{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T23:54:31Z","timestamp":1787961271180,"version":"build-2784847793"},"reference-count":44,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T00:00:00Z","timestamp":1718150400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development program of China","doi-asserted-by":"publisher","award":["2022YFC2403102"],"award-info":[{"award-number":["2022YFC2403102"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development program of China","doi-asserted-by":"publisher","award":["2021A1515012480"],"award-info":[{"award-number":["2021A1515012480"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development program of China","doi-asserted-by":"publisher","award":["2022B1111080007"],"award-info":[{"award-number":["2022B1111080007"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development program of China","doi-asserted-by":"publisher","award":["202103030003"],"award-info":[{"award-number":["202103030003"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development program of China","doi-asserted-by":"publisher","award":["2024A03J0821"],"award-info":[{"award-number":["2024A03J0821"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Natural Science Foundation of Guangdong Province, China","award":["2022YFC2403102"],"award-info":[{"award-number":["2022YFC2403102"]}]},{"name":"Natural Science Foundation of Guangdong Province, China","award":["2021A1515012480"],"award-info":[{"award-number":["2021A1515012480"]}]},{"name":"Natural Science Foundation of Guangdong Province, China","award":["2022B1111080007"],"award-info":[{"award-number":["2022B1111080007"]}]},{"name":"Natural Science Foundation of Guangdong Province, China","award":["202103030003"],"award-info":[{"award-number":["202103030003"]}]},{"name":"Natural Science Foundation of Guangdong Province, China","award":["2024A03J0821"],"award-info":[{"award-number":["2024A03J0821"]}]},{"name":"R&amp;D Plan Project in Key Fields of Guangdong Province, China","award":["2022YFC2403102"],"award-info":[{"award-number":["2022YFC2403102"]}]},{"name":"R&amp;D Plan Project in Key Fields of Guangdong Province, China","award":["2021A1515012480"],"award-info":[{"award-number":["2021A1515012480"]}]},{"name":"R&amp;D Plan Project in Key Fields of Guangdong Province, China","award":["2022B1111080007"],"award-info":[{"award-number":["2022B1111080007"]}]},{"name":"R&amp;D Plan Project in Key Fields of Guangdong Province, China","award":["202103030003"],"award-info":[{"award-number":["202103030003"]}]},{"name":"R&amp;D Plan Project in Key Fields of Guangdong Province, China","award":["2024A03J0821"],"award-info":[{"award-number":["2024A03J0821"]}]},{"name":"Guangzhou Research and Development Plan in Key Fields, China","award":["2022YFC2403102"],"award-info":[{"award-number":["2022YFC2403102"]}]},{"name":"Guangzhou Research and Development Plan in Key Fields, China","award":["2021A1515012480"],"award-info":[{"award-number":["2021A1515012480"]}]},{"name":"Guangzhou Research and Development Plan in Key Fields, China","award":["2022B1111080007"],"award-info":[{"award-number":["2022B1111080007"]}]},{"name":"Guangzhou Research and Development Plan in Key Fields, China","award":["202103030003"],"award-info":[{"award-number":["202103030003"]}]},{"name":"Guangzhou Research and Development Plan in Key Fields, China","award":["2024A03J0821"],"award-info":[{"award-number":["2024A03J0821"]}]},{"name":"Guangzhou Science and Technology Plan Project, China","award":["2022YFC2403102"],"award-info":[{"award-number":["2022YFC2403102"]}]},{"name":"Guangzhou Science and Technology Plan Project, China","award":["2021A1515012480"],"award-info":[{"award-number":["2021A1515012480"]}]},{"name":"Guangzhou Science and Technology Plan Project, China","award":["2022B1111080007"],"award-info":[{"award-number":["2022B1111080007"]}]},{"name":"Guangzhou Science and Technology Plan Project, China","award":["202103030003"],"award-info":[{"award-number":["202103030003"]}]},{"name":"Guangzhou Science and Technology Plan Project, China","award":["2024A03J0821"],"award-info":[{"award-number":["2024A03J0821"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioengineering"],"abstract":"<jats:p>Advanced glycation end product (AGE) accumulation due to diabetes causes vascular and neurological lesions, delaying healing. The use of stem cells could overcome these