{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:34:32Z","timestamp":1760146472791,"version":"build-2065373602"},"reference-count":29,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T00:00:00Z","timestamp":1730937600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Grant-in-Aid for Early Career Scientists","doi-asserted-by":"publisher","award":["18K17248","21K17177","JP20im0210221"],"award-info":[{"award-number":["18K17248","21K17177","JP20im0210221"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Science and Technology of Japan","doi-asserted-by":"publisher","award":["18K17248","21K17177","JP20im0210221"],"award-info":[{"award-number":["18K17248","21K17177","JP20im0210221"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioengineering"],"abstract":"<jats:p>To develop a safer bone-bonding device that promotes early osseointegration with cortical bone perforation, novel subperiosteal device geometries were proposed and evaluated for their ability to facilitate surrounding bone formation and enhance bone-bonding strength. This study used animal experiments and mechanical testing to assess the performance of these designs. The experimental device consisted of two main components: a rounded rectangular plate and a centrally positioned cylinder. To promote the recruitment of bone-marrow-derived factors, slits were incorporated into the cylinder, and a center hole was created directly above it. Four device variations, differing by the presence or absence of the slits and center hole, were fabricated and then subjected to tensile tests for mechanical property evaluation. In the animal experiments, the devices were bilaterally placed on rat tibiae, and after four weeks, bone-bonding strength tests were performed. Additionally, micro-computed tomography and histological analysis of undecalcified sections were conducted. All devices demonstrated early osseointegration, and geometric design differences, specifically the presence or absence of the slits and center hole, significantly affected the mechanical properties and bone induction. However, no significant differences in bone-bonding strength were detected. These findings suggest that the newly formed bone inside the slits and center hole contributes to the reinforcement of the device.<\/jats:p>","DOI":"10.3390\/bioengineering11111122","type":"journal-article","created":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T04:22:56Z","timestamp":1730953376000},"page":"1122","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Novel Subperiosteal Device Geometry and Investigation of Efficacy on Surrounding Bone Formation and Bone-Bonding Strength"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-3118-2018","authenticated-orcid":false,"given":"Yoshiya","family":"Kaisaka","sequence":"first","affiliation":[{"name":"Department of Maxillofacial Orthognathics, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, 1-5-45, Yushima, Bunkyo-ku, Tokyo 113-8549, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5801-2122","authenticated-orcid":false,"given":"Masayoshi","family":"Uezono","sequence":"additional","affiliation":[{"name":"Department of Maxillofacial Orthognathics, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, 1-5-45, Yushima, Bunkyo-ku, Tokyo 113-8549, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5674-9918","authenticated-orcid":false,"given":"Masaki","family":"Inoue","sequence":"additional","affiliation":[{"name":"Department of Maxillofacial Orthognathics, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, 1-5-45, Yushima, Bunkyo-ku, Tokyo 113-8549, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuo","family":"Takakuda","sequence":"additional","affiliation":[{"name":"Laboratory for Biomaterials and Bioengineering, Institute of Science Tokyo, 2-3-10 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-0062, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0580-4510","authenticated-orcid":false,"given":"Keiji","family":"Moriyama","sequence":"additional","affiliation":[{"name":"Department of Maxillofacial Orthognathics, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, 1-5-45, Yushima, Bunkyo-ku, Tokyo 113-8549, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1111\/jopr.12310","article-title":"Osseoperception in dental implants: A systematic review","volume":"25","author":"Mishra","year":"2016","journal-title":"J. Prosthodont."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.jormas.2019.01.011","article-title":"From rigid bone plate fixation to stable dynamic osteosynthesis in mandibular and craniomaxillo-facial surgery: Historical evolution of concepts and technical developments","volume":"120","author":"Bekara","year":"2019","journal-title":"J. Stomatol. Oral Maxillofac. Surg."},{"key":"ref_3","first-page":"e31476","article-title":"Modern anchorage systems in orthodontics","volume":"14","author":"Umalkar","year":"2022","journal-title":"Cureus"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1563\/AAID-JOI-D-11-00191","article-title":"Nerve damage assessment following implant placement in human cadaver jaws: An ex vivo comparative study","volume":"40","author":"Murat","year":"2014","journal-title":"J. Oral Implantol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1563\/aaid-joi-D-20-00148","article-title":"Radiographic and nasal endoscopic observation of accidentally perforated anterior nasal cavity with dental implants: Case reports with 5\u201323 years of follow-up","volume":"47","author":"Park","year":"2021","journal-title":"J. Oral Implantol."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Inchingolo, A.M., Malcangi, G., Costa, S., Fatone, M.C., Avantario, P., Campanelli, M., Piras, F., Patano, A., Ferrara, I., and Di Pede, C. (2023). Tooth complications after orthodontic miniscrews insertion. Int. J. Environ. Res. Public Health, 20.","DOI":"10.3390\/ijerph20021562"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0889-5406(95)70140-0","article-title":"A new device for absolute anchorage for orthodontics","volume":"107","author":"Block","year":"1995","journal-title":"Am. J. Orthod. Dentofac. Orthop."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"278.e1","DOI":"10.1016\/j.ajodo.2006.10.020","article-title":"Osseointegration and biomechanical properties of the onplant system","volume":"132","author":"Chen","year":"2007","journal-title":"Am. J. Orthod. Dentofac. Orthop."