{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T02:18:35Z","timestamp":1790993915666,"version":"4.1.0"},"reference-count":50,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T00:00:00Z","timestamp":1731456000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioengineering"],"abstract":"<jats:p>Upper Crossed Syndrome (UCS), described by Vladimir Janda, is characterized by postural changes involving the cervical spine and trunk, leading to biomechanical limitations and cervicoscapulobrachial pain. This study proposes a mesotherapy protocol, termed the 8:1 block, to address cervicoscapulobrachialgia by targeting the scapulae and associated musculature. The scapula, central to shoulder girdle kinematics, often exhibits dyskinesis and muscular imbalances, notably the pattern referred to as scapular upper trapping (SUT). SUT involves scapular elevation, medial rotation, and shoulder protraction, contributing to cervicobrachial pain. The protocol includes a comprehensive assessment of muscle tone changes and biomechanical considerations, highlighting the importance of the scapula in upper limb movement and posture. Key anatomical changes involve tightened upper trapezius, levator scapulae, and pectoralis minor muscles, with weakened middle trapezius and serratus anterior. The mesotherapy approach targets these imbalances through specific injection points to alleviate muscle tension and correct postural deviations. Case studies from our clinic demonstrate the protocol\u2019s effectiveness in reducing pain and restoring scapular biomechanics. Patients reported significant improvements in pain relief and functional outcomes, underscoring the clinical utility of the 8:1 block in treating cervicoscapulobrachialgia. This protocol offers a feasible, cost-effective intervention that enhances the efficacy of traditional therapeutic exercises by addressing underlying muscular and biomechanical dysfunctions. In conclusion, the 8:1 block mesotherapy protocol provides a novel approach to managing cervicoscapulobrachial pain by focusing on scapular biomechanics and muscle tension. Further studies are needed to validate these findings and refine the protocol for broader clinical application.<\/jats:p>","DOI":"10.3390\/bioengineering11111142","type":"journal-article","created":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T08:09:28Z","timestamp":1731485368000},"page":"1142","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Upper Crossed Syndrome and Scapulae Upper-Trapping: A Mesotherapy Protocol in Cervicoscapulobrachial Pain\u2014The 8:1 Block"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-0725-7940","authenticated-orcid":false,"given":"Luyddy","family":"Pires","sequence":"first","affiliation":[{"name":"Orthopedics, Brazilian Institute of Regenerative Medicine (BIRM), Indaiatuba 13334-170, SP, Brazil"},{"name":"Regenerative Medicine, Orthoregen International Course, Indaiatuba 13334-170, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-8938-5498","authenticated-orcid":false,"given":"Napoliane","family":"Santos","sequence":"additional","affiliation":[{"name":"Orthopedics, Brazilian Institute of Regenerative Medicine (BIRM), Indaiatuba 13334-170, SP, Brazil"},{"name":"Regenerative Medicine, Orthoregen International Course, Indaiatuba 13334-170, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Vitor","family":"Lana","sequence":"additional","affiliation":[{"name":"Medical School, Max Planck University Center (UniMAX), Indaiatuba 13343-060, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4394-1209","authenticated-orcid":false,"given":"Alex Pontes","family":"de Macedo","sequence":"additional","affiliation":[{"name":"Orthopedics, Brazilian Institute of Regenerative Medicine (BIRM), Indaiatuba 13334-170, SP, 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(1997). Janda Compendium, O.P.T.P."},{"key":"ref_2","first-page":"576","article-title":"The Pose of the Body as Related to the Type of the Cranium and the Direction of the Visual Plane","volume":"40","author":"Stevens","year":"1901","journal-title":"Buffalo Med. J."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.2307\/4578305","article-title":"A resume, with comments, of the available literature relating to posture","volume":"42","author":"Schwartz","year":"1927","journal-title":"Public Health Rep."