{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T12:54:23Z","timestamp":1771505663006,"version":"3.50.1"},"reference-count":38,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T00:00:00Z","timestamp":1730851200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioengineering"],"abstract":"<jats:p>Osteoarthritis (OA) is one of the most common joint diseases worldwide, predominantly present in elderly people. Being a major source of pain for patients, it is debilitating and leads inevitably to a reduction in quality of life. The management of OA needs a personalized and multidimensional approach, resulting in the emergence of new regenerative and non-invasive methods, such as the use of micrografts. In this pilot study, Rigenera\u00ae Technology was employed to obtain micrografts of cartilage tissue to be injected into the knees of 10 patients with osteoarthritic pain. To assess the efficacy of the treatment concerning pain reduction at this site, patients were asked to complete KOOS and WOMAC questionnaire and a VAS test before and after the procedure. The results presented in this article show how Rigenera\u00ae treatment can potentially improve OA symptoms, alleviating pain in patients.<\/jats:p>","DOI":"10.3390\/bioengineering11111119","type":"journal-article","created":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T04:03:24Z","timestamp":1730865804000},"page":"1119","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Efficacy of Autologous Micrografting Technology in Managing Osteoarthritis Pain: A Pilot Study"],"prefix":"10.3390","volume":"11","author":[{"given":"Camilo Partezani","family":"Helito","sequence":"first","affiliation":[{"name":"Grupo de Joelho, Instituto de Ortopedia e Traumatologia, Hospital das Cl\u00ednicas HCFMUSP, Faculdade de Medicina, Universidade de S\u00e3o Paulo, S\u00e3o Paulo 05403-010, Brazil"},{"name":"Hospital S\u00edrio Liban\u00eas, S\u00e3o Paulo 01308-901, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1598-5268","authenticated-orcid":false,"given":"Valeria","family":"Pessei","sequence":"additional","affiliation":[{"name":"Department Chemistry, Biology, Biotechnology, University of Perugia, 06123 Perugia, Italy"},{"name":"SHRO Italia Foundation ETS, via Sestriere 17, 10060 Candiolo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecilia","family":"Zaniboni","sequence":"additional","affiliation":[{"name":"Department Chemistry, Biology, Biotechnology, University of Perugia, 06123 Perugia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilie","family":"Muntean","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3 Hospital Sant Joan de D\u00e9u de Martorell, 08760 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/s41392-023-01330-w","article-title":"Osteoarthritis: Pathogenic signaling pathways and therapeutic targets","volume":"8","author":"Yao","year":"2023","journal-title":"Signal Transduct. 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