{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:03:56Z","timestamp":1787317436373,"version":"build-2736575974"},"reference-count":32,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T00:00:00Z","timestamp":1724803200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62331021"],"award-info":[{"award-number":["62331021"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["20YF1402400"],"award-info":[{"award-number":["20YF1402400"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shanghai Sailing Program","award":["62331021"],"award-info":[{"award-number":["62331021"]}]},{"name":"Shanghai Sailing Program","award":["20YF1402400"],"award-info":[{"award-number":["20YF1402400"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioengineering"],"abstract":"<jats:p>As medical imaging technologies advance, these tools are playing a more and more important role in assisting clinical disease diagnosis. The fusion of biomedical imaging and multi-modal information is profound, as it significantly enhances diagnostic precision and comprehensiveness. Integrating multi-organ imaging with genomic information can significantly enhance the accuracy of disease prediction because many diseases involve both environmental and genetic determinants. In the present study, we focused on the fusion of imaging-derived phenotypes (IDPs) and polygenic risk score (PRS) of diseases from different organs including the brain, heart, lung, liver, spleen, pancreas, and kidney for the prediction of the occurrence of nine common diseases, namely atrial fibrillation, heart failure (HF), hypertension, myocardial infarction, asthma, type 2 diabetes, chronic kidney disease, coronary artery disease (CAD), and chronic obstructive pulmonary disease, in the UK Biobank (UKBB) dataset. For each disease, three prediction models were developed utilizing imaging features, genomic data, and a fusion of both, respectively, and their performances were compared. The results indicated that for seven diseases, the model integrating both imaging and genomic data achieved superior predictive performance compared to models that used only imaging features or only genomic data. For instance, the Area Under Curve (AUC) of HF risk prediction was increased from 0.68 \u00b1 0.15 to 0.79 \u00b1 0.12, and the AUC of CAD diagnosis was increased from 0.76 \u00b1 0.05 to 0.81 \u00b1 0.06.<\/jats:p>","DOI":"10.3390\/bioengineering11090872","type":"journal-article","created":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T05:34:49Z","timestamp":1724823289000},"page":"872","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Integrating Multi-Organ Imaging-Derived Phenotypes and Genomic Information for Predicting the Occurrence of Common Diseases"],"prefix":"10.3390","volume":"11","author":[{"given":"Meng","family":"Liu","sequence":"first","affiliation":[{"name":"Human Phenome Institute, Fudan University, Shanghai 201203, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longyu","family":"Sun","sequence":"additional","affiliation":[{"name":"Human Phenome Institute, Fudan University, Shanghai 201203, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengting","family":"Sun","sequence":"additional","affiliation":[{"name":"Human Phenome Institute, Fudan University, Shanghai 201203, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xumei","family":"Hu","sequence":"additional","affiliation":[{"name":"Human Phenome Institute, Fudan University, Shanghai 201203, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Li","sequence":"additional","affiliation":[{"name":"Human Phenome Institute, Fudan University, Shanghai 201203, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyao","family":"Yu","sequence":"additional","affiliation":[{"name":"Human Phenome Institute, Fudan University, Shanghai 201203, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8890-4973","authenticated-orcid":false,"given":"Chengyan","family":"Wang","sequence":"additional","affiliation":[{"name":"Human Phenome Institute, Fudan University, Shanghai 201203, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinping","family":"Ren","sequence":"additional","affiliation":[{"name":"Ultrasound Department, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinlian","family":"Ma","sequence":"additional","affiliation":[{"name":"Radiology Department, Jiangyin Affiliated Hospital of Nanjing University of Chinese Medicine, 130 Renmin Middle Road, Jiangyin 214400, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Cui, C., Yang, H., Wang, Y., Zhao, S., Asad, Z., Coburn, L.A., Wilson, K.T., Landman, B.A., and Huo, Y. 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