problems. Although many studies have shown the potential beneficial effects of stem cell therapies in the treatment of chronic and refractory skin ulcers, their delivery methods are still under investigation. Human periodontal ligament stem cells (hPDLSCs) can spontaneously differentiate into myofibroblasts in specific cultures; therefore, they have the potential to effectively treat diabetic wounds and may also have applications in the field of medical cosmetics. The myofibroblastic differentiation ability of hPDLSCs in the presence of AGEs was evaluated by the expression of \u03b1-SMA and COL1A1 using RT-qPCR and WB technology. Wound healing in diabetic mice, induced by streptozotocin (STZ) and assessed using H&amp;E staining, Masson staining, and immunohistochemical (IHC) and immunofluorescence (IF) staining, was used to validate the effects of hPDLSCs. In the wound tissues, the expression of \u03b1-SMA, COL1A1, CD31, CD206, iNOS, and vimentin was detected. The findings indicated that in H-DMEM, the expression of COL1A1 exhibited a significant decrease, while \u03b1-SMA demonstrated an increase in P7 cells, ignoring the damage from AGEs (p &lt; 0.05). In an STZ-induced diabetic C57BL\/6J mice whole-skin defect model, the healing rate of the hPDLSCs treatment group was significantly higher than that in the models (on the 7th day, the rate was 65.247% vs. 48.938%, p &lt; 0.05). hPDLSCs have been shown to spontaneously differentiate into myofibroblasts in H-DMEM and resist damage from AGEs in both in vivo and in vitro models, suggesting their potential in the field of cosmetic dermatology.<\/jats:p>","DOI":"10.3390\/bioengineering11060602","type":"journal-article","created":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T03:52:53Z","timestamp":1718337173000},"page":"602","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Human Periodontal Ligament Stem Cells (hPDLSCs) Spontaneously Differentiate into Myofibroblasts to Repair Diabetic Wounds"],"prefix":"10.3390","volume":"11","author":[{"given":"Yuxiao","family":"Li","sequence":"first","affiliation":[{"name":"Institute of Biomedicine and Guangdong Provincial Key Laboratory of Bioengineering Medicine, Jinan University, Guangzhou 510632, China"},{"name":"School of Stomatology, Jinan University, Guangzhou 510632, China"},{"name":"The First Affiliated Hospital of Jinan University, Guangzhou 510632, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Su","sequence":"additional","affiliation":[{"name":"Institute of Biomedicine and Guangdong Provincial Key Laboratory of Bioengineering Medicine, Jinan University, Guangzhou 510632, China"},{"name":"School of Stomatology, Jinan University, Guangzhou 510632, China"},{"name":"The First Affiliated Hospital of Jinan University, Guangzhou 510632, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoyu","family":"Tao","sequence":"additional","affiliation":[{"name":"Institute of Biomedicine and Guangdong Provincial Key Laboratory of Bioengineering Medicine, Jinan University, Guangzhou 510632, China"},{"name":"School of Stomatology, Jinan University, Guangzhou 510632, China"},{"name":"The First Affiliated Hospital of Jinan University, Guangzhou 510632, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Cai","sequence":"additional","affiliation":[{"name":"Institute of Biomedicine and Guangdong Provincial Key Laboratory of Bioengineering Medicine, Jinan University, Guangzhou 510632, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueping","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Stomatology, Jinan University, Guangzhou 510632, China"},{"name":"The First Affiliated Hospital of Jinan University, Guangzhou 510632, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiying","family":"Zhou","sequence":"additional","affiliation":[{"name":"School of Stomatology, Jinan University, Guangzhou 510632, China"},{"name":"The First Affiliated Hospital of Jinan University, Guangzhou 510632, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yadong","family":"Huang","sequence":"additional","affiliation":[{"name":"Institute of Biomedicine and Guangdong Provincial Key Laboratory of Bioengineering Medicine, Jinan University, Guangzhou 510632, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9790-5823","authenticated-orcid":false,"given":"Qi","family":"Xiang","sequence":"additional","affiliation":[{"name":"Institute of Biomedicine and Guangdong Provincial Key Laboratory of Bioengineering Medicine, Jinan University, Guangzhou 510632, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1210\/js.2019-00160","article-title":"Advanced glycation end products (ages), receptor for ages, diabetes, and bone: Review of the literature","volume":"3","author":"Asadipooya","year":"2019","journal-title":"J. Endocr. Soc."