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"339.e19","DOI":"10.1016\/j.ajodo.2007.08.014","article-title":"Anchorage capacity of osseointegrated and conventional anchorage systems: A randomized controlled trial","volume":"133","author":"Feldmann","year":"2008","journal-title":"Am. J. Orthod. Dentofac. Orthop."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1002\/jbm.b.32913","article-title":"Hydroxyapatite\/collagen nanocomposite-coated titanium rod for achieving rapid osseointegration onto bone surface","volume":"101","author":"Uezono","year":"2013","journal-title":"J. Biomed. Mater. Res. B Appl. Biomater."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.biomaterials.2018.02.010","article-title":"A multifaceted coating on titanium dictates osteoimmunomodulation and osteo\/angio-genesis towards ameliorative osseointegration","volume":"162","author":"Bai","year":"2018","journal-title":"Biomaterials"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.actbio.2023.07.048","article-title":"Surface modification of titanium implants with Mg-containing coatings to promote osseointegration","volume":"169","author":"Wang","year":"2023","journal-title":"Acta Biomater."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1177\/0022034513518561","article-title":"Bone morphogenetic proteins: Facts, challenges, and future perspectives","volume":"93","author":"Carreira","year":"2014","journal-title":"J. Dent. Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.actbio.2019.07.009","article-title":"Biomodulation of an implant for enhanced bone-implant anchorage","volume":"96","author":"Raina","year":"2019","journal-title":"Acta Biomater."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Zhu, L., Liu, Y., Wang, A., Zhu, Z., Li, Y., Zhu, C., Che, Z., Liu, T., Liu, H., and Huang, L. (2022). Application of BMP in bone tissue engineering. Front. Bioeng. Biotechnol., 10.","DOI":"10.3389\/fbioe.2022.810880"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1111\/j.1600-0501.2008.01630.x","article-title":"Effects of simvastatin on bone healing around titanium implants in osteoporotic rats","volume":"20","author":"Du","year":"2009","journal-title":"Clin. Oral Implants Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1111\/joor.12438","article-title":"The influence of statins on osseointegration: A systematic review of animal model studies","volume":"43","author":"Sendyk","year":"2016","journal-title":"J. Oral Rehabil."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"110888","DOI":"10.1016\/j.injury.2023.110888","article-title":"The effect of drugs on implant osseointegration- A narrative review","volume":"54","author":"Zidrou","year":"2023","journal-title":"Injury"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"241","DOI":"10.22203\/eCM.v032a16","article-title":"Optimisation of BMP-2 dosage for the osseointegration of porous titanium implants in an ovine model","volume":"32","author":"Hunziker","year":"2016","journal-title":"Eur. Cell. Mater."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Wychowa\u0144ski, P., Starzy\u0144ska, A., Adamska, P., S\u0142upecka-Ziemilska, M., Sobocki, B.K., Chmielewska, A., Wysocki, B., Alterio, D., Marvaso, G., and Jereczek-Fossa, B.A. (2021). Methods of topical administration of drugs and biological active substances for dental implants-A narrative review. Antibiotics, 10.","DOI":"10.3390\/antibiotics10080919"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.ijom.2016.10.017","article-title":"The influence of cortical bone perforation on guided bone regeneration in humans","volume":"46","author":"Tarnow","year":"2017","journal-title":"Int. J. Oral Maxillofac. Surg."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3109\/17453678008990763","article-title":"In vivo studies of bone grafts. The possibility of vascular anastomoses in healing bone","volume":"51","author":"Albrektsson","year":"1980","journal-title":"Acta Orthop. Scand."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Kim, D.G., Kim, K.H., Jo, Y., Lee, J.Y., Park, Y.J., Chung, C.P., Seol, Y.J., and Han, J.S. (2020). Bone regeneration into side openings and hollow inner channel of a dental implant. J. Mech. Behav. Biomed. Mater., 101.","DOI":"10.1016\/j.jmbbm.2019.103416"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Mathey, E., Pelletier, M.H., Walsh, W.R., Gall, K., and Carpenter, D. (2024). Implant Strength Contributes to the Osseointegration Strength of Porous Metallic Materials. J. Biomech. Eng., 146.","DOI":"10.1115\/1.4065405"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/j.ortho.2019.08.013","article-title":"Distribution and amount of stresses caused by insertion or removal of orthodontic miniscrews into the maxillary bone: A finite element analysis","volume":"17","author":"Ghorbanyjavadpour","year":"2019","journal-title":"Int. Orthod."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1080\/10255842.2021.2012765","article-title":"Bone stress and damage distributions during dental implant insertion: A novel dynamic FEM analysis","volume":"25","author":"Demirbas","year":"2022","journal-title":"Comput. Methods Biomech. Biomed. Eng."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1097\/ID.0b013e31820fb7d4","article-title":"Horizontal pull-out strength of orthodontic infrazygomatic mini-implant: An in vitro study","volume":"20","author":"Chen","year":"2011","journal-title":"Implant Den."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1146\/annurev.cellbio.16.1.191","article-title":"Bone development","volume":"16","author":"Olsen","year":"2000","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1111\/joa.13858","article-title":"Identification of distinct subpopulations of Gli1-lineage cells in the mouse mandible","volume":"243","author":"Zhang","year":"2023","journal-title":"J. Anat."}],"container-title":["Bioengineering"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2306-5354\/11\/11\/1122\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:27:38Z","timestamp":1760113658000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2306-5354\/11\/11\/1122"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,7]]},"references-count":29,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2024,11]]}},"alternative-id":["bioengineering11111122"],"URL":"https:\/\/doi.org\/10.3390\/bioengineering11111122","relation":{},"ISSN":["2306-5354"],"issn-type":[{"type":"electronic","value":"2306-5354"}],"subject":[],"published":{"date-parts":[[2024,11,7]]}}}