{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T01:39:59Z","timestamp":1782178799740,"version":"3.54.5"},"reference-count":51,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2024,12,7]],"date-time":"2024-12-07T00:00:00Z","timestamp":1733529600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioengineering"],"abstract":"<jats:p>Introduction: 3D printing technology has gained considerable interest in the domain of orbital illnesses owing to its capacity to transform diagnosis, surgery planning, and treatment. This systematic review seeks to deliver a thorough examination of the contemporary applications of 3D printing in the treatment of ocular problems, encompassing tumors, injuries, and congenital defects. This systematic review of recent studies has examined the application of patient-specific 3D-printed models for preoperative planning, personalized implants, and prosthetics. Methods: This systematic review was conducted according to the PRISMA guidelines. The PICOS is \u201cWhat are the current advances and applications of 3D printing for the management of orbital pathology?\u201d The databases analyzed for the research phase are MEDLINE, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), ClinicalTrials.gov, ScienceDirect, Scopus, CINAHL, and Web of Science. Results: Out of 314 studies found in the literature, only 12 met the inclusion and exclusion criteria. From the included studies, it is evident that 3D printing can be a useful technology for the management of trauma and oncological pathologies of the orbital region. Discussion: 3D printing proves to be very useful mainly for the purpose of improving the preoperative planning of a surgical procedure, allowing for better preparation by the surgical team and a reduction in operative time and complications. Conclusions: 3D printing has proven to be an outstanding tool in the management of orbit pathology. Comparing the advantages and disadvantages of such technology, the former far outweigh the latter.<\/jats:p>","DOI":"10.3390\/bioengineering11121238","type":"journal-article","created":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T04:01:37Z","timestamp":1733716897000},"page":"1238","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Progress in 3D Printing Applications for the Management of Orbital Disorders: A Systematic Review"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-6691-0304","authenticated-orcid":false,"given":"Luca","family":"Michelutti","sequence":"first","affiliation":[{"name":"Clinic of Maxillofacial Surgery, Head-Neck and NeuroScience Department, University Hospital of Udine, 33100 Udine, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8395-5272","authenticated-orcid":false,"given":"Alessandro","family":"Tel","sequence":"additional","affiliation":[{"name":"Clinic of Maxillofacial Surgery, Head-Neck and NeuroScience Department, University Hospital of Udine, 33100 Udine, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Robiony","sequence":"additional","affiliation":[{"name":"Clinic of Maxillofacial Surgery, Head-Neck and NeuroScience Department, University Hospital of Udine, 33100 Udine, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Sembronio","sequence":"additional","affiliation":[{"name":"Clinic of Maxillofacial Surgery, Head-Neck and NeuroScience Department, University Hospital of Udine, 33100 Udine, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Nocini","sequence":"additional","affiliation":[{"name":"Section of Ear Nose and throat (ENT), Department of Medical and Surgical Sciences, Dentistry, Gynecology and Pediatrics, University of Verona, 37124 Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6463-5000","authenticated-orcid":false,"given":"Edoardo","family":"Agosti","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Piazza Spedali Civili 1, 25123 Brescia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3741-0639","authenticated-orcid":false,"given":"Tamara","family":"Ius","sequence":"additional","affiliation":[{"name":"Neurosurgery Unit, Head-Neck and NeuroScience Department, University Hospital of Udine, p.le S. Maria della Misericordia 15, 33100 Udine, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8424-0068","authenticated-orcid":false,"given":"Caterina","family":"Gagliano","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, University of Enna \u201cKore\u201d, Piazza dell\u2019Universit\u00e0, 94100 Enna, Italy"},{"name":"Mediterranean Foundation \u201cG.B. Morgagni\u201d, 95125 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0999-5545","authenticated-orcid":false,"given":"Marco","family":"Zeppieri","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University Hospital of Udine, 33100 Udine, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,7]]},"reference":[{"key":"ref_1","first-page":"e37","article-title":"Three-Dimensional Printing Surgical Applications","volume":"15","author":"AlAli","year":"2015","journal-title":"Eplasty"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2309499016684077","DOI":"10.1177\/2309499016684077","article-title":"The Use of Three-Dimensional Printing Technology in Orthopaedic Surgery","volume":"25","author":"Wong","year":"2017","journal-title":"J. Orthop. Surg. 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