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Khalid, M., Petroianu, G., and Adem, A. (2022). Advanced glycation end products and diabetes mellitus: Mechanisms and perspectives. Biomolecules, 12.","DOI":"10.3390\/biom12040542"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/s41581-020-0278-5","article-title":"Genetics of diabetes mellitus and diabetes complications","volume":"16","author":"Cole","year":"2020","journal-title":"Nat. Rev. Nephrol."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Cano Sanchez, M., Lancel, S., Boulanger, E., and Neviere, R. (2018). Targeting oxidative stress and mitochondrial dysfunction in the treatment of impaired wound healing: A systematic review. Antioxidants, 7.","DOI":"10.3390\/antiox7080098"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1038\/sj.jid.5700613","article-title":"Formation and function of the myofibroblast during tissue repair","volume":"127","author":"Hinz","year":"2007","journal-title":"J. Investig. Dermatol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"5113","DOI":"10.1111\/jcmm.17535","article-title":"Novel prospects for scarless wound healing: The roles of myofibroblasts and adipocytes","volume":"26","author":"Teng","year":"2022","journal-title":"J. Cell. Mol. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1016\/j.ajpath.2022.08.003","article-title":"Transforming growth factor-\u03b2 receptor\u2013mediated, p38 mitogen-activated protein kinase\u2013dependent signaling drives enhanced myofibroblast differentiation during skin wound healing in mice lacking hyaluronan synthases 1 and 3","volume":"192","author":"Wang","year":"2022","journal-title":"Am. J. Pathol."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Jagadeeshaprasad, M.G., Govindappa, P.K., Nelson, A.M., Noble, M.D., and Elfar, J.C. (2023). 4-Aminopyridine induces nerve growth factor to improve skin wound healing and tissue regeneration. Biomedicines, 10.","DOI":"10.3390\/biomedicines10071649"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Schuster, R., Younesi, F., Ezzo, M., and Hinz, B. (2022). The Role of myofibroblasts in physiological and pathological tissue repair. Cold Spring Harb. Perspect. Biol., 15.","DOI":"10.1101\/cshperspect.a041231"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/j.1067-1927.2005.130102.x","article-title":"Perspective article: Tissue repair, contraction, and the myofibroblast","volume":"13","author":"Chaponnier","year":"2005","journal-title":"Wound Repair Regen."},{"key":"ref_11","first-page":"33","article-title":"Effects of streptozotocin-induced diabetes on proliferation and differentiation abilities of mesenchymal stem cells derived from subcutaneous and visceral adipose tissues","volume":"125","author":"Ghorbani","year":"2017","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2821","DOI":"10.1002\/jcp.25012","article-title":"Effect of diabetes mellitus on adipocyte-derived stem cells in rat","volume":"230","author":"Jumabay","year":"2015","journal-title":"J. Cell. Physiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1111\/j.1600-051X.2011.01716.x","article-title":"Isolation and characterization of human periodontal ligament (PDL) stem cells (PDLSCs) from the inflamed PDL tissue: In vitro and in vivo evaluations","volume":"38","author":"Park","year":"2011","journal-title":"J. Clin. Periodontol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"104280","DOI":"10.1016\/j.jprot.2021.104280","article-title":"Proteomic profile of human stem cells from dental pulp and periodontal ligament","volume":"245","author":"Lei","year":"2021","journal-title":"J. Proteom."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"103259","DOI":"10.1016\/j.jdent.2019.103259","article-title":"Stem cells in the periodontal ligament differentiated into osteogenic, fibrogenic and cementogenic lineages for the regeneration of the periodontal complex","volume":"92","author":"Liu","year":"2020","journal-title":"J. Dent."