0.015) ground reaction forces during the loading phase, with a notable increase in vertical ground reaction force during the toe-off phase (p &lt; 0.001). In-shoe displacement showed significant decreased movement in the forefoot medial (p &lt; 0.001) and rearfoot (medial: p &lt; 0.001, lateral: p &lt; 0.001) and significant increased displacement in the midfoot (medial: p = 0.002, lateral: p &lt; 0.001). Impact severity on the hallux significantly decreased (p &lt; 0.001), while impact on the small toes showed no significant reduction (p = 0.067). Conclusions: Raised toe box running shoes offer an effective means of reducing toe injuries caused by long-distance running.<\/jats:p>","DOI":"10.3390\/bioengineering11050457","type":"journal-article","created":{"date-parts":[[2024,5,3]],"date-time":"2024-05-03T09:39:47Z","timestamp":1714729187000},"page":"457","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Toe Box Shape of Running Shoes Affects In-Shoe Foot Displacement and Deformation: A Randomized Crossover Study"],"prefix":"10.3390","volume":"11","author":[{"given":"Chengyuan","family":"Zhu","sequence":"first","affiliation":[{"name":"Faculty of Sports Science, Ningbo University, Ningbo 315211, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7438-6290","authenticated-orcid":false,"given":"Yang","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Faculty of Engineering, The Hong Kong Polytechnic University, Hong Kong SAR, China"},{"name":"Faculty of Engineering, University of Szeged, 6700 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufan","family":"Xu","sequence":"additional","affiliation":[{"name":"Faculty of Sports Science, Ningbo University, Ningbo 315211, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aojie","family":"Zhu","sequence":"additional","affiliation":[{"name":"Faculty of Sports Science, Ningbo University, Ningbo 315211, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien S.","family":"Baker","sequence":"additional","affiliation":[{"name":"Faculty of Sports Science, Ningbo University, Ningbo 315211, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[{"name":"Faculty of Sports Science, Ningbo University, Ningbo 315211, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2187-9440","authenticated-orcid":false,"given":"Yaodong","family":"Gu","sequence":"additional","affiliation":[{"name":"Faculty of Sports Science, Ningbo University, Ningbo 315211, China"},{"name":"Faculty of Engineering, University of Szeged, 6700 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,5,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"284","DOI":"10.2165\/00007256-200737040-00003","article-title":"The History of the Marathon: 1976-Present","volume":"37","author":"Burfoot","year":"2007","journal-title":"Sports Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"43","DOI":"10.5334\/paah.226","article-title":"Foot Morphology and Running Gait Pattern between the Left and Right Limbs in Recreational Runners","volume":"7","author":"Pan","year":"2023","journal-title":"Phys. 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