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Hospital","award":["2022FY066"],"award-info":[{"award-number":["2022FY066"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioengineering"],"abstract":"<jats:p>This study aimed to investigate the effect of the transverse sinus (TS) stenosis (TSS) position caused by arachnoid granulation on patients with venous pulsatile tinnitus (VPT) and to further identify the types of TSS that are of therapeutic significance for patients. Multiphysics interaction models of six patients with moderate TSS caused by arachnoid granulation and virtual stent placement in TSS were reconstructed, including three patients with TSS located in the middle segment of the TS (group 1) and three patients with TTS in the middle and proximal involvement segment of the TS (group 2). The transient multiphysics interaction simulation method was applied to elucidate the differences in biomechanical and acoustic parameters between the two groups. The results revealed that the blood flow pattern at the TS and sigmoid sinus junction was significantly changed depending on the stenosis position. Preoperative patients had increased blood flow in the TSS region and TSS downstream where the blood flow impacted the vessel wall. In group 1, the postoperative blood flow pattern, average wall pressure, vessel wall vibration, and sound pressure level of the three patients were comparable to the preoperative state. However, the postoperative blood flow velocity decreased in group 2. The postoperative average wall pressure, vessel wall vibration, and sound pressure level of the three patients were significantly improved compared with the preoperative state. Intravascular intervention therapy should be considered for patients with moderate TSS caused by arachnoid granulations in the middle and proximal involvement segment of the TS. TSS might not be considered the cause of VPT symptoms in patients with moderate TSS caused by arachnoid granulation in the middle segment of the TS.<\/jats:p>","DOI":"10.3390\/bioengineering11060612","type":"journal-article","created":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T08:48:31Z","timestamp":1718614111000},"page":"612","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Effect of Transverse Sinus Stenosis Caused by Arachnoid Granulation on Patients with Venous Pulsatile Tinnitus: A Multiphysics Interaction Simulation Investigation"],"prefix":"10.3390","volume":"11","author":[{"given":"Zhenxia","family":"Mu","sequence":"first","affiliation":[{"name":"Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengfei","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shifeng","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihui","family":"Zhuang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heyu","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, College of Chemistry and Life Science, Beijing University of Technology, Beijing 100124, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youjun","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, College of Chemistry and Life Science, Beijing University of Technology, Beijing 100124, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shusheng","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guopeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenchang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ximing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s11596-022-2691-4","article-title":"Analysis of Etiology, Diagnosis, and Treatment Strategy and Efficacy of Pulsatile Tinnitus Caused by Abnormal Vascular Anatomy","volume":"43","author":"Lv","year":"2023","journal-title":"Curr. Med. Sci."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"6286","DOI":"10.1007\/s00330-020-07630-x","article-title":"Computational fluid dynamics study of the effect of transverse sinus stenosis on the blood flow pattern in the ipsilateral superior curve of the sigmoid sinus","volume":"31","author":"Han","year":"2021","journal-title":"Eur. Radiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1016\/S0140-6736(13)60142-7","article-title":"Tinnitus","volume":"382","author":"Baguley","year":"2013","journal-title":"Lancet"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"E586","DOI":"10.1212\/WNL.0000000000005948","article-title":"Hemodynamic assessments of venous pulsatile tinnitus using 4D-flow MRI","volume":"91","author":"Li","year":"2018","journal-title":"Neurology"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.jbiomech.2016.12.012","article-title":"Sigmoid sinus cortical plate dehiscence induces pulsatile tinnitus through amplifying sigmoid sinus venous sound","volume":"52","author":"Tian","year":"2017","journal-title":"J. Biomech."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1002\/lary.28168","article-title":"Pattern and severity of transverse sinus stenosis in patients with pulsatile tinnitus associated with sigmoid sinus wall anomalies","volume":"130","author":"Hewes","year":"2020","journal-title":"Laryngoscope"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Mu, Z., Li, X., Zhao, D., Qiu, X., Dai, C., Meng, X., Huang, S., Gao, B., Lv, H., and Li, S. (2022). Hemodynamics study on the relationship between the sigmoid sinus wall dehiscence and the blood flow pattern of the transverse sinus and sigmoid sinus junction. J. Biomech., 135.","DOI":"10.1016\/j.jbiomech.2022.111022"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.wneu.2017.06.168","article-title":"Computational Fluid Dynamics Simulation of Hemodynamic Alterations in Sigmoid Sinus Diverticulum and Ipsilateral Upstream Sinus Stenosis After Stent Implantation in Patients with Pulsatile Tinnitus","volume":"106","author":"Han","year":"2017","journal-title":"World Neurosurg."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1007\/s00062-023-01268-0","article-title":"Blood Flow Velocity: A Decision Tool for Stenting Indication in Venous Pulsatile Tinnitus","volume":"33","author":"Checkouri","year":"2023","journal-title":"Clin. Neuroradiol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.crad.2021.02.022","article-title":"Relentless pulsatile tinnitus secondary to dural sinovenous stenosis: Is endovascular sinus stenting the answer?","volume":"76","author":"Farid","year":"2021","journal-title":"Clin. Radiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1136\/neurintsurg-2020-016636","article-title":"Torrents of torment: Turbulence as a mechanism of pulsatile tinnitus secondary to venous stenosis revealed by high-fidelity computational fluid dynamics","volume":"13","author":"Pereira","year":"2021","journal-title":"J. Neurointerventional Surg."