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Onizuka, S., and Iwata, T. (2019). Application of periodontal ligament-derived multipotent mesenchymal stromal cell sheets for periodontal regeneration. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20112796"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1111\/jre.12455","article-title":"Efficacy of stem cells on periodontal regeneration: Systematic review of pre-clinical studies","volume":"52","author":"Tassi","year":"2017","journal-title":"J. Periodontal Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1111\/j.1600-051X.2010.01597.x","article-title":"Validation of human periodontal ligament-derived cells as a reliable source for cytotherapeutic use","volume":"37","author":"Iwata","year":"2010","journal-title":"J. Clin. Periodontol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"9836518","DOI":"10.1155\/2020\/9836518","article-title":"Immunomodulatory properties of stem cells in periodontitis: Current status and future prospective","volume":"2020","author":"Wang","year":"2020","journal-title":"Stem Cells Int."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1089\/scd.2013.0490","article-title":"Periodontal-Ligament-Derived stem cells exhibit the capacity for long-term survival, self-renewal, and regeneration of multiple tissue types in vivo","volume":"23","author":"Menicanin","year":"2014","journal-title":"Stem Cells Dev."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"srep11660","DOI":"10.1038\/srep11660","article-title":"Investigation of multipotent postnatal stem cells from human maxillary sinus membrane","volume":"5","author":"Guo","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"503","DOI":"10.4103\/jisp.jisp_92_18","article-title":"Direct application of autologous periodontal ligament stem cell niche in treatment of periodontal osseous defects: A randomized controlled trial","volume":"22","author":"Vandana","year":"2018","journal-title":"J. Indian Soc. Periodontol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.reth.2018.07.002","article-title":"Periodontal regeneration with autologous periodontal ligament-derived cell sheets\u2014A safety and efficacy study in ten patients","volume":"9","author":"Iwata","year":"2018","journal-title":"Regen. Ther."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"20377","DOI":"10.1002\/jcp.28639","article-title":"Spontaneous differentiation of periodontal ligament stem cells into myofibroblast during ex vivo expansion","volume":"234","author":"Iwasaki","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"678322","DOI":"10.3389\/fphar.2021.678322","article-title":"Transforming growth factor-\u03b23\/recombinant human-like collagen\/chitosan freeze-dried sponge primed with human periodontal ligament stem cells promotes bone regeneration in calvarial defect rats","volume":"12","author":"Huang","year":"2021","journal-title":"Front. Pharmacol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.ajps.2022.03.003","article-title":"Sequentially releasing self-healing hydrogel fabricated with TGF\u03b23-microspheres and bFGF to facilitate rat alveolar bone defect repair","volume":"17","author":"Yu","year":"2022","journal-title":"Asian J. Pharm. Sci."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/j.1601-6343.2005.00331.x","article-title":"The efficacy of mesenchymal stem cells to regenerate and repair dental structures","volume":"8","author":"Shi","year":"2005","journal-title":"Orthod. Craniofacial Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/j.1601-0825.2009.01593.x","article-title":"Utility of PDL progenitors for in vivo tissue regeneration: A report of 3 cases","volume":"16","author":"Feng","year":"2010","journal-title":"Oral Dis."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.retram.2016.09.003","article-title":"The role of myofibroblasts in wound healing","volume":"64","author":"Hinz","year":"2016","journal-title":"Curr. Res. Transl. Med."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"6836","DOI":"10.1002\/jcp.30380","article-title":"Human antigen R promotes lung fibroblast differentiation to myofibroblasts and increases extracellular matrix production","volume":"236","author":"Aloufi","year":"2021","journal-title":"J. Cell. Physiol."