{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T15:34:26Z","timestamp":1791819266593,"version":"4.3.4"},"reference-count":20,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T00:00:00Z","timestamp":1732752000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioengineering"],"abstract":"<jats:p>Dental implants are essential for the prosthetic rehabilitation of edentulous patients, requiring adequate bone volume and density for osseointegration and load support. The posterior region of the maxilla, commonly deficient in bone quality and quantity, represents a clinical challenge. This case series reports an analysis involving 69 dental implants in the atrophic maxilla of nine patients. The procedures adopted combined alloplastic hydroxyapatite grafting and leukocyte platelet-rich fibrin (L-PRF) applied to the alveolar ridge and maxillary sinus lift. With an average follow up of three years after the installation of the prostheses, an implant success rate of 98.5% was observed, showing integration and functional stability. The strategy of combining hydroxyapatite with L-PRF proved to be effective in increasing bone volume and promoting osseointegration. These findings indicate that the technique and biomaterials are viable for rehabilitating atrophic maxillae in the posterior region, offering long-lasting clinical results and a high success rate.<\/jats:p>","DOI":"10.3390\/bioengineering11121207","type":"journal-article","created":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T09:21:23Z","timestamp":1732785683000},"page":"1207","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Long-Term Success of Dental Implants in Atrophic Maxillae: A 3-Year Case Series Using Hydroxyapatite and L-PRF"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7024-915X","authenticated-orcid":false,"given":"Marco Andre Lomba","family":"Alves","sequence":"first","affiliation":[{"name":"Post-Graduation Program in Dentistry, Fluminense Federal University, Niteroi 24220-140, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakson","family":"Both","sequence":"additional","affiliation":[{"name":"Independent Researcher, Dois Vizinhos 85660-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5775-0222","authenticated-orcid":false,"given":"Carlos Fernando","family":"Mour\u00e3o","sequence":"additional","affiliation":[{"name":"Department of Periodontology, School of Dental Medicine Tufts University, Boston, MA 02111, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruna","family":"Ghiraldini","sequence":"additional","affiliation":[{"name":"Dental Research Division, Dentistry School, Universidade Paulista, S\u00e3o Paulo 04710-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Bezerra","sequence":"additional","affiliation":[{"name":"Oral Surgery and Periodontology Department, S\u00e3o Paulo University, Ribeir\u00e3o Preto 14040-904, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8027-8293","authenticated-orcid":false,"given":"Jose Mauro","family":"Granjeiro","sequence":"additional","affiliation":[{"name":"Clinical Research Laboratory, Dentistry School, Universidade Federal Fluminense, Niteroi 24220-140, Brazil"},{"name":"National Institute of Metrology, Quality and Technology (INMETRO), Duque de Caxias 25250-020, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8414-3775","authenticated-orcid":false,"given":"Suelen Cristina","family":"Sartoretto","sequence":"additional","affiliation":[{"name":"Clinical Research Laboratory, Dentistry School, Universidade Federal Fluminense, Niteroi 24220-140, Brazil"},{"name":"Oral Surgery Department, Fluminense Federal University, Niteroi 24220-140, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5759-7926","authenticated-orcid":false,"given":"Monica Diuana","family":"Calasans-Maia","sequence":"additional","affiliation":[{"name":"Clinical Research Laboratory, Dentistry School, Universidade Federal Fluminense, Niteroi 24220-140, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,28]]},"reference":[{"key":"ref_1","first-page":"129","article-title":"Cosci versus Summers technique for crestal sinus lift: 3-year results from a randomised controlled trial","volume":"7","author":"Esposito","year":"2014","journal-title":"Eur. J. Oral Implantol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"101731","DOI":"10.1016\/j.jebdp.2022.101731","article-title":"Effect of autogenous bone graft site on dental implant survival and donor site complications: A systematic review and meta-analysis","volume":"22","author":"McKenna","year":"2022","journal-title":"J. Evid.-Based Dent. Pract."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"166","DOI":"10.2340\/aos.v83.40255","article-title":"Comparison of the clinical efficacy of bone grafting and bone grafting combined with guided tissue regeneration in periodontal regenerative therapy: A meta-analysis","volume":"83","author":"Zhang","year":"2024","journal-title":"Acta Odontol. Scand."