{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:41:09Z","timestamp":1791229269208,"version":"4.1.0"},"reference-count":30,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T00:00:00Z","timestamp":1744156800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"China International Medical Exchange Foundation","award":["No. Z-2017-24-2028-20"],"award-info":[{"award-number":["No. Z-2017-24-2028-20"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioengineering"],"abstract":"<jats:p>Objective: To explore the synergistic effect of HA380 hemoperfusion adsorbent combined with continuous veno-venous hemodiafiltration (CVVHDF) in the treatment of septic shock. Patients and methods: This retrospective study included 56 adult septic shock patients who underwent blood purification treatment in the Surgical Intensive Care Unit (SICU) of Third Affiliated Hospital of Sun Yat-sen University from 1 September 2022 to 1 April 2024. Twenty patients received a combination therapy of HA380 hemoperfusion and CVVHDF, while 36 patients received only CVVHDF treatment. Inflammatory markers such as white blood cells (WBC), procalcitonin (PCT), and interleukin-6 (IL-6) were evaluated. Changes in acute physiology and chronic health status evaluation system (APACHE II) scores, sequential organ failure (SOFA) scores, and outcomes at 7 and 28 days after treatment were recorded. Result: After 24 h of treatment, the levels of PCT and IL-6 in the combined group decreased significantly (p &lt; 0.05). The 7-day and 28-day mortality rates of the combined group were 25% and 30%, respectively, while the mortality rates of the CVVHDF group were 27.8% and 50%, respectively. Conclusion: HA380 hemoperfusion combined with CVVHDF was safe and effective in treating patients with septic shock.<\/jats:p>","DOI":"10.3390\/bioengineering12040400","type":"journal-article","created":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T05:03:07Z","timestamp":1744174987000},"page":"400","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["HA380 Hemoperfusion Combined with Continuous Veno-Venous Hemodiafiltration for the Treatment of Septic Shock"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7869-1137","authenticated-orcid":false,"given":"Yuling","family":"An","sequence":"first","affiliation":[{"name":"Department of Surgical Intensive Care Unit (SICU), Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Surgical Intensive Care Unit (SICU), Fuwai Yunnan Cardiovascular Hospital, No.528, Shahe North Road, Kunming 650021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjuan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Surgical Intensive Care Unit (SICU), Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinqin","family":"He","sequence":"additional","affiliation":[{"name":"Department of Surgical Intensive Care Unit (SICU), Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Surgical Intensive Care Unit (SICU), Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6830-7012","authenticated-orcid":false,"given":"Xin","family":"Sui","sequence":"additional","affiliation":[{"name":"Department of Surgical Intensive Care Unit (SICU), Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomeng","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Surgical Intensive Care Unit (SICU), Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huimin","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Surgical Intensive Care Unit (SICU), Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)","volume":"315","author":"Singer","year":"2016","journal-title":"JAMA"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1007\/s00134-020-06151-x","article-title":"Incidence and mortality of hospital- and ICU-treated sepsis: Results from an updated and expanded systematic review and meta-analysis","volume":"46","author":"Mellhammar","year":"2020","journal-title":"Intensive Care Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1159\/000510982","article-title":"Effect of Extracorporeal Blood Purification on Mortality in Sepsis: A Meta-Analysis and Trial Sequential Analysis","volume":"50","author":"Snow","year":"2021","journal-title":"Blood Purif."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"e1063","DOI":"10.1097\/CCM.0000000000005337","article-title":"Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021","volume":"49","author":"Evans","year":"2021","journal-title":"Crit. Care Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1007\/s10047-017-0970-9","article-title":"Differences in CVVH vs. CVVHDF in the management of sepsis-induced acute kidney injury in critically ill patients","volume":"20","author":"Premuzic","year":"2017","journal-title":"J. Artif. Organs"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"488","DOI":"10.21037\/atm.2020.03.48","article-title":"The therapeutic effect of high-volume hemofiltration on sepsis: A systematic review and meta-analysis","volume":"8","author":"Yin","year":"2020","journal-title":"Ann. Transl. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1007\/s00134-022-06810-1","article-title":"Hemoperfusion in the intensive care unit","volume":"48","author":"Ricci","year":"2022","journal-title":"Intensive Care Med."},{"key":"ref_8","first-page":"8112","article-title":"The effect of HA330 hemoperfusion adsorbent method on inflammatory markers and end-organ damage levels in sepsis: A retrospective single center study","volume":"26","author":"Erkurt","year":"2022","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e19058","DOI":"10.1097\/MD.0000000000019058","article-title":"Clinical effects of hemoperfusion combined with pulse high-volume hemofiltration on septic shock","volume":"99","author":"Chu","year":"2020","journal-title":"Medicine"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1159\/000507013","article-title":"Use of Fluoride as a Marker Solute to Quantify the Current Effective Delivered Dose in Continuous Renal Replacement Therapy: An \u201cin vitro\u201d Study","volume":"49","author":"Villa","year":"2020","journal-title":"Blood Purif."