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Mu, Z., Liu, L., Sun, Y., Gao, B., Lv, H., Zhao, P., Liu, Y., and Wang, Z. (2021). Multiphysics coupling numerical simulation of flow-diverting stents in the treatment of patients with pulsatile tinnitus. Int. J. Numer. Meth. Biomed., 37.","DOI":"10.1002\/cnm.3526"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1007\/s10439-005-4388-9","article-title":"Fluid-structure coupled CFD simulation of the left ventricular flow during filling phase","volume":"33","author":"Cheng","year":"2005","journal-title":"Ann. Biomed. Eng."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"13","DOI":"10.3233\/BME-201171","article-title":"Investigation of two-way fluid-structure interaction of blood flow in a patient-specific left coronary artery","volume":"33","author":"Athani","year":"2022","journal-title":"Bio-Med. Mater. Eng."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1007\/s10237-023-01737-y","article-title":"Hemodynamic study of blood flow in the aorta during the interventional robot treatment using fluid-structure interaction","volume":"22","author":"Zhu","year":"2023","journal-title":"Biomech. Model Mechanobiol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1080\/10255842.2019.1593386","article-title":"A study on relationship between pulsatile tinnitus and temporal bone pneumatization grade","volume":"22","author":"Tian","year":"2019","journal-title":"Comput. Methods Biomech. Biomed. Eng."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1016\/j.anl.2021.01.013","article-title":"Hydroacoustic analysis and extraluminal compression surgical insights of venous pulsatile tinnitus","volume":"48","author":"Hsieh","year":"2021","journal-title":"Auris Nasus Larynx"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Mu, Z., Zhuang, L., Zhao, P., Gao, B., Liu, Y., Wang, Z., Yang, S., and Wang, X. (2023). Multiphysics Interaction Analysis of the Therapeutic Effects of the Sigmoid Sinus Wall Reconstruction in Patients with Venous Pulsatile Tinnitus. Bioengineering, 10.","DOI":"10.3390\/bioengineering10060715"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s13367-011-0002-x","article-title":"Fluid-structure interaction analysis on the effects of vessel material properties on blood flow characteristics in stenosed arteries under axial rotation","volume":"23","author":"Cho","year":"2011","journal-title":"Korea-Aust. Rheol. J."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1002\/pamm.201310100","article-title":"Numerical Modeling of Fluid-Structure Interaction of Blood in a Vein by Simulating Conservation of Mass and Linear Momentum with the Finite Element Method in FEniCS","volume":"13","author":"Lofink","year":"2013","journal-title":"PAMM"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1002\/cnm.2647","article-title":"Biomechanical investigation of thoracolumbar spine in different postures during ejection using a combined finite element and multi-body approach","volume":"30","author":"Du","year":"2014","journal-title":"Int. J. Numer. Meth. Biomed."},{"key":"ref_22","first-page":"1091","article-title":"Measuring and modeling basic properties of the human middle ear and ear canal. Part III: Eardrum impedances, transfer functions and model calculations","volume":"84","author":"Hudde","year":"1998","journal-title":"Acta Acust. United Acust."},{"key":"ref_23","first-page":"894","article-title":"Measuring and Modeling Basic Properties of the Human Middle Ear and Ear Canal. Part II: Ear Canal, Middle Ear Cavities, Eardrum, and Ossicles","volume":"84","author":"Hudde","year":"1998","journal-title":"Acta Acust. United Acust."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"E7","DOI":"10.1097\/MAO.0000000000002452","article-title":"Sound Measurement in Patient-Specific 3D Printed Bench Models of Venous Pulsatile Tinnitus","volume":"41","author":"Valluru","year":"2020","journal-title":"Otol. Neurotol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.medengphy.2020.10.008","article-title":"Hemodynamic study of the therapeutic effects of the different degrees of sigmoid sinus diverticulum reconstruction on patients","volume":"86","author":"Huang","year":"2020","journal-title":"Med. Eng. Phys."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1215636","DOI":"10.3389\/fneur.2023.1215636","article-title":"Causes and outcomes of revision surgery in subjects with pulsatile tinnitus","volume":"14","author":"Shim","year":"2023","journal-title":"Front. Neurol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1177\/1591019920974185","article-title":"Venous sinus stenting for the treatment of isolated pulsatile tinnitus: Results of a prospective trial","volume":"27","author":"Patsalides","year":"2021","journal-title":"Interv. Neuroradiol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1097\/MAO.0000000000004075","article-title":"Resurfacing Dehiscence(s) Without Reducing Diverticulum Effectively Silences Pulsatile Tinnitus: Novel Surgical Techniques for Diverticulum and Intraoperative Microphone Monitoring","volume":"45","author":"Hsieh","year":"2023","journal-title":"Otol. Neurotol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1177\/15910199211062025","article-title":"Study on the correlation between hemodynamic status of the transverse sinus-sigmoid sinus and the clinical efficacy of sigmoid sinus wall reconstruction","volume":"28","author":"Li","year":"2021","journal-title":"Interv. Neuroradiol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"6059697","DOI":"10.1155\/2018\/6059697","article-title":"The Characteristic and Short-Term Prognosis of Tinnitus Associated with Sudden Sensorineural Hearing Loss","volume":"2018","author":"Ding","year":"2018","journal-title":"Neural Plast."}],"container-title":["Bioengineering"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2306-5354\/11\/6\/612\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:59:12Z","timestamp":1760108352000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2306-5354\/11\/6\/612"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,15]]},"references-count":30,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2024,6]]}},"alternative-id":["bioengineering11060612"],"URL":"https:\/\/doi.org\/10.3390\/bioengineering11060612","relation":{},"ISSN":["2306-5354"],"issn-type":[{"value":"2306-5354","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,15]]}}}