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.jmpt.2018.02.002","article-title":"Effectiveness of Therapeutic Exercise on Forward Head Posture: A Systematic Review and Meta-analysis","volume":"41","author":"Sheikhhoseini","year":"2018","journal-title":"J. Manip. Physiol. Ther."},{"key":"ref_5","unstructured":"Iannotti, J.P., and Parker, R.D. (2013). The Netter Collection of Medical Illustrations (Frank H. Netter, MD). Musculoskeletal System, Part 1: Upper Limb, Elsevier. [2nd ed.]."},{"key":"ref_6","unstructured":"Neumann, D.A. (2011). Cinesiologia do Aparelho Musculoesquel\u00e9tico: Fundamentos Para Reabilita\u00e7\u00e3o, Elsevier. [3rd ed.]."},{"key":"ref_7","unstructured":"Levangie, P.K., Norkin, C.C., and Lewek, M.D. (2019). Joint Structure & Function: A Comprehensive Analysis, McGraw Hill. [6th ed.]."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Headache Classification Committee of the International Headache Society (IHS) (2013). The International Classification of Headache Disorders, 3rd edition (beta version). Cephalalgia, 33, 629\u2013808.","DOI":"10.1177\/0333102413485658"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1007\/s00586-004-0864-4","article-title":"The prevalence of neck pain in the world population: A systematic critical review of the literature","volume":"15","author":"Fejer","year":"2006","journal-title":"Eur. Spine J."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Kazeminasab, S., Nejadghaderi, S.A., Amiri, P., Pourfathi, H., Araj-Khodaei, M., Sullman MJ, M., Kolahi, A.A., and Safiri, S. (2022). Neck pain: Global epidemiology, trends and risk factors. BMC Musculoskelet. Disord., 23.","DOI":"10.1186\/s12891-021-04957-4"},{"key":"ref_11","first-page":"YC14","article-title":"Cervicobrachial pain\u2014How Often is it Neurogenic?","volume":"10","author":"Gangavelli","year":"2016","journal-title":"J. Clin. Diagn. Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1007\/s00264-010-1203-5","article-title":"Degenerative cervical spondylolisthesis: A systematic review","volume":"35","author":"Jiang","year":"2011","journal-title":"Int. Orthop. (SICOT)"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"447","DOI":"10.5606\/tftrd.2023.12037","article-title":"Pectoralis minor syndrome","volume":"68","year":"2022","journal-title":"Turk. J. Phys. Med. Rehabil."},{"key":"ref_14","first-page":"469","article-title":"Pectoralis minor syndrome\u2014Review of pathoanatomy, diagnosis, and management of the primary cause of neurogenic thoracic outlet syndrome","volume":"2","author":"Ahmed","year":"2022","journal-title":"JSES Rev. Rep. Tech."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1097\/01.CSMR.0000306421.85919.9c","article-title":"Common tendinopathies in the upper and lower extremities","volume":"5","author":"Scott","year":"2006","journal-title":"Curr. Sports Med. Rep."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"101629","DOI":"10.1016\/j.disamonth.2023.101629","article-title":"Prevalence, diagnosis and management of musculoskeletal disorders in elite athletes: A mini-review","volume":"70","year":"2024","journal-title":"Dis.-A-Mon."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Vila, H., Barreiro, A., Ay\u00e1n, C., Ant\u00fanez, A., and Ferragut, C. (2022). The Most Common Handball Injuries: A Systematic Review. Int. J. Environ. Res. Public Health, 19.","DOI":"10.3390\/ijerph191710688"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s12178-023-09826-2","article-title":"Epidemiology of Common Injuries in the Volleyball Athlete","volume":"16","author":"Young","year":"2023","journal-title":"Curr. Rev. Musculoskelet. Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1136\/bjsports-2022-105674","article-title":"Diagnosis, prevention and treatment of common shoulder injuries in sport: Grading the evidence\u2014A statement paper commissioned by the Danish Society of Sports Physical Therapy (DSSF)","volume":"57","author":"Liaghat","year":"2023","journal-title":"Br. J. Sports Med."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1249\/JSR.0000000000001075","article-title":"Etiology and Prevention of Common Injuries in Golf","volume":"22","author":"Hasley","year":"2023","journal-title":"Curr. Sports Med. Rep."