{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T17:14:49Z","timestamp":1760116489912,"version":"build-2065373602"},"reference-count":24,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T00:00:00Z","timestamp":1731024000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"An ecosystem for digital twins in healthcare (EDITH)","award":["101083771","713673","823712","101092749","190134524"],"award-info":[{"award-number":["101083771","713673","823712","101092749","190134524"]}]},{"name":"European Union\u2019s Horizon 2020 research and innovation program","award":["101083771","713673","823712","101092749","190134524"],"award-info":[{"award-number":["101083771","713673","823712","101092749","190134524"]}]},{"name":"CompBioMed2","award":["101083771","713673","823712","101092749","190134524"],"award-info":[{"award-number":["101083771","713673","823712","101092749","190134524"]}]},{"name":"CREXDATA","award":["101083771","713673","823712","101092749","190134524"],"award-info":[{"award-number":["101083771","713673","823712","101092749","190134524"]}]},{"name":"ELVIS\u2014ELEM Virtual Heart Populations for Supercomputers","award":["101083771","713673","823712","101092749","190134524"],"award-info":[{"award-number":["101083771","713673","823712","101092749","190134524"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioengineering"],"abstract":"<jats:p>Silent Brain Infarction (SBI) is increasingly recognized in patients with cardiac conditions, particularly Atrial Fibrillation (AF) in elderly patients and those undergoing Transcatheter Aortic Valve Implantation (TAVI). While these infarcts often go unnoticed due to a lack of acute symptoms, they are associated with a threefold increase in stroke risk and are considered a precursor to ischemic stroke. Moreover, accumulating evidence suggests that SBI may contribute to the development of dementia, depression, and cognitive decline, particularly in the elderly population. The burden of SBI is substantial, with studies showing that up to 11 million Americans may experience a silent stroke annually. In AF patients, silent brain infarcts are common and can lead to progressive brain damage, even in those receiving anticoagulation therapy. The use of cerebral embolic protection devices (CEPDs) during TAVI has been explored to mitigate the risk of stroke; however, their efficacy remains under debate. Despite advancements in TAVI technology, cerebrovascular events, including silent brain lesions, continue to pose significant challenges, underscoring the need for improved preventive strategies and therapeutic approaches. We propose a device consisting of a strut structure placed at the base of the treated artery to model the potential risk of cerebral embolisms caused by atrial fibrillation, thromboembolism, or dislodged debris of varying potential TAVI patients. The study has been carried out in two stages. Both are based on computational fluid dynamics (CFD) coupled with the Lagrangian particle tracking method. The first stage of the work evaluates a variety of strut thicknesses and inter-strut spacings, contrasting with the device-free baseline geometry. The analysis is carried out by imposing flow rate waveforms characteristic of healthy and AF patients. Boundary conditions are calibrated to reproduce physiological flow rates and pressures in a patient\u2019s aortic arch. In the second stage, the optimal geometric design from the first stage was employed, with the addition of lateral struts to prevent the filtration of particles and electronegatively charged strut surfaces, studying the effect of electrical forces on the clots if they are considered charged. Flowrate boundary conditions were used to emulate both healthy and AF conditions. Results from numerical simulations coming from the first stage indicate that the device blocks particles of sizes larger than the inter-strut spacing. It was found that lateral strut space had the highest impact on efficacy. Based on the results of the second stage, deploying the electronegatively charged device in all three aortic arch arteries, the number of particles entering these arteries was reduced on average by 62.6% and 51.2%, for the healthy and diseased models respectively, matching or surpassing current oral anticoagulant efficacy. In conclusion, the device demonstrated a two-fold mechanism for filtering emboli: (1) while the smallest particles are deflected by electrostatic repulsion, avoiding micro embolisms, which could lead to cognitive impairment, the largest ones are mechanically filtered since they cannot fit in between the struts, effectively blocking the full range of particle sizes analyzed in this study. The device presented in this manuscript offers an anticoagulant-free method to prevent stroke and SBIs, imperative given the growing population of AF and elderly patients.<\/jats:p>","DOI":"10.3390\/bioengineering11111127","type":"journal-article","created":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T04:02:54Z","timestamp":1731038574000},"page":"1127","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Performance Assessment of an Electrostatic Filter-Diverter Stent Cerebrovascular Protection Device: Evaluation of a Range of Potential Electrostatic Fields Focusing on Small Particles"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3302-6667","authenticated-orcid":false,"given":"Beatriz","family":"Eguzkitza","sequence":"first","affiliation":[{"name":"Barcelona Supercomputing Center, Computer Applications in Science and Engineering, 08034 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 A.","family":"Navia","sequence":"additional","affiliation":[{"name":"Cardiac Surgery Service Department, University Hospital, Austral University, Pilar B1630FHB, Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2592-1426","authenticated-orcid":false,"given":"Guillaume","family":"Houzeaux","sequence":"additional","affiliation":[{"name":"Barcelona Supercomputing Center, Computer Applications in Science and Engineering, 08034 Barcelona, Spain"},{"name":"ELEM Biotech SL, 08003 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Constantine","family":"Butakoff","sequence":"additional","affiliation":[{"name":"ELEM Biotech SL, 08003 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariano","family":"V\u00e1zquez","sequence":"additional","affiliation":[{"name":"Barcelona Supercomputing Center, Computer Applications in Science and Engineering, 08034 Barcelona, Spain"},{"name":"ELEM Biotech SL, 08003 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1038\/nrcardio.2013.162","article-title":"Silent cerebral infarcts associated with cardiac disease and procedures","volume":"10","author":"Hassel","year":"2013","journal-title":"Nat. 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