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"c179","DOI":"10.1159\/000339789","article-title":"KDIGO clinical practice guidelines for acute kidney injury","volume":"120","author":"Khwaja","year":"2012","journal-title":"Nephron Clin. Pract."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"R4","DOI":"10.1186\/cc3913","article-title":"A comparison of admission and worst 24-hour Acute Physiology and Chronic Health Evaluation II scores in predicting hospital mortality: A retrospective cohort study","volume":"10","author":"Ho","year":"2006","journal-title":"Crit. Care"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s13613-020-0648-y","article-title":"Prescription of CRRT: A pathway to optimize therapy","volume":"10","author":"Karkar","year":"2020","journal-title":"Ann. Intensive Care"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1097\/MCC.0000000000000890","article-title":"Blood purification in sepsis and systemic inflammation","volume":"27","author":"Feng","year":"2021","journal-title":"Curr. Opin. Crit. Care"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Hellman, T., Uusalo, P., and Jarvisalo, M.J. (2021). Renal Replacement Techniques in Septic Shock. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms221910238"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"3964","DOI":"10.12659\/MSM.916767","article-title":"Effect of High-Volume Hemofiltration in Critically Ill Patients: A Systematic Review and Meta-Analysis","volume":"25","author":"Junhai","year":"2019","journal-title":"Med. Sci. Monit."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1093\/pcmedi\/pbab005","article-title":"Blood purification for sepsis: An overview","volume":"4","author":"Zhang","year":"2021","journal-title":"Precis. Clin. Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1159\/000505565","article-title":"Efficacy of HA330 Hemoperfusion Adsorbent in Patients Followed in the Intensive Care Unit for Septic Shock and Acute Kidney Injury and Treated with Continuous Venovenous Hemodiafiltration as Renal Replacement Therapy","volume":"49","author":"Kacar","year":"2020","journal-title":"Blood Purif."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"3029","DOI":"10.3892\/etm.2017.4854","article-title":"Blood purification treatment initiated at the time of sepsis diagnosis effectively attenuates serum HMGB1 upregulation and improves patient prognosis","volume":"14","author":"Zheng","year":"2017","journal-title":"Exp. Ther. Med."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1159\/000489921","article-title":"Biocompatibility and Cytotoxic Evaluation of New Sorbent Cartridges for Blood Hemoperfusion","volume":"46","author":"Ankawi","year":"2018","journal-title":"Blood Purif."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/s41392-021-00679-0","article-title":"The signal pathways and treatment of cytokine storm in COVID-19","volume":"6","author":"Yang","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"6515","DOI":"10.12998\/wjcc.v11.i27.6515","article-title":"Blood purification for treatment of non-liquefied multiple liver abscesses and improvement of T-cell function: A case report","volume":"11","author":"Tang","year":"2023","journal-title":"World J. Clin. Cases"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1159\/000514149","article-title":"The Efficacy of Resin Hemoperfusion Cartridge on Inflammatory Responses during Adult Cardiopulmonary Bypass","volume":"51","author":"He","year":"2022","journal-title":"Blood Purif."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1097\/SHK.0000000000000305","article-title":"Procalcitonin Levels in Survivors and Nonsurvivors of Sepsis: Systematic Review and Meta-Analysis","volume":"43","author":"Arora","year":"2015","journal-title":"Shock"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1186\/s13054-023-04750-w","article-title":"Prognostic differences in sepsis caused by gram-negative bacteria and gram-positive bacteria: A systematic review and meta-analysis","volume":"27","author":"Tang","year":"2023","journal-title":"Crit. Care"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"156056","DOI":"10.1016\/j.cyto.2022.156056","article-title":"Alterations in levels of cytokine following treatment to predict outcome of sepsis: A meta-analysis","volume":"161","author":"Li","year":"2023","journal-title":"Cytokine"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Brain, M., Winson, E., Roodenburg, O., and McNeil, J. (2017). Non anti-coagulant factors associated with filter life in continuous renal replacement therapy (CRRT): A systematic review and meta-analysis. BMC Nephrol., 18.","DOI":"10.1186\/s12882-017-0445-5"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s13054-023-04323-x","article-title":"Cytokine hemoadsorption with CytoSorb((R)) in post-cardiac arrest syndrome, a pilot randomized controlled trial","volume":"27","author":"Monard","year":"2023","journal-title":"Crit. Care"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1097\/CCM.0000000000002826","article-title":"Treatment Outcome of Combined Continuous Venovenous Hemofiltration and Hemoperfusion in Acute Paraquat Poisoning: A Prospective Controlled Trial","volume":"46","author":"Li","year":"2018","journal-title":"Crit. Care Med."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s13054-025-05284-z","article-title":"Sorbents therapies in burn patients with septic shock on continuous kidney replacement therapy: An added value for a selected population","volume":"29","author":"Mariano","year":"2025","journal-title":"Crit. Care"}],"container-title":["Bioengineering"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2306-5354\/12\/4\/400\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:12:55Z","timestamp":1760029975000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2306-5354\/12\/4\/400"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,9]]},"references-count":30,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,4]]}},"alternative-id":["bioengineering12040400"],"URL":"https:\/\/doi.org\/10.3390\/bioengineering12040400","relation":{},"ISSN":["2306-5354"],"issn-type":[{"value":"2306-5354","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,9]]}}}