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1177\/15563316231172107","article-title":"Management of Common Football-Related Injuries About the Shoulder","volume":"19","author":"Apostolakos","year":"2023","journal-title":"HSS J."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1249\/JSR.0000000000001036","article-title":"A Guide to Indoor Rock Climbing Injuries","volume":"22","author":"Leung","year":"2023","journal-title":"Curr. Sports Med. Rep."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1001\/jama.1952.03680010031007","article-title":"Diagnosis and Treatment of Scapulocostal Syndrome","volume":"150","author":"Russek","year":"1952","journal-title":"JAMA J. Am. Med. Assoc."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1093\/ptj\/pzz165","article-title":"The Coupled Kinematics of Scapulothoracic Upward Rotation","volume":"100","author":"Lawrence","year":"2020","journal-title":"Phys. Ther."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.ptsp.2022.10.005","article-title":"Accuracy of infrared thermography in detecting tendinopathy: A systematic review with meta-analysis","volume":"58","author":"Kamonseki","year":"2022","journal-title":"Phys. Ther. Sport"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1080\/10833196.2016.1223575","article-title":"The use of medical infrared thermography in the detection of tendinopathy: A systematic review","volume":"21","author":"Chaudhry","year":"2016","journal-title":"Phys. Ther. Rev."},{"key":"ref_27","first-page":"392","article-title":"Descri\u00e7\u00e3o do m\u00e9todo de avalia\u00e7\u00e3o postural de Portland State University","volume":"6","year":"2005","journal-title":"Fisioter. Bras."},{"key":"ref_28","first-page":"139","article-title":"Os Principais Softwares Utilizados na Biofotogrametria Computadorizada para Avalia\u00e7\u00e3o Postural: Uma Revis\u00e3o Sistem\u00e1tica","volume":"4","author":"Santos","year":"2018","journal-title":"Movimenta"},{"key":"ref_29","first-page":"299","article-title":"Biofotogrametria confiabilidade das medidas do protocolo do software para avalia\u00e7\u00e3o postural (SAPO)","volume":"13","author":"Souza","year":"2011","journal-title":"Rev. Bras. Cineantropometria Desempenho Hum."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1080\/09593985.2017.1318419","article-title":"Intra-rater and inter-rater reliability of the standardized ultrasound protocol for assessing subacromial structures","volume":"33","author":"Ellegaard","year":"2017","journal-title":"Physiother. Theory Pract."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1136\/rapm-2022-103682","article-title":"Sonoanatomy and an ultrasound scanning protocol of the intramuscular innervation pattern of the infraspinatus muscle","volume":"48","author":"Lee","year":"2023","journal-title":"Reg. Anesth. Pain Med."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1002\/mus.27638","article-title":"Quantitative muscle analysis in facioscapulohumeral muscular dystrophy using whole-body fat-referenced MRI: Protocol development, multicenter feasibility, and repeatability","volume":"66","author":"Widholm","year":"2022","journal-title":"Muscle Nerve"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1080\/00913847.1989.11709889","article-title":"Levator Scapulae Syndrome","volume":"17","author":"Estwanik","year":"1989","journal-title":"Physician Sportsmed."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0004-9514(14)60646-2","article-title":"Levator scapulae action during shoulder movement: A possible mechanism for shoulder pain of cervical origin","volume":"32","author":"Behrsin","year":"1986","journal-title":"Aust. J. Physiother."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.jelekin.2016.10.008","article-title":"Are chronic neck pain, scapular dyskinesis and altered scapulothoracic muscle activity interrelated?: A case-control study with surface and fine-wire EMG","volume":"31","author":"Castelein","year":"2016","journal-title":"J. Electromyogr. Kinesiol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1179\/jmt.1994.2.2.43","article-title":"The Levator Scapulae: Making the Con\u2014NECK\u2014Tion","volume":"2","author":"Kuzmich","year":"1994","journal-title":"J. Man. Manip. Ther."