{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T21:00:37Z","timestamp":1792011637193,"version":"4.4.0"},"reference-count":47,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T00:00:00Z","timestamp":1718064000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioengineering"],"abstract":"<jats:p>Cataracts are characterized by the crystalline lens of the eye becoming cloudy, and dry eye disease (DED) is a multifactorial disease in which the homeostasis of the tear film is lost. As the prevalence of both diseases increases with age, there is a high prevalence of DED among patients who are candidates for cataract surgery. In recent years, cataract surgery has evolved from vision restoration surgery to refractive surgery. To achieve good surgical outcomes, it is necessary to minimize postoperative refractive error in intraocular lens (IOL) power calculation, which requires accurate preoperative keratometry measurements. A stable tear film is important for the accuracy and reproducibility of keratometry measurements, and DED may have a deleterious effect. In this study, original articles that focused primarily on findings related to this topic were evaluated. A systematic review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Although appropriate DED diagnoses were not presented in the articles evaluated in this review, it was confirmed that the clinical signs of DED, particularly the shortening of the tear film break-up time (TBUT), negatively impact IOL power calculations. Improvement in these clinical signs might mitigate the negative effects on these calculations.<\/jats:p>","DOI":"10.3390\/bioengineering11060597","type":"journal-article","created":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T12:11:00Z","timestamp":1718107860000},"page":"597","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Management of Dry Eye Disease for Intraocular Lens Power Calculation in Cataract Surgery: A Systematic Review"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6026-8226","authenticated-orcid":false,"given":"Atsushi","family":"Kawahara","sequence":"first","affiliation":[{"name":"Yoshida Eye Hospital, 2-31-8, Hondori, Hakodate 041-0851, Hokkaido, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/S0140-6736(17)30544-5","article-title":"Cataracts","volume":"390","author":"Liu","year":"2017","journal-title":"Lancet"},{"key":"ref_2","unstructured":"GBD 2019 Blindness and Vision Impairment Collaborators, and Vision Loss Expert Group of the Global Burden of Disease Study (2021). Causes of blindness and vision impairment in 2020 and trends over 30 years, and prevalence of avoidable blindness in relation to VISION 2020: The Right to Sight: An analysis for the Global Burden of Disease Study. Lancet Glob. Health, 9, e144\u2013e160."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1177\/1120672119893291","article-title":"Femtosecond laser-assisted cataract surgery: A review","volume":"30","author":"Roberts","year":"2020","journal-title":"Eur. J. Ophthalmol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"14673","DOI":"10.1038\/s41598-020-71545-2","article-title":"Inter-ocular and inter-visit differences in ocular biometry and refractive outcomes after cataract surgery","volume":"10","author":"Choi","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Chen, Y., and Xia, X. (2016). Comparison of the Orbscan II topographer and the iTrace aberrometer for the measurements of keratometry and corneal diameter in myopic patients. BMC Ophthalmol., 16.","DOI":"10.1186\/s12886-016-0210-8"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.jtos.2017.05.008","article-title":"TFOS DEWS II Definition and Classification Report","volume":"15","author":"Craig","year":"2017","journal-title":"Ocul. Surf."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1111\/opo.12888","article-title":"The global prevalence of dry eye disease: A Bayesian view","volume":"41","author":"Papas","year":"2021","journal-title":"Ophthalmic Physiol. Opt."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/j.jtos.2020.07.003","article-title":"Ageing and the natural history of dry eye disease: A prospective registry-based cross-sectional study","volume":"18","author":"Wang","year":"2020","journal-title":"Ocul. Surf."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1097\/IIO.0000000000000170","article-title":"Effects of Aging in Dry Eye","volume":"57","year":"2017","journal-title":"Int. Ophthalmol. Clin."