},{"key":"ref_31","first-page":"101","article-title":"In vitro culturing of adult stem cells: The importance of serum and atmospheric oxygen","volume":"1376","year":"2022","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1902\/jop.2013.120541","article-title":"Optimal medium formulation for the long-term expansion and maintenance of human periodontal ligament stem cells","volume":"84","author":"Jung","year":"2013","journal-title":"J. Periodontol."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Dworza\u0144ski, J., Strycharz-Dudziak, M., Kliszczewska, E., Kie\u0142czykowska, M., Dworza\u0144ska, A., Drop, B., and Polz-Dacewicz, M. (2020). Glutathione peroxidase (GPx) and superoxide dismutase (SOD) activity in patients with diabetes mellitus type 2 infected with Epstein-Barr virus. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0230374"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1007\/s11033-018-4516-x","article-title":"Mesenchymal stem cell dysfunction in diabetes","volume":"46","author":"Fijany","year":"2019","journal-title":"Mol. Biol. Rep."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1186\/s13287-019-1362-2","article-title":"Applicability of adipose-derived mesenchymal stem cells in treatment of patients with type 2 diabetes","volume":"10","author":"Qi","year":"2019","journal-title":"Stem Cell Res. Ther."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"79","DOI":"10.3389\/fimmu.2019.00079","article-title":"Cell based therapy for type 1 diabetes: Should we take hyperglycemia into account?","volume":"10","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_37","first-page":"5440","article-title":"Berberine improves advanced glycation end products-induced osteogenic differentiation responses in human periodontal ligament stem cells through the canonical Wnt\/\u03b2-catenin pathway","volume":"19","author":"Zhang","year":"2019","journal-title":"Mol. Med. Rep."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1359537","DOI":"10.1155\/2023\/1359537","article-title":"Current therapeutic modalities for the management of chronic diabetic wounds of the foot","volume":"2023","author":"Oyebode","year":"2023","journal-title":"J. Diabetes Res."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.jtv.2021.09.004","article-title":"Icariin improves cutaneous wound healing in streptozotocin-induced diabetic rats","volume":"31","author":"Singh","year":"2021","journal-title":"J. Tissue Viability"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"918223","DOI":"10.3389\/fimmu.2022.918223","article-title":"Fibroblasts: Immunomodulatory factors in refractory diabetic wound healing","volume":"13","author":"Liu","year":"2022","journal-title":"Front. Immunol."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Santonocito, S., Ferlito, S., Polizzi, A., Ronsivalle, V., Sclafani, R., Valletta, A., Giudice, A.L., Cavalcanti, R., Spagnuolo, G., and Isola, G. (2022). Therapeutic and metagenomic potential of the biomolecular therapies against periodontitis and the oral microbiome: Current evidence and future perspectives. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232213708"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1111\/odi.12175","article-title":"Local application of periodontal ligament stromal cells promotes soft tissue regeneration","volume":"20","author":"Baik","year":"2014","journal-title":"Oral Dis."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1111\/odi.13325","article-title":"Diabetes alters the involvement of myofibroblasts during periodontal wound healing","volume":"26","author":"Retamal","year":"2020","journal-title":"Oral Dis."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/odi.12773","article-title":"Role of myofibroblasts in normal and pathological periodontal wound healing","volume":"24","author":"Smith","year":"2018","journal-title":"Oral Dis."}],"container-title":["Bioengineering"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2306-5354\/11\/6\/602\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:57:32Z","timestamp":1760108252000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2306-5354\/11\/6\/602"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,12]]},"references-count":44,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2024,6]]}},"alternative-id":["bioengineering11060602"],"URL":"https:\/\/doi.org\/10.3390\/bioengineering11060602","relation":{},"ISSN":["2306-5354"],"issn-type":[{"value":"2306-5354","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,12]]}}}