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"888","DOI":"10.11607\/jomi.6288","article-title":"Bone Volume Dynamics and Implant Placement Torque in Horizontal Bone Defects Reconstructed with Autologous or Xenogeneic Block Bone: A Randomized, Controlled, Split-Mouth, Prospective Clinical Trial","volume":"33","author":"Lima","year":"2018","journal-title":"Int. J. Oral Maxillofac. Implant."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1111\/jop.12998","article-title":"Immunological response of allogeneic bone grafting: A systematic review of prospective studies","volume":"49","author":"Moraschini","year":"2020","journal-title":"J. Oral Pathol. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s10006-019-00777-y","article-title":"Horizontal ridge augmentation using xenogenous bone graft-systematic review","volume":"23","author":"Carvalho","year":"2019","journal-title":"Oral Maxillofac. Surg."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Zhao, R., Yang, R., Cooper, P.R., Khurshid, Z., Shavandi, A., and Ratnayake, J. (2021). Bone Grafts and Substitutes in Dentistry: A Review of Current Trends and Developments. Molecules, 26.","DOI":"10.3390\/molecules26103007"},{"key":"ref_8","first-page":"3613","article-title":"Hydroxyapatite\u2014Past, Present, and Future in Bone Regeneration","volume":"7","author":"Kattimani","year":"2016","journal-title":"Bone Tissue Regen. Insights"},{"key":"ref_9","unstructured":"Garside, M. (2018). Biomaterials for Bone Regeneration: The Role of Hydroxyapatite in Supporting Bone Healing. Front. Bioeng. Biotechnol., 6."},{"key":"ref_10","first-page":"e1","article-title":"The importance of the leukocyte concentration in the leukocyte and platelet-rich fibrin (L-PRF) preparation","volume":"111","year":"2010","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol."},{"key":"ref_11","first-page":"247","article-title":"Comparison of the efficacy of allograft and hydroxyapatite with L-PRF in horizontal and vertical augmentation","volume":"86","author":"Lee","year":"2015","journal-title":"J. Periodontol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"5474","DOI":"10.1016\/j.biomaterials.2005.02.002","article-title":"Porosity of 3D biomaterial scaffolds and osteogenesis","volume":"26","author":"Karageorgiu","year":"2005","journal-title":"Biomaterials"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Anis, M., Abdelrahman, A.R., Attia, R., and Zahran, A. (2024). Tomographic assessment of bone changes in atrophic maxilla treated by split-crest technique and dental implants with platelet-rich fibrin and NanoBone\u00ae versus platelet-rich fibrin alone: Randomized controlled trial. BMC Oral Health, 24.","DOI":"10.1186\/s12903-024-04420-5"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"e20240020","DOI":"10.1590\/1807-2577.02024","article-title":"Tomographic assessment of bone volume changes following regeneration with titanium Mesh in the maxillary aanterior region. A retrospective clinical study","volume":"53","author":"Rocha","year":"2024","journal-title":"Rev. Odontol. UNESP"},{"key":"ref_15","first-page":"9065423","article-title":"The Use of Titanium Mesh in Guided Bone Regeneration: A Systematic Review","volume":"7","author":"Briguglio","year":"2019","journal-title":"Int. J. Dent."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1111\/jcpe.12601","article-title":"Histological analysis and gene expression profile following augmentation of the anterior maxilla using rhBMP-2\/ACS versus autogenous bone graft","volume":"43","author":"Susin","year":"2016","journal-title":"J. Clin. Periodontol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e2347","DOI":"10.1097\/GOX.0000000000002347","article-title":"Safety and Efficacy of Recombinant Human Bone Morphogenetic Protein-2 (rhBMP-2) in Craniofacial Surgery","volume":"7","author":"Ramly","year":"2019","journal-title":"Plast. Reconstr. Surg. Glob. Open"},{"key":"ref_18","first-page":"272","article-title":"The All-on-Four\u00ae treatment concept for the edentulous maxilla: A case report","volume":"33","author":"Malo","year":"2007","journal-title":"J. Oral Implantol."},{"key":"ref_19","first-page":"535","article-title":"The All-on-Four concept: A treatment for the edentulous maxilla","volume":"15","author":"Malo","year":"2013","journal-title":"Clin. Implant. Dent. Relat. Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1111\/cid.12068","article-title":"The All-on-Four Treatment Concept: A Systematic Review","volume":"16","author":"Patzelt","year":"2014","journal-title":"Clin. Implant Dent. Relat. 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