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Kawahara, A. (2023). Treatment of Dry Eye Disease (DED) in Asia: Strategies for Short Tear Film Breakup Time-Type DED. Pharmaceutics, 15.","DOI":"10.3390\/pharmaceutics15112591"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.2147\/OPTH.S120159","article-title":"The Prospective Health Assessment of Cataract Patients\u2019 Ocular Surface (PHACO) study: The effect of dry eye","volume":"11","author":"Trattler","year":"2017","journal-title":"Clin. Ophthalmol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1007\/s00347-013-2964-1","article-title":"Schleimpflug photography detects alterations in corneal density and thickness in patients with dry eye disease","volume":"111","author":"Meyer","year":"2014","journal-title":"Ophthalmologe"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"103999","DOI":"10.1016\/j.jfo.2023.04.016","article-title":"Effect of dry eye on the reliability of keratometry for cataract surgery planning","volume":"47","author":"Yang","year":"2024","journal-title":"J. Fran\u00e7ais d\u2019Ophtalmologie"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/j.jfo.2019.03.032","article-title":"Management of dry eye disease to optimize cataract surgery outcomes: Two tables for a daily clinical practice","volume":"42","author":"Labetoulle","year":"2019","journal-title":"J. Fran\u00e7ais d\u2019Ophtalmologie"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"9124","DOI":"10.1038\/s41598-021-88589-7","article-title":"A randomized, prospective study of the effects of 3% diquafosol on ocular sur-face following cataract surgery","volume":"11","author":"Kim","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_16","first-page":"221","article-title":"Report of the national eye institute\/industry workshop on clinical trials in dry eyes","volume":"21","author":"Lemp","year":"1995","journal-title":"CLAO J."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1097\/01.ico.0000214802.40313.fa","article-title":"Dysfunctional tear syndrome: A Delphi approach to treatment recommendations","volume":"25","author":"Behrens","year":"2006","journal-title":"Cornea"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"(2007). The definition and classification of dry eye disease: Report of the Definition and Classification Subcommittee of the International Dry Eye WorkShop. Ocul. Surf., 2007, 75\u201392.","DOI":"10.1016\/S1542-0124(12)70081-2"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1002\/jrsm.1411","article-title":"Risk-of-bias VISualization (robvis): An R package and Shiny web app for visualizing risk-of-bias assessments","volume":"12","author":"McGuinness","year":"2021","journal-title":"Res. Synth. Methods"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Hiraoka, T., Asano, H., Ogami, T., Nakano, S., Okamoto, Y., Yamada, Y., and Oshika, T. (2022). Influence of Dry Eye Disease on the Measurement Repeatability of Corneal Curvature Radius and Axial Length in Patients with Cataract. J. Clin. Med., 11.","DOI":"10.3390\/jcm11030710"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"759","DOI":"10.3928\/1081597X-20210826-01","article-title":"Should Artificial Tears Be Used during the Preoperative Assessment of Toric IOLs before Age-Related Cataract Surgery? The TORIDE Study","volume":"37","author":"Rochet","year":"2021","journal-title":"J. Refract. Surg."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Kim, J., Kim, M.K., Ha, Y., Paik, H.J., and Kim, D.H. (2021). Improved accuracy of intraocular lens power calculation by preoperative management of dry eye disease. BMC Ophthalmol., 21.","DOI":"10.1186\/s12886-021-02129-5"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2709","DOI":"10.2147\/OPTH.S264520","article-title":"The Effect of Lifitegrast on Refractive Accuracy and Symptoms in Dry Eye Patients Undergoing Cataract Surgery","volume":"14","author":"Hovanesian","year":"2020","journal-title":"Clin. Ophthalmol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1016\/j.jcrs.2015.01.016","article-title":"Effect of tear osmolarity on repeatability of keratometry for cataract surgery planning","volume":"41","author":"Epitropoulos","year":"2015","journal-title":"J. Cataract. Refract. Surg."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.jcrs.2019.03.023","article-title":"An algorithm for the preoperative diagnosis and treatment of ocular surface disorders","volume":"45","author":"Starr","year":"2019","journal-title":"J. Cataract. Refract. Surg."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1001\/jamaophthalmol.2013.4503","article-title":"Development and validation of the Dry Eye-Related Quality-of-Life Score questionnaire","volume":"131","author":"Sakane","year":"2013","journal-title":"JAMA Ophthalmol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1097\/ICO.0b013e318294b0c0","article-title":"Psychometric properties and validation of the Standard Patient Evaluation of Eye Dryness questionnaire","volume":"32","author":"Ngo","year":"2013","journal-title":"Cornea"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.jtos.2017.05.001","article-title":"TFOS DEWS II Diagnostic Methodology report","volume":"15","author":"Wolffsohn","year":"2017","journal-title":"Ocul. Surf."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/j.ajo.2010.10.032","article-title":"Tear osmolarity in the diagnosis and management of dry eye disease","volume":"151","author":"Lemp","year":"2011","journal-title":"Am. J. Ophthalmol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.clae.2009.12.010","article-title":"Validation of the 5-Item Dry Eye Questionnaire (DEQ-5): Discrimination across self-assessed severity and aqueous tear deficient dry eye diagnoses","volume":"33","author":"Chalmers","year":"2010","journal-title":"Contact Lens Anterior Eye"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1001\/archopht.118.5.615","article-title":"Reliability and validity of the Ocular Surface Disease Index","volume":"118","author":"Schiffman","year":"2000","journal-title":"Arch. Ophthalmol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.jtos.2017.05.003","article-title":"TFOS DEWS II Epidemiology Report","volume":"15","author":"Stapleton","year":"2017","journal-title":"Ocul. Surf."