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Materials and methods: Three-dimensional facial soft tissue data were obtained for 24 patients. The wireframe template was established by identifying 34 facial landmarks and then forming a template on the face with the MeshLab 2020 software. The angle asymmetry index was automatically scored using the template. The mirroring and overlapping technique is accepted as the golden standard method to diagnose facial asymmetry by acquiring deviation values of one\u2019s face. Consistency rates between the two methodologies were determined through a statistical comparison of the angle asymmetry index and deviation values. Results: Overall consistency rates in the labial, mandibular angle, cheek, chin, and articular regions were 87.5%, 95.8%, 87.5%, 91.7%, and 100%, respectively. Regions with consistency rates in three dimensions of more than 85% are the x-axis and the z-axis of all regions and the y-axis of the mandibular angle, chin, and articular region. Conclusions: Soft tissue facial asymmetry can be diagnosed accurately and effectively by using a three-dimensional soft tissue spatial angle wireframe template. Precise localization of asymmetry can be offered, and indiscernible tiny asymmetry can be identified.<\/jats:p>","DOI":"10.3390\/bioengineering12010079","type":"journal-article","created":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T10:44:23Z","timestamp":1737024263000},"page":"79","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Comparison of Mirroring and Overlapping Analysis and Three-Dimensional Soft Tissue Spatial Angle Wireframe Template in Evaluating Facial Asymmetry"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-8583-9068","authenticated-orcid":false,"given":"Gengchen","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Orthodontics, Peking University School and Hospital of Stomatology, National Center of Stomatology, Beijing 100081, China"},{"name":"National Clinical Research Center for Oral Diseases, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing 100081, China"},{"name":"Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Lyu","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Peking University School and Hospital of Stomatology, National Center of Stomatology, Beijing 100081, China"},{"name":"National Clinical Research Center for Oral Diseases, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing 100081, China"},{"name":"Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aonan","family":"Wen","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Oral Diseases, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing 100081, China"},{"name":"Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China"},{"name":"Center of Digital Dentistry, Department of Prosthodontics, Peking University School and Hospital of Stomatology, National Center of Stomatology, Beijing 100081, China"},{"name":"Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health, Beijing 100081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijiao","family":"Zhao","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Oral Diseases, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing 100081, China"},{"name":"Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China"},{"name":"Center of Digital Dentistry, Department of Prosthodontics, Peking University School and Hospital of Stomatology, National Center of Stomatology, Beijing 100081, China"},{"name":"Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health, Beijing 100081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Wang","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Oral Diseases, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing 100081, China"},{"name":"Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China"},{"name":"Center of Digital Dentistry, Department of Prosthodontics, Peking University School and Hospital of Stomatology, National Center of Stomatology, Beijing 100081, China"},{"name":"Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health, Beijing 100081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Peking University School and Hospital of Stomatology, National Center of Stomatology, Beijing 100081, China"},{"name":"National Clinical Research Center for Oral Diseases, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing 100081, China"},{"name":"Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huichun","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Peking University School and Hospital of Stomatology, National Center of Stomatology, Beijing 100081, China"},{"name":"National Clinical Research Center for Oral Diseases, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing 100081, China"},{"name":"Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingjin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Peking University School and Hospital of Stomatology, National Center of Stomatology, Beijing 100081, China"},{"name":"National Clinical Research Center for Oral Diseases, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing 100081, China"},{"name":"Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Peking University School and Hospital of Stomatology, National Center of Stomatology, Beijing 100081, China"},{"name":"National Clinical Research Center for Oral Diseases, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing 100081, China"},{"name":"Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Peking University School and Hospital of Stomatology, National Center of Stomatology, Beijing 100081, China"},{"name":"National Clinical Research Center for Oral Diseases, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing 100081, China"},{"name":"Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7625-4600","authenticated-orcid":false,"given":"Dawei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Peking University School and Hospital of Stomatology, National Center of Stomatology, Beijing 100081, China"},{"name":"National Clinical Research Center for Oral Diseases, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing 100081, China"},{"name":"Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,16]]},"reference":[{"key":"ref_1","first-page":"341","article-title":"Facial asymmetry: Etiology, evaluation, and management","volume":"34","author":"Cheong","year":"2011","journal-title":"Chang Gung Med. 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