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"243","DOI":"10.36076\/ppj.2002\/5\/243","article-title":"Prevalence of cervical facet joint pain in chronic neck pain","volume":"5","author":"Manchikanti","year":"2002","journal-title":"Pain Physician"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.mayocp.2014.09.008","article-title":"Epidemiology, diagnosis, and treatment of neck pain","volume":"90","author":"Cohen","year":"2015","journal-title":"Mayo Clin. Proc."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"323","DOI":"10.36076\/ppj.2009\/12\/323","article-title":"Systematic review of diagnostic utility and therapeutic effectiveness of cervical facet joint interventions","volume":"12","author":"Falco","year":"2009","journal-title":"Pain Physician"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1053\/j.trap.2016.10.002","article-title":"Cervical spine pain related to the facet joints","volume":"19","author":"Candido","year":"2015","journal-title":"Tech. Reg. Anesth. Pain Manag."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1053\/j.sult.2005.02.006","article-title":"Facet, nerve root, and epidural block","volume":"26","author":"Hodge","year":"2005","journal-title":"Semin. Ultrasound CT MRI"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"298","DOI":"10.26574\/maedica.2020.15.3.298","article-title":"Anatomical Variations of the Suprascapular Notch and its Importance in Suprascapular Entrapment Neuropathy","volume":"15","author":"Bagoji","year":"2020","journal-title":"Maedica"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"25554","DOI":"10.52965\/001c.25554","article-title":"Treatment of suprascapular nerve entrapment syndrome","volume":"13","author":"Leider","year":"2021","journal-title":"Orthop. Rev."},{"key":"ref_44","unstructured":"Bishop, K.N., and Varacallo, M. (2023). Anatomy, Shoulder and Upper Limb, Dorsal Scapular Nerve. StatPearls, StatPearls Publishing."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s12565-019-00495-1","article-title":"Anatomical entrapment of the dorsal scapular and long thoracic nerves, secondary to brachial plexus piercing variation","volume":"95","author":"Williams","year":"2020","journal-title":"Anat. Sci. Int."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"3542848","DOI":"10.1155\/2020\/3542848","article-title":"Mesotherapy: From Historical Notes to Scientific Evidence and Future Prospects","volume":"2020","author":"Mammucari","year":"2020","journal-title":"Sci. World J."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1590\/S0365-05962011000100013","article-title":"Mesoterapia: Uma revis\u00e3o bibliogr\u00e1fica","volume":"86","author":"Herreros","year":"2011","journal-title":"An. Bras. Dermatol."},{"key":"ref_48","first-page":"336","article-title":"The role of mesotherapy in the management of spinal pain. A randomized controlled study","volume":"174","author":"Brauneis","year":"2023","journal-title":"La Clin. Ter."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"436959","DOI":"10.1155\/2012\/436959","article-title":"Role of Mesotherapy in Musculoskeletal Pain: Opinions from the Italian Society of Mesotherapy","volume":"2012","author":"Mammucari","year":"2012","journal-title":"Evid.-Based Complement. Altern. Med."},{"key":"ref_50","first-page":"611","article-title":"Best practices for extracorporeal shockwave therapy in musculoskeletal medicine: Clinical application and training consideration","volume":"14","author":"Tenforde","year":"2022","journal-title":"PM R J. Inj. Funct. Rehabil."}],"container-title":["Bioengineering"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2306-5354\/11\/11\/1142\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:31:31Z","timestamp":1760113891000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2306-5354\/11\/11\/1142"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,13]]},"references-count":50,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2024,11]]}},"alternative-id":["bioengineering11111142"],"URL":"https:\/\/doi.org\/10.3390\/bioengineering11111142","relation":{},"ISSN":["2306-5354"],"issn-type":[{"value":"2306-5354","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,13]]}}}