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1111\/aos.14408","article-title":"Variations in keratometric values (K-value) after administration of three different eye drops\u2014Effects on the intraocular lens calculations in relation to cataract surgery","volume":"98","author":"Jensen","year":"2020","journal-title":"Acta Ophthalmol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ajo.2020.08.024","article-title":"Influence of Artificial Tears on Keratometric Measurements in Cataract Patients","volume":"221","author":"Leydolt","year":"2021","journal-title":"Am. J. Ophthalmol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.clae.2020.01.002","article-title":"The impact of exposure on the magnitude of astigmatism formed within the precorneal tear film over the central optical zone of the cornea in ocular surface disease","volume":"43","author":"Patel","year":"2020","journal-title":"Contact Lens Anterior Eye"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.jtos.2017.05.006","article-title":"TFOS DEWS II Management and Therapy Report","volume":"15","author":"Jones","year":"2017","journal-title":"Ocul. Surf."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.jtos.2016.09.003","article-title":"New Perspectives on Dry Eye Definition and Diagnosis: A Consensus Report by the Asia Dry Eye Society","volume":"15","author":"Tsubota","year":"2017","journal-title":"Ocul. Surf."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s10384-018-00645-4","article-title":"Tear-film-oriented diagnosis for dry eye","volume":"63","author":"Yokoi","year":"2019","journal-title":"Jpn. J. Ophthalmol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"3654","DOI":"10.1007\/s12325-022-02194-2","article-title":"Efficacy and Safety of the Long-Acting Diquafosol Ophthalmic Solution DE-089C in Patients with Dry Eye: A Randomized, Double-Masked, Placebo-Controlled Phase 3 Study","volume":"39","author":"Hori","year":"2022","journal-title":"Adv. Ther."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Ishikawa, S., Sasaki, T., Maruyama, T., Murayama, K., and Shinoda, K. (2023). Effectiveness and Adherence of Dry Eye Patients Who Switched from Short- to Long-Acting Diquafosol Ophthalmic Solution. J. Clin. Med., 12.","DOI":"10.3390\/jcm12134495"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"von K\u00fcgelgen, I. (2021). Molecular pharmacology of P2Y receptor subtypes. Biochem. Pharmacol., 187.","DOI":"10.1016\/j.bcp.2020.114361"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1089\/jop.2016.0092","article-title":"Comparison of Short-Term Effects of Diquafosol and Rebamipide on Mucin 5AC Level on the Rabbit Ocular Surface","volume":"33","author":"Hori","year":"2017","journal-title":"J. Ocul. Pharmacol. Ther."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"9091","DOI":"10.1038\/s41598-019-45475-7","article-title":"Tear film lipid layer increase after diquafosol instillation in dry eye patients with meibomian gland dysfunction: A randomized clinical study","volume":"9","author":"Fukuoka","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1089\/jop.2021.0083","article-title":"Impact of Diquafosol Ophthalmic Solution on Tear Film and Dry Eye Symptom in Type 2 Diabetic Dry Eye: A Pilot Study","volume":"38","author":"Zhang","year":"2022","journal-title":"J. Ocul. Pharmacol. Ther."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1038\/eye.2015.125","article-title":"Three percent diquafosol ophthalmic solution as an additional therapy to existing artificial tears with steroids for dry-eye patients with Sj\u00f6gren\u2019s syndrome","volume":"29","author":"Yokoi","year":"2015","journal-title":"Eye"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.exer.2015.10.013","article-title":"Diquafosol promotes corneal epithelial healing via intracellular calcium-mediated ERK activation","volume":"143","author":"Byun","year":"2016","journal-title":"Exp. Eye Res."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1097\/ICO.0000000000000429","article-title":"Efficacy and safety of topical diquafosol ophthalmic solution for treatment of dry eye: A systematic review of randomized clinical trials","volume":"34","author":"Wu","year":"2015","journal-title":"Cornea"}],"container-title":["Bioengineering"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2306-5354\/11\/6\/597\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:57:09Z","timestamp":1760108229000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2306-5354\/11\/6\/597"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,11]]},"references-count":47,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2024,6]]}},"alternative-id":["bioengineering11060597"],"URL":"https:\/\/doi.org\/10.3390\/bioengineering11060597","relation":{},"ISSN":["2306-5354"],"issn-type":[{"value":"2306-5354","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,11]]}}}